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    WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF
    13.
    发明申请
    WATER-PROCESSABLE SILICONE-CONTAINING PREPOLYMERS AND USES THEREOF 有权
    含水硅油的预处理剂及其用途

    公开(公告)号：US20160033683A1

    公开(公告)日：2016-02-04

    申请号：US14883142

    申请日：2015-10-14

    Applicant: Novartis AG

    Inventor： Jinyu Huang ,  Frank Chang ,  Robert Scott ,  Arturo Norberto Medina ,  Venkat Shankar ,  Selma Kuyu ,  Dawn Alison Smith ,  Daqing Wu

    IPC: G02B1/04 ,  C08J3/075

    CPC classification number: G02B1/043 ,  C08G77/20 ,  C08G77/42 ,  C08G77/442 ,  C08J3/075 ,  C08J2343/04 ,  C08J2383/08 ,  C08L83/10 ,  C08L101/14 ,  C08L83/04

    Abstract: The invention provide a class of water-processable polymerizable prepolymers which comprises (1) siloxane-containing monomeric units derived at least one siloxane containing monomer having one hydrophilic group or chain and/or polysiloxane-containing crosslinking units derived from at least one hydrophilized polysiloxane or chain-extended polysiloxane crosslinker; (2) hydrophilic monomeric units derived from one or more hydrophilic vinylic monomers; and (3) from about 0.05% to about 5% by weight of polymerizable units each having a pendant or terminal, ethylenically-unsaturated group and free of any polysiloxane segment. The prepolymer comprises from about 20% to about 50% by weight of silicone relative to the total weight of the prepolymer and has a high water solubility or dispersibility of at least about 5% by weight in water and suitable for making silicone hydrogel contact lenses.

    Abstract translation: 本发明提供了一类可水加工的可聚合预聚物，其包含（1）衍生自至少一种含有一个含硅氧烷的单体的含硅氧烷的单体单元，所述单体具有一个亲水基团或链和/或含聚硅氧烷的交联单元，其衍生自至少一种亲水化聚硅氧烷或 链延长聚硅氧烷交联剂; （2）衍生自一种或多种亲水乙烯基单体的亲水单体单元; 和（3）约0.05％至约5％重量的各自具有侧基或末端的可聚合单元，烯属不饱和基团并且不含任何聚硅氧烷链段。 预聚物相对于预聚物的总重量包含约20重量％至约50重量％的硅氧烷，并且在水中具有至少约5重量％的高水溶性或分散性，并且适于制备硅酮水凝胶隐形眼镜。

    METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS
    14.
    发明申请
    METHOD FOR DETERMINING THE SURFACE CONCENTRATION OF CARBOXYL GROUPS ON A LENS 有权
    确定镜片上羧基组合物表面浓度的方法

    公开(公告)号：US20140356965A1

    公开(公告)日：2014-12-04

    申请号：US14289046

    申请日：2014-05-28

    Applicant: Novartis AG

    Inventor： Xinming Qian ,  Frank Chang ,  Troy Vernon Holland ,  Yongxing Qiu ,  Venkat Shankar

    IPC: G01N33/44

    CPC classification number: B29D11/00865 ,  B29D11/00951 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14 ,  C08L33/26

    Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

    Abstract translation: 本发明涉及硅胶水凝胶隐形眼镜表面上的羧基的合格和定量的方法。 本发明的方法包括以下步骤：（a）获得硅酮水凝胶隐形眼镜，每个硅胶水凝胶隐形眼镜包括硅酮水凝胶镜片主体（即散装材料）及其上的涂层，其中硅酮水凝胶镜片主体由透镜制剂 不含任何包含一个或多个羧基的可聚合组分，其中该涂层包含具有羧基的聚合物; （b）将给定数量的硅酮水凝胶隐形眼镜浸入固定体积的具有乙酸盐作为抗衡阴离子的带正电荷的染料的C1-C4醇溶液中，所述正电荷染料在给定的初始浓度下持续一段足以染色硅酮水凝胶 隐形眼镜; 和（c）确定每个硅氧水凝胶隐形眼镜的羧基浓度和/或硅氧水凝胶隐形眼镜上涂层的厚度。

    Method for determining the surface concentration of carboxyl groups on a lens
    19.
    发明授权
    Method for determining the surface concentration of carboxyl groups on a lens 有权

    公开(公告)号：US09950483B2

    公开(公告)日：2018-04-24

    申请号：US14289046

    申请日：2014-05-28

    Applicant: Novartis AG

    Inventor： Xinming Qian ,  Frank Chang ,  Troy Vernon Holland ,  Yongxing Qiu ,  Venkat Shankar

    IPC: G02B1/04 ,  C23C14/54 ,  C23C16/52 ,  B29D11/00

    CPC classification number: B29D11/00865 ,  B29D11/00951 ,  G02B1/043 ,  C08L83/04 ,  C08L101/14 ,  C08L33/26

    Abstract: The invention is related to a method for qualifying and quantifying carboxyl groups on the surfaces of a silicone hydrogel contact lens. The method of the invention comprises the steps of: (a) obtaining silicone hydrogel contact lenses each of which comprises a silicone hydrogel lens body (i.e., bulk material) and a coating thereon, wherein the silicone hydrogel lens body is obtained from a lens formulation free of any polymerizable component including one or more carboxyl groups, wherein the coating comprises a polymer having carboxyl groups; (b) immersing a given number of the silicone hydrogel contact lenses in a fixed volume of a C1-C4 alcohol solution of a positively-charged dye having acetate as counter anion at a given initial concentration for a time period sufficient to stain the silicone hydrogel contact lens; and (c) determining the concentration of carboxyl groups per each silicone hydrogel contact lens and/or the thickness of the coating on the silicone hydrogel contact lens.

    METHOD FOR PRODUCING CONTACT LENSES WITH DURABLE LUBRICIOUS COATINGS THEREON
    20.
    发明申请
    METHOD FOR PRODUCING CONTACT LENSES WITH DURABLE LUBRICIOUS COATINGS THEREON 有权
    用于制造具有耐久性润滑涂层的接触镜片的方法

    公开(公告)号：US20170068019A1

    公开(公告)日：2017-03-09

    申请号：US15249587

    申请日：2016-08-29

    Applicant: Novartis AG

    Inventor： Xinming Qian ,  Frank Chang ,  Yasuo Matsuzawa ,  Venkat Shankar

    IPC: G02B1/04 ,  C08J7/12

    CPC classification number: G02B1/043 ,  B29D11/00048 ,  B29D11/00067 ,  B29D11/00125 ,  C08J7/123 ,  C08J2383/08 ,  C08J2433/02 ,  C08J2471/00 ,  C08J2477/00

    Abstract: The invention is related to a method for producing silicone hydrogel contact lenses with a stable lubricious hydrogel coating thereon. A method of the invention comprises forming a plasma-reactive hydrophilic polymer hybrid base coating having reactive functional groups on a silicone hydrogel contact lens and heating the silicone hydrogel contact lens with the hybrid base coating in an aqueous solution of a water-soluble and thermally crosslinkable hydrophilic polymeric material to form a stable lubricious hydrogel coating thereon.

    Abstract translation: 本发明涉及一种在其上具有稳定的润滑性水凝胶涂层的硅酮水凝胶隐形眼镜的制造方法。 本发明的方法包括在硅氧烷水凝胶隐形眼镜上形成具有反应性官能团的等离子体反应性亲水聚合物混合基底涂层，并将该硅酮水凝胶隐形眼镜与混合基底涂层在水溶性和热交联性水溶液中加热 亲水性聚合物材料，以在其上形成稳定的润滑性水凝胶涂层。

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