中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

34 records (took 0.019 seconds)

    Method for the biotechnological production of flavone glycoside dihydrochalcones
    13.
    发明授权
    Method for the biotechnological production of flavone glycoside dihydrochalcones 有权

    公开(公告)号：US10538797B2

    公开(公告)日：2020-01-21

    申请号：US15322768

    申请日：2015-06-27

    Applicant: SYMRISE AG

    Inventor： Maren Thomsen ,  Jakob Ley ,  Egon Gross ,  Winfried Hinrichs ,  Uwe Bornscheuer

    IPC: C12P19/60 ,  C12P17/06 ,  A23L27/30

    Abstract: The invention relates to a method for producing flavone glycoside dihydrochalcones, having the following steps: (a) providing a transgenic microorganism containing (i) a first nucleic acid portion (A) containing a gene which codes for a bacterial chalcone isomerase and (ii) a second nucleic acid portion (B) containing a gene which codes for a bacterial enoate reductase, (b) adding one or more flavone glycosides to the transgenic microorganism under conditions which allow the simultaneous isomerization and reduction of the flavone glycoside into the flavone glycoside dihydrochalcone, and optionally (d) isolating and purifying the final product, wherein the nucleic acid portion (A) (1) is a nucleotide sequence according to SEQ ID NO:1, in which the nucleic acid portion (A′) according to SEQ ID NO:3 has been cut out, or (2) is an amino acid sequence according to SEQ ID NO:2, in which the amino acid portion (A′) according to SEQ ID NO:4 has been cut out.

    Compounds and Mixtures Influencing Inflammatory States
    17.
    发明申请
    Compounds and Mixtures Influencing Inflammatory States 审中-公开
    影响炎症状态的化合物和混合物

    公开(公告)号：US20130251730A1

    公开(公告)日：2013-09-26

    申请号：US13782391

    申请日：2013-03-01

    Applicant: SYMRISE AG

    Inventor： Jakob Ley ,  Katharina Reichelt ,  Marcus Götz ,  Maria Blings ,  Veronika Somoza ,  Jessica Walker ,  Joel Michael Walker

    IPC: A61K31/192 ,  C07D311/58 ,  A23L1/30 ,  C07D311/32 ,  A61K45/06 ,  C07C65/40 ,  A61K31/353

    CPC classification number: A61K31/192 ,  A23L33/105 ,  A61K8/365 ,  A61K8/498 ,  A61K31/352 ,  A61K31/353 ,  A61K45/06 ,  A61K2800/10 ,  A61Q19/00 ,  C07C65/40 ,  C07D311/32 ,  C07D311/58 ,  A61K2300/00

    Abstract: Suggested is a compound of the formula (X) or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies: R1 means hydrogen or methyl, R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, or R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms, for use in a method for the prophylaxis and/or treatment of inflammation.

    Abstract translation: 建议式（X）的化合物或式（X）化合物的任何盐或含有两种或更多种不同式（X）化合物的任何混合物或两种或更多种不同的 式（X）或一种或多种不同的式（X）化合物和一种或多种式（X）化合物的不同盐，其中对于R 1，R 2和R 3在每个式（X ）适用：R 1表示氢或甲基，R 2表示具有5个碳原子和一个氧原子的有机残基或不表示R 3表示具有10个碳原子和一个或多个氧原子的有机残基，或R 1和R 2与 位置4和5中的碳原子和结合到位置4的碳原子的氧原子形成环，并且包含5个碳原子和一个氧原子或不存在，并且R 3表示具有10个碳原子和一个或多个氧原子的有机残基 ，用于预防和/或治疗的方法 炎症。

    Compositions Comprising Guaifenesin and Flavour Compounds Containing an Isovanillyl Group
    19.
    发明申请
    Compositions Comprising Guaifenesin and Flavour Compounds Containing an Isovanillyl Group 有权

    公开(公告)号：US20210386686A1

    公开(公告)日：2021-12-16

    申请号：US17284323

    申请日：2018-10-09

    Applicant: SYMRISE AG

    Inventor： Veronika Somoza ,  Leopoldo Beltran ,  Joachim Hans ,  Jakob Ley

    IPC: A61K31/09 ,  A61K45/06 ,  A61K47/26 ,  A61K9/00

    Abstract: The present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group. In particular, the present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of guaifenesin and one or more flavour compounds containing an isovanillyl group for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of one or more flavour compound(s) containing an isovanillyl group for masking or inhibiting the bitter taste of guaifenesin or of guaifenesin comprising compositions.

Patent Agency Ranking