公开(公告)号：US06545242B1

公开(公告)日：2003-04-08

申请号：US09971302

申请日：2001-10-04

申请人： William F. Butler

发明人： William F. Butler

IPC分类号： B23K1122

CPC分类号： A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

摘要： A method and apparatus for removing the needle portion of a hypodermic syringe and simultaneously sterilizing and destroying the needle portion of a hypodermic syringe, thereby eliminating the risk of infection by microorganisms that may be present in or on the needle. When a syringe is inserted into the apparatus, the needle is heated to a temperature sufficient to melt or at least soften the needle, and sufficient to inactivate any virus, bacteria, yeast, or other microorganism remaining on or within the needle. The needle also is cur at the location of melting so that the needle is removed from the remaining portion of the syringe. The heating and cutting elements are part of a disposable cartridge, which also contains the cut-off needle portions.

摘要翻译： 一种用于去除皮下注射器的针部分并同时消毒和破坏皮下注射器的针部分的方法和装置，从而消除可能存在于针中或针上的微生物感染的风险。 当将注射器插入设备中时，将针加热到足以熔化或至少软化针的温度，并足以灭活残留在针上或针内的任何病毒，细菌，酵母或其它微生物。 针也在熔化的位置处弯曲，使得针从注射器的剩余部分移除。 加热和切割元件是一次性盒的一部分，其也包含截止针部分。

公开(公告)号：US06315953B1

公开(公告)日：2001-11-13

申请号：US09240931

申请日：1999-01-29

申请人： Donald E. Ackley ,  William F. Butler ,  Paul D. Swanson

发明人： Donald E. Ackley ,  William F. Butler ,  Paul D. Swanson

IPC分类号： G01N1500

CPC分类号： G11C13/0019 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2400/0415 ,  B01L2400/0421 ,  B82Y5/00 ,  B82Y10/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  F04B19/006 ,  G01N27/44743 ,  G11C13/0014 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L2924/0002 ,  C12Q2565/515 ,  C12Q2565/607 ,  H01L2924/00

摘要： An electronic device for performing active biological operations includes a support substrate, a second substrate, a source of illumination, and an edge illumination layer. The support substrate includes first and second surfaces and a via between the first and second surfaces to permit fluid flow through the substrate. The second substrate includes a first surface that is adapted to be disposed in facing arrangement with the second surface of the first substrate. The second substrate includes an array of microlocations wherein the array is adapted to receive the fluid. A sealant is disposed between the second face of the support substrate and the first face of the second substrate. The device includes a source of illumination and an edge illumination layer having an input adapted to receive the illumination from the source, and an output adapted to direct the illumination to the array. The edge illumination layer is disposed adjacent to and between the support substrate and the second substrate. The illumination from the edge illumination layer is directed substantially parallel to the support substrate and second substrate and illuminates the array.

摘要翻译： 用于进行主动生物操作的电子设备包括支撑衬底，第二衬底，照明源和边缘照明层。 支撑衬底包括第一表面和第二表面以及第一和第二表面之间的通路，以允许流体流过衬底。 第二基板包括适于与第一基板的第二表面相对布置的第一表面。 第二衬底包括微阵列阵列，其中阵列适于接收流体。 密封剂设置在支撑基板的第二面和第二基板的第一面之间。 该装置包括照明源和具有适于从源极接收照明的输入的边缘照明层，以及适于将照明引导到阵列的输出。 边缘照明层设置在支撑基板和第二基板之间并且位于支撑基板和第二基板之间。 来自边缘照明层的照明基本上平行于支撑基板和第二基板并照亮阵列。

公开(公告)号：US6099803A

公开(公告)日：2000-08-08

申请号：US26618

申请日：1998-02-20

申请人： Donald E. Ackley ,  Paul D. Swanson ,  Scott O. Graham ,  Elizabeth L. Mather ,  Timothy L. LeClair ,  William F. Butler

发明人： Donald E. Ackley ,  Paul D. Swanson ,  Scott O. Graham ,  Elizabeth L. Mather ,  Timothy L. LeClair ,  William F. Butler

IPC分类号： B01J19/00 ,  B01L3/00 ,  C07H21/00 ,  C07K1/04 ,  C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  F04B19/00 ,  G01N27/447 ,  G11C13/02 ,  G11C19/00 ,  H01L21/336 ,  H01L21/98 ,  H01L29/78 ,  G01N15/06

CPC分类号： G11C13/0019 ,  B01J19/0046 ,  B01J19/0093 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/5085 ,  B82Y10/00 ,  B82Y5/00 ,  C07H21/00 ,  C07K1/045 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6837 ,  F04B19/006 ,  G01N27/44743 ,  G11C13/0014 ,  G11C19/00 ,  H01L25/50 ,  H01L29/6656 ,  H01L29/6659 ,  H01L29/66628 ,  H01L29/7834 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L2200/0647 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2400/0415 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G11C13/04 ,  H01L2924/0002

摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. Preferably, the volume of the flow cell is more advantageously interrogated through use of relatively large collection and return electrodes, such as where the area of those electrodes relative to the footprint of the flowcell is at least 40%. In yet another embodiment, a first collection electrode is disposed adjacent an array, with a second collection electrode disposed on the at least an opposite portion of the array. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell. In yet another embodiment, a concentric ring design is provided. Various flip chip embodiments are disclosed.

摘要翻译： 制造方法和用于进行活性生物操作的装置利用各种结构有利地将收集的生物材料收集并提供到微位置阵列。 在一个实施例中，设备包括聚焦电极以帮助材料从收集电极到阵列的方向和输送。 优选地，使用一个或多个中间传输电极，最优选地在收集电极和阵列之间单调减小尺寸，以便降低电流密度不匹配。 在另一方面，流动池被利用在装置上以提供包含待分析物质的溶液的容纳物。 优选地，通过使用相对较大的收集和返回电极更有利地询问流动池的体积，例如那些电极相对于流动池的覆盖区的面积至少为40％。 在另一个实施例中，第一收集电极邻近阵列设置，第二收集电极设置在阵列的至少相对的部分上。 优选地，收集电极的组合面积是流动池的占地面积的实质部分，优选地至少50％。 在另一个实施例中，提供了同心环设计。 公开了各种倒装芯片实施例。

公开(公告)号：US5736706A

公开(公告)日：1998-04-07

申请号：US707923

申请日：1996-09-10

申请人： William F. Butler

发明人： William F. Butler

IPC分类号： A61L11/00 ,  A61G12/00 ,  A61M5/32 ,  B09B3/00 ,  B23K11/22

CPC分类号： B09B3/0075 ,  A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

摘要： A method and apparatus for sterilizing and destroying a syringe needle includes a rotating needle carriage that receives a needle in a loading position. The needle carriage is rotated downwardly to a cut-off position. At the cut-off position, two opposing contact blades pinch the needle, which electrically connects the positive and negative terminals of a battery. Current flows through the contact blades and the needle, thereby melting the needle. A slight further rotation of the needle carriage causes the contact blades to shear the needle. The sheared portion of the needle then falls into a waste compartment in the bottom of the apparatus. When the syringe is removed from the needle carriage, the needle carriage rotates upwardly and returns to the loading position.

摘要翻译： 用于消毒和破坏注射器针头的方法和装置包括：旋转针架，其在加载位置接收针头。 针架向下旋转至切断位置。 在切断位置，两个相对的接触片夹住针，电连接电池的正极和负极端子。 电流流过接触叶片和针头，从而熔化针头。 针架的稍微进一步旋转导致接触片剪切针。 针的剪切部分然后落入设备底部的废物隔间中。 当注射器从针架移除时，针托架向上旋转并返回到装载位置。

公开(公告)号：US06821729B2

公开(公告)日：2004-11-23

申请号：US09952459

申请日：2001-09-12

申请人： Donald E. Ackley ,  William F. Butler ,  Paul D. Swanson

发明人： Donald E. Ackley ,  William F. Butler ,  Paul D. Swanson

IPC分类号： C12Q168

CPC分类号： G11C13/0019 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0654 ,  B01L2300/0877 ,  B01L2400/0415 ,  B01L2400/0421 ,  B82Y5/00 ,  B82Y10/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  F04B19/006 ,  G01N27/44743 ,  G11C13/0014 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L2924/0002 ,  C12Q2565/515 ,  C12Q2565/607 ,  H01L2924/00

摘要： An electronic device for performing active biological operations includes an optically confining region including a support substrate having a via and a chip disposed in a facing arrangement with the support substrate, the chip including an array of electrodes disposed thereon. An optically accessible top member is disposed in a facing arrangement with the support substrate opposite the chip. The device further includes a source of illumination and an edge illumination layer having an input adapted to receive illumination from the source, and a terminal edge that outputs the illumination, the edge illumination layer being disposed adjacent to the support substrate. Illumination from the terminal edge of the illumination layer is directed into the optically confining region.

摘要翻译： 用于执行主动生物学操作的电子设备包括光学限制区域，其包括具有通孔和支撑衬底的支撑衬底，所述通孔和芯片以与支撑衬底相对的方式布置，所述芯片包括布置在其上的电极阵列。 光学可接近的顶部构件以与芯片相对的支撑衬底的面对布置设置。 该装置还包括照明源和边缘照明层，边缘照明层具有适于从源极接收照明的输入端和输出照明的端子边缘，边缘照明层邻近支撑基板设置。 来自照明层的终端边缘的照明被引导到光学限制区域中。

公开(公告)号：US5091621A

公开(公告)日：1992-02-25

申请号：US532021

申请日：1990-06-01

申请人： William F. Butler

发明人： William F. Butler

IPC分类号： A61M5/32 ,  B23H9/00

CPC分类号： B23H9/005 ,  A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

摘要： A method and apparatus for destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining a first opening therethrough, a needle receiving enclosure in the chamber movable between the first and second surfaces and defining a second opening therethrough which is coaxial with the first opening, a first electrical contact on the needle receiving enclosure, a second electrical contact on the second surface and being in registry with the second opening, power source connected to the first and second contacts, a waste collector disposed in the housing beneath and in communication with the burn chamber, the waste collector being removable from the housing and a mechanism that moves the needle receiving enclosure toward the first opening; so that when the needle is inserted through the first and second openings to be in contacting relationship to the needle receiving enclosure and the needle receiving means is moved toward the second surface, the tip of the needle engages the second contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collector.

摘要翻译： 一种用于破坏注射器针的方法和装置，具有壳体，在壳体中具有相对关系的第一和第二壁，并在其间限定针燃烧室，第一和第二表面之间的距离至少为针的长度， 第一表面限定穿过其中的第一开口，所述腔室中的针接收外壳在第一和第二表面之间可移动并且限定与第一开口同轴的第二开口，针接收外壳上的第一电接触， 在所述第二表面上并与所述第二开口对准的电源，连接到所述第一和第二触点的电源，设置在所述壳体内的与所述燃烧室连通的废料收集器，所述废物收集器可从所述壳体移除， 使针接收外壳朝向第一开口移动; 使得当针穿过第一和第二开口以与针接收外壳处于接触关系时，针接收装置朝向第二表面移动时，针的尖端接合闭合触点之间的电路的第二触点 并且沿着其长度的至少大部分熔化针，并将所得到的熔化废物落入废物收集器中。

公开(公告)号：US5268549A

公开(公告)日：1993-12-07

申请号：US889041

申请日：1992-05-26

申请人： William F. Butler

发明人： William F. Butler

IPC分类号： A61G12/00 ,  A61M5/32 ,  B23H9/00 ,  B23H9/10 ,  B23K11/22

CPC分类号： B23H9/005 ,  A61M5/3278 ,  A61M2005/3283

摘要： A method and apparatus for sterilizing and destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining an opening therethrough, a needle receiver in the chamber, a first electrical contact on the needle receiver, a second electrical contact comprising an electrically conductive surface secured within the burn chamber and or added substantially perpendicular to the face of the needle receiver and the surface in alignment with the central line of the needle receiver, power source connected to the first and second contacts and, a waste collector disposed in the housing beneath and in communication with the burn chamber, the waste collector being removable from the housing; so that when the needle is inserted through the opening, it is in contacting relationship with the first electrical contact, the length of the needle then engages the second electrical contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collector.

摘要翻译： 一种用于消毒和破坏注射器针的方法和装置，具有壳体，在壳体中具有相对关系的第一和第二壁，并在其间限定针燃烧室，第一和第二表面之间的距离至少为针的长度 ，所述第一表面限定穿过其中的开口，所述腔室中的针接收器，所述针接收器上的第一电接触件，第二电触头，包括固定在所述燃烧室内的导电表面，并且基本上垂直于所述针的表面 接收器和与针接收器的中心线对准的表面，电源连接到第一和第二触点，以及设置在壳体内并与燃烧室连通的废物收集器，废物收集器可从壳体 ; 使得当针穿过开口插入时，其与第一电接触件处于接触关系，然后针的长度接合第二电触点，闭合触点之间的电路并且沿着其长度的至少大部分熔化针 所产生的熔化废物落入废物收集器。

公开(公告)号：US06309601B1

公开(公告)日：2001-10-30

申请号：US08846876

申请日：1997-05-01

申请人： Robert D. Juncosa ,  William F. Butler ,  Lei Wu ,  Robert H. Cormack

发明人： Robert D. Juncosa ,  William F. Butler ,  Lei Wu ,  Robert H. Cormack

IPC分类号： G01N1500

CPC分类号： G01N21/6458 ,  B01J19/0046 ,  B01J19/0093 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00614 ,  B01J2219/00621 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00686 ,  B01J2219/00689 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01L3/5027 ,  B01L3/502761 ,  B01L3/5085 ,  B01L2200/025 ,  B01L2200/143 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0877 ,  B01L2400/0421 ,  B82Y5/00 ,  B82Y10/00 ,  C07B2200/11 ,  C07H21/00 ,  C07K1/04 ,  C07K1/045 ,  C07K1/047 ,  C12Q1/6813 ,  C12Q1/6816 ,  C12Q1/6825 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B60/14 ,  G01N21/6452 ,  G01N21/76 ,  G11C13/0014 ,  G11C13/0019 ,  G11C13/04 ,  G11C19/00 ,  H01L25/50 ,  H01L2924/0002 ,  C12Q2565/515 ,  C12Q2565/607 ,  H01L2924/00

摘要： An optical detection system is adapted for detection of biological reactions. An excitation source illuminates a portion of an object to be examined, the portion preferably comprising one microlocation out of an array of microlocations. An intervening optical detection platform serves to direct the excitation radiation to the portion of the object to be illuminated. A detector receives the emitted radiation from the object to be examined, the detector being characterized in that the diameter of the region examined by the detector is the same as or smaller than the diameter of the illuminated region, and comprises less than the entire surface of the object to be examined, and most preferably images a whole or a part of a single microlocation. In operation, a microscopy system is formed in which the excitation radiation is substantially in focus at the surface of the object to be examined. In one aspect of this invention, the optical detection platform includes an excitation detector that measures reflected excitation radiation from the object to be examined. This information is compared to prestored information regarding the location of the microlocations and interstitial regions on the object to be examined, whereby alignment information is obtained. The excitation radiation may then be precisely directed to a given microlocation or portion thereof to perform the examining through the system.

摘要翻译： 光学检测系统适用于生物反应的检测。 激发源照亮待检查对象的一部分，该部分优选地包括微位置阵列中的一个微位置。 中间光学检测平台用于将激发辐射引导到被照射物体的部分。 检测器接收来自待检测物体的发射的辐射，检测器的特征在于检测器检查的区域的直径等于或小于照射区域的直径，并且包括小于整个表面 要检查的对象，最优选地，图像是单个微位置的全部或一部分。 在操作中，形成显微镜系统，其中激发辐射基本上在待检查对象的表面上聚焦。 在本发明的一个方面，光学检测平台包括一个激励检测器，该激励检测器测量被检测物体的反射激发辐射。 将该信息与关于待检查对象上的微位置和间质区域的位置的预先存储的信息进行比较，从而获得对准信息。 然后可以将激发辐射精确地引导到给定的微定位或其部分以通过系统进行检查。

公开(公告)号：US5264675A

公开(公告)日：1993-11-23

申请号：US840102

申请日：1992-02-24

申请人： William F. Butler

发明人： William F. Butler

IPC分类号： A61M5/32 ,  B23H9/00 ,  H05B3/00

CPC分类号： B23H9/005 ,  A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

摘要： A method and apparatus for destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining a first opening therethrough, needle receiver in the chamber movable between the first and second surfaces and defining a second opening therethrough which is coaxial with the first opening, a first electrical contact on the needle receiver, a first electrical contact on the needle receiver, a second electrical contact on the second surface and being in association with the second opening, power source connected to the first and second contacts, a waste collector disposed in the housing beneath and in communication with the burn chamber, the waste collector being removable from the housing, and spring loaded needle guide for moving the needle receiver toward the first opening; so that when the needle is inserted through the first and second openings to be in contacting relationship to the needle receiver and the needle receiver is moved toward the second surface, the tip of the needle engages the second contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collector.

摘要翻译： 一种用于破坏注射器针的方法和装置，具有壳体，在壳体中具有相对关系的第一和第二壁，并在其间限定针燃烧室，第一和第二表面之间的距离至少为针的长度， 第一表面限定穿过其中的第一开口，腔室中的针接收器可在第一和第二表面之间移动并且限定与第一开口同轴的第二开口，针接收器上的第一电接触，针上的第一电接触 接收器，在第二表面上的与第二开口相关联的第二电触点，连接到第一和第二触点的电源，设置在壳体内并与燃烧室连通的废物收集器，废物收集器可移除 以及弹簧加载的针引导件，用于将针头接收器移向第一开口; 使得当针穿过第一和第二开口以与针接收器处于接触关系并且针接收器朝向第二表面移动时，针的尖端接合闭合触点之间的电路并熔化的第二触点 该针沿着其长度至少大部分，所得到的熔化废物落入废物收集器。