公开(公告)号：US07528190B2

公开(公告)日：2009-05-05

申请号：US11240697

申请日：2005-09-30

Applicant: Brian J. Wayton ,  Hong Ding ,  Michael W. Cox

Inventor： Brian J. Wayton ,  Hong Ding ,  Michael W. Cox

IPC: C08L31/00 ,  C08B67/00 ,  H01B1/12 ,  B05D1/02

CPC classification number: C09D5/002 ,  C08G18/4063 ,  C08G18/6229 ,  C08G18/672 ,  C08G18/686 ,  C08G2150/50 ,  C08K3/013 ,  C08K3/04 ,  C08K5/0025 ,  C09D5/24 ,  C09D167/06 ,  C09D175/04 ,  C09D175/14 ,  C08L67/06

Abstract: The present invention provides for a sealer/primer that is generally cured at low bake temperatures. The composition utilizes a resin system to provide both conductivity and adhesion of the coating onto plastic substrates. The present invention uses a polyester, such as one that includes unsaturated polyester, in combination with other resins, including an acrylic, crosslinking agent and conductive pigment to create a conductive primer that can be cured at low temperatures. The composition can be applied through traditional application equipment, seals the surface of the substrate to which it is applied, and cures to an acceptable surface for further processing, such as painting.

Abstract translation: 本发明提供通常在低烘烤温度下固化的密封剂/底漆。 该组合物利用树脂体系来提供涂层在塑料基材上的导电性和粘附性。 本发明使用包括不饱和聚酯的聚酯与其它树脂组合，包括丙烯酸，交联剂和导电颜料，以产生可在低温下固化的导电底漆。 该组合物可以通过传统的应用设备施加，密封其所施加的基底的表面，并固化到可接受的表面以进行进一步加工，例如涂漆。

公开(公告)号：US07504512B2

公开(公告)日：2009-03-17

申请号：US10820097

申请日：2004-04-07

Applicant: David J. Augeri ,  Steven A. Baumeister ,  Milan Bruncko ,  Daniel A. Dickman ,  Hong Ding ,  Jurgen Dinges ,  Stephen W. Fesik ,  Philip J. Hajduk ,  Aaron R. Kunzer ,  William McClellan ,  David G. Nettesheim ,  Thorsten Oost ,  Andrew M. Petros ,  Saul H. Rosenberg ,  Wang Shen ,  Sheela A. Thomas ,  Xilu Wang ,  Michael D. Wendt

Inventor： David J. Augeri ,  Steven A. Baumeister ,  Milan Bruncko ,  Daniel A. Dickman ,  Hong Ding ,  Jurgen Dinges ,  Stephen W. Fesik ,  Philip J. Hajduk ,  Aaron R. Kunzer ,  William McClellan ,  David G. Nettesheim ,  Thorsten Oost ,  Andrew M. Petros ,  Saul H. Rosenberg ,  Wang Shen ,  Sheela A. Thomas ,  Xilu Wang ,  Michael D. Wendt

IPC: C07C211/00 ,  A61K31/445

CPC classification number: C07D207/27 ,  A61K31/18 ,  A61K31/4015 ,  A61K31/44 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  C07C311/51 ,  C07C323/30 ,  C07C323/37 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D203/26 ,  C07D207/06 ,  C07D209/08 ,  C07D209/52 ,  C07D209/54 ,  C07D211/22 ,  C07D211/74 ,  C07D213/54 ,  C07D213/61 ,  C07D213/64 ,  C07D213/70 ,  C07D213/78 ,  C07D215/12 ,  C07D221/20 ,  C07D231/12 ,  C07D235/08 ,  C07D235/26 ,  C07D239/26 ,  C07D249/04 ,  C07D263/32 ,  C07D263/56 ,  C07D263/58 ,  C07D277/56 ,  C07D277/64 ,  C07D295/205 ,  C07D295/26 ,  C07D317/60 ,  C07D333/28 ,  C07D333/56 ,  C07D333/70 ,  C07D417/12 ,  C07D451/02

Abstract: N-Benzoyl arylsulfonamides having the formula are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

Abstract translation: 具有下式的N-苯甲酰基芳基磺酰胺是BCL-X1抑制剂，可用于促进凋亡。 还公开了BCL-X1抑制组合物和促进哺乳动物细胞凋亡的方法。

公开(公告)号：US20070072860A1

公开(公告)日：2007-03-29

申请号：US11600445

申请日：2006-11-16

Applicant: Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt ,  Alexander Shoemaker ,  Michael Mitten

Inventor： Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron Kunzer ,  Christopher Lynch ,  William McClellan ,  Cheol-Min Park ,  Andrew Petros ,  Xiaohong Song ,  Xilu Wang ,  Noah Tu ,  Michael Wendt ,  Alexander Shoemaker ,  Michael Mitten

IPC: A61K31/53 ,  A61K31/501 ,  A61K31/497 ,  A61K31/444 ,  A61K31/4439 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D295/155 ,  C07C311/51 ,  C07D205/04 ,  C07D207/06 ,  C07D207/08 ,  C07D207/09 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D207/20 ,  C07D207/24 ,  C07D207/50 ,  C07D209/02 ,  C07D209/52 ,  C07D211/14 ,  C07D211/20 ,  C07D211/26 ,  C07D211/34 ,  C07D211/38 ,  C07D211/42 ,  C07D211/46 ,  C07D211/48 ,  C07D211/58 ,  C07D211/62 ,  C07D211/70 ,  C07D211/72 ,  C07D213/36 ,  C07D213/38 ,  C07D213/42 ,  C07D213/70 ,  C07D213/74 ,  C07D213/81 ,  C07D213/82 ,  C07D215/12 ,  C07D231/12 ,  C07D231/56 ,  C07D233/06 ,  C07D233/22 ,  C07D233/24 ,  C07D233/61 ,  C07D233/64 ,  C07D235/08 ,  C07D239/06 ,  C07D239/20 ,  C07D239/38 ,  C07D241/04 ,  C07D249/18 ,  C07D257/04 ,  C07D261/20 ,  C07D263/12 ,  C07D263/22 ,  C07D263/58 ,  C07D265/30 ,  C07D267/10 ,  C07D273/01 ,  C07D277/04 ,  C07D277/36 ,  C07D277/74 ,  C07D295/185 ,  C07D295/30 ,  C07D307/14 ,  C07D307/22 ,  C07D307/81 ,  C07D309/14 ,  C07D309/20 ,  C07D317/66 ,  C07D333/20 ,  C07D333/34 ,  C07D335/02 ,  C07D401/10 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D413/04 ,  C07D451/02 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D491/04 ,  C07D491/048 ,  C07D491/08 ,  C07D498/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

公开(公告)号：US20060125769A1

公开(公告)日：2006-06-15

申请号：US11008400

申请日：2004-12-09

Applicant: Hong Ding

Inventor： Hong Ding

IPC: G09G3/36

CPC classification number: G09G3/3406 ,  G02F2001/13312 ,  G09G2320/0606 ,  G09G2320/0633 ,  G09G2360/144

Abstract: An electronic device may include a liquid crystal display, a photosensor, a light, and a controller. The liquid crystal display may have first and second transparent substrates and a liquid crystal material between the first and second transparent substrates. The photosensor may be on a portion of the first transparent substrate so that the first transparent substrate is between the photosensor and the second transparent substrate, and the light may be configured to provide illumination for the electronic device. The controller may be coupled to the photosensor and the light, and the controller may be configured to vary an intensity of the illumination from the light responsive to an intensity of light incident of the photosensor. Related displays are also discussed.

公开(公告)号：US08853209B2

公开(公告)日：2014-10-07

申请号：US13088206

申请日：2011-04-15

Applicant: Xiaohong Song ,  Hong Ding ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Cheol-Min Park ,  Zhi-Fu Tao ,  Xilu Wang ,  Aaron R. Kunzer

Inventor： Xiaohong Song ,  Hong Ding ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Cheol-Min Park ,  Zhi-Fu Tao ,  Xilu Wang ,  Aaron R. Kunzer

IPC: C07D209/42 ,  C07D403/04

CPC classification number: C07D209/42 ,  C07D403/04

Abstract: Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mdl-1 protein, such as leukemia and lymphoma, are disclosed.

Abstract translation: 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了诸如白血病和淋巴瘤的Md1-1蛋白。

公开(公告)号：US08757689B2

公开(公告)日：2014-06-24

申请号：US13521503

申请日：2010-02-12

Applicant: Hong Ding

Inventor： Hong Ding

IPC: B66C1/04

CPC classification number: B66C1/04 ,  H01F7/0257

Abstract: The present invention provides a kind of permanent magnetic lifting device, which has: a housing, at the bottom of which is a clamping surface for clamping objects; fixed magnet(s), set in housing relatively fixed to housing; a turnable magnet, set in housing relatively turnable to fixed magnet. When turnable magnet is in the first position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is zero magnetic force; when turnable magnet is in the third position relative to fixed magnet, the magnetic force generated by fixed magnet and turnable magnet to clamping surface is the maximum magnetic force. The permanent magnetic lifting device also has a positioning mechanism for second position to position the turnable magnet in the second position relative to fixed magnet, fixed magnet and turnable magnet generate trial clamping magnetic force to clamping surface for clamping objects on trial.

Abstract translation: 本发明提供一种永磁提升装置，其具有：壳体，其底部是夹紧物体的夹紧面; 固定磁体，设置在与壳体相对固定的壳体中; 固定在壳体内的可转动磁体可相对转动到固定磁体。 当可转动磁体相对于固定磁体位于第一位置时，由固定磁体和可转动磁体产生的夹紧磁力对零位磁力; 当可转动磁体相对于固定磁体位于第三位置时，由固定磁铁和可转动磁体产生的夹紧磁力对夹紧表面是最大的磁力。 永磁提升装置还具有用于第二位置的定位机构，用于将可转动磁体相对于固定磁体，固定磁体和可转动磁体定位在第二位置，以将试件夹紧磁力产生到夹紧表面，用于在试验中夹紧物体。

公开(公告)号：US08188077B2

公开(公告)日：2012-05-29

申请号：US13049569

申请日：2011-03-16

Applicant: Hong Ding ,  Steven W. Elmore ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Michael D. Wendt

Inventor： Hong Ding ,  Steven W. Elmore ,  Laura A. Hexamer ,  Aaron R. Kunzer ,  Cheol-Min Park ,  Andrew J. Souers ,  Gerard M. Sullivan ,  Michael D. Wendt

IPC: A61K31/5377 ,  A61K31/5375 ,  A61K31/435 ,  A61K31/437 ,  C07D413/02 ,  C07D241/02 ,  C07D295/00 ,  C07D211/00

CPC classification number: C07D211/58 ,  C07C311/51 ,  C07C2601/14 ,  C07C2603/74 ,  C07D295/112 ,  C07D295/195 ,  C07D417/04

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

公开(公告)号：US08168647B2

公开(公告)日：2012-05-01

申请号：US12449180

申请日：2007-12-17

Applicant: Lihong Hu ,  Xu Shen ,  Hualiang Jiang ,  Liguang Lou ,  Hong Ding ,  Yong Shao ,  Hankun Zhang

Inventor： Lihong Hu ,  Xu Shen ,  Hualiang Jiang ,  Liguang Lou ,  Hong Ding ,  Yong Shao ,  Hankun Zhang

IPC: C07D519/04 ,  A61K31/475 ,  A61P35/00

CPC classification number: C07D519/04

Abstract: The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.

Abstract translation: 本发明提供由下式1表示的长春花碱衍生物或其生理上可接受的盐，其制备，用途和包含所述衍生物的药物组合物。 所述长春花碱衍生物显示对肿瘤细胞系的抑制活性，可用作治疗恶性肿瘤的药物。

公开(公告)号：US08084607B2

公开(公告)日：2011-12-27

申请号：US12390945

申请日：2009-02-23

Applicant: Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron R. Kunzer ,  Christopher L. Lynch ,  William J. McClellan ,  Cheol-min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Noah P. Tu ,  Xilu Wang ,  Michael D. Wendt

Inventor： Milan Bruncko ,  Hong Ding ,  Steven Elmore ,  Aaron R. Kunzer ,  Christopher L. Lynch ,  William J. McClellan ,  Cheol-min Park ,  Andrew M. Petros ,  Xiaohong Song ,  Noah P. Tu ,  Xilu Wang ,  Michael D. Wendt

IPC: C07D241/04 ,  C07D295/00

CPC classification number: C07D277/74 ,  C04B35/632 ,  C07C323/25 ,  C07C2601/16 ,  C07D205/04 ,  C07D207/16 ,  C07D211/46 ,  C07D211/60 ,  C07D211/74 ,  C07D213/70 ,  C07D213/75 ,  C07D233/06 ,  C07D233/84 ,  C07D239/06 ,  C07D263/58 ,  C07D277/36 ,  C07D295/13 ,  C07D295/192 ,  C07D307/64 ,  C07D335/02 ,  C07D401/12 ,  C07D403/04 ,  C07D409/12 ,  C07D487/04 ,  C07D487/08

Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

公开(公告)号：US07981888B2

公开(公告)日：2011-07-19

申请号：US12104319

申请日：2008-04-16

Applicant: Xiaohong Song ,  Hong Ding ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Cheol-Min Park ,  Zhi-Fu Tao ,  Xilu Wang ,  Aaron R. Kunzer

Inventor： Xiaohong Song ,  Hong Ding ,  Steven W. Elmore ,  Milan Bruncko ,  David J. Madar ,  Andrew J. Souers ,  Cheol-Min Park ,  Zhi-Fu Tao ,  Xilu Wang ,  Aaron R. Kunzer

IPC: A61K31/535

CPC classification number: C07D209/42 ,  C07D403/04

Abstract: Compounds of Formula I wherein A1, B1, C1, D1, E1, F1 and L1 are as defined herein, which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein, such as leukemia and lymphoma, are disclosed.

Abstract translation: 其中A1，B1，C1，D1，E1，F1和L1如本文所定义的式I化合物，其抑制抗细胞凋亡Mcl-1蛋白的活性，含有该化合物的组合物，以及治疗涉及过表达或未调节的疾病的方法 公开了Mcl-1蛋白，如白血病和淋巴瘤。