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公开(公告)号：US20210396721A1
公开(公告)日：2021-12-23
申请号：US17354234
申请日：2021-06-22
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Martin Gilar , Joseph D. Michienzi , Wade P. Leveille , Geoff C. Gerhardt , Jeffrey Musacchio , Jason F. Hill , Sylvain G. Cormier
Abstract: The exemplary embodiments may provide a collective insulating sleeve for a plurality of chromatography columns or may provide separate insulating sleeve for each of the chromatography columns in a plurality. As a result, column ovens are not needed, and pre-heaters may not be required for each chromatography column in some exemplary embodiments. Thus, parallel column arrangements in the exemplary embodiments may be more compact than conventional arrangements.
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公开(公告)号：US11061003B2
公开(公告)日：2021-07-13
申请号：US16601860
申请日：2019-10-15
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Keith Fadgen , Peyton C. Beals , Sylvain Gilles Cormier , Richard Wayne Andrews , Geoff C. Gerhardt , Jordan Kornfeld , Thomas S. McDonald
Abstract: Described are a method and apparatus for diluting a chromatographic sample. The method includes repeating an alternating acquisition of sample fluidic plugs each having an incremental volume of sample and diluent fluidic plugs each having an incremental volume of diluent to obtain a stack of alternating sample and diluent fluidic plugs. The stack is inserted into a flow of a mobile phase in a chromatography system. Alternatively, the method includes repeating the steps of injecting an incremental volume of sample into a chromatographic system flow and providing an incremental volume of mobile phase into the chromatographic system flow. In either implementation, the dilution ratio of the sample equals the sum of the incremental volumes of the sample and the diluent or mobile phase divided by the sum of the incremental volumes of the sample.
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公开(公告)号：US20200041463A1
公开(公告)日：2020-02-06
申请号：US16601860
申请日：2019-10-15
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Keith Fadgen , Peyton C. Beals , Sylvain Gilles Cormier , Richard Wayne Andrews , Geoff C. Gerhardt , Jordan Kornfeld , Thomas S. McDonald
Abstract: Described are a method and apparatus for diluting a chromatographic sample. The method includes repeating an alternating acquisition of sample fluidic plugs each having an incremental volume of sample and diluent fluidic plugs each having an incremental volume of diluent to obtain a stack of alternating sample and diluent fluidic plugs. The stack is inserted into a flow of a mobile phase in a chromatography system. Alternatively, the method includes repeating the steps of injecting an incremental volume of sample into a chromatographic system flow and providing an incremental volume of mobile phase into the chromatographic system flow. In either implementation, the dilution ratio of the sample equals the sum of the incremental volumes of the sample and the diluent or mobile phase divided by the sum of the incremental volumes of the sample.
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14.发明授权公开(公告)号：US09952186B2
公开(公告)日：2018-04-24
申请号：US15050929
申请日：2016-02-23
Applicant: Waters Technologies Corporation
Inventor： Bernard Bunner , Geoff C. Gerhardt , Theodore A. Dourdeville
IPC: G01L13/02 , G01N30/32 , B01L3/00 , G01N30/34 , G01N30/00 , G01L15/00 , G01L19/00 , G05D7/06 , G01N30/36 , G01L9/00 , B01D15/16
CPC classification number: G01N30/32 , B01D15/163 , B01L3/502746 , B01L2200/0605 , B01L2200/146 , B01L2300/0663 , B01L2300/0867 , B01L2300/0883 , B01L2300/14 , B01L2400/0487 , B01L2400/082 , B01L2400/086 , G01L9/0026 , G01L9/0042 , G01L9/0055 , G01L13/02 , G01L13/025 , G01L15/00 , G01L19/0023 , G01N30/00 , G01N30/34 , G01N30/36 , G01N2030/326 , G05D7/0676 , Y10T137/7762 , B01D15/40
Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.
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公开(公告)号：US12259369B2
公开(公告)日：2025-03-25
申请号：US17057361
申请日：2019-05-20
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Thomas S. McDonald , Joseph D. Michienzi , Jeffrey Musacchio , Rachel Mumma , Keith Fadgen , Geoff C. Gerhardt
IPC: G01N30/06 , B01D15/16 , B01D15/22 , B01D15/38 , B01J20/24 , B01J20/28 , B01J20/288 , B01J20/32 , G01N1/40 , G01N30/00 , G01N30/54 , G01N30/60 , G01N30/88
Abstract: Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
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Patent Agency Ranking
公开(公告)号：US12247962B2
公开(公告)日：2025-03-11
申请号：US17057242
申请日：2019-05-20
Applicant: Waters Technologies Corporation
Inventor： Martin Gilar , Thomas S. McDonald , Joseph D. Michienzi , Jeffrey Musacchio , Rachel Mumma , Keith Fadgen , Geoff C. Gerhardt
Abstract: Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
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公开(公告)号：US20210396722A1
公开(公告)日：2021-12-23
申请号：US17354296
申请日：2021-06-22
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Martin Gilar , Joseph D. Michienzi , Wade P. Leveille , Geoff C. Gerhardt , Jeffrey Musacchio , Jason F. Hill , Sylvain G. Cormier
Abstract: Exemplary embodiments eliminate the need for column ovens in serial column chromatography arrangements and systems by using insulated sleeves. The insulated sleeves may encase individual chromatography columns or clusters of chromatography columns. The use of the insulated sleeves allows the chromatography columns to be positioned in close proximity to each other. This may decrease the overall size of a serial column chromatography arrangement and may reduce costs by not requiring the column ovens.
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公开(公告)号：US20190234915A1
公开(公告)日：2019-08-01
申请号：US16382083
申请日：2019-04-11
Applicant: Waters Technologies Corporation
Inventor： Geoff C. Gerhardt , Keith Fadgen , Joseph D. Michienzi , Bernard Bunner
CPC classification number: G01N30/38 , B01L3/502715 , B01L3/502738 , B01L3/567 , B01L2200/0689 , B01L2400/0622 , B01L2400/0644 , F04D15/00 , F04D29/086 , F16K99/0013 , G01N30/20 , G01N2030/202
Abstract: A method may include reducing fluid flow between a rotor and a microfluidic device. The method may further include reducing a sealing force between the rotor and the microfluidic device. The method may also include rotating the rotor relative to the microfluidic device, at the reduced sealing force, to change a fluid pathway therebetween. The method may additionally include reestablishing the sealing force to produce a fluid tight seal between the rotor and the microfluidic device. Moreover, the method may include reestablishing the fluid flow between the rotor and the microfluidic device.
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19.发明授权公开(公告)号：US09768004B2
公开(公告)日：2017-09-19
申请号：US14552872
申请日：2014-11-25
Applicant: Waters Technologies Corporation
Inventor： Michael O. Fogwill , Joseph D. Michienzi , James P. Murphy , Geoff C. Gerhardt
CPC classification number: H01J49/10 , H01J49/0431 , Y10T29/5313
Abstract: The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer. The ion source includes a first conduit for receiving eluent from the chromatography device, a heater for heating at least a portion of said first conduit, a second conduit in fluid communication with the first conduit, an inlet for receiving eluent from said second conduit and introducing the eluent into an ion source region to form a plume of gas and/or liquid in the ion source region, and an ionization promoting inlet for injecting an ionization promoting fluid into the ion source region to interact with the plume to promote ionization of at least some of the plume.
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20.发明申请公开(公告)号：US20160169843A1
公开(公告)日：2016-06-16
申请号：US15050929
申请日：2016-02-23
Applicant: Waters Technologies Corporation
Inventor： Bernard Bunner , Geoff C. Gerhardt , Theodore A. Dourdeville
CPC classification number: G01N30/32 , B01D15/163 , B01L3/502746 , B01L2200/0605 , B01L2200/146 , B01L2300/0663 , B01L2300/0867 , B01L2300/0883 , B01L2300/14 , B01L2400/0487 , B01L2400/082 , B01L2400/086 , G01L9/0026 , G01L9/0042 , G01L9/0055 , G01L13/02 , G01L13/025 , G01L15/00 , G01L19/0023 , G01N30/00 , G01N30/34 , G01N30/36 , G01N2030/326 , G05D7/0676 , Y10T137/7762 , B01D15/40
Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.
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