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1.发明授权Devices for molecular biological analysis and diagnostics including waveguides 有权用于分子生物学分析和诊断的设备，包括波导公开(公告)号：US06821729B2
公开(公告)日：2004-11-23
申请号：US09952459
申请日：2001-09-12
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0877 , B01L2400/0415 , B01L2400/0421 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An electronic device for performing active biological operations includes an optically confining region including a support substrate having a via and a chip disposed in a facing arrangement with the support substrate, the chip including an array of electrodes disposed thereon. An optically accessible top member is disposed in a facing arrangement with the support substrate opposite the chip. The device further includes a source of illumination and an edge illumination layer having an input adapted to receive illumination from the source, and a terminal edge that outputs the illumination, the edge illumination layer being disposed adjacent to the support substrate. Illumination from the terminal edge of the illumination layer is directed into the optically confining region.
摘要翻译： 用于执行主动生物学操作的电子设备包括光学限制区域，其包括具有通孔和支撑衬底的支撑衬底，所述通孔和芯片以与支撑衬底相对的方式布置，所述芯片包括布置在其上的电极阵列。 光学可接近的顶部构件以与芯片相对的支撑衬底的面对布置设置。 该装置还包括照明源和边缘照明层，边缘照明层具有适于从源极接收照明的输入端和输出照明的端子边缘，边缘照明层邻近支撑基板设置。 来自照明层的终端边缘的照明被引导到光学限制区域中。
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2.发明授权Electronic device for performing active biological operations and method of using same 失效用于进行活性生物操作的电子装置及其使用方法公开(公告)号：US06726880B1
公开(公告)日：2004-04-27
申请号：US09596657
申请日：2000-06-19
申请人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
发明人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
IPC分类号： G01N1500
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/50273 , B01L3/502761 , B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2200/0689 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0816 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An electronic device for performing biological operations includes a support substrate and an array of microlocations disposed on the substrate. The array of microlocations include electronically addressable electrodes. A first collection electrode is disposed on the substrate and adjacent to a first side of the array of microlocations. A second collection electrode is disposed on the substrate and adjacent to a second side of the array of microlocations, the second side of the array being opposite of the first side such that the array of microlocations is disposed between the first and second collection electrodes. A flow cell is supported on the substrate. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell.
摘要翻译： 用于进行生物学操作的电子设备包括支撑衬底和布置在衬底上的微位置阵列。 微位置阵列包括电子寻址电极。 第一收集电极设置在基板上并与微位置阵列的第一侧相邻。 第二收集电极设置在衬底上并且与微位置阵列的第二侧相邻，阵列的第二侧与第一侧相对，使得微位置阵列设置在第一和第二采集电极之间。 流动池被支撑在基底上。 优选地，收集电极的组合面积是流动池的占地面积的实质部分，优选地至少50％。
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3.发明授权Devices for molecular biological analysis and diagnostics including waveguides 失效用于分子生物学分析和诊断的设备，包括波导公开(公告)号：US06315953B1
公开(公告)日：2001-11-13
申请号：US09240931
申请日：1999-01-29
IPC分类号： G01N1500
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0877 , B01L2400/0415 , B01L2400/0421 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An electronic device for performing active biological operations includes a support substrate, a second substrate, a source of illumination, and an edge illumination layer. The support substrate includes first and second surfaces and a via between the first and second surfaces to permit fluid flow through the substrate. The second substrate includes a first surface that is adapted to be disposed in facing arrangement with the second surface of the first substrate. The second substrate includes an array of microlocations wherein the array is adapted to receive the fluid. A sealant is disposed between the second face of the support substrate and the first face of the second substrate. The device includes a source of illumination and an edge illumination layer having an input adapted to receive the illumination from the source, and an output adapted to direct the illumination to the array. The edge illumination layer is disposed adjacent to and between the support substrate and the second substrate. The illumination from the edge illumination layer is directed substantially parallel to the support substrate and second substrate and illuminates the array.
摘要翻译： 用于进行主动生物操作的电子设备包括支撑衬底，第二衬底，照明源和边缘照明层。 支撑衬底包括第一表面和第二表面以及第一和第二表面之间的通路，以允许流体流过衬底。 第二基板包括适于与第一基板的第二表面相对布置的第一表面。 第二衬底包括微阵列阵列，其中阵列适于接收流体。 密封剂设置在支撑基板的第二面和第二基板的第一面之间。 该装置包括照明源和具有适于从源极接收照明的输入的边缘照明层，以及适于将照明引导到阵列的输出。 边缘照明层设置在支撑基板和第二基板之间并且位于支撑基板和第二基板之间。 来自边缘照明层的照明基本上平行于支撑基板和第二基板并照亮阵列。
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4.发明授权Advanced active electronic devices for molecular biological analysis and diagnostics 失效用于分子生物学分析和诊断的高级有源电子设备
公开(公告)号：US6099803A
公开(公告)日：2000-08-08
申请号：US26618
申请日：1998-02-20
申请人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
发明人： Donald E. Ackley , Paul D. Swanson , Scott O. Graham , Elizabeth L. Mather , Timothy L. LeClair , William F. Butler
IPC分类号： B01J19/00 , B01L3/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G01N27/447 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , G01N15/06
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01L3/502707 , B01L3/502761 , B01L3/5085 , B82Y10/00 , B82Y5/00 , C07H21/00 , C07K1/045 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C19/00 , H01L25/50 , H01L29/6656 , H01L29/6659 , H01L29/66628 , H01L29/7834 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00626 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0877 , B01L2400/0415 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G11C13/04 , H01L2924/0002
摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. Preferably, the volume of the flow cell is more advantageously interrogated through use of relatively large collection and return electrodes, such as where the area of those electrodes relative to the footprint of the flowcell is at least 40%. In yet another embodiment, a first collection electrode is disposed adjacent an array, with a second collection electrode disposed on the at least an opposite portion of the array. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell. In yet another embodiment, a concentric ring design is provided. Various flip chip embodiments are disclosed.
摘要翻译： 制造方法和用于进行活性生物操作的装置利用各种结构有利地将收集的生物材料收集并提供到微位置阵列。 在一个实施例中，设备包括聚焦电极以帮助材料从收集电极到阵列的方向和输送。 优选地，使用一个或多个中间传输电极，最优选地在收集电极和阵列之间单调减小尺寸，以便降低电流密度不匹配。 在另一方面，流动池被利用在装置上以提供包含待分析物质的溶液的容纳物。 优选地，通过使用相对较大的收集和返回电极更有利地询问流动池的体积，例如那些电极相对于流动池的覆盖区的面积至少为40％。 在另一个实施例中，第一收集电极邻近阵列设置，第二收集电极设置在阵列的至少相对的部分上。 优选地，收集电极的组合面积是流动池的占地面积的实质部分，优选地至少50％。 在另一个实施例中，提供了同心环设计。 公开了各种倒装芯片实施例。
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5.发明授权Methods for fabricating multi-component devices for molecular biological analysis and diagnostics 有权制造用于分子生物学分析和诊断的多组分装置的方法公开(公告)号：US06254827B1
公开(公告)日：2001-07-03
申请号：US09240920
申请日：1999-01-29
IPC分类号： G01N1506
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/3276 , G01N27/44743 , G01N33/5438 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： A method for manufacturing a multicomponent flip-chip device is disclosed. The device includes a chip disposed adjacent to a substrate, the substrate including a via therethrough. The device is adapted to receive a fluid to be placed on the substrate, wherein the fluid then flows through the via down to the chip. The chip includes a sealant free region and a sealant receiving region. The method includes the steps of placing a chip adjacent to a substrate. Light is exposed to the substrate and through the via, down onto the surface of the chip. A light-curable, wickable sealant is applied to the interface between the substrate and the chip, wherein the light at least partially cures the sealant to preclude the sealant from flowing to the sealant free region. Additional curing of sealant may also be performed.
摘要翻译： 公开了一种制造多组件倒装芯片器件的方法。 该装置包括与衬底相邻设置的芯片，该衬底包括穿过其中的通孔。 该装置适于接收待放置在基底上的流体，其中流体然后经过通道向下流到芯片。 该芯片包括无密封区域和密封剂接收区域。 该方法包括将芯片放置在与衬底相邻的步骤。 光暴露于基板并通过通孔，下降到芯片的表面上。 可光固化的可警告的密封剂被施加到基底和芯片之间的界面上，其中光至少部分地固化密封剂以防止密封剂流到无密封剂区域。 还可以进行密封剂的附加固化。
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公开(公告)号：US6068818A
公开(公告)日：2000-05-30
申请号：US239569
申请日：1999-01-29
IPC分类号： B01J19/00 , B01L3/00 , C07B61/00 , C07H21/00 , C07K1/04 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/00 , G01N27/447 , G11C13/02 , G11C19/00 , H01L21/336 , H01L21/98 , H01L29/78 , G01N1/14
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01L3/502707 , B01L3/502761 , B01L3/5085 , B82Y10/00 , B82Y5/00 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C19/00 , H01L25/50 , H01L29/6656 , H01L29/6659 , H01L29/66628 , H01L29/7834 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0858 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B01L3/502715 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , G11C13/04 , H01L2924/0002
摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. Preferably, the volume of the flow cell is more advantageously interrogated through use of relatively large collection and return electrodes, such as where the area of those electrodes relative to the footprint of the flowcell is at least 40%. In yet another embodiment, a first collection electrode is disposed adjacent an array, with a second collection electrode disposed on the at least an opposite portion of the array. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell. In yet another embodiment, a concentric ring design is provided. Various flip-chip embodiments are disclosed. A preferred embodiment utilizes a relatively small number of components, for example, five components, for a flip-chip device. A first substrate includes a via, through which solution flows to the underlying analytical chip, which a sealant between the chip and the first substrate. An overlying flow cell contains the solution. Novel manufacturing techniques are provided for utilizing the via as a shadow mask to constrain the flow of the sealant. A multiple site array system includes a row select and column select, which are preferably memory, and most preferably shift register memory. An improved current output circuit is of the current mirror type and serves to output selected current based upon input from the column select and row select.
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7.发明授权公开(公告)号：US06540961B1
公开(公告)日：2003-04-01
申请号：US09532364
申请日：2000-03-21
IPC分类号： G01N100
CPC分类号： G11C13/0019 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00644 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502707 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , B01L2300/0858 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/44743 , G11C13/0014 , G11C13/04 , G11C19/00 , H01L25/50 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： An electronic device performs active biological operations such as, for example, the analysis of a solution containing charged biological materials. The device can take the form of a flow cell that includes an inlet chamber and an outlet chamber connected to a flow cell chamber. An array containing a plurality of electrodes is contained within the flow cell chamber. Inlet and outlet ports are provided in the inlet chamber and outlet chamber, respectively. The inlet and outlet chambers advantageously have substantially constant cross-sectional flow areas.
摘要翻译： 电子设备执行活性生物学操作，例如分析含有带电生物材料的溶液。 该装置可以采取流动池的形式，其包括连接到流动池室的入口室和出口室。 包含多个电极的阵列包含在流动池室内。 入口和出口分别设置在入口室和出口室中。 入口和出口室有利地具有基本恒定的横截面流动面积。
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公开(公告)号：US06225059B1
公开(公告)日：2001-05-01
申请号：US09240489
申请日：1999-01-29
IPC分类号： C12Q168
CPC分类号： H01L25/50 , B01J19/0046 , B01J19/0093 , B01J2219/00315 , B01J2219/00317 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00686 , B01J2219/00689 , B01J2219/00702 , B01J2219/00713 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L3/502715 , B01L3/502761 , B01L3/5085 , B01L2200/0647 , B01L2200/0689 , B01L2200/12 , B01L2300/0636 , B01L2300/0645 , B01L2300/0877 , B01L2300/0887 , B01L2400/0415 , B82Y5/00 , B82Y10/00 , C07B2200/11 , C07H21/00 , C07K1/04 , C07K1/045 , C07K1/047 , C12Q1/6813 , C12Q1/6816 , C12Q1/6825 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B60/14 , F04B19/006 , G01N27/3276 , G01N27/44743 , G01N33/5438 , G11C13/0014 , G11C13/0019 , G11C13/04 , G11C19/00 , H01L2924/0002 , C12Q2565/515 , C12Q2565/607 , H01L2924/00
摘要： Methods of manufacture and devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. In one embodiment, a device includes focusing electrodes to aid in the direction and transport of materials from a collection electrode to an array. Preferably, one or more intermediate transportation electrodes are utilized, most preferably of monotonically decreasing size between the collection electrode and the array, so as to reduce current density mismatches. In another aspect, a flow cell is utilized over devices to provide containment of solution containing materials to be analyzed. Preferably, the volume of the flow cell is more advantageously interrogated through use of relatively large collection and return electrodes, such as where the area of those electrodes relative to the footprint of the flowcell is at least 40%. In yet another embodiment, a first collection electrode is disposed adjacent an array, with a second collection electrode disposed on the at least an opposite portion of the array. Preferably, the combined area of the collection electrodes is a substantial fraction, preferably at least 50% of the area of the footprint of the flow cell. In yet another embodiment, a concentric ring design is provided. Various flip-chip embodiments are disclosed. A preferred embodiment utilizes a relatively small number of components, for example, five components, for a flip-chip device. A first substrate includes a via, through which solution flows to the underlying analytical chip, which a sealant between the chip and the first substrate. An overlying flow cell contains the solution. Novel manufacturing techniques are provided for utilizing the via as a shadow mask to constrain the flow of the sealant. A multiple site array system includes a row select and column select, which are preferably memory, and most preferably shift register memory. An improved current output circuit is of the current mirror type and serves to output selected current based upon input from the column select and row select.
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公开(公告)号：US20140072002A1
公开(公告)日：2014-03-13
申请号：US14024607
申请日：2013-09-11
IPC分类号： H01S5/00
CPC分类号： H01S5/0085 , B82Y20/00 , H01S5/0014 , H01S5/0078 , H01S5/0428 , H01S5/06226 , H01S5/1085 , H01S5/22 , H01S5/34313 , H01S5/4006 , H01S5/50
摘要： Disclosed are systems and methods for using a semiconductor optical amplifier (SOA) as an optical modulator for pulsed signals. In accordance with the principles of the invention, the SOA can be biased with a negative voltage to suppress transmission and improve modulator extinction and biased with a positive pulsed signal with sufficient amplitude to forward bias the amplifier (SOA), both transmitting the carrier and increasing its amplitude by means of a gain provided by the SOA under forward biased conditions. In addition, the forward bias voltage may be selected to compensate for losses within the SOA.
摘要翻译： 公开了使用半导体光放大器（SOA）作为脉冲信号的光调制器的系统和方法。 根据本发明的原理，SOA可以用负电压偏置以抑制传输并改善调制器消光并且利用具有足够幅度的正脉冲信号来偏置放大器（SOA）的正向偏置，从而传输载波并增加 其幅度通过SOA在正向偏置条件下提供的增益。 此外，可以选择正向偏置电压来补偿SOA内的损耗。
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10.发明授权公开(公告)号：US06743211B1
公开(公告)日：2004-06-01
申请号：US09448107
申请日：1999-11-23
申请人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
发明人： Mark R. Prausnitz , Mark G. Allen , Sebastien Henry , Devin V. McAllister , Donald E. Ackley , Thomas Jackson
IPC分类号： A61M500
CPC分类号： A61M37/0015 , A61B5/14514 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150076 , A61B5/150083 , A61B5/150099 , A61B5/150213 , A61B5/150229 , A61B5/150389 , A61B5/150412 , A61B5/150503 , A61B5/150984 , A61B5/151 , A61B17/205 , A61M5/422 , A61M5/425 , A61M2037/0023 , A61M2037/003 , A61M2037/0053 , B33Y80/00
摘要： Microneedle devices and methods of use thereof are provided for the enhanced transport of molecules, including drugs and biological molecules, across tissue by improving the interaction of microneedles and a deformable, elastic biological barrier, such as human skin. The devices and methods act to (1) limit the elasticity, (2) adapt to the elasticity, (3) utilize alternate ways of creating the holes for the microneedles to penetrate the biological barrier, other than the simply direct pressure of the microneedle substrate to the barrier surface, or (4) any combination of these methods. In preferred embodiments for limiting the elasticity of skin, the microneedle device includes features suitable for stretching, pulling, or pinching the skin to present a more rigid, less deformable, surface in the area to which the microneedles are applied (i.e. penetrate). In a preferred embodiments for adapting the device to the elasticity of skin, the device comprising one or more extensions interposed between the substrate and the base end of at least a portion of the microneedles.
摘要翻译： 提供微针装置及其使用方法用于通过改善微针和可变形的弹性生物屏障（例如人皮肤）的相互作用来增强跨组织的分子（包括药物和生物分子）的转运。 装置和方法用于（1）限制弹性，（2）适应弹性，（3）除了微针衬底的简单直接压力之外，利用替代方式产生微针穿透生物屏障的孔 或（4）这些方法的任何组合。 在用于限制皮肤弹性的优选实施例中，微针装置包括适于拉伸，拉伸或夹紧皮肤以在微针施加的区域（即，穿透）上呈现更刚性，更不易变形的表面的特征。 在用于使装置适应皮肤弹性的优选实施例中，该装置包括一个或多个延伸部，该延伸部插入到基底和至少一部分微针的基端之间。
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