公开(公告)号：US10349872B2

公开(公告)日：2019-07-16

申请号：US14980260

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Yunfeng Lu ,  Jay Mung

IPC: A61B5/00 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/053

Abstract: A single, optimal, fused sensor glucose value may be calculated based on respective sensor glucose values of a plurality of redundant working electrodes (WEs) of a glucose sensor. Respective electrochemical impedance spectroscopy (EIS) procedures may be performed for each of the WEs to obtain values of membrane resistance (Rmem) for each WE. A noise value and a calibration factor (CF) value may be calculated for each WE, and respective fusion weights may be calculated for Rmem, noise, and CF for each WE. An overall fusion weight may then be calculated based on the WE's Rmem fusion weight, noise fusion weight, and CF fusion weight, such that a single, optimal, fused sensor glucose value may be calculated based on the respective overall fusion weight and sensor glucose value of each of the plurality of redundant working electrodes.

公开(公告)号：US20170185733A1

公开(公告)日：2017-06-29

申请号：US14980293

申请日：2015-12-28

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Keith Nogueira ,  Taly G. Engel ,  Benyamin Grosman ,  Xiaolong Li ,  Bradley C. Liang ,  Rajiv Shah ,  Mike C. Liu ,  Andy Y. Tsai ,  Andrea Varsavsky ,  Jeffrey Nishida

IPC: G06F19/00 ,  G06N3/12 ,  G06N99/00

CPC classification number: G06N20/00 ,  A61B5/14532 ,  A61B5/14735 ,  A61B5/1495 ,  A61B5/6849 ,  G06N3/126 ,  G16H40/40

Abstract: A method for retrospective calibration of a glucose sensor uses stored values of measured working electrode current (Isig) to calculate a final sensor glucose (SG) value retrospectively. The Isig values may be preprocessed, discrete wavelet decomposition applied. At least one machine learning model, such as, e.g., Genetic Programming (GP) and Regression Decision Tree (DT), may be used to calculate SG values based on the Isig values and the discrete wavelet decomposition. Other inputs may include, e.g., counter electrode voltage (Vcntr) and Electrochemical Impedance Spectroscopy (EIS) data. A plurality of machine learning models may be used to generate respective SG values, which are then fused to generate a fused SG. Fused SG values may be filtered to smooth the data, and blanked if necessary.

公开(公告)号：US09603561B2

公开(公告)日：2017-03-28

申请号：US14260755

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/1495 ,  A61B5/145 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US20150164383A1

公开(公告)日：2015-06-18

申请号：US14260948

申请日：2014-04-24

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1495 ,  A61B5/1459 ,  A61M5/172 ,  A61B5/00 ,  A61M5/142 ,  A61B5/145 ,  A61B5/1473

CPC classification number: A61B5/14532 ,  A61B5/0004 ,  A61B5/14503 ,  A61B5/1455 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/7221 ,  A61B5/7278 ,  A61B2560/0223 ,  A61B2560/0238 ,  A61B2562/06 ,  A61M5/142 ,  A61M5/14244 ,  A61M5/1723 ,  A61M2005/1726 ,  A61M2205/3306 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/50 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/005 ,  A61M2230/201 ,  C12Q1/006 ,  G01N21/00 ,  G01N21/59 ,  G01N21/84 ,  G01N27/27 ,  G01N27/3274 ,  G01N27/4163 ,  G01N33/49 ,  G01N33/66 ,  G01N2201/127

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US12114972B2

公开(公告)日：2024-10-15

申请号：US16773422

申请日：2020-01-27

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Georgios Mallas ,  Andrea Varsavsky ,  Peter Ajemba ,  Jeffrey Nishida ,  Keith Nogueira ,  Elaine Gee ,  Leonardo Nava-Guerra ,  Jing Liu ,  Sadaf S. Seleh ,  Taly G. Engel ,  Benyamin Grosman ,  Steven Lai ,  Luis A. Torres ,  Chi A. Tran ,  David M. Sniecinski

IPC: A61B5/145 ,  A61B5/1468

CPC classification number: A61B5/14532 ,  A61B5/1468 ,  A61B2560/0223 ,  A61B2562/16

Abstract: A continuous glucose monitoring system may utilize electrode current (Isig) signals, Electrochemical Impedance Spectroscopy (EIS), and Vcntr values to optimize sensor glucose (SG) calculation in such a way as to enable reduction of the need for blood glucose (BG) calibration requests from users.

公开(公告)号：US11642454B2

公开(公告)日：2023-05-09

申请号：US16893145

申请日：2020-06-04

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Chia-Hung Chiu ,  Rebecca K. Gottlieb ,  Ellis Garai ,  Akhil Srinivasan ,  Andrea Varsavsky ,  Adam S. Trock ,  Ashwin K. Rao ,  Hsifu Wang ,  Daniel E. Pesantez ,  Isabella Ella Miya ,  Xinrui Zhang ,  Guruguhan Meenakshisundaram

IPC: A61M5/172 ,  A61M5/142 ,  A61M39/10 ,  A61M5/162 ,  A61M37/00 ,  A61M5/168

CPC classification number: A61M5/14248 ,  A61M5/162 ,  A61M5/16831 ,  A61M5/1723 ,  A61M37/0015 ,  A61M39/10 ,  A61M2005/14252 ,  A61M2037/0023 ,  A61M2205/50 ,  A61M2205/8206 ,  A61M2205/8243 ,  A61M2230/201

Abstract: A fluid infusion system includes a housing configured to be adhesively coupled to an anatomy of the user. The housing comprises a communication device configured to wirelessly communicate a physiological characteristic to a communication component of a fluid infusion device. The fluid infusion system includes a fluid flow path from the fluid infusion device into the anatomy of the user, and the fluid flow path is configured to extend from the housing for insertion into the anatomy of the user.

公开(公告)号：US11406295B2

公开(公告)日：2022-08-09

申请号：US16522062

申请日：2019-07-25

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Xiaolong Li ,  Mike C. Liu ,  Yuxiang Zhong ,  Ning Yang

IPC: A61B5/1455 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61B5/1468 ,  G01N21/00 ,  G01N27/416 ,  G01N33/49 ,  G01N33/66 ,  G01N21/84 ,  G01N27/27 ,  C12Q1/00 ,  G01N21/59 ,  G01N27/327

Abstract: Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.

公开(公告)号：US11382527B2

公开(公告)日：2022-07-12

申请号：US17115752

申请日：2020-12-08

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Andrea Varsavsky ,  Fei Yu ,  Ning Yang

IPC: A61B5/0537 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/00 ,  A61M5/158 ,  A61B5/0538 ,  A61B5/1473 ,  A61B5/1495 ,  A61B5/1486 ,  G01N27/02 ,  A61M5/172 ,  A61M5/142

Abstract: Electrochemical Impedance Spectroscopy (EIS) is used in conjunction with continuous glucose monitors and continuous glucose monitoring (CGM) to enable in-vivo sensor calibration, gross (sensor) failure analysis, and intelligent sensor diagnostics and fault detection. An equivalent circuit model is defined, and circuit elements are used to characterize sensor behavior.

公开(公告)号：US20220095964A1

公开(公告)日：2022-03-31

申请号：US17546112

申请日：2021-12-09

Applicant: Medtronic MiniMed, Inc.

Inventor： Jeffrey Nishida ,  Andrea Varsavsky ,  Taly G. Engel ,  Keith Nogueira ,  Andy Y. Tsai ,  Peter Ajemba

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  G01N27/327

Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.

公开(公告)号：US11213230B2

公开(公告)日：2022-01-04

申请号：US15840515

申请日：2017-12-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Jeffrey Nishida ,  Andrea Varsavsky ,  Taly G. Engel ,  Keith Nogueira ,  Andy Y. Tsai ,  Peter Ajemba

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  G01N27/327 ,  A61M5/172 ,  A61B5/1486

Abstract: A method for optional external calibration of a calibration-free glucose sensor uses values of measured working electrode current (Isig) and EIS data to calculate a final sensor glucose (SG) value. Counter electrode voltage (Vcntr) may also be used as an input. Raw Isig and Vcntr values may be preprocessed, and low-pass filtering, averaging, and/or feature generation may be applied. SG values may be generated using one or more models for predicting SG calculations. When an external blood glucose (BG) value is available, the BG value may also be used in calculating the SG values. A SG variance estimate may be calculated for each predicted SG value and modulated, with the modulated SG values then fused to generate a fused SG. A Kalman filter, as well as error detection logic, may be applied to the fused SG value to obtain a final SG, which is then displayed to the user.