公开(公告)号：US20180105430A1

公开(公告)日：2018-04-19

申请号：US15557368

申请日：2016-03-11

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： Eric C. Carnes ,  C. jeffrey Brinker ,  Darren Dunphy ,  Trevin Heisey

IPC: C01B33/18

CPC classification number: C01B33/18 ,  A61K9/5115 ,  A61K9/5123 ,  A61K33/00 ,  B82Y40/00 ,  C01B37/02 ,  C01P2004/64 ,  C01P2006/14 ,  C01P2006/17

Abstract: The present invention relates to the discovery that mesoporous silica nanoparticles may be modified in pore size from the natural mesophase by generating mesoporous materials in binary, ternary or multiphase surfactant systems to produce biphasic, triphasic or multiphase mesoporous structures. Thus, the present invention relates to methods of producing biphase, triphasic and multiphase mesoporous structures with finely tuned mesopore size and protocells which are produced therefrom and mesoporous silica nanoparticles obtained therefrom. The resulting mesoporous nanostructures may be used to create protocells having unique cargo loading and release characteristics. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

公开(公告)号：US09943580B2

公开(公告)日：2018-04-17

申请号：US15023653

申请日：2014-09-11

Applicant: STC.UNM ,  LEIDOS, INC

Inventor： David S. Peabody ,  Bryce Chackerian ,  James Pannucci ,  Gabriel M. Gutierrez ,  Amy Rene Noe ,  Scott Budd Winram ,  Steve Chienwen Huang

IPC: A61K39/39 ,  A61K39/015 ,  C12N7/00 ,  C12N15/10 ,  A61K39/00 ,  A61K35/76

CPC classification number: A61K39/015 ,  A61K35/76 ,  A61K39/39 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/55566 ,  C07K2319/40 ,  C12N7/00 ,  C12N15/1037 ,  C12N2795/18122 ,  C12N2795/18123 ,  C12N2795/18134 ,  Y02A50/412

Abstract: Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an anti-malaria mimotope.

公开(公告)号：US09921339B2

公开(公告)日：2018-03-20

申请号：US14673692

申请日：2015-03-30

Applicant: STC.UNM

Inventor： Anthony Robert Menicucci ,  Thomas P. Caudell ,  Andrea A. Mammoli

IPC: G01W1/00 ,  G01W1/10 ,  G01J5/00 ,  H02J3/00 ,  G06Q10/04 ,  G06Q50/06 ,  H02J3/38

CPC classification number: G01W1/10 ,  G01J5/00 ,  G01J2001/4266 ,  G06Q10/04 ,  G06Q50/06 ,  H02J3/00 ,  H02J3/383 ,  H02J2003/007 ,  Y02E10/563 ,  Y02E60/76 ,  Y04S10/54 ,  Y04S40/22 ,  Y10T307/533 ,  Y10T307/604

Abstract: The present invention is an apparatus and method of forecasting solar energy irradiance potential and subsequent photovoltaic output in a region. The apparatus and method includes collecting meteorological data for a given region and then estimating irradiance levels using parameters collected from the meteorological data. Solar energy production is then simulated using the collected meteorological data, estimated irradiance levels, and physical characteristics of a solar generating system in the given region at a predetermined time.

公开(公告)号：US20180072572A1

公开(公告)日：2018-03-15

申请号：US15565670

申请日：2016-04-08

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： Richard Alan Kemp ,  Diane Dickie ,  Bernadette A. Hernandez-Sanchez ,  Timothy N. Labert

IPC: C01B25/08 ,  C07F9/50

CPC classification number: C01B25/08 ,  B82Y30/00 ,  B82Y40/00 ,  C01P2002/72 ,  C01P2004/04 ,  C01P2004/64 ,  C07F9/5045 ,  C22C1/00 ,  Y10S977/773 ,  Y10S977/81 ,  Y10S977/825 ,  Y10S977/896

Abstract: The present invention provides a novel solution or route for metal phosphide (MPx) nanomaterials from the thermal decomposition of metal bis[bis(diisopropylphosphino)amide], M[N(PPri2)2]2, and/or single-source precursors. Synthetic routes to MPx nanomaterials may be used in energy applications including batteries, semiconductors, magnets, catalyst, lasers, inks, electrocatalysts and photodiodes.

公开(公告)号：US20180049531A1

公开(公告)日：2018-02-22

申请号：US15556606

申请日：2016-03-10

Applicant: STC.UNM

Inventor： Zayd Leseman ,  Mohammadhosein Ghasemi Baboly ,  Bruce C. Lamartine

IPC: A45D19/00

CPC classification number: A45D19/0008 ,  A45D2019/0075 ,  A45D2019/0091 ,  A45D2200/205 ,  A61Q5/06

Abstract: Provided is a method for treating a fiber, including: imparting a pattern from a diffraction grating onto a fiber surface. The pattern is capable of diffracting incident polychromatic light into one or more dispersed visible colors, the fiber is not coated and the pattern is imparted directly onto the surface of the fiber.

公开(公告)号：US09880445B1

公开(公告)日：2018-01-30

申请号：US14744909

申请日：2015-06-19

Applicant: STC.UNM

Inventor： Wolfgang G. Rudolph ,  Cristina Rodriguez

IPC: G02F1/35 ,  G02F1/37 ,  H01S3/00 ,  G02F2/02

CPC classification number: G02F1/37 ,  G02F1/3544 ,  G02F2001/354 ,  G02F2001/3548

Abstract: Systems and methods implementing a stack on a substrate, where the stack includes a plurality of films structured as layers to convert radiation incident to the stack to radiation of a nonlinear optical signal different from the incident radiation or to a harmonic of the incident radiation, can be used in a variety of applications. The stack can be structured having parameters selected with respect to conversion efficiency and bandwidth the converted radiation. Additional systems and methods can be used in a variety of applications.

公开(公告)号：US20180024001A1

公开(公告)日：2018-01-25

申请号：US15706440

申请日：2017-09-15

Applicant: STC.UNM

Inventor： Steven R.J. BRUECK ,  Alexander NEUMANN ,  Payman ZARKESH-HA

IPC: G01J1/06 ,  G01J3/18 ,  G01J1/44 ,  H01L27/144 ,  H01L31/0232 ,  H01L31/02 ,  H01L31/0216 ,  G02B6/122 ,  G02B6/12 ,  G02B6/124 ,  G01J3/28 ,  H01L31/103

CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  G02B2006/12061 ,  G02B2006/12107 ,  G02B2006/12138 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

公开(公告)号：US09855217B2

公开(公告)日：2018-01-02

申请号：US15023110

申请日：2014-09-18

Applicant: STC.UNM ,  National Technology & Engineering Solutions of Sandia, LLC

Inventor： C. Jeffrey Brinker ,  Yu-Shen Lin

IPC: A61K9/14 ,  A61K9/127 ,  A61K31/7088 ,  B82Y5/00 ,  A61K9/51 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  C12N15/88 ,  B82Y15/00

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

公开(公告)号：US20170362441A1

公开(公告)日：2017-12-21

申请号：US15537241

申请日：2015-12-18

Applicant: STC.UNM

Inventor： Richard Alan Kemp ,  Mahmoud Reda Taha

IPC: C09C1/48 ,  D01F9/127 ,  D01F1/10 ,  D01F9/22 ,  C08F120/44

CPC classification number: C09C1/482 ,  C08F120/44 ,  C09C1/48 ,  D01F1/10 ,  D01F9/1275 ,  D01F9/21 ,  D01F9/225

Abstract: A method and precursor for making carbon fibers and the like comprising carbon black modified with at least one cyclic compound promoter. A source of the carbon black may be recycled materials such as recycled tires or recycled plastics. The carbon black is modified by attaching at least one cyclic compound promoter to the outer periphery of the carbon black.

公开(公告)号：US09844684B2

公开(公告)日：2017-12-19

申请号：US15304306

申请日：2015-04-30

Applicant: STC.UNM

Inventor： Shuang Luan ,  Daniel Andres Riofrio Almeida

IPC: A61N5/10 ,  G06N3/00 ,  G06F19/00

CPC classification number: A61N5/1031 ,  A61N5/10 ,  A61N5/1001 ,  A61N5/1007 ,  A61N5/103 ,  A61N5/1084 ,  A61N2005/101 ,  A61N2005/1024 ,  A61N2005/1034 ,  G06F19/00 ,  G06F19/325 ,  G06N3/006 ,  G16H20/40

Abstract: An optimization technique for use with radiation therapy planning that combines stochastic optimization techniques such as Particle Swarm Optimization (PSO) with deterministic techniques to solve for optimal and reliable locations for delivery of radiation doses to a targeted tumor while minimizing the radiation dose experienced by the surrounding critical structures such as normal tissues and organs.