公开(公告)号：US20130079663A1

公开(公告)日：2013-03-28

申请号：US13521632

申请日：2011-01-10

申请人： Patrice Caillat ,  Francois Berger ,  Raymond Campagnolo ,  Marie-Line Cosnier ,  Affif Zaccaria

发明人： Patrice Caillat ,  Francois Berger ,  Raymond Campagnolo ,  Marie-Line Cosnier ,  Affif Zaccaria

IPC分类号： A61B10/02

CPC分类号： A61B10/02 ,  A61B10/0045

摘要： The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device (1) according to the invention comprises: a sampling tip (2) having a contacting end intended to be introduced into a medium containing said fluid, and the or each capturing unit which is bound to said end and which comprises a capture substrate (3) defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer (4) designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.

摘要翻译： 本发明涉及一种瞬时接触至少一个用于捕获生物靶标的体液与含有它们的体液的装置，一种用于回收被捕获的靶物进行分析的方法，以及用于接触和回收包括在所述单元中的捕获基质的系统。 本发明涉及特别在体内从人体液中获得的样品，例如， 循环体液，所述流体可能含有作为靶标的蛋白质，寡核苷酸如RNA或DNA，抗体，酶或细胞。 根据本发明的接触装置（1）包括：采样尖端（2），其具有旨在被引入到包含所述流体的介质中的接触端，并且所述或每个捕获单元与所述端部结合并且包括捕获 基底（3）限定被覆盖有至少一个生物相容性和多孔交联聚合物层（4）的靶捕获表面，所述生物相容性和多孔交联聚合物层（4）被设计成保留或每个捕获底物，并且仅允许包括小于限制尺寸的靶的生物粒子通过 所述捕获底物或每个捕获底物在所述接触之后可通过溶解或每层回收的方式。

公开(公告)号：US06566170B1

公开(公告)日：2003-05-20

申请号：US09701435

申请日：2000-12-18

申请人： François Marion ,  Jean-Louis Pornin ,  Claude Massit ,  Patrice Caillat

发明人： François Marion ,  Jean-Louis Pornin ,  Claude Massit ,  Patrice Caillat

IPC分类号： H01L2148

CPC分类号： H01L23/10 ,  B81C1/00269 ,  B81C3/002 ,  B81C2203/019 ,  B81C2203/032 ,  H01L21/50 ,  H01L2224/29011 ,  H01L2224/29013 ,  H01L2224/73103 ,  H01L2224/73203 ,  H01L2224/81191 ,  H01L2924/01079 ,  H01L2924/16152 ,  H01L2924/00012

摘要： Device comprising a carrier (100) and at least one cover (104) able to be bonded to the carrier to form with the carrier at least one cavity (114) having a controlled atmosphere around at least one component (102). In accordance with the invention, at least one of either the cover or the carrier is provided with at least one wedge (110) in fusible material and a strip of insulation (112) formed around said component, and before bonding, the wedge of fusible material is of sufficient thickness to prevent the strip of insulation (112) from coming into contact both with the cover and with the carrier when they are assembled together. Particular application to the encapsulation of electronic, mechanical or electromagnetic components.

摘要翻译： 装置包括载体（100）和至少一个盖子（104），所述至少一个盖子能够与所述载体结合以与所述载体形成至少一个具有围绕至少一个部件（102）的受控气氛的空腔（114）。 根据本发明，覆盖物或载体中的至少一个在易熔材料中设置有至少一个楔形物（110）和围绕所述构件形成的绝缘条（112），并且在粘合之前，可熔融的楔形物 材料具有足够的厚度，以防止绝缘条（112）在组装在一起时与盖和载体接触。特别适用于电子，机械或电磁部件的封装。

公开(公告)号：US5853603A

公开(公告)日：1998-12-29

申请号：US747929

申请日：1996-11-12

申请人： Patrice Caillat

发明人： Patrice Caillat

IPC分类号： H01L21/822 ,  H01L21/66 ,  H01L21/82 ,  H01L27/04 ,  H01L21/00 ,  B44C1/22

CPC分类号： H01L22/22

摘要： A method of manufacturing a microelectric device containing, on a substrate, a plurality of interconnected elements, comprising the steps of manufacturing on a substrate cells of elements, testing of the cells in order to distinguish the valid cells, formation of junction bands in an electrical conductive material connecting at least one valid cell, the junction bands being formed in fields, each field comprising an overlapping area with at least one neighboring field.

摘要翻译： 一种制造在基板上包含多个相互连接的元件的微电子器件的方法，包括以下步骤：在衬底上制造元件的元件，测试电池以区分有效电池，在电气中形成接合带 连接至少一个有效单元的导电材料，所述结带在场中形成，每个场包括与至少一个相邻场的重叠区域。

公开(公告)号：US5450206A

公开(公告)日：1995-09-12

申请号：US242607

申请日：1994-05-13

申请人： Patrice Caillat ,  Guy Parat ,  Gerard Nicolas

发明人： Patrice Caillat ,  Guy Parat ,  Gerard Nicolas

IPC分类号： H01L21/60 ,  G01B11/14 ,  H01L21/66 ,  H05K13/08 ,  G01B11/00

CPC分类号： G01B11/14 ,  H01L22/12

摘要： A process for checking the conformity of hybridization balls present on a chip or a substrate and its implementation device are provided. The process includes positioning the hybridization balls of the electronic component or substrate near a strip transparent to a predetermined wavelength. The hybridization balls are partially flattened against the strip by positioning the electronic component or substrate at a previously defined distance from the transparent strip. The previously defined distance corresponds to a theoretical reference ball height less an acceptable deviation between the theoretical reference ball height and a minimum height of the hybridization balls. The partial flattening creates ball flats on the hybridization balls at the strip. The hybridization balls are illuminated with a light beam of the predetermined wavelength that is emitted through the strip. A portion of the light beam reflected back through the strip by the hybridization balls to be checked and is acquired. Finally, conformity or nonconformity of the hybridization balls to be checked is determined as a function of the portion of said light beam reflected back by each of the hybridization balls.

摘要翻译： 提供了一种用于检查存在于芯片或基板上的杂交球的一致性的方法及其实现装置。 该方法包括将电子部件或基板的杂交球定位在预定波长透明的条带附近。 通过将电子部件或基板定位在与透明条带预先限定的距离处，将杂交球部分地压平在条带上。 先前定义的距离对应于理论参考球高度减去理论参考球高度和杂交球的最小高度之间的可接受的偏差。 部分平坦化在条带上的杂交球上产生球平面。 用通过条带发射的预定波长的光束照射杂交球。 光束的一部分通过条带反射回通过待检查的杂交球并被获取。 最后，将要检查的杂交球的一致性或不合格确定为由每个杂交球反射的所述光束的部分的函数。

公开(公告)号：US07894912B2

公开(公告)日：2011-02-22

申请号：US12071664

申请日：2008-02-25

申请人： Alim-Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat ,  Stephan Chabardes

发明人： Alim-Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat ,  Stephan Chabardes

IPC分类号： A61N1/00

CPC分类号： A61N1/0529 ,  A61N1/0534

摘要： A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen. A deep electrical neurostimulation system comprising an electrical pulse generator and at least one such lead having its electrodes electrically connected to said generator.

摘要翻译： 用于深脑电刺激的导线，被插入到诸如心室或囊肿或蛛网膜下腔的液体腔中，所述引线包括：具有限定内腔的侧壁的生物相容性材料的管状体，所述管状体适合于 将其长度的至少一部分插入患者身体的内部，以便到达刺激区域; 靠近管状体的远端设置的电极; 以及用于可移除地插入所述管状体的内腔中的刚性探针; 其特征在于，其中所述管状体具有不是直线的平衡形状，不同于探针的形状并且呈现一个且仅一个弯曲部，并且其具有足够的柔性和弹性以通过可逆地变形来跟随所述探针的形状， 探针插入内腔。 一种深电神经刺激系统，包括电脉冲发生器和至少一个这样的引线，其电极与所述发生器电连接。

公开(公告)号：US20110002526A1

公开(公告)日：2011-01-06

申请号：US12769057

申请日：2010-04-28

申请人： Magalie Faivre ,  Patrice Caillat ,  Myriam-Laure Cubizolles ,  Christine Peponnet ,  Claude Vauchier

发明人： Magalie Faivre ,  Patrice Caillat ,  Myriam-Laure Cubizolles ,  Christine Peponnet ,  Claude Vauchier

IPC分类号： G06K9/78

CPC分类号： G01N33/86

摘要： A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.

摘要翻译： 一种对血液样品中含有的血小板计数的方法，所述方法具有以下步骤：将所述样品与适合于与凝血细胞特异性结合的荧光标记物混合; 和用于抑制所述血小板激活的药剂; 将样品（E）引入到具有至少一个透明面的流体室（CF）中; 在静止照明下通过荧光显微镜获取所述样品的至少一个数字图像（IN）; 以及通过图像处理计算机装置（O）计数存在于所述图像或每个图像中的血小板（T）。 用于实施该方法的装置。

公开(公告)号：US20090317835A1

公开(公告)日：2009-12-24

申请号：US12307195

申请日：2007-07-12

申请人： Marie-Line Cosnier ,  Patrice Caillat ,  Franck Martin ,  François Berger

发明人： Marie-Line Cosnier ,  Patrice Caillat ,  Franck Martin ,  François Berger

IPC分类号： G01N33/567 ,  A61B10/02

CPC分类号： A61B10/02 ,  A61B10/0291 ,  A61B2010/0216 ,  A61B2017/320008

摘要： A microtechnological device (6) for sampling cells on or in a tissue or other element of the body. It comprises a support (12) having at least one surface of interest (14) on which is present at least one recovery zone (10) comprised of a bottom wall (22) equipped with a plurality of protuberances (24). Preferably, the microtechnological device comprises at least one recovery zone covered with a coating that has the power to attract the cells to be sampled.

摘要翻译： 一种微技术装置（6），用于在身体的组织或其他元件上或组织中采集细胞。 它包括具有至少一个感兴趣的表面（14）的支撑件（12），在该至少一个表面上存在至少一个由配备有多个突起（24）的底壁（22）组成的回收区（10）。 优选地，微技术装置包括至少一个被涂覆层覆盖的回收区域，该涂层具有吸引待采样单元的功率。

公开(公告)号：US20080255646A1

公开(公告)日：2008-10-16

申请号：US12071664

申请日：2008-02-25

申请人： Alim-Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat ,  Stephan Chabardes

发明人： Alim-Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat ,  Stephan Chabardes

IPC分类号： A61N1/04

CPC分类号： A61N1/0529 ,  A61N1/0534

摘要： A lead for deep brain electrical stimulation, to be inserted into liquid cavities, such as ventricles, or cysternae or subarachnoidal spaces, the lead comprising: a tubular body of biocompatible material having a side wall defining a lumen, said tubular body being suitable for being inserted over at least a fraction of its length into the inside of a patient's body in order to reach a region for stimulation; electrodes disposed close to a distal end of the tubular body; and a rigid stylet for inserting removably into the lumen of said tubular body; the lead being wherein said tubular body has an equilibrium shape that is not rectilinear, being different from the shape of the stylet and presenting one and only one bend, and that is sufficiently flexible and elastic to follow the shape of said stylet by deforming reversibly when the stylet is inserted into the lumen. A deep electrical neurostimulation system comprising an electrical pulse generator and at least one such lead having its electrodes electrically connected to said generator.

摘要翻译： 用于深脑电刺激的导线，被插入到诸如心室或囊肿或蛛网膜下腔的液体腔中，所述引线包括：具有限定内腔的侧壁的生物相容性材料的管状体，所述管状体适合于 将其长度的至少一部分插入患者身体的内部，以便到达刺激区域; 靠近管状体的远端设置的电极; 以及用于可移除地插入所述管状体的内腔中的刚性探针; 其特征在于，其中所述管状体具有不是直线的平衡形状，不同于探针的形状并且呈现一个且仅一个弯曲部，并且其具有足够的柔性和弹性以通过可逆地变形来跟随所述探针的形状， 探针插入内腔。 一种深电神经刺激系统，包括电脉冲发生器和至少一个这样的引线，其电极与所述发生器电连接。

公开(公告)号：US20070078495A1

公开(公告)日：2007-04-05

申请号：US10575700

申请日：2004-10-05

申请人： Patrice Caillat ,  Alain Bourgerette ,  Francois Vacherand ,  Alim-Louis Benabid

发明人： Patrice Caillat ,  Alain Bourgerette ,  Francois Vacherand ,  Alim-Louis Benabid

IPC分类号： A61N1/00

CPC分类号： A61N1/36082 ,  A61N1/36064 ,  A61N1/37229

摘要： This invention relates to a cerebral electrostimulation device containing a commutation device (300) comprising at least one input and several outputs each connected to at least one biocompatible electrode or at least one active area (202) of a biocompatible electrode (200), the commutation device (300) being used to selectively connect at least one input to one or more outputs. This electrostimulation device may be used for methods of diagnostic or therapy for the treatment of some pathologies, for example such as epilepsy or Parkinson's disease.

摘要翻译： 本发明涉及一种包含换向装置（300）的脑电刺激装置，该换向装置包括至少一个输入和多个输出，每个输出和多个输出连接到生物相容性电极（200）的至少一个生物相容性电极或至少一个有效区域（202），所述换向 设备（300）用于选择性地将至少一个输入连接到一个或多个输出。 该电刺激装置可以用于诊断或治疗用于治疗某些病症的方法，例如癫痫或帕金森病。

公开(公告)号：US20060163063A1

公开(公告)日：2006-07-27

申请号：US10522599

申请日：2003-08-28

申请人： Nathalie Picollet-Dahan ,  Patrice Caillat ,  Frederic Revol-Cavalier ,  Francois Chatelain ,  Fabien Sauter

发明人： Nathalie Picollet-Dahan ,  Patrice Caillat ,  Frederic Revol-Cavalier ,  Francois Chatelain ,  Fabien Sauter

IPC分类号： G01N33/487 ,  C12Q1/00

CPC分类号： G01N33/48728 ,  B01L3/5085

摘要： A device for measuring electrical activity of biological elements, including a substrate that has lower and upper faces and at least one through opening, the opening being delimited by a set of walls. Two plates are placed on either side of the lower and upper faces of the substrate and delimit, with the set of walls, a chamber. Each of the plates is provided, on its face lying opposite the substrate, with at least one electrode facing the opening in the substrate. Each of the plates further has at least one channel that starts inside the chamber and connects the chamber to the outside of the device, and the chamber communicates with the outside of the device only through the channels.