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    METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES
    1.
    发明申请
    METHODS AND APPARATUS FOR USE OF OPTICAL FORCES FOR IDENTIFICATION, CHARACTERIZATION AND/OR SORTING OF PARTICLES 审中-公开
    用于识别，表征和/或分配颗粒的光学强度的方法和装置

    公开(公告)号：US20100108577A1

    公开(公告)日：2010-05-06

    申请号：US12545624

    申请日：2009-08-21

    申请人： Mark M. Wang ,  Eugene Tu ,  Luis M. Pestana ,  Andrew E. Senyei ,  James P. O'Connell ,  Tina S. Nova ,  Kristie L. Lykstad ,  Jeffrey M. Hall ,  William F. Butler

    发明人： Mark M. Wang ,  Eugene Tu ,  Luis M. Pestana ,  Andrew E. Senyei ,  James P. O'Connell ,  Tina S. Nova ,  Kristie L. Lykstad ,  Jeffrey M. Hall ,  William F. Butler

    IPC分类号： B07C5/36

    CPC分类号： G01N15/1463 ,  B07C5/34 ,  G01N15/1459 ,  G01N30/02 ,  G01N2015/1486 ,  G01N2015/149 ,  H05H3/04 ,  B01D2015/3895

    摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a particle may be characterized by determining its optophoretic constant or signature. For example, a diseased cell has a different optophoretic constant from a healthy cell, thereby providing information, or the basis for sorting. In the event of physical sorting, various forces may be used for separation, including fluidic forces, such as through the use of laminar flow, or optical forces, or mechanical forces, such as through adhesion. Various techniques for measuring the dielectric constant of particles are provided.

    摘要翻译： 提供了用于以独特且非常有用的方式将光与颗粒（包括但不限于生物物质如细胞）相互作用的装置和方法。 电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。 在生物学中，该技术代表了探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。 在一个方面，粒子的特征可以在于确定其荧光特性常数或特征。 例如，患病细胞与健康细胞具有不同的视觉波动常数，从而提供信息或分选的基础。 在物理分选的情况下，各种力可以用于分离，包括流体力，例如通过使用层流，或光学力，或机械力，例如通过粘附。 提供了用于测量颗粒的介电常数的各种技术。

    Method for separation of particles
    3.
    发明授权
    Method for separation of particles 有权
    分离颗粒的方法

    公开(公告)号：US06815664B2

    公开(公告)日：2004-11-09

    申请号：US09993318

    申请日：2001-11-14

    申请人： Mark M. Wang ,  Eugene Tu ,  James P. O'Connell ,  Kristie L. Lykstad ,  William F. Butler

    发明人： Mark M. Wang ,  Eugene Tu ,  James P. O'Connell ,  Kristie L. Lykstad ,  William F. Butler

    IPC分类号： H01S300

    CPC分类号： G01N15/1463 ,  B07C5/34 ,  G01N15/1459 ,  G01N30/02 ,  G01N2015/1486 ,  G01N2015/149 ,  H05H3/04 ,  B01D2015/3895

    摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a method is provided for separating particles by flowing the particles within a first constrained path, the first constrained path having an input and an output, and a sorting region, the sorting region coupling to a second constrained path, the second constrained path including an output, illuminating the sorting region with a moving optical gradient, characterized in that certain of the particles flow in a laminar manner between the first inlet and the output of the first constrained path, and selected particles are diverted from the first constrained path to the second constrained path under the force of the moving optical gradient.

    摘要翻译： 提供了用于以独特且非常有用的方式将光与颗粒（包括但不限于生物物质如细胞）相互作用的装置和方法。 电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。 在生物学中，该技术代表了探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。 在一个方面，提供了一种用于通过在第一约束路径内流动所述粒子来分离颗粒的方法，所述第一约束路径具有输入和输出，以及分选区域，所述分选区域耦合到第二约束路径，所述第二约束路径 路径，其包括输出，用移动的光学梯度照亮分选区域，其特征在于，某些颗粒以层状方式在第一约束路径的第一入口和输出之间流动，并且选定的颗粒从第一约束路径 到移动光学梯度的力的第二约束路径。

    Method and apparatus for destroying a syringe needle
    5.
    发明授权
    Method and apparatus for destroying a syringe needle 失效
    破坏注射器针头的方法和装置

    公开(公告)号：US5091621A

    公开(公告)日：1992-02-25

    申请号：US532021

    申请日：1990-06-01

    申请人： William F. Butler

    发明人： William F. Butler

    IPC分类号： A61M5/32 ,  B23H9/00

    CPC分类号： B23H9/005 ,  A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

    摘要： A method and apparatus for destroying a syringe needle, having a housing, first and second walls in opposed relationship in the housing and defining therebetween a needle burn chamber, the distance between the first and second surfaces being at least the length of the needle, the first surface defining a first opening therethrough, a needle receiving enclosure in the chamber movable between the first and second surfaces and defining a second opening therethrough which is coaxial with the first opening, a first electrical contact on the needle receiving enclosure, a second electrical contact on the second surface and being in registry with the second opening, power source connected to the first and second contacts, a waste collector disposed in the housing beneath and in communication with the burn chamber, the waste collector being removable from the housing and a mechanism that moves the needle receiving enclosure toward the first opening; so that when the needle is inserted through the first and second openings to be in contacting relationship to the needle receiving enclosure and the needle receiving means is moved toward the second surface, the tip of the needle engages the second contact closing the circuit between the contacts and melting the needle along at least most of its length with the resultant melted waste falling into the waste collector.

    摘要翻译： 一种用于破坏注射器针的方法和装置，具有壳体，在壳体中具有相对关系的第一和第二壁，并在其间限定针燃烧室，第一和第二表面之间的距离至少为针的长度， 第一表面限定穿过其中的第一开口，所述腔室中的针接收外壳在第一和第二表面之间可移动并且限定与第一开口同轴的第二开口，针接收外壳上的第一电接触， 在所述第二表面上并与所述第二开口对准的电源，连接到所述第一和第二触点的电源，设置在所述壳体内的与所述燃烧室连通的废料收集器，所述废物收集器可从所述壳体移除， 使针接收外壳朝向第一开口移动; 使得当针穿过第一和第二开口以与针接收外壳处于接触关系时，针接收装置朝向第二表面移动时，针的尖端接合闭合触点之间的电路的第二触点 并且沿着其长度的至少大部分熔化针，并将所得到的熔化废物落入废物收集器中。

    Method and apparatus for electrically destroying a syringe needle
    8.
    发明授权
    Method and apparatus for electrically destroying a syringe needle 失效
    电针破坏注射器针头的方法和装置

    公开(公告)号：US5736706A

    公开(公告)日：1998-04-07

    申请号：US707923

    申请日：1996-09-10

    申请人： William F. Butler

    发明人： William F. Butler

    IPC分类号： A61L11/00 ,  A61G12/00 ,  A61M5/32 ,  B09B3/00 ,  B23K11/22

    CPC分类号： B09B3/0075 ,  A61M5/3278 ,  A61M2005/3283 ,  Y10S83/944

    摘要： A method and apparatus for sterilizing and destroying a syringe needle includes a rotating needle carriage that receives a needle in a loading position. The needle carriage is rotated downwardly to a cut-off position. At the cut-off position, two opposing contact blades pinch the needle, which electrically connects the positive and negative terminals of a battery. Current flows through the contact blades and the needle, thereby melting the needle. A slight further rotation of the needle carriage causes the contact blades to shear the needle. The sheared portion of the needle then falls into a waste compartment in the bottom of the apparatus. When the syringe is removed from the needle carriage, the needle carriage rotates upwardly and returns to the loading position.

    摘要翻译： 用于消毒和破坏注射器针头的方法和装置包括：旋转针架，其在加载位置接收针头。 针架向下旋转至切断位置。 在切断位置，两个相对的接触片夹住针，电连接电池的正极和负极端子。 电流流过接触叶片和针头，从而熔化针头。 针架的稍微进一步旋转导致接触片剪切针。 针的剪切部分然后落入设备底部的废物隔间中。 当注射器从针架移除时，针托架向上旋转并返回到装载位置。

    Method of separating particles using an optical gradient
    10.
    发明授权
    Method of separating particles using an optical gradient 有权
    使用光学梯度分离颗粒的方法

    公开(公告)号：US06784420B2

    公开(公告)日：2004-08-31

    申请号：US09993377

    申请日：2001-11-14

    申请人： Mark M. Wang ,  Eugene Tu ,  James P. O'Connell ,  Kristie L. Lykstad ,  William F. Butler

    发明人： Mark M. Wang ,  Eugene Tu ,  James P. O'Connell ,  Kristie L. Lykstad ,  William F. Butler

    IPC分类号： H01S300

    CPC分类号： G01N15/1456 ,  B07C5/34 ,  G01N15/1459 ,  G01N15/1463 ,  G01N30/00 ,  G01N30/02 ,  G01N2015/1486 ,  G01N2015/149 ,  H05H3/04 ,  B01D2015/3895

    摘要： Apparatus and methods are provided for interacting light with particles, including but not limited to biological matter such as cells, in unique and highly useful ways. Optophoresis consists of subjecting particles to various optical forces, especially optical gradient forces, and more particularly moving optical gradient forces, so as to obtain useful results. In biology, this technology represents a practical approach to probing the inner workings of a living cell, preferably without any dyes, labels or other markers. In one aspect, a method is provided for interacting an optical gradient field in three dimensions with a particle by interfering two beams to generate a plurality of planar fronts, providing a plurality of particles in a medium, and moving the planar fronts relative to the particles, whereby the particles are separated at least in part based upon the dielectric constant of the particles.

    摘要翻译： 提供了用于以独特且非常有用的方式将光与颗粒（包括但不限于生物物质如细胞）相互作用的装置和方法。 电渗疗法包括使颗粒经受各种光学力，特别是光学梯度力，尤其是移动的光学梯度力，从而获得有用的结果。 在生物学中，该技术代表了探测活细胞内部运作的实际方法，优选没有任何染料，标签或其他标记物。 在一个方面，提供了一种用于通过干扰两个光束来将三维光学梯度场与粒子相互作用以产生多个平面前沿，在介质中提供多个粒子并相对于粒子移动平面前沿的方法 其中颗粒至少部分地基于颗粒的介电常数被分离。