公开(公告)号：US20100267048A1

公开(公告)日：2010-10-21

申请号：US12740857

申请日：2008-10-29

申请人： Hirotaka Tanaka ,  Masanori Tanaka ,  Chizu Asahara ,  Fumihisa Kitawaki

发明人： Hirotaka Tanaka ,  Masanori Tanaka ,  Chizu Asahara ,  Fumihisa Kitawaki

IPC分类号： G01N33/53 ,  C12M1/34

CPC分类号： G01N33/721 ,  G01N33/541 ,  G01N33/543 ,  G01N33/723 ,  G01N33/726 ,  Y10T436/105831 ,  Y10T436/25125 ,  Y10T436/2525 ,  Y10T436/25375

摘要： Hemoglobin in a sample solution is quickly and reliably denatured; at the same time, quick and accurate measurement of hemoglobin and a hemoglobin derivative is realized. In a method for measuring hemoglobin and a hemoglobin derivative, and a reagent composition, a measurement kit, an analysis device, and an analysis system used in the method, a sample solution containing a blood component is treated with a nonionic surfactant, an oxidizing agent, and a metal salt to denature hemoglobin in the sample solution to measure the hemoglobin, and thereafter the amount of a hemoglobin derivative in the sample is measured by an immunological method using an antibody specifically binding to a denatured site of the denatured hemoglobin derivative.

摘要翻译： 样品溶液中的血红蛋白迅速可靠地变性; 同时，实现血红蛋白和血红蛋白衍生物的快速准确测定。 在本方法中使用的血红蛋白和血红蛋白衍生物，试剂组合物，测定试剂盒，分析装置和分析系统的测定方法中，将含有血液成分的试样溶液用非离子性表面活性剂，氧化剂 和金属盐，使样品溶液中的血红蛋白变性，测定血红蛋白，然后用特异性结合变性血红蛋白衍生物的变性部位的抗体的免疫学方法测定样品中的血红蛋白衍生物的量。

公开(公告)号：US07754151B2

公开(公告)日：2010-07-13

申请号：US11910513

申请日：2006-03-24

申请人： Fumihisa Kitawaki ,  Hirotaka Tanaka ,  Kenji Watanabe

发明人： Fumihisa Kitawaki ,  Hirotaka Tanaka ,  Kenji Watanabe

IPC分类号： G01N9/30

CPC分类号： B01F3/08 ,  B01F13/0059 ,  B01F15/0233 ,  B01F2215/0037 ,  G01N21/07 ,  G01N35/00069 ,  G01N2035/00495 ,  G01N2035/00524 ,  Y10T436/111666 ,  Y10T436/2575

摘要： Herein disclosed is a liquid homogenizer for mixing two or more liquids, comprising: a rotator (1) rotatable around a rotation axis; at least two liquid-mixing chambers (6, 10) formed in the rotator, and being different from each other in distance from the rotation axis; and at least two channels (8) through which one of the liquid-mixing chambers is communicated with the other of the liquid-mixing chambers (6, 10), wherein the liquid-mixing chambers (6, 10) include an outer liquid-mixing chamber (10) and an inner liquid-mixing chamber (6) close to the rotation axis in comparison with the outer liquid-mixing chamber, when the rotator (1) is rotating around the rotation axis, the liquids are shifted by a centrifugal force to the outer liquid-mixing chamber from the inner liquid-mixing chamber through the channels (8), and agitated to be mixed by turbulent flows in the outer liquid-mixing chamber.

摘要翻译： 本文公开了一种用于混合两种或更多种液体的液体均化器，包括：可围绕旋转轴线旋转的旋转体（1） 形成在旋转体中的至少两个液体混合室（6,10），并且与旋转轴线的距离彼此不同; 和至少两个通道（8），其中一个液体混合室通过该通道与另一个液体混合室（6,10）连通，其中液体混合室（6,10）包括外部液体 - 混合室（10）和与外部液体混合室相比靠近旋转轴线的内部混合室（6），当旋转体（1）围绕旋转轴线旋转时，液体被离心 通过通道（8）从内部液体混合室向外部液体混合室施力，并搅拌以在外部混合室中被湍流混合。

公开(公告)号：US08921052B2

公开(公告)日：2014-12-30

申请号：US11918394

申请日：2006-04-12

申请人： Hirotaka Tanaka ,  Masanori Tanaka ,  Fumihisa Kitawaki

发明人： Hirotaka Tanaka ,  Masanori Tanaka ,  Fumihisa Kitawaki

IPC分类号： G01N33/53 ,  C12M1/00 ,  G01N33/72

CPC分类号： G01N33/72 ,  G01N33/5302 ,  G01N33/721

摘要： A sample solution including blood components is processed with a denaturalization reagent comprising a nonionic surface-activating agent and an oxidizing agent to denaturalize a hemoglobin derivative in the sample solution, and thereafter, an immunoassay is performing utilizing an antibody that is specific to a denaturalized site of the hemoglobin derivative to measure the amount of the hemoglobin derivative in the sample. Therefore, when performing assay of hemoglobin derivative, denaturalization of hemoglobin can be performed speedily and reliably while minimizing adverse effects of the denaturalization reagent on immune reaction.

摘要翻译： 包含血液成分的样品溶液用包含非离子表面活性剂和氧化剂的变性试剂处理以使样品溶液中的血红蛋白衍生物变性，然后利用对变性部位特异性的抗体进行免疫测定 的血红蛋白衍生物以测量样品中血红蛋白衍生物的量。 因此，当进行血红蛋白衍生物的测定时，可以快速可靠地进行血红蛋白的变性，同时使变性反应物对免疫反应的不良影响最小化。

公开(公告)号：US20080293074A1

公开(公告)日：2008-11-27

申请号：US11918394

申请日：2006-04-12

申请人： Hirotaka Tanaka ,  Masanori Tanaka ,  Fumihisa Kitawaki

发明人： Hirotaka Tanaka ,  Masanori Tanaka ,  Fumihisa Kitawaki

IPC分类号： G01N33/53 ,  C12M1/00

CPC分类号： G01N33/72 ,  G01N33/5302 ,  G01N33/721

摘要： A sample solution including blood components is processed with a denaturalization reagent comprising a nonionic surface-activating agent and an oxidizing agent to denaturalize a hemoglobin derivative in the sample solution, and thereafter, an immunoassay is performing utilizing an antibody that is specific to a denaturalized site of the hemoglobin derivative to measure the amount of the hemoglobin derivative in the sample. Therefore, when performing assay of hemoglobin derivative, denaturalization of hemoglobin can be performed speedily and reliably while minimizing adverse effects of the denaturalization reagent on immune reaction.

摘要翻译： 包含血液成分的样品溶液用包含非离子表面活性剂和氧化剂的变性试剂处理以使样品溶液中的血红蛋白衍生物变性，然后利用对变性部位特异性的抗体进行免疫测定 的血红蛋白衍生物以测量样品中血红蛋白衍生物的量。 因此，当进行血红蛋白衍生物的测定时，可以快速可靠地进行血红蛋白的变性，同时使变性反应物对免疫反应的不良影响最小化。

公开(公告)号：US20070292964A1

公开(公告)日：2007-12-20

申请号：US11574315

申请日：2005-09-08

申请人： Fumihisa Kitawaki ,  Hirotaka Tanaka

发明人： Fumihisa Kitawaki ,  Hirotaka Tanaka

IPC分类号： G01N21/17

CPC分类号： B01L3/502715 ,  B01L2300/0636 ,  B01L2300/0806 ,  B01L2400/0409 ,  G01N21/59 ,  G01N33/54373 ,  G01N35/00069

摘要： Herein disclosed is a measuring equipment, comprising: a light source (13); a light receiving unit (14) disposed in spaced relationship with the light source (13); a device (11) disposed between the light source (13) and the light receiving unit (14); the device (11) having a reaction part (12) for accommodating therein a solid phase support (121), a test substance in a specimen, and a test reagent operative to react with any one of the solid phase support (121) and the test substance, the solid phase support (121) having a surface having a specific binding substance fixed thereon, the specific binding substance being specifically reactive with the test substance, in which, the specific binding substance is adapted to have a plurality of concavities and convexities (123) formed on the solid phase support with the test reagent and the test substance introduced into the reaction part (12) and reacted with each other, the light source (13) is operative to produce a light to transmit through the solid phase support (121) and scan the device (11), the light transmitted through the solid phase support (121) having a signal indicative of the concavities and convexities (123) on the solid phase support (121), the signal of the light indicative of the concavities and convexities (123) transmitted through the solid phase support (121) being detected by the light receiving unit (14).

摘要翻译： 本文公开了一种测量设备，包括：光源（13）; 与光源（13）间隔开设置的光接收单元（14）; 设置在光源（13）和光接收单元（14）之间的装置（11）; 所述装置（11）具有用于容纳固相载体（121）的反应部分（12），试样中的试验物质和可与任一种固相载体（121）和 所述固体相载体（121）具有固定有特异性结合物质的表面，所述特异性结合物质与被检物质特异性反应，特异性结合物质适于具有多个凹凸 （123），其与所述测试试剂和所述测试物质在所述固相载体上形成并引入到所述反应部分（12）中并且彼此反应，所述光源（13）可操作以产生透射通过所述固相载体 （121）并扫描所述装置（11），透射通过所述固相支架（121）的光具有指示所述固相支撑件（121）上的凹凸（123）的信号，所述s 点亮由光接收单元（14）检测到的表示透过固相支撑件（121）的凹凸的光。

公开(公告)号：US20060144802A1

公开(公告)日：2006-07-06

申请号：US11317618

申请日：2005-12-23

申请人： Fumihisa Kitawaki ,  Toshihiko Yoshioka ,  Hirotaka Tanaka ,  Hirofumi Sugimoto ,  Masanori Tanaka

发明人： Fumihisa Kitawaki ,  Toshihiko Yoshioka ,  Hirotaka Tanaka ,  Hirofumi Sugimoto ,  Masanori Tanaka

IPC分类号： B01D33/15 ,  G01N1/00 ,  H01R3/08 ,  B01D61/00

CPC分类号： B01L3/502738 ,  B01F9/0014 ,  B01F13/0059 ,  B01F15/0201 ,  B01F15/0233 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502753 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0688 ,  G01N1/38 ,  G01N33/491 ,  G01N2035/1032 ,  Y10T436/25

摘要： Herein discloses is a testing device, comprising therein an inlet port introducing a blood specimen thereinto, a blood separating chamber held in fluid communication with the inlet port through a fluid passageway to receive a blood specimen, and a hemolyzed blood chamber having accommodated therein a hemolyzed blood fluid. The testing device is operative to be rotated around a rotation center and stop from being rotated to have the blood specimen accommodated in the blood separating chamber into blood cells and a blood plasma fluid, and the blood separating chamber is held in fluid communication with the passageway merging area through a fluid passageway to have the blood plasma fluid separated from the blood specimen flowed through the fluid passageway, in such a manner that the hemolyzed blood fluid is mixed and diluted with the blood plasma fluid in the passageway merging area at a predetermined dilution ratio.

摘要翻译： 本文公开了一种检测装置，其中包括将血液样本引入其中的入口端口，通过流体通道保持与入口流体连通以接收血液样本的血液分离室，以及溶血血液腔室，其中容纳有溶血的 血液 该测试装置可操作以围绕旋转中心旋转并停止旋转以使血液分离室中的血液样本容纳在血细胞和血浆中，血液分离室与通道保持流体连通 通过流体通道将血液流体从血液样本分离出流过流体通道的方式使得溶血的血液与通道合并区域中的血浆流体以预定稀释度混合和稀释 比。

公开(公告)号：US07790470B2

公开(公告)日：2010-09-07

申请号：US10588546

申请日：2005-03-23

申请人： Akihito Kamei ,  Fumihisa Kitawaki ,  Tatsurou Kawamura ,  Hiroshi Nakayama ,  Nobuyuki Shigetou

发明人： Akihito Kamei ,  Fumihisa Kitawaki ,  Tatsurou Kawamura ,  Hiroshi Nakayama ,  Nobuyuki Shigetou

IPC分类号： G01N1/00 ,  G01N33/00 ,  G01N21/00 ,  G01N15/06 ,  G01N33/53

CPC分类号： B01F5/0057 ,  B01F1/0022 ,  B01F5/0206 ,  B01F2215/0037 ,  G01N21/03 ,  G01N21/76 ,  G01N2035/00544 ,  Y10T436/25

摘要： A method capable of stirring a liquid sample and a reagent promptly and easily includes the following steps (A) and (B). In step (A), using a cell including: a liquid sample retaining section having a plurality of particles; and a liquid sample supply inlet, a liquid sample containing an analyte is supplied from the liquid sample supply inlet to the liquid sample retaining section. In step (B), the liquid sample and a specific binding substance capable of specifically binding to the analyte are stirred by the movement of the particles caused by the flow of the liquid sample in the cell resulting from the supply of the liquid sample, to obtain a liquid mixture. The electric charge of at least the surface of the particles and the electric charge of the specific binding substance have the same polarity in the liquid mixture.

摘要翻译： 能够迅速且容易地搅拌液体样品和试剂的方法包括以下步骤（A）和（B）。 在步骤（A）中，使用包括：具有多个颗粒的液体样品保留部分的细胞; 将液体试样供给口从液体试样供给口供给到液体试样保持部。 在步骤（B）中，液体样品和能够特异性结合分析物的特异性结合物质由于由液体样品供应而导致的液体样品流动引起的颗粒运动而被搅拌至 获得液体混合物。 至少颗粒表面的电荷和特定结合物质的电荷在液体混合物中具有相同的极性。

公开(公告)号：US20100096276A1

公开(公告)日：2010-04-22

申请号：US12444077

申请日：2007-10-01

申请人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

发明人： Shinki Kojima ,  Tomohiro Yamamoto ,  Fumihisa Kitawaki ,  Tetsuo Yukimasa

IPC分类号： G01N27/26

CPC分类号： G01N27/3272 ,  C12Q1/005 ,  C12Q1/006

摘要： A multicomponent analysis sensor for measuring two or more kinds of the subjects to be measured by using redox reactions, which is a multicomponent analysis sensor comprising a liquid sample inlet from which a liquid sample containing two or more kinds of the subjects to be measured is introduced, a first measurement chamber, a second measurement chamber, a first channel connecting the above-described liquid sample inlet to the above-described first measurement chamber and a second channel connecting the above-described first measurement chamber to the second measurement chamber, wherein the above-described first measurement chamber and the above-described second measurement chamber respectively have a working electrode and a counter electrode. A first reagent layer containing an enzyme and an electron transfer substance is provided in the first channel or the first chamber, while another reagent layer containing an enzyme is provided in the second channel or the second chamber.

摘要翻译： 一种多组分分析传感器，用于通过使用氧化还原反应来测量要测量的两种或更多种待测对象，所述氧化还原反应是包含液体样品入口的多组分分析传感器，其中引入含有两种或更多种待测对象的液体样品 第一测量室，第二测量室，将上述液体样品入口连接到上述第一测量室的第一通道和将上述第一测量室连接到第二测量室的第二通道，其中， 上述第一测量室和上述第二测量室分别具有工作电极和对电极。 在第一通道或第一室中设置含有酶和电子转移物质的第一试剂层，而在第二通道或第二室中设置含有酶的试剂层。

公开(公告)号：US20130231588A1

公开(公告)日：2013-09-05

申请号：US13884212

申请日：2012-04-04

申请人： Takaomi Fukuhara ,  Toshifumi Nanjo ,  Fumihisa Kitawaki

发明人： Takaomi Fukuhara ,  Toshifumi Nanjo ,  Fumihisa Kitawaki

IPC分类号： A61B10/02

CPC分类号： A61B10/02 ,  A61B10/0275

摘要： Provided is a biological tissue collecting tool capable of reducing a variation in the amount of collected biological tissue at the time of collecting the biological tissue from a biological aperture. A biological tissue collecting tool 10 according to the present invention includes: an exterior body 3 having first space formed therein and having a first collection opening 2 formed in a wall thereof, the exterior body 3 having such a shape as to be insertable in a biological aperture; a collecting portion 15 disposed in the first space such that the collecting portion 15 is movable in the first space, the collecting portion 15 being configured to collect a part of biological tissue that protrudes into the first space through the first collection opening 2; and an operating portion 7 connected to the collecting portion 15, the operating portion 7 allowing the collecting portion 15 to be operated from outside of the exterior body 3.

摘要翻译： 提供了一种生物组织收集工具，其能够减少在从生物孔收集生物组织时收集的生物组织的量的变化。 根据本发明的生物组织收集工具10包括：外部主体3，其具有形成在其中的第一空间，并且具有形成在其壁中的第一收集开口2，外部主体3具有可插入生物体的形状 光圈; 收集部15，设置在第一空间中，使得收集部15能够在第一空间中移动，收集部15构成为收集通过第一收集开口2突出到第一空间的生物体的一部分; 以及连接到收集部分15的操作部分7，允许收集部分15从外部主体3的外部操作的操作部分7。

公开(公告)号：US20100062414A1

公开(公告)日：2010-03-11

申请号：US12593986

申请日：2008-04-04

申请人： Tomohiro Yamamoto ,  Tetsuo Yukimasa ,  Ryou Hamada ,  Fumihisa Kitawaki ,  Nobuhiko Ozaki

发明人： Tomohiro Yamamoto ,  Tetsuo Yukimasa ,  Ryou Hamada ,  Fumihisa Kitawaki ,  Nobuhiko Ozaki

IPC分类号： C12Q1/00 ,  G01N31/22 ,  C12M1/34 ,  G01N21/00 ,  H01R43/00

CPC分类号： G01N33/558 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0621 ,  B01L2300/043 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/087 ,  B01L2400/0406 ,  B01L2400/0633 ,  B01L2400/0688 ,  Y10T29/49117

摘要： A sample liquid analytical chip that whilst being of simple structure, has a reaction region and a detection region isolated from each other and further has liquid feed control means for a sample liquid, thereby realizing speedy reliable analysis. The sample liquid analytical chip comprises a tubular sample liquid transfer channel with its both ends open, a reaction reagent layer disposed on the internal wall surface of the sample liquid transfer channel and a detection region for detecting any physical or chemical change of the sample liquid. In the sample liquid analytical chip, the sample liquid transfer channel at an area of its wall surface is provided an opening and a lid fitted to the opening. Portion of the lid forms a hinge in cooperation with the wall surface.

摘要翻译： 一种样品液体分析芯片，其结构简单，具有彼此隔离的反应区域和检测区域，并且还具有用于样品液体的液体进料控制装置，从而实现了快速可靠的分析。 样品液体分析芯片包括其两端打开的管状样品液体传输通道，设置在样品液体传送通道的内壁表面上的反应试剂层和用于检测样品液体的任何物理或化学变化的检测区域。 在样品液体分析芯片中，在其壁表面的区域处的样品液体输送通道设置有开口和装配到开口的盖子。 盖的一部分与壁表面配合形成铰链。