-
公开(公告)号：US20240115740A1
公开(公告)日：2024-04-11
申请号：US18254851
申请日：2021-11-30
发明人： Andrew TSOURKAS , Feifan YU
CPC分类号： A61K49/0032 , A61K49/0056 , A61K49/16 , C07K16/2863 , C07K16/32 , A61K2123/00
摘要： This invention relates to the compositions and methods for labeling antibodies and other proteins and targeting agents with a helical bundle protein that is functionalized with cargo. Cargos can include but are not limited to fluorescent dyes, haptens (e.g. biotin), contrast agents (e.g. gadolinium, radionuclides), chelated metals, therapeutic agents, sensitizers, or other small molecules. Specifically, provided herein are compositions having a helical bundle, that has been labeled at precisely defined locations with cargo, and that can be conjugated, attached or fused to an antibody or other targeting agent.
-
12.发明公开公开(公告)号：US20240091387A1
公开(公告)日：2024-03-21
申请号：US17767847
申请日：2020-10-09
发明人： Brett J. BERMAN
CPC分类号： A61K49/0056 , A61B18/18 , A61P25/00 , A61B2018/1807
摘要： The present invention provides methods for guiding preservation of human neurons or human nerves during surgery, as well as labeling and mapping nerves in targeted organs for map-guided surgery, by administering a fluorescently-labeled peptide that specifically binds to the human neurons or human nerves. The invention further provides human neuron or nerve targeting molecules comprising fluorescently-labeled peptides that specifically bind to human neurons or human nerves and compositions thereof.
-
13.发明公开公开(公告)号：US20240084273A1
公开(公告)日：2024-03-14
申请号：US18451280
申请日：2023-08-17
发明人： Sang Jae KIM
IPC分类号： C12N9/12 , A23L33/18 , A61K8/64 , A61K8/66 , A61K47/64 , A61K49/00 , A61Q19/00 , C07K7/08 , C07K14/00 , G01N33/58
CPC分类号： C12N9/1276 , A23L33/18 , A61K8/64 , A61K8/66 , A61K47/64 , A61K49/0002 , A61K49/0043 , A61K49/0056 , A61Q19/00 , C07K7/08 , C07K14/00 , G01N33/582 , A61K38/00 , C07K2319/10
摘要： The present invention relates to a conjugate of cell penetrating peptide and an active ingredient; and its use. Specifically, a conjugate including a cell penetrating peptide which is a peptide comprising any one amino acid sequence of SEQ ID NO: 1 to SEQ ID NO: 156, a fragment of any one sequence of SEQ ID NO: 1 to SEQ ID NO: 156, or a peptide having above 80% homology with the above-mentioned sequence; and a composition comprising the same are disclosed.
-
公开(公告)号：US20240042063A1
公开(公告)日：2024-02-08
申请号：US18331904
申请日：2023-06-08
CPC分类号： A61K49/0056 , G01N33/84 , C07K7/06 , A61K47/65 , A61K47/42 , A61B5/0071 , A61K47/64 , C07K14/00 , G01N2033/0003
摘要： Provided herein are, inter alia, pH-triggered compounds and compositions comprising one or more peptides that are capable of inserting into a lipid bilayer below a certain pH. Treatment, imaging, diagnostic, and other uses of such compounds and compositions are also provided.
-
公开(公告)号：US20240041972A1
公开(公告)日：2024-02-08
申请号：US18130049
申请日：2023-04-03
CPC分类号： A61K38/08 , A61K47/646 , A61K47/64 , A61K38/179 , A61K38/195 , A61K38/208 , A61K49/0032 , A61K49/0056 , A61K38/00
摘要： The current invention pertains to a molecular conjugate comprising an antagonist of a cell surface receptor specific to a target cell and an immune effector, such as a T cell modulator, conjugated to the antagonist. The target cell can be a cell responsible for development of a disease in a subject, for example, a cancer cell. In certain embodiments, the immune effector is an immune effector protein or an immune effector fragment thereof. The current invention also pertains to a method of treating a disease in a subject, the method comprising administering to the subject a pharmaceutically effective amount of the molecular conjugates of the current invention to the subject. The methods of the current invention can be used to treat cancer, such as breast cancer, ovarian cancer, prostate cancer, lung cancer, pancreatic cancer, or melanoma.
-
16.发明授权公开(公告)号：US11884687B2
公开(公告)日：2024-01-30
申请号：US16489884
申请日：2018-03-01
发明人： Pedro Gois , Fabio Santos
CPC分类号： C07F5/025 , A61K47/55 , A61K47/60 , A61K47/643 , A61K47/66 , A61K47/6951 , A61K49/0039 , A61K49/0052 , A61K49/0054 , A61K49/0056
摘要： Tri-component multi-functional boronated complexes (B-complexes), featuring reversible covalent bonds, are described, which incorporate a drug; a water-soluble moiety (e.g. polyethylene glycol (PEG) chains, cyclodextrins); and a targeting unit. A B-complex core was assembled in one step, and proved to be stable in different biocompatible conditions, such as human plasma, though reversible for example in the presence of glutathione (GSH). This platform enabled the modular construction of the multifunctional conjugates exhibiting high selectivity towards, for example, folate-receptor-positive MDA-MB-231 cancer cells, having an IC50 in the low nanomolar range.
-
公开(公告)号：US20240025965A1
公开(公告)日：2024-01-25
申请号：US18295068
申请日：2023-04-03
申请人： Jai Prakash , Universiteit Twente
发明人： Jai Prakash
CPC分类号： C07K14/70546 , A61K49/0045 , C07K14/78 , C07K7/08 , C07K7/06 , A61K47/62 , A61K47/60 , A61P1/16 , A61K49/0056 , A61K38/00
摘要： The disclosure relates to integrin binding peptides, pharmaceutical compositions comprising the peptides and to uses thereof as therapeutic, diagnostic, imaging and targeting agents.
-
公开(公告)号：US20230416320A1
公开(公告)日：2023-12-28
申请号：US18330459
申请日：2023-06-07
CPC分类号： C07K14/4728 , G01N33/582 , G01N33/84 , G01N21/77 , A61K49/0004 , A61K49/0041 , A61K49/0056 , C07K2319/20 , C07K2319/60 , G01N2333/4727 , G01N2021/7786
摘要： A chemigenetic calcium indicator and a method of measuring calcium are provided. The chemigenetic calcium indicator includes a calcium-binding protein domain attached to a ligand binding protein domain. The method of measuring calcium includes administering a chemigenetic calcium indicator to a subject and determining changes in fluorescence, the chemigenetic calcium indicator including a ligand binding protein domain having a calcium-binding protein domain and a dye-ligand conjugate attached thereto.
-
公开(公告)号：US20230390405A1
公开(公告)日：2023-12-07
申请号：US18035526
申请日：2021-11-11
CPC分类号： A61K47/64 , A61K41/0052 , A61K41/0057 , A61K49/0056 , A61P29/02
摘要： Provided herein are conjugates of retrograde tracers and cell-deactivating agents useful in targeting the nerve cells' body (soma) of neurons that are associated with pain, spasm or tonus, as well as methods of controllable selective deactivating of these nerve cells and devices for executing the methods.
-
公开(公告)号：US20230381327A1
公开(公告)日：2023-11-30
申请号：US18248674
申请日：2021-10-12
发明人： Léo MARX , Viktoriia POSTUPALENKO , Origéne Franz NYANGUILE , Jean-Manuel SEGURA , Mathilde Lucile Colette PANTIN , Patrick GARROUSTE , Frederic LEVY
CPC分类号： A61K47/64 , A61K47/60 , A61K47/6415 , A61K49/106 , A61K49/14 , A61K49/0043 , A61K49/0056 , A61K47/6855 , A61K47/6803
摘要： The present invention relates to compounds (reactive conjugates) for the chemical modification of therapeutic antibodies or proteins. The compounds enable the regioselective attachment of payloads to an antibody or antibody fragment in one single step, thereby producing a modified antibody or modified antibody fragment, which can be used for diagnosing, monitoring, imaging or treating disease.
-
-
-
-
-
-
-
-
-
搜索结果
1191 条记录 (耗时 0.066 秒)
