公开(公告)号：US20110264166A1

公开(公告)日：2011-10-27

申请号：US13176109

申请日：2011-07-05

申请人： Alim Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat

发明人： Alim Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat

IPC分类号： A61N1/36 ,  A61N1/05 ,  B82Y5/00

CPC分类号： A61N1/0529 ,  A61N1/0531

摘要： A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod.A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.

摘要翻译： 铅的深电神经刺激，铅包括：生物相容性材料棒; 以及还具有生物相容性材料的刀片，其固定到所述杆的一端并与其对齐; 其中所述刀片具有两个主表面和设置在所述两个主面中的至少一个上的多个电极，所述两个主面以二维构型，所述电极连接到设置在所述杆的内部或表面上的导体元件。 一种深电神经刺激系统，包括：用于深电神经刺激的电脉冲发生器; 以及上述类型的至少一个引线，其电极与所述电脉冲发生器电连接。

公开(公告)号：US20090012593A1

公开(公告)日：2009-01-08

申请号：US12216305

申请日：2008-07-02

申请人： Alim Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat

发明人： Alim Louis Benabid ,  Fabien Sauter-Starace ,  Patrice Caillat

IPC分类号： A61N1/05

CPC分类号： A61N1/0529 ,  A61N1/0531

摘要： A lead for deep electrical neurostimulation, the lead comprising: a rod of biocompatible material; and a blade, also of biocompatible material, secured to one end of said rod and in alignment therewith; in which said blade presents two main faces and a plurality of electrodes disposed on at least one of said two main faces in a two-dimensional configuration, said electrodes being connected to conductor elements disposed inside or on a surface of said rod. A deep electrical neurostimulation system comprising: an electrical pulse generator for deep electrical neurostimulation; and at least one lead of the above-described type, having its electrodes electrically connected to said electrical pulse generator.

摘要翻译： 铅的深电神经刺激，铅包括：生物相容性材料棒; 以及还具有生物相容性材料的刀片，其固定到所述杆的一端并与其对齐; 其中所述刀片具有两个主表面和设置在所述两个主面中的至少一个上的多个电极，所述两个主面以二维构型，所述电极连接到设置在所述杆的内部或表面上的导体元件。 一种深电神经刺激系统，包括：用于深电神经刺激的电脉冲发生器; 以及上述类型的至少一个引线，其电极与所述电脉冲发生器电连接。

公开(公告)号：US06803228B1

公开(公告)日：2004-10-12

申请号：US09868043

申请日：2001-06-14

申请人： Patrice Caillat ,  Charles Rosilio

发明人： Patrice Caillat ,  Charles Rosilio

IPC分类号： C12Q168

CPC分类号： G01N33/5438 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/00722 ,  C12Q1/6837 ,  C40B40/06 ,  C40B60/14

摘要： The present invention relates to a method to produce a biochip and to a biochip, said biochip being composed particularly of biological probes grafted onto a conductive polymer. The method according to the invention comprises the following steps: a) structuring of a substrate so as to obtain on said substrate microtroughs comprising in their base a layer of a material capable of initiating and promoting the adhesion onto said layer of a film of a pyrrole and functionalised pyrrole copolymer by electropolymerisation, b) collective electropolymerisation, so as to form an electropolymerised film of a pyrrole and functionalised pyrrole copolymer on the base of said microtroughs, c) direct or indirect fixation of functionalised oligonucleotides by microdeposition or a liquid jet printing technique.

摘要翻译： 本发明涉及一种生产生物芯片和生物芯片的方法，所述生物芯片特别由接枝在导电聚合物上的生物探针组成。本发明的方法包括以下步骤：a）将基底结构化成 在所述基材微通道上获得能够通过电聚合引发和促进在所述吡咯和官能化吡咯共聚物的膜上的粘合层的材料层，b）集体电聚合，以便形成电聚合膜 在所述微通道的基底上的吡咯和官能化的吡咯共聚物，c）通过微沉积或液体喷射印刷技术直接或间接固定官能化的寡核苷酸。

公开(公告)号：US06630359B1

公开(公告)日：2003-10-07

申请号：US09744252

申请日：2001-01-31

申请人： Patrice Caillat ,  Jean-Frédéric Clerc

发明人： Patrice Caillat ,  Jean-Frédéric Clerc

IPC分类号： H01L2100

CPC分类号： C12Q1/001 ,  B01J2219/00317 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  C40B60/14 ,  G01N33/5438

摘要： A chemical or biological analysis multi-point micro-system including a structure equipped with micro-wells, each micro-well being intended to receive a reagent coupled with a conductive polymer. Each micro-well includes a reception electrode on which the reagent is fixed by the conductive polymer with which it is coupled. Each micro-well also includes a counter-electrode arranged so as to be able to apply, in a volume of the micro-well, an electric field between its counter-electrode and its reception electrode. The structure further enables the simultaneous connection of all the reception electrodes to a first electric potential and enables the simultaneous connection of all the counter-electrodes to a second electric potential to be able to set up the electric field.

摘要翻译： 包括装配有微孔的结构的化学或生物分析多点微系统，每个微孔旨在接收与导电聚合物偶联的试剂。 每个微孔包括接收电极，试剂通过其接合的导电聚合物固定在该接收电极上。 每个微孔还包括布置成能够在微孔的体积中施加在其对电极和其接收电极之间的电场的对电极。 该结构还能够将所有接收电极同时连接到第一电位，并且能够将所有对电极同时连接到能够建立电场的第二电位。

公开(公告)号：US06453553B1

公开(公告)日：2002-09-24

申请号：US09463228

申请日：2000-02-14

申请人： Patrice Caillat ,  Claude Massit

发明人： Patrice Caillat ,  Claude Massit

IPC分类号： H01B4300

CPC分类号： H01R13/2414 ,  H01L21/486 ,  H01L23/49827 ,  H01L2924/0002 ,  H01R43/007 ,  Y10T29/49126 ,  Y10T29/49204 ,  Y10T29/49222 ,  Y10T29/49227 ,  H01L2924/00

摘要： A process for manufacturing an anisotropic conducting film including an insulating film in which holes are formed. Conducting inserts are located in the holes. First ends of the inserts project from one side of the insulating film, from a substrate in which compartments are formed on one surface, corresponding to the distribution of inserts on the insulating film, the shape of the compartments being complementary to the shape of the first ends of the inserts. The manufacturing process includes the steps of using a substrate with compartments with a tipped finish, producing an insulating film above the substrate with holes facing the compartments, producing conducting inserts in the holes and the compartments, and separating the insulating film in which the conducting inserts are formed.

摘要翻译： 一种制造各向异性导电膜的方法，其包括形成有孔的绝缘膜。 导电插入件位于孔中。 插入物的第一端从绝缘膜的一侧从与一个表面上形成隔室的基板相对应于绝缘膜上的插入物的分布伸出，隔室的形状与第一 刀片末端。 该制造方法包括以下步骤：使用具有带顶端面的隔室的基板，在基板的上方产生绝缘膜，孔面向隔室，在孔和隔室中产生导电插入件，并且分离绝缘膜，其中导电插入件 形成。

公开(公告)号：US5861322A

公开(公告)日：1999-01-19

申请号：US658684

申请日：1996-06-05

申请人： Patrice Caillat ,  David Henry

发明人： Patrice Caillat ,  David Henry

IPC分类号： H05K1/18 ,  H01L21/48 ,  H01L21/68 ,  H01L23/32 ,  H05K1/14 ,  H05K3/36 ,  H01L21/60

CPC分类号： H01L21/6835 ,  H01L21/4857 ,  H01L2221/68345 ,  H01L2224/16145 ,  H01L2224/16225 ,  H01L2224/32225 ,  H01L2224/48227 ,  H01L2224/73204 ,  H01L2924/01078 ,  H01L2924/15174 ,  H01L2924/15184 ,  H01L2924/15311 ,  H01L2924/16152

摘要： The process includes the following steps: forming a layer of meltable material (102) on an initial substrate (100); forming a first layer of dielectric material (104) and engraving this layer (104) to form openings (106) therein; forming metal blocks (108) in the openings (106); depositing a metal layer (110) covering the blocks; engraving the metal layer (110) to form conducting tracks (112); forming a layer of dielectric material (114) covering the conducting tracks and engraving this layer (114) to form openings therein; forming metal blocks (118) in these openings; separating the interconnection substrate from the initial substrate by heating the meltable material to a temperature equal to or exceeding its melting temperature.

摘要翻译： 该方法包括以下步骤：在初始基底（100）上形成一层可熔化材料（102）; 形成第一层介电材料（104）并雕刻该层（104）以在其中形成开口（106）; 在所述开口（106）中形成金属块（108）; 沉积覆盖块的金属层（110）; 雕刻金属层（110）以形成导电轨道（112）; 形成覆盖所述导电轨道并刻蚀所述层（114）的介电材料层（114）以在其中形成开口; 在这些开口中形成金属块（118） 通过将可熔材料加热至等于或超过其熔融温度的温度，将互连基板与初始基板分离。

公开(公告)号：US5734106A

公开(公告)日：1998-03-31

申请号：US605044

申请日：1996-03-01

申请人： Patrice Caillat

发明人： Patrice Caillat

IPC分类号： G01L1/18 ,  G01D11/24 ,  G01P15/125 ,  H01L23/02 ,  G01P15/00 ,  G01L9/00 ,  H01G7/00

CPC分类号： B81C1/0023 ,  G01D11/245 ,  G01P15/125 ,  G01P2015/0817

摘要： The integrated electronic sensor for characterizing physical quantities comprises a substrate (5) having a characterizing member (3) and a cover (9) maintained in the vicinity of and in front of the characterizing member (3) by means of at least one ball (11) bearing on the substrate (5), so as to provide a first spacing between the cover (9) and the substrate and is characterized in that the cover has a boss (15) facing the characterizing member (3) so as to define a second spacing between the cover (9) and the member, which is smaller than the spacing between the cover and the substrate.

摘要翻译： PCT No.PCT / FR94 / 01141 Sec。 371日期1996年3月1日 102（e）1996年3月1日PCT PCT 1994年9月29日PCT公布。 出版物WO95 / 09367 日期1995年4月6日用于表征物理量的集成电子传感器包括具有表征构件（3）的基板（5）和保持在特征构件（3）的前方附近的盖（9），借助于 至少一个支撑在所述基底（5）上的球（11），以便在所述盖（9）和所述基底之间提供第一间隔，其特征在于，所述盖具有面向所述表征构件（3）的凸台（15） ），以便限定盖（9）和构件之间的第二间隔，其小于盖和基板之间的间隔。

公开(公告)号：US09642602B2

公开(公告)日：2017-05-09

申请号：US13521632

申请日：2011-01-10

申请人： Patrice Caillat ,  François Berger ,  Raymond Campagnolo ,  Marie-Line Cosnier ,  Affif Zaccaria

发明人： Patrice Caillat ,  François Berger ,  Raymond Campagnolo ,  Marie-Line Cosnier ,  Affif Zaccaria

IPC分类号： A61B10/02 ,  A61B10/00

CPC分类号： A61B10/02 ,  A61B10/0045

摘要： The invention relates to a device for transiently contacting at least one unit for capturing biological targets with a body fluid containing them, a method for recovering the captured targets for analysis, and a system for contacting and recovering a capture substrate included in said unit. The invention relates to samples obtained in particular in vivo from body fluids of the human body, e.g. circulating body fluids, said fluids possibly containing, as targets, proteins, oligonucleotides such as RNA or DNA, antibodies, enzymes or cells. A contacting device (1) according to the invention comprises: —a sampling tip (2) having a contacting end intended to be introduced into a medium containing said fluid, and—the or each capturing unit which is bound to said end and which comprises a capture substrate (3) defining a target capturing surface covered with at least one biocompatible and porous crosslinked polymer layer (4) designed to retain the or each capture substrate and only to allow biological particles including targets smaller than a limiting size to pass through, in such a way that the or each capture substrate is recoverable after said contacting by dissolution of the or each layer.

公开(公告)号：US08699777B2

公开(公告)日：2014-04-15

申请号：US12769057

申请日：2010-04-28

申请人： Magalie Faivre ,  Patrice Caillat ,  Myriam-Laure Cubizolles ,  Christine Peponnet ,  Claude Vauchier

发明人： Magalie Faivre ,  Patrice Caillat ,  Myriam-Laure Cubizolles ,  Christine Peponnet ,  Claude Vauchier

IPC分类号： G06K9/00

CPC分类号： G01N33/86

摘要： A method of counting thrombocytes contained in a sample of blood, the method having the steps: mixing said sample with: fluorescent markers suitable for bonding specifically with the thrombocytes; and an agent for inhibiting activation of said thrombocytes; introducing the sample (E) into a fluidic chamber (CF) having at least one transparent face; acquiring at least one digital image (IN) of said sample by fluorescence microscopy under stationary illumination; and counting the thrombocytes (T) present in said or each image by image processing computer means (O). Apparatus for implementing the method.

摘要翻译： 一种对血液样品中含有的血小板计数的方法，所述方法具有以下步骤：将所述样品与适合于与凝血细胞特异性结合的荧光标记物混合; 和用于抑制所述血小板激活的药剂; 将样品（E）引入到具有至少一个透明面的流体室（CF）中; 在静止照明下通过荧光显微镜获取所述样品的至少一个数字图像（IN）; 以及通过图像处理计算机装置（O）计数存在于所述图像或每个图像中的血小板（T）。 用于实施该方法的装置。

公开(公告)号：US20140008224A1

公开(公告)日：2014-01-09

申请号：US13984964

申请日：2011-02-11

申请人： Vincent Agache ,  Patrice Caillat ,  Pierre Puget

发明人： Vincent Agache ,  Patrice Caillat ,  Pierre Puget

IPC分类号： B03C5/00

CPC分类号： B03C5/005 ,  B03C5/026 ,  B03C2201/26

摘要： A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.

摘要翻译： 检测存在于液体中的感兴趣的分析物的检测方法。 检测方法包括以下步骤：通过最初通过液体介电电泳形成的液体手指的毛细管断裂在第一表面上形成液滴。 这样形成的液滴各自与面对第一表面布置的不同检测表面接触。 每个液滴中存在的感兴趣的分析物在相应的检测表面被检测。