公开(公告)号：US20200276536A1

公开(公告)日：2020-09-03

申请号：US16802868

申请日：2020-02-27

Applicant: Research Triangle Institute

Inventor： Qinghe Zheng ,  Marty Lail ,  Shaojun Zhou

IPC: B01D53/22 ,  B01D53/047 ,  B01D53/04

Abstract: The present disclosure provides methods to use calcium cobalt zirconium perovskites as oxygen-selective sorbents for the separation of oxygen from a gas mixture such as air. Systems and high temperature oxygen detectors are also provided. In a preferred embodiment, the perovskite is configured as a membrane.

公开(公告)号：US20200165555A1

公开(公告)日：2020-05-28

申请号：US16695550

申请日：2019-11-26

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Leah Marie Johnson ,  Ninell Pollas Mortensen ,  Ginger Denison Rothrock ,  Nicolas D. Huffman

IPC: C12M1/00 ,  B29C64/40 ,  C12N5/00

Abstract: A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.

公开(公告)号：US20200062699A1

公开(公告)日：2020-02-27

申请号：US16612680

申请日：2018-05-10

Applicant: Research Triangle Institute

Inventor： Yanan ZHANG ,  Thuy NGUYEN ,  Nadezhda GERMAN

IPC: C07C275/38 ,  A61P25/30 ,  C07D213/643 ,  C07D205/04 ,  C07D207/335 ,  C07D211/38 ,  C07D215/12 ,  C07D239/26 ,  C07D295/135 ,  C07D333/20 ,  C07D487/08 ,  C07D491/107

Abstract: The present invention provides novel diarylurea derivatives (compounds of formula (I)) and their uses. The compounds of the present invention are demonstrated to be allosteric modulators of the CB1 receptor, and therefore useful for the treatment of diseases and conditions mediated by CB1.

公开(公告)号：US10481070B2

公开(公告)日：2019-11-19

申请号：US16398400

申请日：2019-04-30

Applicant: Research Triangle Institute

Inventor： Anthony Clint Clayton ,  Howard Jerome Walls ,  David S. Ensor ,  Andrei Yurievich Khlystov

IPC: G01N15/00 ,  G01N21/00 ,  G01N15/14 ,  G01N21/53 ,  G01N15/06 ,  G01N15/02 ,  G01N21/64 ,  C12Q3/00

Abstract: Sample monitoring and flow control systems and methods are disclosed for monitoring of airborne particulates. A system may include a particle collection filter. The system also includes a fluid moving device for moving a sample through the particle collection filter. Further, the system includes a light source configured to direct irradiating light towards the particle collection filter. The system also includes a light detector positioned to receive the irradiating light passing through the particle collection filter and configured to generate a signal representative of an amount of the received light. Further, the system includes a controller configured to receive the signal and to control the fluid moving device based on the amount of the received light.

公开(公告)号：US20190330675A1

公开(公告)日：2019-10-31

申请号：US16455067

申请日：2019-06-27

Applicant: Research Triangle Institute

Inventor： David S. Ensor ,  Howard Jerome Walls ,  Karin K. Foarde ,  Susanne Vera Hering ,  Steven Russel Spielman

IPC: C12Q1/24

Abstract: An aerosol collection system and method. The system includes a bio-aerosol delivery device configured to supply bioparticles in a gas stream, a moisture exchange device including a partition member coupled to the gas stream and configured to humidify or dehumidify the bioparticles in the gas stream, and an aerosol collection medium downstream from the moisture exchange device and configured to collect the bioparticles. The method includes delivering bioparticles in a gas stream, humidifying or dehumidifying the bioparticles in the gas stream by transport of water across a partition member and into a vapor phase of the gas stream, and collecting the bioparticles by a collection medium.

公开(公告)号：US20190322644A1

公开(公告)日：2019-10-24

申请号：US16341597

申请日：2017-10-11

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  Kenneth S. REHDER

IPC: C07D401/12 ,  C07D403/12 ,  C07D417/14 ,  C07D233/90 ,  C07D401/04 ,  C07D249/10 ,  C07D401/14

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) with heterocyclic cores and uses of such agonists.

公开(公告)号：US20190270073A1

公开(公告)日：2019-09-05

申请号：US16320116

申请日：2017-07-26

Applicant: Research Triangle Institute

Inventor： Marty Lail ,  Paul Mobley ,  Jonathan Peters ,  Sree Nandita Akunuri ,  Joshua J. Hlebak

IPC: B01J23/68 ,  B01J23/652 ,  B01J21/04 ,  B01J37/03 ,  B01J37/02 ,  B01J37/08 ,  C07D301/03 ,  C01B32/40

Abstract: The present disclosure provides mixed molybdenum oxide catalysts, methods for preparing epoxides from olefins and CO2 using them, and methods of making the mixed molybdenum oxide catalysts by impregnation or co-precipitation. In a preferred embodiment, the mixed molybdenum oxide catalysts are silver/molybdenum oxide catalysts, ruthenium/molybdenum oxide catalysts, or a combination thereof.

公开(公告)号：US10377718B2

公开(公告)日：2019-08-13

申请号：US15023510

申请日：2015-06-05

Applicant: Research Triangle Institute ,  Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

IPC: C07D231/14 ,  A61K45/06 ,  A61K31/415 ,  C07D405/12 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/496 ,  C07D413/12 ,  C07D403/12 ,  C07D403/06 ,  C07D407/12

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20190201877A1

公开(公告)日：2019-07-04

申请号：US16296746

申请日：2019-03-08

Applicant: Research Triangle Institute

Inventor： Jian-Ping Shen ,  Marty Lail ,  Brian Turk ,  Paul D. Mobley ,  Jason S. Norman ,  Laura Douglas ,  Jonathan Peters

IPC: B01J23/835 ,  C07C11/02 ,  B01J23/83 ,  B01J23/89 ,  C07C31/04 ,  C07C13/20 ,  C07C11/22 ,  C07C11/06 ,  C07C15/46 ,  C10J3/46 ,  B01J35/00 ,  C01B32/40 ,  C10J3/72 ,  C07C29/156 ,  C07C11/04 ,  B01J23/74 ,  B01J23/76 ,  C07C2/84 ,  C07C5/42 ,  C07D301/03 ,  C01B3/40 ,  C10G27/00 ,  B01J23/889 ,  B01J23/00 ,  B01J23/78 ,  B01J23/80 ,  C07C9/06

CPC classification number: B01J23/835 ,  B01J23/002 ,  B01J23/74 ,  B01J23/76 ,  B01J23/78 ,  B01J23/80 ,  B01J23/83 ,  B01J23/8892 ,  B01J23/8906 ,  B01J35/002 ,  B01J37/03 ,  B01J37/14 ,  B01J37/18 ,  B01J2523/00 ,  B01J2523/821 ,  C01B3/40 ,  C01B32/40 ,  C01B2203/0238 ,  C01B2203/1047 ,  C01B2203/1064 ,  C01B2203/1088 ,  C01B2203/1235 ,  C07C2/84 ,  C07C5/42 ,  C07C9/06 ,  C07C11/02 ,  C07C11/04 ,  C07C11/06 ,  C07C11/22 ,  C07C13/20 ,  C07C15/46 ,  C07C29/156 ,  C07C31/04 ,  C07C2521/04 ,  C07C2521/06 ,  C07C2521/08 ,  C07C2523/46 ,  C07C2523/74 ,  C07C2523/78 ,  C07C2523/80 ,  C07C2523/83 ,  C07C2523/835 ,  C07C2523/889 ,  C07C2523/89 ,  C07C2601/16 ,  C07D301/03 ,  C10G27/00 ,  C10G2400/22 ,  C10G2400/30 ,  C10J3/463 ,  C10J3/725 ,  C10J2300/0969 ,  C10J2300/0986 ,  C10J2300/1653 ,  Y02E20/18 ,  Y02P20/52 ,  B01J2523/31 ,  B01J2523/43 ,  B01J2523/842 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/845 ,  B01J2523/72 ,  B01J2523/13 ,  B01J2523/17 ,  B01J2523/22 ,  B01J2523/27

Abstract: This invention is directed to novel mixed transition metal iron (II/III) catalysts for the extraction of oxygen from CO2 and the selective reaction with organic compounds.

公开(公告)号：US20190127419A1

公开(公告)日：2019-05-02

申请号：US16090728

申请日：2017-03-23

Applicant: Research Triangle Institute ,  The Regents of the University of California

Inventor： Scott RUNYON ,  Danni HARRIS ,  Rainer REINSCHEID ,  Yanyan ZHANG ,  Carla HASSLER

IPC: C07K5/068 ,  C07K5/083 ,  A61P25/28 ,  C07K5/087 ,  C07K5/097 ,  C07K5/08 ,  C07K5/103 ,  C07K5/107 ,  C07K7/06 ,  A61P25/18 ,  A61P25/30 ,  A61P3/04

Abstract: Neuropeptide S receptor agonists are provided. The NPS agonists include trimeric, tetrameric, pentameric or hexameric peptidomimetic analogs exhibiting affinity for and activity at the neuropeptide S receptor. The peptidomimetic molecules may be useful in the treatment of disorders, syndromes and conditions mediated by modulation of the neuropeptide S receptor such as substance abuse, narcolepsy, insomnia, obesity, cognitive decline, dementia, Alzheimer's disease, panic disorder, generalized anxiety, PTSD, phobias, schizophrenia and as supportive medication during any kind of cessation program in cognitive behavioral therapy, such as drug addiction, eating disorders and gambling.