公开(公告)号：US10038955B2

公开(公告)日：2018-07-31

申请号：US14926873

申请日：2015-10-29

申请人： InCube Labs, LLC

发明人： Mir Imran

IPC分类号： H04R1/44 ,  H04R1/08 ,  H04R1/46 ,  H04R17/02 ,  B63C11/26 ,  H04B11/00

CPC分类号： H04R1/44 ,  B63C11/26 ,  H04B11/00 ,  H04R1/083 ,  H04R1/46 ,  H04R17/02 ,  H04R2217/03 ,  H04R2410/07 ,  H04R2460/13

摘要： Embodiments of the invention provide a system, apparatus and methods for underwater voice communication by a diver to other divers and surface ships. In many embodiments, the system includes a mouthpiece voice communication apparatus having a microphone for sensing the diver's voice and an acoustic transducer that conducts sound via conduction through the diver's teeth and skull to the cochlea so as to allow the diver to hear sounds. The mouthpiece is adapted to be easily attached to portions of a SCUBA or other underwater breathing apparatus. It may also be attached to or integral with a snorkel or similar apparatus.

公开(公告)号：US10016453B2

公开(公告)日：2018-07-10

申请号：US15709373

申请日：2017-09-19

申请人： INCUBE LABS, LLC

发明人： Mir Imran

IPC分类号： C07K14/00 ,  A61K31/785 ,  C07K14/78 ,  A61L27/22

CPC分类号： A61K31/785 ,  A61L27/227 ,  C07K14/001 ,  C07K14/78

摘要： Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are separated by a porous membrane with the first chamber providing a flow path for a fluid. The membrane includes a coating having a cell binding affinity for the attachment and proliferation of cells to cover the surface of the membrane. The second chamber provides a volume for maintaining the viability of cells disposed in the chamber. The cells can be selected to produce a biochemical compound. The membrane is configured to allow for diffusion of the compound from the second chamber into the flow path as well as allow for diffusion of gases, nutrients and other biochemical compounds.

公开(公告)号：US09795296B2

公开(公告)日：2017-10-24

申请号：US13457456

申请日：2012-04-26

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61B5/1455 ,  A61B5/00 ,  A61B5/08 ,  B63C11/26 ,  B63C11/18

CPC分类号： A61B5/0002 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/6803 ,  A61B5/682 ,  A61B2562/0204 ,  A61B2562/0238 ,  B63C11/186 ,  B63C11/26

摘要： Embodiments of the invention provide a system, apparatus and methods for measurement of biometric data of a diver. In many embodiments, the system includes a mouthpiece having a sensor device comprising a light emitter and detector configured to emit and detect light at a wavelength having an absorbance correlated with a level of a blood gas saturation e.g., oxygen, nitrogen, CO2. The emitter is positioned to emit light onto oral tissue of the diver and the detector positioned to detect light which is received from the oral tissue either by transmittance of light through the oral tissue or by reflection of light from the tissue. The target oral tissue can include one or both of gum or buccal tissue. Such embodiments allow data to be collected without having to wear additional sensors or measurement devices and allow for measurement of blood gas levels as the diver breaths through their mouthpiece.

公开(公告)号：US09764131B2

公开(公告)日：2017-09-19

申请号：US14755840

申请日：2015-06-30

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/30 ,  A61N1/32 ,  A61N1/04 ,  A61K9/00 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

公开(公告)号：US20170231547A1

公开(公告)日：2017-08-17

申请号：US15431621

申请日：2017-02-13

申请人： Incube Labs, LLC

发明人： Mir Imran

IPC分类号： A61B5/20 ,  A61N1/05 ,  A61N1/36 ,  A61B5/00

CPC分类号： A61B5/205 ,  A61B5/6853 ,  A61M25/04 ,  A61M2025/0002 ,  A61N1/0514 ,  A61N1/0551 ,  A61N1/36007

摘要： Embodiments of the invention provide apparatus and methods for testing the efficacy of nerve stimulation therapy to treat patients who have urinary dysfunction prior to the implantation of an apparatus to treat the dysfunction. The apparatus and methods provide means to selectively stimulate the pudendal nerve with high and low frequency current to produce a physiologic response involved in the urination process (e.g., relaxation of the urinary sphincter and contraction of the bladder) and then measure information relating to the response. Particular embodiments involve the introduction of a urethral catheter configured to both fill the bladder and test the ability to control bladder voiding by applying stimulation current to the pudendal nerve and then measure the response information such as bladder pressure, urinary sphincter pressure and urinary flow rate. The catheter can include at least two electrodes and separate pressure sensors positioned for measuring the urinary sphincter and bladder pressure.

公开(公告)号：US20170203110A1

公开(公告)日：2017-07-20

申请号：US15410712

申请日：2017-01-19

申请人： Incube Labs, LLC

发明人： Mir Imran

IPC分类号： A61N1/372 ,  A61N1/36

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/3605 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/37247

摘要： A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.

公开(公告)号：US20170203100A1

公开(公告)日：2017-07-20

申请号：US15410692

申请日：2017-01-19

申请人： Incube Labs, LLC

发明人： Mir Imran

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/3605 ,  A61N1/36139 ,  A61N1/36171 ,  A61N1/37247

摘要： A system for controlling urination in a patient includes an implantable controller and an external device. The implantable controller includes circuitry and electrodes for stimulating the pudenal nerves in order to control urination. In addition, the implantable controller includes sensors for determining information on bladder fullness and for transmitting such information to an external device which is used for controlling the implanted controller. The external device will display when bladder filling exceeds a safe threshold level, allowing the patient and a caregiver to take appropriate steps to allow the patient to urinate.

公开(公告)号：US09620027B2

公开(公告)日：2017-04-11

申请号：US14211297

申请日：2014-03-14

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Joel M. Harris

IPC分类号： A61B5/00 ,  A61B5/04 ,  A61M21/00 ,  G09B5/04 ,  G06F3/01

CPC分类号： G09B5/04 ,  A61B5/0006 ,  A61B5/04001 ,  A61B5/4812 ,  A61B5/6814 ,  A61B5/7405 ,  A61M21/00 ,  A61M2021/0027 ,  G06F3/015 ,  G06F2203/011

摘要： Embodiments of the invention provide apparatus, systems and methods for detecting neurological activity indicative of a dream state of a human. Many embodiments of the invention provide apparatus, systems and methods for detecting neurological activity of a human indicative of a dream state or the onset thereof and delivering an input to the user (such as an audio or other sensory input) during the dream state. Particular embodiments of the invention provide systems and methods for detecting neurological activity indicative of the onset or occurrence of a dream state of a human and delivering an audio or other sensory input during the user's dream state. The audio input may be used for learning, delivering messages to the user's subconscious, and/or promoting a state of relaxation.

公开(公告)号：US09220916B2

公开(公告)日：2015-12-29

申请号：US13710407

申请日：2012-12-10

申请人： InCube Labs, LLC

发明人： Mir Imran

IPC分类号： A61N1/00 ,  A61B5/02 ,  A61N5/06 ,  A61N1/36 ,  H01R13/52 ,  A61N1/375 ,  A61N1/05 ,  A61N1/37

CPC分类号： A61N5/0622 ,  A61N1/0529 ,  A61N1/0536 ,  A61N1/36 ,  A61N1/36064 ,  A61N1/37 ,  A61N1/375 ,  A61N1/3754 ,  A61N5/0601 ,  A61N2005/063 ,  H01R13/5224 ,  H01R2201/12

摘要： Embodiments described herein provide methods for treating various conditions and diseases using an optical signal. In one or more embodiments an apparatus is providing having an optical window, which is used to deliver an optical signal to provide stimulation to one or more tissue sites in the body such as the brain, optic nerve, eye, ganglia, spine, or other like site. The optical signals can be used to treat a variety of neurological diseases and conditions including epilepsy, migraine headaches and chronic pain. In particular applications the optical signals can be used to treat, inhibit or prevent epileptic or other neurological seizures by providing an optical input to a foci or surrounding tissue in the brain causing the seizure. The optical signal may also be combined with an electrical signal to produce an aggregate effect in tissue for treating the disease or condition such as a neurological disease or condition.

摘要翻译： 本文所述的实施方案提供了使用光信号处理各种病症和疾病的方法。 在一个或多个实施例中，装置提供具有光学窗口，其用于递送光学信号以向身体中的一个或多个组织部位提供刺激，例如脑，视神经，眼睛，神经节，脊柱或其它 像网站。 光信号可用于治疗各种神经疾病和病症，包括癫痫，偏头痛和慢性疼痛。 在特定应用中，光学信号可用于通过向脑中的焦点或周围组织提供光学输入来引起癫痫发作，来治疗，抑制或预防癫痫或其它神经系统发作。 光信号还可以与电信号组合以在组织中产生用于治疗疾病或病症如神经疾病或病症的聚集效应。

公开(公告)号：US09138160B2

公开(公告)日：2015-09-22

申请号：US14224900

申请日：2014-03-25

申请人： InCube Labs, LLC

发明人： Mir Imran

IPC分类号： A61N1/00 ,  A61B5/046 ,  A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/39 ,  A61N1/05 ,  A61N1/37

CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

摘要： Embodiments of the invention provide methods for the detection and treatment of atrial fibrillation (AF) and related conditions. One embodiment provides a method comprising measuring electrical activity of the heart using electrodes arranged on the heart surface to define an area for detecting aberrant electrical activity (AEA) and then using the measured electrical activity (MEA) to detect foci of AEA causing AF. A pacing signal may then be sent to the foci to prevent AF onset. Atrial wall motion characteristics (WMC) may be sensed using an accelerometer placed on the heart and used with MEA to detect AF. The WMC may be used to monitor effectiveness of the pacing signal in preventing AF and/or returning the heart to normal sinus rhythm (NSR). Also, upon AF detection, a cardioversion signal may be sent to the atria using the electrodes to depolarize an atrial area causing AF and return the heart to NSR.

摘要翻译： 本发明的实施方案提供了用于检测和治疗心房颤动（AF）和相关病症的方法。 一个实施例提供了一种方法，其包括使用布置在心脏表面上的电极来测量心脏的电活动，以限定用于检测异常电活动（AEA）的区域，然后使用测量的电活动（MEA）来检测导致AF的AEA的焦点。 然后可以将起搏信号发送到病灶以防止AF发作。 可以使用放置在心脏上的加速度计来感测心房壁运动特征（WMC），并与MEA一起使用以检测AF。 WMC可用于监测起搏信号在预防AF和/或使心脏恢复正常窦性心律（NSR）方面的有效性。 此外，在AF检测时，可以使用电极将心脏复律信号发送到心房，以使引起AF的心房区域去极化并将心脏返回到NSR。