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    Replenishing urease in dialysis systems using urease pouches
    11.
    发明授权
    Replenishing urease in dialysis systems using urease pouches 有权

    公开(公告)号：US10124274B2

    公开(公告)日：2018-11-13

    申请号：US14644576

    申请日：2015-03-11

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: B01D15/20 ,  A61M1/16

    Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis using urease pouches. The sorbent cartridge is configured to allow insertion of a urease pouch or injection of a urease solution into the sorbent cartridge containing a urease pouch. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

    Replenishing urease in dialysis systems using a urease introducer
    13.
    发明授权
    Replenishing urease in dialysis systems using a urease introducer 有权

    公开(公告)号：US10016553B2

    公开(公告)日：2018-07-10

    申请号：US14633852

    申请日：2015-02-27

    Applicant: Medtronic, Inc.

    Inventor： Martin T. Gerber ,  Christopher M. Hobot

    IPC: B01D24/00 ,  A61M1/16 ,  B01D35/00

    CPC classification number: A61M1/1696

    Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The sorbent cartridge is configured to allow an amount of urease to be added to the sorbent cartridge. A urease solution can be injected into the sorbent cartridge to replenish the urease containing module, or solid urease can be added to the sorbent cartridge. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.

    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER
    17.
    发明申请
    CLONIDINE FORMULATION IN A POLYORTHOESTER CARRIER 有权
    多聚体载体中的克隆配位体

    公开(公告)号：US20150374665A1

    公开(公告)日：2015-12-31

    申请号：US14852039

    申请日：2015-09-11

    Applicant: Medtronic, Inc.

    Inventor： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    IPC: A61K31/4168 ,  A61K47/34

    CPC classification number: A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    Abstract: Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    Abstract translation: 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    METHOD AND APPARATUS FOR ZIRCONIUM OXIDE RECHARGING
    18.
    发明申请
    METHOD AND APPARATUS FOR ZIRCONIUM OXIDE RECHARGING 有权
    氧化锆补充剂的方法和装置

    公开(公告)号：US20150251161A1

    公开(公告)日：2015-09-10

    申请号：US14722068

    申请日：2015-05-26

    Applicant: MEDTRONIC, INC.

    Inventor： Bryant J. Pudil ,  Martin T. GERBER ,  Christopher M. Hobot

    IPC: B01J20/34 ,  A61M1/14 ,  B01D15/20 ,  B01J20/06

    CPC classification number: B01J20/3475 ,  A61M1/1696 ,  B01D15/203 ,  B01J20/06

    Abstract: Methods and related apparatuses for sorbent recharging are provided. The methods and related apparatuses for recharging can recharge a specific rechargeable layer of a sorbent material such as zirconium oxide and/or zirconium phosphate in a sorbent cartridge. The methods and apparatuses include passing solutions containing aqueous basic solutions through the zirconium oxide. The apparatus allows for recharging the zirconium oxide, and also for recharging zirconium phosphate, wherein the sorbent materials are contained in reusable sorbent modules.

    Abstract translation: 提供吸附剂再充电的方法和相关设备。 用于再充电的方法和相关装置可对吸附剂盒中的吸附剂材料（例如氧化锆和/或磷酸锆）的特定可再充电层进行再充电。 所述方法和装置包括通过氧化锆通过含有碱性水溶液的溶液。 该装置允许对氧化锆进行再充电，并且还用于对磷酸锆充电，其中吸附剂材料包含在可重复使用的吸附剂模块中。

    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE
    19.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE 有权
    用于治疗术后疼痛的方法和组合

    公开(公告)号：US20140094498A1

    公开(公告)日：2014-04-03

    申请号：US14097983

    申请日：2013-12-05

    Applicant: Medtronic, Inc. ,  WARSAW ORTHOPEDIC, INC.

    Inventor： William F. McKay ,  Amira Wohabrebbi ,  Vanja Margareta King ,  Phillip Edward McDonald ,  Christopher M. Hobot ,  Troy Carter

    IPC: A61K31/4168 ,  A61K47/34

    CPC classification number: A61L31/16 ,  A61K9/0024 ,  A61K9/204 ,  A61K31/4162 ,  A61K31/4168 ,  A61K47/34 ,  A61L31/06 ,  A61L2300/204 ,  A61L2300/402 ,  A61L2300/604

    Abstract: The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.

    Abstract translation: 本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于 在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于 至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

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