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公开(公告)号：US20180222929A1
公开(公告)日：2018-08-09
申请号：US15752866
申请日：2016-08-17
Applicant: Agency for Science, Technology and Research
Inventor： Fuke Wang , Fei Wang , Chaobin He
Abstract: This invention relates to a photoinitiator compound comprising: a polyhedral oligomeric silsesquioxane (POSS) moiety and a photoinitiator moiety, wherein the photoinitiator compound having the structure according to formula (I): [R—SiO1.5]n (I), wherein n is 6, 8, 10 or 12 and R is independently selected from the group consisting of H, linear or branched (hetero)alkyl, linear or branched (hetero)alkenyl, (hetero)aryl, (hetero)alkyl aryl, (hetero)aryl alkyl and a photoinitiator moiety, wherein at least one R is a photoinitiator moiety and the photoinitiator compound is a nanoparticle. The present invention also relates to a method for the production of the photoinitiator compound of the invention, a photopolymerizable composition comprising the photoinitiator compound of the invention, the use of the photoinitiator compound of the invention for photopolymerization. The present invention is further related to a coated substrate comprising the photopolymerizable composition of the invention.
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252.发明授权公开(公告)号：US10045343B2
公开(公告)日：2018-08-07
申请号：US14767542
申请日：2014-02-24
Applicant: Agency for Science, Technology and Research
Inventor： Xi Chen
Abstract: An automatic frequency control (AFC) device is provided. The AFC device includes an input module, a received signal strength indicator (RSSI) module and a carrier frequency offset (CFO) estimation module. The input module down converts and samples a received signal. The RSSI module is coupled to the input module and calculates a RSSI signal in response to the down converted and sampled received signal. The CFO estimation module is coupled to the input module and the RSSI module and calculates a moving average of binary elements of the down converted and sampled received signal. The CFO estimation module continues to calculate the moving average until the AFC converges.
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公开(公告)号：US20180214540A1
公开(公告)日：2018-08-02
申请号：US15939232
申请日：2018-03-28
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Madhavan Nallani , Fabien Decaillot , Zhikang Fu , Xingfang Su
CPC classification number: A61K39/385 , A61K9/0019 , A61K9/1273 , A61K39/12 , A61K47/34 , A61K2039/55566 , A61K2039/6093 , C12N2760/16134
Abstract: The invention relates to methods for eliciting an immune response to an immunogen, and in particular, to such methods using polymersomes as carriers for immunogen.
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公开(公告)号：US10035990B2
公开(公告)日：2018-07-31
申请号：US14651626
申请日：2013-12-10
Inventor： David Paramelle , Nikodem Tomczak , Paul Free , Sierin Lim , Tao Peng
CPC classification number: C12N9/1029 , B82Y5/00 , B82Y40/00 , C12N9/96 , C12Q1/48 , C12Y203/01012 , G01N2333/91057 , Y10T428/2991 , Y10T428/2998
Abstract: The invention relates to a method to encapsulate nanoparticles into a protein cage by inserting the nanoparticles into the core through holes. Currently commercially available nanoparticles can be functionalized using the inventive method. The inventive hybrids have applications in biosensing and bioimaging. The use of an affinity between poly-histidine chains and nitrilotriacetic acid as chelating reagent to obtain the inventive cages and hybrid assemblies by the method according to the invention is shown in FIG. 1.
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公开(公告)号：US20180208663A1
公开(公告)日：2018-07-26
申请号：US15922921
申请日：2018-03-16
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Cheng-I WANG , Peter BRAUER , Siok Ping YEO , Hwee Ching TAN , John Edward CONNOLLY
CPC classification number: C07K16/2866 , A61K38/1709 , A61K39/3955 , A61K47/6849 , A61K2039/505 , A61K2039/57 , C07K16/1036 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/526 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/00
Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.
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Patent Agency Ranking
公开(公告)号：US10023697B2
公开(公告)日：2018-07-17
申请号：US15361313
申请日：2016-11-25
Applicant: International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventor： Gregory Breyta , Julian M. W. Chan , Daniel J. Coady , Amanda C. Engler , Jeannette M. Garcia , Wei Han , James L. Hedrick , Alshakim Nelson , Robert J. Ono , Yi Yan Yang , Mu San Zhang
IPC: C08G73/06 , C08G69/48 , C08G73/02 , A01N43/60 , A01N37/44 , A61K8/88 , A61K31/785 , A61K31/787 , A61Q5/02 , A61Q11/00 , A61Q15/00 , C11D3/48 , D21H17/55 , A61Q17/00 , C11D3/37 , A01N43/40 , A01N37/18 , A61K8/86 , A61Q19/00 , A01N37/12 , A01N37/20 , A01N43/58 , A01N47/06 , A61K8/84 , A61K8/85 , C08G63/91 , C08G64/42 , A61K45/06 , D21H17/56 , D21H21/36 , C08L79/02 , C08L77/04
CPC classification number: C08G69/48 , A01N37/12 , A01N37/18 , A01N37/20 , A01N37/44 , A01N43/40 , A01N43/58 , A01N43/60 , A01N47/06 , A61K8/84 , A61K8/85 , A61K8/86 , A61K8/88 , A61K31/785 , A61K31/787 , A61K45/06 , A61K2800/10 , A61K2800/74 , A61Q5/02 , A61Q11/00 , A61Q15/00 , A61Q17/00 , A61Q17/005 , A61Q19/007 , C08G63/916 , C08G64/42 , C08G73/0206 , C08G73/024 , C08G73/0273 , C08G73/028 , C08G73/0293 , C08G73/0633 , C08G2650/02 , C08G2650/38 , C08G2650/58 , C08L77/04 , C08L79/02 , C11D3/3723 , C11D3/48 , D21H17/55 , D21H17/56 , D21H21/36 , A61K2300/00
Abstract: A number of cationic antimicrobial polymers have been synthesized by a condensation polymerization in bulk. The initial polymer formed has backbone tertiary nitrogens, which are subsequently quaternized using a suitable quaternizing agent (e.g., alkyl halide). The cationic polymers include polyamides, polycarbonates, polypolyureas and polyguanidiniums having a cationic repeat unit comprising the quaternary ammonium nitrogen as a backbone nitrogen. The cationic polymers can be active against Gram-negative, Gram-positive microbes, and/or fungi.
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公开(公告)号：US20180170932A1
公开(公告)日：2018-06-21
申请号：US15899675
申请日：2018-02-20
Applicant: Agency for Science, Technology and Research
Inventor： Soo Yei Ho , Stephanie Eliane BLANCHARD , Athisayamani Jeyaraj DURAISWAMY , Jenefer ALAM , Vikrant Arun ADSOOL
IPC: C07D473/06 , C07D473/08 , A61K31/522 , A61K31/5377
Abstract: The invention relates to the use of compounds of general structure (I) in modulation of the Wnt pathway [Formula should be inserted here] wherein R1, R2, R3, R4 and R5 are each, independently, H or an alkyl group; D is selected from the group consisting of H, halogen, alkyl, cycloalkyl, aryl, and dialkylamino, each (other than H and halogen) being optionally substituted; Ar is an aryl or heteroaryl group, optionally substituted; Cy is an aryl, heteroaryl or a saturated ring containing at least one heteroatom, each being optionally substituted; and n is an integer from 1 to 3.
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公开(公告)号：US20180149608A1
公开(公告)日：2018-05-31
申请号：US15577266
申请日：2016-05-30
Applicant: Agency for Science, Technology and Research
Inventor： Kok Leong Chang , Zi En Ooi , Jie Zhang
IPC: G01N27/12 , G01N27/416
CPC classification number: G01N27/122 , G01N27/12 , G01N27/4167
Abstract: There is provided a sensing device for measuring a level of an analyte. The sensing device includes a sensing element configured to sense the analyte and produce an electrical output which is variable based on the level of the analyte sensed, a measurement circuit including a reference element for providing an electrical property, the measurement circuit being connected to the sensing element and configured to provide a measurement output signal based on the electrical property of the reference element and the electrical output of the sensing element, whereby the measurement output signal indicates the level of the analyte sensed with respect to the electrical property of the reference element. There is also provided a corresponding method of fabricating the sensing device.
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公开(公告)号：US20180119222A1
公开(公告)日：2018-05-03
申请号：US15572772
申请日：2016-05-09
Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , National University Hospital (Singapore) Pte Ltd , National University of Singapore
Inventor： Ruiyang ZOU , Lihan ZHOU , Heng-Phon TOO , Arthur Mark RICHARDS , Lee Lee WONG , Su Ping Carolyn LAM
IPC: C12Q1/6883
CPC classification number: C12Q1/6883 , C12Q2600/158 , C12Q2600/178
Abstract: Present application relates to methods for determining whether a subject has heart failure or is at risk of having heart failure, specifically that of heart failure with reduced left ventricular ejection fraction (HFREF) and a heart failure with preserved left ventricular ejection fraction (HFPEF), comprising determining the level of selected miRNA(s) observed in a sample obtained from the subject and wherein an altered level of the miRNA(s) compared to control indicates that the subject has heart failure or is at risk of developing heart failure. Also encompassed are methods of determining an altered risk of death or disease progression to hospitalization and death based on alteration of selected miRNAs in a sample from the subject and kits thereof.
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公开(公告)号：US09956538B2
公开(公告)日：2018-05-01
申请号：US14764832
申请日：2014-02-13
Applicant: Agency for Science, Technology and Research
Inventor： Jia Min Chin , Siok Wei Tay , Xiaobai Wang , Jianwei Xu , Andy Tzi Sum Hor
CPC classification number: B01J19/12 , A61K9/4808 , A61K9/501 , A61K9/5015 , A61K41/0028 , B01J2219/089 , B01J2219/12 , B82Y5/00 , B82Y30/00 , C05G3/0005 , C05G3/0017 , C05G3/0041 , C05G3/0076 , G21K5/02
Abstract: The invention relates to macro- and micro-liquid marbles (i.e. droplets of liquid with a particulate-based shell), and in particular, to photo-responsive macro- and micro-liquid marbles encapsulating a substance therein. Methods for forming the macro- and micro-liquid marbles, and use of the macro- and micro-liquid marbles, in controlled release applications are also disclosed.
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