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公开(公告)号：US5658780A
公开(公告)日：1997-08-19
申请号：US291932
申请日：1994-08-15
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12Q1/68 , C07H21/04 , C12N15/85
CPC分类号： C12N15/101 , C07K14/4702 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/315 , C12N2310/317 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3517 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave rel A mRNA.
摘要翻译： 分解相关A mRNA的酶RNA分子。
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公开(公告)号：US5811300A
公开(公告)日：1998-09-22
申请号：US311486
申请日：1994-09-23
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C12N9/64 , C12N15/10 , C12N15/113 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/4702 , C12N15/101 , C12N15/113 , C12N15/1131 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/1241 , C12N2310/126 , C12N2310/127 , C12N2310/32 , C12N2310/322 , C12N2310/333 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/3513 , C12N2310/3523 , C12N2310/3527 , C12N2310/3533 , C12N2310/3535
摘要： Enzymatic RNA molecules which cleave TNF-.alpha. mRNA.
摘要翻译： 切割TNF-αmRNA的酶RNA分子。
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公开(公告)号：US5877022A
公开(公告)日：1999-03-02
申请号：US774310
申请日：1996-12-26
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , C12N5/10 , C12N9/00 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122
摘要： Enzymatic RNA molecules which cleave apo(a) mRNA.
摘要翻译： 切割apo（a）mRNA的酶RNA分子。
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公开(公告)号：US5599706A
公开(公告)日：1997-02-04
申请号：US311760
申请日：1994-09-23
IPC分类号： C12N15/09 , A61K31/70 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , C12N5/10 , C12N9/00 , C12N15/113 , C12N15/85 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122
摘要： Enzymatic RNA molecules which cleave apo(a) mRNA.
摘要翻译： 切割apo（a）mRNA的酶RNA分子。
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公开(公告)号：US5877021A
公开(公告)日：1999-03-02
申请号：US585684
申请日：1996-01-12
申请人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
发明人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
IPC分类号： C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C12N9/64 , C12N15/113 , C12Q1/68 , C12N5/08 , C70H21/02
CPC分类号： C07H19/16 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12N15/113 , C12N15/1138 , C12N9/6491 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/3521
摘要： Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1.
摘要翻译： 阻断编码B7-1的mRNA的合成和/或表达的核酸分子。
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公开(公告)号：US5646042A
公开(公告)日：1997-07-08
申请号：US373124
申请日：1995-01-13
IPC分类号： C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12N5/22 , C12N5/16 , C12N9/22 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要： Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译： 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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公开(公告)号：US06194150B1
公开(公告)日：2001-02-27
申请号：US09038073
申请日：1998-03-11
申请人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
发明人： Dan T. Stinchcomb , Thale Jarvis , James McSwiggen
IPC分类号： C07H2104
CPC分类号： C07H19/16 , C07H19/06 , C07H19/10 , C07H19/20 , C07H21/00 , C12N9/6491 , C12N15/113 , C12N15/1138 , C12N2310/122 , C12N2310/123 , C12N2310/126 , C12N2310/3521
摘要： Nucleic acid molecule which blocks synthesis and/or expression of an mRNA encoding B7-1, B7-2, B7-3 and/or CD40.
摘要翻译： 阻断编码B7-1，B7-2，B7-3和/或CD40的mRNA的合成和/或表达的核酸分子。
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公开(公告)号：US5817796A
公开(公告)日：1998-10-06
申请号：US435628
申请日：1995-05-05
IPC分类号： C12N15/09 , A61K31/35 , A61K31/47 , A61K31/70 , A61K35/76 , A61K38/00 , A61K48/00 , A61P9/08 , A61P35/00 , C07H21/04 , C07K14/47 , C12N5/10 , C12N9/00 , C12N9/64 , C12N15/113 , C12R1/91 , C12Q1/68
CPC分类号： C12N15/113 , C07K14/4702 , C12N15/1135 , C12N15/1136 , C12N15/1137 , C12N15/1138 , C12N9/6491 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/315 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/335 , C12N2310/3517
摘要： Enzymatic nucleic acid molecules which cleave c-myb RNA or other RNAs associated with restenosis or cancer.
摘要翻译： 切割c-myb RNA或与再狭窄或癌症相关的其他RNA的酶学核酸分子。
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19.发明授权Compositions, methods and uses for expression of enterobacterium-associated peptides 有权用于表达肠杆菌相关肽的组合物，方法和用途公开(公告)号：US09028809B2
公开(公告)日：2015-05-12
申请号：US13511652
申请日：2010-11-24
IPC分类号： A01N63/00 , A61K39/275 , A61K39/00 , A61K39/02
CPC分类号： A61K39/025 , A61K39/0291 , A61K2039/5256 , A61K2039/53 , C07K14/24 , C12N7/00 , C12N15/86 , C12N2710/24134 , C12N2710/24141 , C12N2710/24143 , C12N2710/24171 , C12N2840/002 , C12N2840/85 , Y02A50/407
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing enterobacterial-associated peptides. In some embodiments, enterobacterial-associated peptides include, but are not limited to plague-associated peptides. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, attenuated or modified vaccinia virus vectors expressing enterobacterial-associated peptides. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达肠细菌相关肽的方法，组合物和用途。 在一些实施方案中，肠细菌相关肽包括但不限于瘟疫相关肽。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于表达肠细菌相关肽的减毒或修饰的痘苗病毒载体。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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20.发明授权公开(公告)号：US09011874B2
公开(公告)日：2015-04-21
申请号：US13510601
申请日：2010-11-22
IPC分类号： A61K49/00 , A61K39/38 , A61K39/295 , A61K39/145 , A61K39/245 , C12Q1/70 , C12N15/863 , A61K39/12 , A61K39/00 , C07K14/005
CPC分类号： C12N15/86 , A61K39/00 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K2319/02 , C12N15/863 , C12N2710/24134 , C12N2710/24143 , C12N2760/16034 , C12N2760/16122 , C12N2760/16134
摘要： Embodiments of the present invention generally disclose methods, compositions and uses for generating and expressing poxvirus constructs. In some embodiments, constructs may contain an influenza virus gene segment. In certain embodiments, methods generally relate to making and using compositions of constructs including, but not limited to, poxvirus vaccine compositions. In other embodiments, vaccine compositions are reported of use in a subject.
摘要翻译： 本发明的实施方案通常公开了用于产生和表达痘病毒构建体的方法，组合物和用途。 在一些实施方案中，构建体可以含有流感病毒基因区段。 在某些实施方案中，方法通常涉及制备和使用构建体的组合物，包括但不限于痘病毒疫苗组合物。 在其它实施方案中，报告了在受试者中使用的疫苗组合物。
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