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公开(公告)号：US20210016276A1
公开(公告)日：2021-01-21
申请号：US15733720
申请日：2019-03-29
Applicant: UNIVERSITY OF WASHINGTON
Inventor： Daniel T. CHIU , Seung Ryoung JUNG , Jingang WANG , Bryant S. FUJIMOTO
IPC: B01L3/00 , G01N15/14 , G01N33/543
Abstract: The present disclosure relates to methods, systems, and devices for performing analyses of biological nanoparticles. More specifically, the present disclosure relates to methods, systems, and devices for performing single biological nanoparticle size determination on a sample while the biological nanoparticle is in transit through a microfluidic chip. In other aspects, the present disclosure relates to methods, systems, and devices for selectively capturing biological nanoparticles on a coated planar surface, the capturing being facilitated by centrifugation.
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公开(公告)号：US20160354777A1
公开(公告)日：2016-12-08
申请号：US14900926
申请日：2014-06-25
Inventor： Daniel T. CHIU , Thomas SCHNEIDER , Jason E. KREUTZ
CPC classification number: B01L3/50273 , B01L3/50851 , B01L7/52 , B01L2200/0605 , B01L2200/0642 , B01L2200/0673 , B01L2300/0627 , B01L2300/0803 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487
Abstract: Devices, systems and apparatuses for the discretization and manipulation of sample volumes are provided. Related methods are also provided.
Abstract translation: 提供了用于离散化和操纵样品体积的装置，系统和装置。 还提供了相关方法。
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13.发明申请HYBRID SEMICONDUCTING POLYMER NANOPARTICLES AS POLARIZATION-SENSITIVE FLUORESCENT PROBES 审中-公开混合型半导体聚合物纳米粒子作为偏振敏感荧光探针公开(公告)号：US20160161475A1
公开(公告)日：2016-06-09
申请号：US14903801
申请日：2014-07-08
Inventor： Daniel T. CHIU , Maxwell ZEIGLER
IPC: G01N33/543 , C09K11/06
CPC classification number: G01N33/54346 , B82Y30/00 , C08G2261/124 , C08G2261/1412 , C08G2261/3142 , C08G2261/3246 , C08G2261/522 , C08G2261/94 , C08L65/00 , C08L2205/02 , C09K11/06 , C09K2211/1416 , C09K2211/1425 , C09K2211/1483 , G01N33/587 , C08L25/18 , C08L23/36
Abstract: Compositions of, methods of making, and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and at least one nonsemiconducting polymer. Compositions of, methods of making and methods of using hybrid nanoparticles comprise at least one semiconducting polymer and non-semiconducting polymers wherein the non-semiconducting polymer comprises more than one non-semiconducting polymer such that at least one non-semiconducting polymer is functionalized for bioconjugation. The hybrid nanoparticles are polarization-sensitive and have low mass ratios with large fluorescence.
Abstract translation: 制备方法和使用混合纳米颗粒的方法的组合物包含至少一种半导体聚合物和至少一种非半导体聚合物。 制备方法和使用混合纳米颗粒的方法的组合物包括至少一种半导体聚合物和非半导体聚合物，其中非半导体聚合物包含多于一种非半导体聚合物，使得至少一种非半导体聚合物被官能化用于生物共轭 。 杂化纳米颗粒是极化敏感的，并且具有低质量比和大的荧光。
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公开(公告)号：US20160018405A1
公开(公告)日：2016-01-21
申请号：US14772608
申请日：2014-03-05
Inventor： Daniel T. CHIU
IPC: G01N33/58
CPC classification number: G01N33/588 , B82Y15/00 , B82Y40/00 , G01N33/6803 , G01N2458/30 , Y10S977/774 , Y10S977/92
Abstract: Methods, systems, compositions and kits are provided for the analysis of target molecules using chromophoric polymer dots conjugated to biomolecules. The use of chromophoric polymer dots improves detection sensitivity and stability when compared with existing techniques. In some aspects, methods, systems, and kits are provided for detecting a target protein using chromophoric polymer dots conjugated to biomolecules in a Western blot analysis. Related methods, systems, compositions and kits are also provided.
Abstract translation: 提供了使用与生物分子缀合的发色聚合物点分析靶分子的方法，系统，组合物和试剂盒。 与现有技术相比，使用发色聚合物点提高了检测灵敏度和稳定性。 在一些方面，提供了用于在蛋白质印迹分析中使用与生物分子缀合的发色聚合物点检测靶蛋白的方法，系统和试剂盒。 还提供了相关方法，系统，组合物和试剂盒。
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公开(公告)号：US20230023536A1
公开(公告)日：2023-01-26
申请号：US17932687
申请日：2022-09-16
Inventor： Daniel T. CHIU , Mengxia ZHAO , Wyatt NELSON , Perry G. SCHIRO
Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare particles in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
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Patent Agency Ranking
公开(公告)号：US20200174005A1
公开(公告)日：2020-06-04
申请号：US16702176
申请日：2019-12-03
Inventor： Daniel T. CHIU , Mengxia ZHAO , Wyatt NELSON , Perry G. SCHIRO
Abstract: Provided herein, among other aspects, are methods and apparatuses for analyzing particles in a sample. In some aspects, the particles can be analytes, cells, nucleic acids, or proteins and contacted with a tag, partitioned into aliquots, detected by a ranking device, and isolated. The methods and apparatuses provided herein may include a microfluidic chip. In some aspects, the methods and apparatuses may be used to quantify rare in a sample, such as cancer cells and other rare cells for disease diagnosis, prognosis, or treatment.
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公开(公告)号：US20200005960A1
公开(公告)日：2020-01-02
申请号：US16309795
申请日：2017-06-13
Applicant: University of Washington
Inventor： Daniel T. CHIU , Jiangbo YU , Yu RONG , Changfeng WU
Abstract: The present disclosure provides organic-inorganic hybrid polymer particles, which have desirable surface chemistry and optical properties that make them particularly suitable for biological and optical applications. The present disclosure also provides methods of making organic-inorganic hybrid polymer particles. The present disclosure also provides methods of using the organic-inorganic hybrid polymer particles for biological and optical applications.
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公开(公告)号：US20190004056A1
公开(公告)日：2019-01-03
申请号：US16041569
申请日：2018-07-20
Inventor： Daniel T. CHIU , Yuhui JIN , Fangmao YE , Changfeng WU , Yang-Hsiang CHAN
Abstract: Polymer nanoparticles and related methods are provided. The polymer particles can include polymer dots having a coating including a polyelectrolyte polymer. Methods of making and using the polymer nanoparticles are also provided.
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公开(公告)号：US20180251827A1
公开(公告)日：2018-09-06
申请号：US15962944
申请日：2018-04-25
Inventor： Daniel T. CHIU , Bryant S. FUJIMOTO , Alexander R. GANSEN , Gloria S. YEN , Robert M. LORENZ
IPC: C12Q1/6851
CPC classification number: C12Q1/6851 , C12Q1/6806 , C12Q2527/146 , C12Q2531/113 , C12Q2545/114
Abstract: Methods, devices and systems for performing digital measurements are provided.
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公开(公告)号：US20240263214A1
公开(公告)日：2024-08-08
申请号：US18581760
申请日：2024-02-20
Inventor： Daniel T. CHIU , Jason E. KREUTZ , Gloria S. YEN , Bryant S. FUJIMOTO
IPC: C12Q1/6816 , G01N15/1434 , G01N21/47 , G01N21/64 , G06T7/62 , G06V20/69
CPC classification number: C12Q1/6816 , G01N15/1434 , G01N21/47 , G01N21/6428 , G06T7/62 , G06V20/695 , G01N2015/1445 , G01N2021/6439 , G06T2207/10056 , G06T2207/30072
Abstract: Methods, devices, and systems for performing digital assays are provided. In certain aspects, the methods, devices, and systems can be used for the amplification and detection of nucleic acids. In certain aspects, the methods, devices, and systems can be used for the recognition, detection, and sizing of droplets in a volume. Also provided are compositions and kits suitable for use with the methods and devices of the present disclosure.
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