公开(公告)号：US20030055447A1

公开(公告)日：2003-03-20

申请号：US09957526

申请日：2001-09-19

Applicant: Advanced Cardiovascular systems, Inc.

Inventor： Jeong S. Lee ,  Edwin Wang ,  Roseminda J. White

IPC: A61M029/00

CPC classification number: A61M25/0045 ,  A61L29/085 ,  A61M25/0009 ,  A61M25/104 ,  C08L77/12 ,  C08L75/04 ,  C08L79/08

Abstract: A catheter having an multilayered shaft section with a first layer formed of a polyimide first material and a second layer formed of a second material. In a presently preferred embodiment, the polyimide material is a thermoset polyimide. However, in alternative embodiments, a thermoplastic polyimide is used. The thermoset polyimide has a very high glass transition temperature (Tg) of approximately 400null C. (as measured by differential scanning calorimetry), and excellent dimensional stability at the processing temperature of polyamides commonly used in catheter components. As a result, during formation and assembly of the catheter, production of a thin polyimide layer with controlled dimensions is facilitated. The polyimide has a high modulus and provides a thin walled yet highly pushable shaft section, while the second layer provides kink resistance. In one embodiment, the second material is selected from the group consisting of a polyamide material and a polyurethane material.

公开(公告)号：US20020082553A1

公开(公告)日：2002-06-27

申请号：US09747553

申请日：2000-12-22

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Jacky G. Duchamp

IPC: A61M029/00

CPC classification number: A61M25/1034 ,  A61M25/104

Abstract: The invention is directed to a catheter assembly and method for making the same. The catheter includes an elongated shaft and an inflatable balloon on a portion of a distal shaft section and in surrounding relation thereto. The balloon has proximal and distal tapered regions and an intermediate region longitudinally disposed therebetween. The balloons distal tapered region has a length at least equal to the proximal tapered region length, preferably greater. The proximal and distal tapered regions each forms a taper outer angle with the catheter shaft with the distal taper outer angle being greater than the proximal taper outer angle.

Abstract translation: 本发明涉及导管组件及其制造方法。 导管包括细长轴和在远端轴部分的一部分上并且与其周围的关系的可膨胀气囊。 气囊具有近端和远端锥形区域以及纵向设置在其间的中间区域。 气囊远端锥形区域具有至少等于近端锥形区域长度的长度，优选更大。 近端和远端锥形区域各自与导管轴形成锥形外角，远端锥形外角大于近端锥形外角。

公开(公告)号：US20020082549A1

公开(公告)日：2002-06-27

申请号：US09746416

申请日：2000-12-21

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Jacky G. Duchamp

IPC: A61M029/00

CPC classification number: A61M25/1034 ,  A61M2025/1063 ,  A61M2025/1093

Abstract: The invention is directed to an intravascular balloon catheter and a method for forming the same. The catheter includes an elongated shaft having proximal and distal ends, a guidewire receiving lumen extending through at least a distal portion of the elongated shaft; and a balloon on a distal shaft section. A distal portion the guidewire receiving lumen has different stiffness along a length thereof.

Abstract translation: 本发明涉及一种血管内气囊导管及其形成方法。 导管包括具有近端和远端的细长轴，延伸穿过细长轴的至少远端部分的导丝接收腔; 和远端轴部分上的气球。 导丝接收腔的远端部分沿其长度具有不同的刚度。

公开(公告)号：US20020082524A1

公开(公告)日：2002-06-27

申请号：US09748089

申请日：2000-12-21

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： David M. Anderson ,  Emmanuel C. Biagtan ,  Wayne E. Cornish ,  Sharon Y. Wong

IPC: A61B005/00

CPC classification number: A61M25/09 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: A guidewire having a flexible coil with a tapered distal tip. Preferably, the flexible coil has a polymer coating at least at its tapered distal portion. The polymer coating may comprise polyurethanes or other suitable polymers. The guidewires of the invention provide desirable performance characteristics, particularly when used to cross relatively tight lesions such as chronic total occlusions.

Abstract translation: 导丝，其具有带锥形远端的柔性线圈。 优选地，柔性线圈至少在其锥形远端部分具有聚合物涂层。 聚合物涂层可以包括聚氨酯或其它合适的聚合物。 本发明的导丝线提供期望的性能特征，特别是当用于交叉相对紧密的损伤（例如慢性完全闭塞）时。

公开(公告)号：US20020081404A1

公开(公告)日：2002-06-27

申请号：US09970817

申请日：2001-10-03

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Stephen G. Schaible ,  Debashis Dutta

IPC: B29D022/00

CPC classification number: A61L29/126 ,  A61M25/10 ,  Y10T428/1334

Abstract: A catheter having an inflatable member formed of a liquid crystal polymeric material. The inflatable member is formed from a blend of a minor amount, preferably less than 10%, of liquid crystal polymer with a major amount of a non-liquid crystal polymer having LCP fibers that are highly oriented in the machine direction. The aspect ratio of the liquid crystal polymeric material fibers is greater than 10, so that the polymer blend has mechanical characteristics similar to a fiber-reinforced composite with improved strength and optimal compliance.

Abstract translation: 一种具有由液晶聚合物材料形成的可膨胀构件的导管。 可膨胀构件由少量，优选小于10％的液晶聚合物与主要量的在机器方向上高度取向的LCP纤维的非液晶聚合物的共混物形成。 液晶聚合物材料纤维的纵横比大于10，使得聚合物共混物具有类似于纤维增强复合材料的机械特征，其具有改进的强度和最佳顺应性。

公开(公告)号：US20020038103A1

公开(公告)日：2002-03-28

申请号：US10005025

申请日：2001-12-04

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Edward A. Estrada ,  Mina W. B. Chow ,  Kenneth L. Wantink ,  Barbara E. Stamberg ,  Chi Le Long

IPC: A61M029/00 ,  A61M031/00 ,  A61M037/00

CPC classification number: A61M25/104 ,  A61M25/007 ,  A61M25/0075 ,  A61M25/09 ,  A61M2025/0063 ,  A61M2025/0183 ,  A61M2025/1079 ,  A61M2025/1093

Abstract: A balloon catheter system generally having an elongated catheter shaft with enhanced flexibility to facilitate more distal advancement within a patient's body lumen. The catheter shaft has a relatively stiff proximal shaft section, a relatively flexible distal shaft section and an intermediate shaft section which provides a smooth, flexible transition between the proximal and distal shaft sections. The intermediate shaft section has an improved construction with a tubular reinforcing member secured by its proximal end to the distal extremity of the proximal shaft section and a distal end secured within the proximal end of the distal shaft section. The tubular reinforcing member preferably has an inner tubular support member which has a proximal end secured to the distal end of the proximal shaft section. Preferably, the proximal shaft section has an outer jacket which extends over the tubular reinforcing member of the intermediate shaft section. Dual lumen and concentric distal shaft sections are describes. Additionally, over-the-wire constructions are described in which the inner and outer tubular members forming part of the distal shaft section extend the length of the catheter.

Abstract translation: 一种气囊导管系统，其通常具有细长的导管轴，该导管轴具有增强的柔性，以便于在患者的体腔内更远的前进。 导管轴具有相对刚性的近端轴部分，相对柔性的远侧轴部分和中间轴部分，其在近端和远端轴部分之间提供平滑的柔性过渡。 中间轴部分具有改进的构造，其中管状加强构件通过其近端固定到近侧轴部分的远端，并且远端固定在远侧轴部分的近端内。 管状加强构件优选地具有内管状支撑构件，其具有固定到近端轴部分的远端的近端。 优选地，近侧轴部分具有在中间轴部分的管状加强件上延伸的外护套。 描述双腔和同心远端轴段。 另外，描述了在线结构，其中形成远侧轴部分的一部分的内部和外部管状构件延伸导管的长度。

公开(公告)号：US20020018866A1

公开(公告)日：2002-02-14

申请号：US09899828

申请日：2001-07-05

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Jeong S. Lee ,  Debashish Dutta

IPC: B65D001/00

CPC classification number: A61L29/06 ,  Y10T428/1386 ,  C08L77/00

Abstract: An inflatable member such as a balloon which is formed at least in part of a polyamide/polyether block copolymer thermoplastic elastomer, commonly referred to as polyether block amide (PEBA). The presently preferred PEBA copolymer is polyamide/polyether polyester copolymer, such as PEBAXnull. The balloon of the invention exhibits high tensile strength, high elongation, and low flexural moduli. The balloon may be formed as a single layer of PEBA, or as a multilayer coextrudate having at least one PEBA layer. The balloon may be 100% PEBA or a blend of PEBA with another polymer, such as nylon.

Abstract translation: 至少部分由聚酰胺/聚醚嵌段共聚物热塑性弹性体形成的可膨胀构件，例如气球，通常称为聚醚嵌段酰胺（PEBA）。 目前优选的PEBA共聚物是聚酰胺/聚醚聚酯共聚物，例如PEBAX。 本发明的气囊显示出高拉伸强度，高伸长率和低弯曲模量。 气囊可以形成为单层PEBA，或者形成为具有至少一个PEBA层的多层共挤出物。 球囊可以是100％PEBA或PEBA与另一种聚合物如尼龙的混合物。

公开(公告)号：US20020009535A1

公开(公告)日：2002-01-24

申请号：US09827977

申请日：2001-04-06

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Eugene T. Michal ,  Christopher J. Buchko ,  Deborah L. Kilpatrick ,  Stephen J. Bigus

IPC: A61L002/00 ,  B05D003/00 ,  A61M029/00

CPC classification number: A61L29/048 ,  A61L29/085 ,  A61L31/047 ,  A61L31/10 ,  A61L2420/08 ,  A61M2025/0056 ,  Y10S623/926 ,  Y10T428/31511 ,  Y10T428/31536 ,  Y10T428/31609 ,  Y10T428/31721 ,  Y10T428/31855 ,  Y10T428/31942 ,  C08L89/00

Abstract: A method of providing a therapeutic, diagnostic or lubricious hydrophilic coating on an intracorporeal medical device and the coated device produced thereby, wherein the coating is durable. In one embodiment, the coating comprises a polymerized base coat and a top coat having a therapeutic, diagnostic or hydrophilic agent, where the base coat has a binding component which binds to the top coat, and a grafting component which binds to the binding component and adheres to the device. In another embodiment, the coating comprises a blend of an agent, a grafting component, and salt. In one embodiment, the therapeutic agent is superoxide dismutase or a superoxide dismutase mimic. The coating of the invention may be applied to a medical device with a polymeric surface such as a polymeric catheter, or a metal device such as a stent coated with a polymeric primer or without a primer.

Abstract translation: 在体外医疗装置上提供治疗性，诊断性或润滑性的亲水性涂层的方法以及由此制造的涂覆装置，其中涂层是耐用的。 在一个实施方案中，涂层包含聚合底涂层和具有治疗性，诊断性或亲水性试剂的面漆，其中底涂层具有结合顶部涂层的结合成分，和接合组分，其结合粘合成分和 遵守设备。 在另一个实施方案中，涂层包含试剂，接枝组分和盐的共混物。 在一个实施方案中，治疗剂是超氧化物歧化酶或超氧化物歧化酶模拟物。 本发明的涂层可以应用于具有聚合物表面的医疗装置，例如聚合物导管，或金属装置，例如涂覆有聚合物底漆或不含底漆的支架。

公开(公告)号：US09950144B2

公开(公告)日：2018-04-24

申请号：US14864551

申请日：2015-09-24

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Mina Chow ,  Dwight A. Ambat ,  Jinhua Chen ,  Eugene T. Michal

IPC: A61M25/06 ,  A61M25/00

CPC classification number: A61M25/06 ,  A61M25/003 ,  A61M25/0071 ,  A61M2025/0034 ,  A61M2025/0037

Abstract: An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.

公开(公告)号：US20150164423A1

公开(公告)日：2015-06-18

申请号：US14620039

申请日：2015-02-11

Applicant: ADVANCED CARDIOVASCULAR SYSTEMS, INC.

Inventor： William E. Webler

IPC: A61B5/00 ,  A61B8/12 ,  A61N5/06 ,  A61B5/02 ,  A61B5/0205

CPC classification number: A61B5/6857 ,  A61B1/00096 ,  A61B1/00183 ,  A61B1/0051 ,  A61B1/3137 ,  A61B5/0062 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/02007 ,  A61B5/02055 ,  A61B5/4836 ,  A61B5/6851 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/6885 ,  A61B8/12 ,  A61B2017/22081 ,  A61B2090/3735 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602

Abstract: Methods and apparatuses for positioning medical devices onto (or close to) a desired portion of the interior wall of an internal channel, such as for scan imaging, for photodynamic therapy and/or for optical temperature measurement. In one embodiment, a catheter assembly has a distal portion that can be changed from a configuration suitable for traversing the internal channel to another configuration suitable for scan at least a spiral section of the interior wall of an internal channel, such as an artery. In one example, the distal portion spirals into gentle contact with (or close to) a spiral section of the artery wall for Optical Coherence Tomography (OCT) scanning. The spiral radius may be changed through the use of a guidewire, a tendon, a spiral balloon, a tube, or other ways.

Abstract translation: 将医疗装置定位在（或接近）内部通道的内壁的期望部分（例如用于扫描成像）用于光动力学治疗和/或用于光学温度测量的方法和装置。 在一个实施例中，导管组件具有远端部分，该远端部分可以从适合于穿过内部通道的构造改变为适于扫描内部通道（例如动脉）的内壁的至少螺旋部分的另一构造。 在一个示例中，远端部分与光学相干断层扫描（OCT）扫描的螺旋形部分螺旋地与动脉壁的螺旋部分（或靠近）螺旋。 可以通过使用导丝，腱，螺旋气囊，管或其它方式来改变螺旋半径。