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公开(公告)号：US20210041422A1
公开(公告)日：2021-02-11
申请号：US17082615
申请日：2020-10-28
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Amir ZAIT , Arnon HOURI YAFIN , Dan GLUCK , Sharon PECKER , Yochay Shlomo ESHEL , Sarah LEVY SCHREIER , Joseph Joel POLLAK
IPC: G01N33/50 , G01N33/49 , G01N15/06 , G01N33/569
Abstract: Apparatus and methods are described including placing a first portion of a biological sample into a source sample portion chamber of a sample carrier, and placing a second portion of the biological sample into a diluted sample portion chamber. The second portion of the biological sample is diluted with respect to the first portion of the biological sample. Using an optical measurement device, a bulk-level measurand of the sample that relates to a parameter of the biological sample as a whole is measured, by performing a measurement upon the first portion of the biological sample. Microscopic images of the second portion of the biological sample are acquired. Other applications are also described.
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公开(公告)号：US20190302099A1
公开(公告)日：2019-10-03
申请号：US16098893
申请日：2017-05-11
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Sarah LEVY SCHREIER , Yochay Shlomo ESHEL , Amir ZAIT , Sharon PECKER
Abstract: Apparatus and methods are described for determining a property of a biological sample. A sample carrier (22) includes one or more sample chambers (40) that define at least a first region (42) and a second region (44), the height of the one or more sample chambers varying between the first and second regions in a predefined manner. A computer processor (28) receives data relating to a first optical measurement that is performed upon a portion of the sample that is disposed within the first region, receives data relating to a second optical measurement that is performed upon a portion of the sample that is disposed within the second region, and determines the property of the sample by using a relationship between the first optical measurement, the second optical measurement, and the predefined variation in height between the regions. Other applications are also described.
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公开(公告)号：US20190087953A1
公开(公告)日：2019-03-21
申请号：US15506997
申请日：2015-08-27
Applicant: S.D. Sight Diagnostics Ltd
Inventor： Noam YORAV-RAPHAEL , Uri WOLFOVITZ , Joseph Joel POLLAK
CPC classification number: G06T7/0012 , G02B21/244 , G06T7/0002 , G06T7/90 , G06T2207/10056 , G06T2207/10061 , G06T2207/30072 , G06T2207/30168
Abstract: A digital microscopy method, comprising: obtaining data representative of a series of images of at least a portion of a cell sample, the images being captured by performing a depth scan using a digital microscope, the series of images being associated with a series of depth levels of the cell sample, wherein the portion encompasses a mapping field, and the mapping field comprises a plurality of focus analysis regions; and calculating, using the images, a focus configuration for at least two of the focus analysis regions within the mapping field, giving rise to data indicative of focus variations within the mapping field.
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公开(公告)号：US20160208306A1
公开(公告)日：2016-07-21
申请号：US15083610
申请日：2016-03-29
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Joseph Joel POLLAK , Arnon HOURI YAFIN , Seth J. SALPETER
CPC classification number: C12Q1/04 , G01N1/2813 , G01N1/38 , G01N15/1463 , G01N15/1475 , G01N21/6428 , G01N21/6486 , G01N33/49 , G01N2015/0065 , G01N2021/6439 , G02B21/361
Abstract: Provided is a method for imaging a blood sample and a kit and system for executing the method. The method includes introducing a cell suspension including red blood cells onto a base surface of a carrier having a vertical height (H) being greater than or equal to a vertical depth (h) of the cell suspension when on the base carrier, the cell suspension including a cell concentration (C) being determined by a defined function; allowing the cells in the cell suspension to settle on the base surface of the carrier to form a monolayer of cells thereon; and acquiring at least one microscope image of at least a portion of the monolayer of cells; wherein the at least one microscope image is obtained by a microscope set to Depth Of Field that is not more than 20% of the vertical height of the cell suspension settled on the base surface.
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公开(公告)号：US20250076176A1
公开(公告)日：2025-03-06
申请号：US18952650
申请日：2024-11-19
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Arnon HOURI YAFIN , Joseph Joel POLLAK , Neta BACHAR , Annael MARCIANO , Sarah LEVY SCHREIER
Abstract: Apparatus and methods are described including acquiring first and second images of a blood sample at respective times and determining whether, between acquisitions of the first and second images, there was motion of an entity, by comparing the first and second images to one another. At least partially in response thereto, the entity is identified, and an output is generated on the output device, at least partially in response to identification of the entity. Other applications are also described.
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Patent Agency Ranking
公开(公告)号：US20230028360A1
公开(公告)日：2023-01-26
申请号：US17783924
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yonatan HALPERIN , Dan GLUCK , Noam YORAV-RAPHAEL , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are described for use with a blood sample. Using a microscope (24), three images of a microscopic imaging field of the blood sample are acquired, each of the images being acquired using respective, different imaging conditions, and the first one of the three images being acquired under violet-light brightfield imaging. Using at least one computer processor (28), an artificial color microscopic image of the microscopic imaging field is generated, by mapping the first one of the three images to a red channel of the artificial color microscopic image, mapping a second one of the three images to a second color channel of the artificial color microscopic image, and mapping a third one of the three images to a third color channel of the artificial color microscopic image. Other applications are also described.
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公开(公告)号：US20230011382A1
公开(公告)日：2023-01-12
申请号：US17783831
申请日：2020-12-10
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Dan GLUCK , Amir ZAIT , Arnon HOURI YAFIN , Yonatan HALPERIN , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK , Sharon PECKER , Peretz YAFIN , Dana BENBASSAT , David BRAILOVSKY , Uriyah PUMERANTZ
Abstract: Apparatus and methods are described use with a bodily sample that contains cells. A microscope (24) is focused, such that a focal plane of the microscope (24) at least approximately coincides with a level at which at least some cells belonging to the sample are at least partially disposed. At least one on-focus microscopic image of the sample, while the focal plane of the microscope (24) approximately coincides with the level. The microscope (24) is focused such that the focal plane of the microscope is offset with respect to the level, at least one off-focus microscopic image of the sample is acquired, while the focal plane of the microscope (24) is offset with respect to the level. A property of at least a portion of the sample is determined, at least partially based upon the on-focus and off-focus images. Other applications are also described.
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公开(公告)号：US20230003622A1
公开(公告)日：2023-01-05
申请号：US17783930
申请日：2020-12-10
Applicant: S.D. SIGHT DIAGNOSTICS LTD
Inventor： Peretz YAFIN , Dan GLUCK , Amir ZAIT , Yochay Shlomo ESHEL , Sarah LEVY , Joseph Joel POLLAK
Abstract: Apparatus and methods are provided including imaging a blood sample that is a cell suspension deposited in a sample chamber. The cells are allowed to settle in the sample chamber to form a monolayer of cells. At least one microscopic image is acquired of the monolayer of cells using a microscope (24) while the microscope is focused at a monolayer-depth-level, and a first platelet count of platelets that have settled within the monolayer, is determined. An additional microscopic image of the simple is acquired, while the microscope is focused at a different depth level from the monolayer-depth-level, and a second platelet count of platelets that have not settled within the monolayer is determined. An output is generated based upon the first and second platelet counts. Other applications are also described.
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公开(公告)号：US20220390372A1
公开(公告)日：2022-12-08
申请号：US17770339
申请日：2020-10-22
Applicant: S.D. SIGHT DIAGNOSTICS LTD.
Inventor： Sharon PECKER , Yochay Shlomo ESHEL , Amir ZAIT , Dan GLUCK , Noam YORAV-RAPHAEL , Arnon HOURI YAFIN , Sarah LEVY SCHREIER , Joseph Joel POLLAK , Daniel LEVNER , Yonatan HALPERIN , Natalie LEZMY , Itamar WEISS
Abstract: Apparatus and methods are described including preparing a blood sample for analysis by depositing the blood sample within a sample chamber (52), and placing the sample chamber, with the blood sample deposited therein, within a microscopy unit (24). One or more microscopic images of the sample chamber (52) with the blood sample deposited therein are acquired, using a microscope of the microscopy unit. Based upon the one or more images, an amount of one or more cell types within the sample chamber that had already settled within the sample chamber, prior to acquisition of the one or more microscopic images is determined. A characteristic of the sample is determined, at least partially in response thereto. Other applications are also described.
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公开(公告)号：US20200049970A1
公开(公告)日：2020-02-13
申请号：US16657473
申请日：2019-10-18
Applicant: S.D. Sight Diagnostics Ltd.
Inventor： Yochay Shlomo ESHEL , Natalie LEZMY , Dan GLUCK , Arnon HOURI YAFIN , Joseph Joel POLLAK
Abstract: Apparatus and methods for analyzing a bodily sample are described. A microscope system acquires one or more microscope images of the bodily sample. A computer processor identifies, in the one or more images, at least one element as being a candidate of a given entity. The computer processor extracts, from the one or more images, at least one candidate-informative feature associated with the candidate of the given entity, and at least one sample-informative feature that is indicative of a characteristic of the bodily sample as a whole. The computer processor processes the candidate-informative feature in combination with the sample-informative feature, and generates an output upon the output device, in response thereto. Other applications are also described.
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