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75 条记录 (耗时 0.049 秒)

    Process for 3,5-di-tert-butylsalicylaldehyde
    14.
    发明授权
    Process for 3,5-di-tert-butylsalicylaldehyde 失效
    3,5-二叔丁基水杨醛的方法

    公开(公告)号：US5324860A

    公开(公告)日：1994-06-28

    申请号：US144577

    申请日：1993-10-27

    申请人： Yun Gao ,  Xiaoyi Nie

    发明人： Yun Gao ,  Xiaoyi Nie

    IPC分类号： C07C45/45 ,  C07C45/56 ,  C07C47/565 ,  C07C37/11 ,  C07C39/06

    CPC分类号： C07C45/565

    摘要： A process for the synthesis of 3-5-tert-butylsalicylaldehyde from 2,4-di-tert-butylphenol and hexamethylenetetramine is disclosed. The reaction provides 3,5-tert-butylsalicylaldehyde in commercially attractive yields from readily available starting materials.

    摘要翻译： 公开了从2,4-二叔丁基苯酚和六亚甲基四胺合成3-5-叔丁基水杨醛的方法。 该反应提供3,5-二叔丁基水杨醛，其商业上有吸引力的产率来自容易获得的原料。

    Application of puerarin in the preparation of P2X3 mediated drugs for pain/nervous system diseases
    16.
    发明授权
    Application of puerarin in the preparation of P2X3 mediated drugs for pain/nervous system diseases 失效
    应用葛根素制备P2X3介导的药物用于疼痛/神经系统疾病

    公开(公告)号：US08362070B2

    公开(公告)日：2013-01-29

    申请号：US12922245

    申请日：2010-06-29

    申请人： Shangdong Liang ,  Changshui Xu ,  Yun Gao ,  Guilin Li ,  Jiari Lin ,  Shuangmei Liu ,  Han Liu ,  Jun Zhang ,  Xin Li

    发明人： Shangdong Liang ,  Changshui Xu ,  Yun Gao ,  Guilin Li ,  Jiari Lin ,  Shuangmei Liu ,  Han Liu ,  Jun Zhang ,  Xin Li

    IPC分类号： A61K31/35 ,  A61K31/70

    CPC分类号： A61K31/352

    摘要： The invention relates to the new usage of puerarin in the field of pharmaceutical products, in other words, it relates to the application of puerarin in the preparation of drugs for P2X3 mediated pain/nervous system diseases. The experiment shows that puerarin can inhibit pain-related behavioral responses, subsequently immunohistochemical analysis, in situ hybridization, RT-PCR, protein blotting and other techniques were utilized to observe the inhibition of puerarin on mRNA and protein expression of P2X3 receptor in dorsal root ganglion of rats with neuropathic pain and in dorsal root ganglion and sensory nerve ending in the burn model of rats, it was found by using whole-cell patch clamp technique that puerarin can significantly reduce the electric current activated by P2X3 receptor agonist in the neuron of dorsal root ganglion of rats with neuropathic pain. The experiment proves that the mechanism for the inhibitory effects of puerarin on acute and chronic pain is to block the transmission of pain sense information that is mediated by P2X3 receptor in primary sensory neurons. The invention provides a kind of new method for the prevention and treatment on acute and chronic pain, and it also indicates that puerarin can act as a antagonist for P2X3 receptor, which will be helpful for the application of drugs in the prevention and treatment on P2X3 receptor involved nervous system diseases.

    摘要翻译： 本发明涉及葛根素在药物领域的新用途，换句话说，涉及葛根素在制备P2X3介导的疼痛/神经系统疾病药物中的应用。 实验表明，葛根素可以抑制疼痛相关的行为反应，随后免疫组化分析，原位杂交，RT-PCR，蛋白质印迹等技术用于观察葛根素对背根神经节P2X3受体mRNA和蛋白表达的抑制作用 的大鼠神经性疼痛和背根神经节和感觉神经结束于大鼠烧伤模型，通过使用全细胞膜片钳技术发现，葛根素可以显着降低P2X3受体激动剂在背侧神经元中活化的电流 神经性疼痛大鼠根神经节。 实验证明，葛根素对急性和慢性疼痛的抑制作用机制是阻断P2X3受体介导的疼痛感知信息在原发感觉神经元中的传播。 本发明提供了一种预防和治疗急性和慢性疼痛的新方法，也表明葛根素可以作为P2X3受体的拮抗剂，有利于药物在P2X3的预防和治疗中的应用 受体涉及神经系统疾病。

    ANTI-COUNTERFEIT FILM WITH AN AMPHICHROIC PATTERN AND A PREPARATION METHOD THEREOF
    18.
    发明申请
    ANTI-COUNTERFEIT FILM WITH AN AMPHICHROIC PATTERN AND A PREPARATION METHOD THEREOF 有权
    具有AMPHICHROIC图案的防伪膜及其制备方法

    公开(公告)号：US20110256351A1

    公开(公告)日：2011-10-20

    申请号：US13125749

    申请日：2009-06-09

    申请人： Liangheng Xu ,  Lanxin Dong ,  Yun Gao ,  Zhixi Zhang

    发明人： Liangheng Xu ,  Lanxin Dong ,  Yun Gao ,  Zhixi Zhang

    IPC分类号： B32B3/30 ,  G03F7/20

    CPC分类号： C09K19/0403 ,  C09K19/406 ,  C09K2019/0448 ,  C09K2219/03

    摘要： An anti-counterfeit film comprising an amphichroic pattern is prepared by (1) mixing a polymerizable liquid crystal material of chiral structure and a photoinitiator, blade-coating the mixture on a base film and then drying; (2) partially exposing the resulting material produced in step (1) using a positioned UV lamp, then drying and exposing in an UV radiation to obtain a desired film. The film prepared by the method has an amphichroic pattern which typically presents a red and green picture when being vertically observed, the original red and green respectively changes into green and blue when being observed at a certain incline angel. The anti-counterfeit film is characterized by obvious color change, easy identification, practicability and convenience, thus facilitating promotion and application.

    摘要翻译： 通过（1）将手性结构的可聚合液晶材料和光引发剂混合，将该混合物刮涂在基膜上，然后干燥，制备包含两性图案的防伪膜。 （2）使用定位的UV灯将步骤（1）中产生的所得材料部分曝光，然后在UV辐射下干燥和曝光以获得所需的膜。 通过该方法制备的薄膜具有两性图案，其在垂直观察时通常呈现红色和绿色图像，当以某种倾斜角度观察​​时，原始红色和绿色分别变为绿色和蓝色。 防伪膜的特点是颜色变化明显，易于识别，实用性和便利性，促进推广应用。