公开(公告)号：US10829427B2

公开(公告)日：2020-11-10

申请号：US16063347

申请日：2016-12-16

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Yuliang Liu ,  Qi Wei ,  Xinpeng Ma ,  Gang Huang

IPC: C07C50/32 ,  C07C311/08 ,  C07C311/21 ,  C07C225/30 ,  C07C233/91 ,  C07C233/18 ,  C07C271/30 ,  C07C205/46 ,  C07C311/09 ,  C07C233/31 ,  C07D317/70 ,  C07C311/51 ,  A61K9/00 ,  A61K9/51 ,  A61P35/00 ,  C07C233/33 ,  C07C233/42 ,  C07D295/116

Abstract: Provided herein are naphthoquinones compounds such as those with a hydrogen bond donating group of the formula (I): wherein: R1, R2, R3, R4, R5, and n are as defined herein. Also provided herein are pharmaceutical composition of the present compounds and methods of treatment using the compounds including their use in the treatment of cancer.

公开(公告)号：US10272099B2

公开(公告)日：2019-04-30

申请号：US14783344

申请日：2014-04-08

Applicant: The Board of Regents of the University of Texas System ,  The Board of Trustees of the University of Illinois

Inventor： Paul J. Hergenrother ,  David A. Boothman ,  Joseph S. Bair ,  Lifen Cao ,  Jinming Gao ,  Xiumei Huang ,  Xiuquan Luo ,  Xinpeng Ma ,  Zachary R. Moore ,  Elizabeth I. Parkinson

IPC: A61K31/353 ,  A61K31/4745 ,  A61K31/131 ,  A61K31/706 ,  A61K45/06 ,  C12Q1/6886 ,  A61K31/4738

Abstract: The therapies described herein can be selectively lethal toward a variety of different cancer cell types and cancer conditions in a subject. The combination therapies described herein can be useful for the management, treatment, control, or adjunct treatment of diseases, where the selective lethality is beneficial in chemotherapeutic therapy, particularly where the disease is accompanied by elevated levels of NQO1.

公开(公告)号：US10098971B2

公开(公告)日：2018-10-16

申请号：US15369701

申请日：2016-12-05

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Gang Huang ,  Tian Zhao ,  Xinpeng Ma ,  Yiguang Wang ,  Yang Li ,  Baran D. Sumer

IPC: A61K49/00 ,  G01N33/84 ,  G01N33/58 ,  C08F8/30 ,  C08F8/42 ,  C08F8/32 ,  C08F8/34 ,  C09B69/10 ,  G01N21/64

Abstract: The present disclosure relates to polymers which contain a hydrophobic and hydrophilic segment which is sensitive to pH. In some aspects, the polymers form a micelle which is sensitive to pH and results in a change in fluorescence based upon the particular pH. In some aspects, the disclosure also provides methods of using the polymers for the imaging of cellular or extracellular environment or delivering a drug.

公开(公告)号：US12091486B2

公开(公告)日：2024-09-17

申请号：US17810591

申请日：2022-07-01

Applicant: The Board of Regents of The University of Texas System

Inventor： Jinming Gao ,  David Boothman ,  Kejin Zhou ,  Xiaonan Huang ,  Yiguang Wang

IPC: C08F293/00 ,  A61K9/107 ,  A61K9/127 ,  A61K9/50 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69 ,  A61K49/00 ,  A61P35/00 ,  C07D311/92 ,  C08F299/02 ,  C08G81/02 ,  G01N33/58

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K47/6907 ,  A61K49/0032 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  A61P35/00 ,  C07D311/92 ,  C08F299/024 ,  C08G81/025 ,  G01N33/582 ,  A61K49/005 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises




wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US11376324B2

公开(公告)日：2022-07-05

申请号：US16081911

申请日：2017-03-02

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Zhijian Chen ,  Min Luo ,  Zhaohui Wang ,  Hua Wang ,  Haocheng Cai ,  Gang Huang ,  Yang-Xin Fu

IPC: A61K39/39 ,  A61K39/00 ,  A61K9/51 ,  A61K47/32 ,  A61K47/58 ,  B82Y5/00 ,  A61K9/00 ,  A61K45/06 ,  A61K39/145

Abstract: In some aspects, the present disclosure provides vaccine compositions comprising an antigen and a diblock copolymer wherein the diblock copolymer is pH responsive. In some embodiments, these compositions activate the STING and/or the interferon receptor pathways. In some embodiments, the diblock copolymer hits a pKa from about 6 to about 7.5. Also provided herein are methods of treatment using these compositions to treat an infectious disease or cancer.

公开(公告)号：US09872926B2

公开(公告)日：2018-01-23

申请号：US15297862

申请日：2016-10-19

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Kejin Zhou ,  Baran D. Sumer

IPC: A61K9/00 ,  A61K49/00 ,  G01N21/64 ,  G01N33/50

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

公开(公告)号：US20170320993A1

公开(公告)日：2017-11-09

申请号：US15662184

申请日：2017-07-27

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  David BOOTHMAN ,  Kejin ZHOU ,  Xiaonan HUANG ,  Yiguang WANG

IPC: C08F293/00 ,  A61K47/68 ,  C07D311/92 ,  A61K49/00 ,  A61K47/58 ,  A61K31/352 ,  A61K31/337 ,  A61K9/50 ,  A61K9/127 ,  A61K9/107 ,  A61K31/704 ,  C08F220/34

CPC classification number: C08F293/005 ,  A61K9/1075 ,  A61K9/1273 ,  A61K9/5031 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K47/58 ,  A61K47/62 ,  A61K47/6811 ,  A61K47/6845 ,  A61K49/0032 ,  A61K49/005 ,  A61K49/0054 ,  A61K49/0056 ,  A61K49/0082 ,  C07D311/92 ,  C08F220/34 ,  C08F2438/01

Abstract: Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R′ is —H or —CH3, wherein R is —NR1R2, wherein R1 and R2 are alkyl groups, wherein R1 and R2 are the same or different, wherein R1 and R2 together have from 5 to 16 carbons, wherein R1 and R2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.

公开(公告)号：US09511152B2

公开(公告)日：2016-12-06

申请号：US13827197

申请日：2013-03-14

Applicant: The Board of Regents of the University of Texas System

Inventor： Jinming Gao ,  Kejin Zhou ,  Baran D. Sumer

IPC: A61K9/14 ,  A61K49/00 ,  G01N21/64

CPC classification number: A61K49/0054 ,  A61K49/0032 ,  A61K49/0082 ,  G01N21/6486 ,  G01N33/502

Abstract: The present invention relates to pH-tunable, highly activatable multicolored fluorescent nanoplatforms and methods of using the nanoplatforms in a variety of applications including, but not limited to, investigating fundamental cell physiological processes such as pH regulation in endocytic vesicles, endosome/lysosome maturation, and effect of pH on receptor cycling and trafficking of subcellular organelles.

Abstract translation: 本发明涉及pH可调节的，高活性的多色荧光纳米平台，以及在各种应用中使用纳米平台的方法，包括但不限于研究基本细胞生理过程，如内吞泡囊中的pH调节，内体/溶酶体成熟， 以及pH对受体循环和运输亚细胞器的影响。