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公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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Patent Agency Ranking
公开(公告)号：US20170182496A1
公开(公告)日：2017-06-29
申请号：US15457633
申请日：2017-03-13
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald Danehy , Jorge Fonseca , Jayanthi Prasad
CPC classification number: B01L3/56 , B01L3/0275 , B01L3/0293 , B01L2200/025 , B01L2300/161 , G01N35/1011 , G01N35/1074 , G01N2035/103
Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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公开(公告)号：US09604218B2
公开(公告)日：2017-03-28
申请号：US14020390
申请日：2013-09-06
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald Danehy , Jorge Fonseca , Jayanthi Prasad
CPC classification number: B01L3/56 , B01L3/0275 , B01L3/0293 , B01L2200/025 , B01L2300/161 , G01N35/1011 , G01N35/1074 , G01N2035/103
Abstract: A system for preparing biological sample contains a body including a proximal side and a distal side, a plurality of mandrels, a plurality of resilient elements, a plurality of fluid dispensers, and one or more samples. The mandrels are moveably positioned within the body, where each resilient element engages a respective one of the mandrels. Each of the fluid dispensers is configured to engage a distal end of a corresponding one of the mandrels. Each sample comprises a solution containing one or more nucleic acid sequences contained within at least one of the fluid dispensers.
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公开(公告)号：US20150080247A1
公开(公告)日：2015-03-19
申请号：US14385730
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan W. Foster , Jorge Fonseca , Kevin Maher
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
Abstract translation: 提供了用于进行生物反应的系统。 该系统包括包括基底和多个反应位点的芯片。 多个反应位点各自被配置为包括至多一个纳升级的液体样品。 此外，该系统包括被配置为启动液体样品内的生物反应的控制系统。 该系统还包括被配置为检测芯片上的生物反应的检测系统。 根据各种实施方案，芯片包括至少20000个反应位点。 在其它实施方案中，芯片包括至少30000个反应位点。
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：USD699369S1
公开(公告)日：2014-02-11
申请号：US29448100
申请日：2013-03-08
Applicant: Life Technologies Corporation
Designer： Jorge Fonseca
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