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37 条记录 (耗时 0.034 秒)

    Method of screening compounds using a nanoporous silicon support containing macrowells for cells
    28.
    发明授权
    Method of screening compounds using a nanoporous silicon support containing macrowells for cells 失效
    使用包含用于细胞的孔眼的纳米多孔硅载体筛选化合物的方法

    公开(公告)号：US07312046B2

    公开(公告)日：2007-12-25

    申请号：US10787015

    申请日：2004-02-25

    申请人： Vicki I. Chin ,  Sangeeta N. Bhatia ,  Michael J. Sailor ,  Boyce E. Collins

    发明人： Vicki I. Chin ,  Sangeeta N. Bhatia ,  Michael J. Sailor ,  Boyce E. Collins

    IPC分类号： C12Q1/02 ,  C12Q1/18 ,  C12Q1/20 ,  C12N1/00 ,  C12N5/00 ,  C12M1/00 ,  C12M3/00

    CPC分类号： G01N33/5014 ,  C12M25/14 ,  C12M29/10 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5067 ,  G01N33/5088 ,  G01N33/552 ,  G01N2500/20

    摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients by means such as perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that promotes cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The supports are sufficiently robust that they may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.

    摘要翻译： 提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。 每个细胞或一组细胞在单独的大孔中生长，并通过诸如用流体灌注纳米多孔硅载体的方式提供营养。 大孔可以在0.2和200微米之间，并且涂覆有促进细胞粘附的物质。 含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。 载体足够坚固，可将其组装成较大的反应器以模拟器官功能或用于生产生物分子。

    Nanoporous silicon support containing macropores for use as a bioreactor
    29.
    发明授权
    Nanoporous silicon support containing macropores for use as a bioreactor 失效
    含有大孔的纳米多孔硅载体用作生物反应器

    公开(公告)号：US06734000B2

    公开(公告)日：2004-05-11

    申请号：US09981691

    申请日：2001-10-12

    申请人： Vicki I. Chin ,  Sangeeta N. Bhatia ,  Michael J. Sailor ,  Boyce E. Collins

    发明人： Vicki I. Chin ,  Sangeeta N. Bhatia ,  Michael J. Sailor ,  Boyce E. Collins

    IPC分类号： C12M1114

    CPC分类号： G01N33/5014 ,  C12M25/14 ,  C12M29/10 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5067 ,  G01N33/5088 ,  G01N33/552 ,  G01N2500/20

    摘要： A nanoporous silicon support comprising a plurality of macropores is provided to function as a bioreactor for the maintenance of cells in culture in a differentiated state. Each cell or group of cells is grown in an individual macropore and is provided with nutrients such as by perfusion of the nanoporous silicon support with fluid. The macropores may be between 0.2 and 200 microns and be coated with a substance that provides cell adhesion. The support containing cells may be used to used to test compounds for biological activity, metabolism, toxicity, mutagenicity, carcinogenicity or to characterize novel or unknown comounds. The support is sufficiently robust that it may be assembled into larger reactors to simulate organ function or be used for the production of biomolecules.

    摘要翻译： 提供包含多个大孔的纳米多孔硅载体用作生物反应器，用于维持分化状态的培养中的细胞。 每个细胞或一组细胞在单个大孔中生长并且提供营养物质，例如通过用流体灌注纳米多孔硅载体。 大孔可以在0.2至200微米之间，并且涂覆有提供细胞粘附的物质。 含有细胞的载体可用于测试化合物的生物活性，代谢，毒性，致突变性，致癌性或表征新颖或未知的化合物。 支架足够坚固，可将其装配到较大的反应器中以模拟器官功能或用于生产生物分子。

    Implantable access device
    30.
    发明授权
    Implantable access device 失效
    植入式接入设备

    公开(公告)号：US5741228A

    公开(公告)日：1998-04-21

    申请号：US390014

    申请日：1995-02-17

    申请人： Gregory H. Lambrecht ,  Joshua Makower ,  Sangeeta N. Bhatia ,  David McDonald ,  Ashish Khera ,  J. Christopher Flaherty ,  Alan K. Plyley ,  Russell J. Redmond ,  Claude A. Vidal

    发明人： Gregory H. Lambrecht ,  Joshua Makower ,  Sangeeta N. Bhatia ,  David McDonald ,  Ashish Khera ,  J. Christopher Flaherty ,  Alan K. Plyley ,  Russell J. Redmond ,  Claude A. Vidal

    IPC分类号： A61M37/00 ,  A61M39/02 ,  A61M39/26 ,  A61M11/00

    CPC分类号： A61M39/0208 ,  A61M2039/0211 ,  A61M39/26 ,  A61M5/14276

    摘要： An implantable access device for allowing repeat access to a site, space, device, or other object, fluid, tissue or region within the body of a patient. The implantable device, in one embodiment, includes a housing having an elongated open guidance channel that leads to an entrance orifice, a valve assembly communicating with the entrance orifice, and an exit orifice. The device permits access via the percutaneous insertion of an accessing filament such as a needle through the entrance orifice and into the valve assembly, which opens to allow the passage of fluids or other filaments such as guide wires or optical fibers. The device can be used for the introduction of therapeutic agents, for the infusion or withdrawal of fluids, or for the introduction of sensing, sampling, or treatment devices to another implanted device or to regions within the patient.

    摘要翻译： 一种用于允许重复访问患者体内的部位，空间，装置或其它物体，流体，组织或区域的可植入进入装置。 在一个实施例中，可植入装置包括具有通向入口孔的细长的开放引导通道，与入口孔连通的阀组件和出口孔的壳体。 该装置允许通过经由插入通过入口孔的入口细丝经皮插入进入阀组件而进入，阀组件打开以允许诸如导丝或光纤之类的流体或其它细丝通过。 该装置可用于引入治疗剂，用于输注或取出流体，或用于将感测，取样或治疗装置引入另一种植入装置或患者体内的区域。