公开(公告)号：US20240210736A1

公开(公告)日：2024-06-27

申请号：US18600985

申请日：2024-03-11

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Shinichi IKEDA ,  Xiaoyan JIANG ,  Kazuo TSUBOTA ,  Toshihide KURIHARA

IPC: G02C7/06 ,  A01K67/02 ,  A61K9/00 ,  A61K31/575

CPC classification number: G02C7/06 ,  A01K67/02 ,  A61K9/0048 ,  A61K31/575 ,  A01K2227/105 ,  A01K2267/03

Abstract: A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention/suppression agent.

公开(公告)号：US20240165422A1

公开(公告)日：2024-05-23

申请号：US18551167

申请日：2022-03-18

Applicant: Tsubota Laboratory, Inc.

Inventor： Motoshi HAYANO ,  Kazuo TSUBOTA ,  Yasue MITSUKURA

IPC: A61N5/06

CPC classification number: A61N5/0622 ,  A61N2005/0632 ,  A61N2005/0645 ,  A61N2005/0661

Abstract: The present disclosure relates to an apparatus and method for controlling biological function by stimulation by light of a specific wavelength, such as violet light, which is irradiated at a specific blinking frequency, and an apparatus and method for improving light environment. An illustrative apparatus for controlling biological function includes at least one light source 10 which irradiates light of a specific wavelength, and a controller 20 which is configured to control irradiation conditions including a blinking frequency of the light source 10.

公开(公告)号：US20240041806A1

公开(公告)日：2024-02-08

申请号：US18266102

申请日：2021-09-01

Applicant: Tsubota Laboratory, Inc.

Inventor： Kazuo Tsubota ,  Toshihide Kurihara ,  Shinichi Ikeda ,  Kiwako Mori ,  Xiaoyan Jiang

IPC: A61K31/192 ,  A61K9/00 ,  A61P27/10 ,  G01N33/50

CPC classification number: A61K31/192 ,  A61K9/0048 ,  A61P27/10 ,  G01N33/5058

Abstract: The present invention provides a screening method for searching a component inhibiting the PERK pathway and/or the ATF6 pathway, and by obtaining, by the screening method, an active ingredient inhibiting myopia progression without impairing normal growth of the eyeballs (emmetropization) in children, provides eyedrops and a composition containing the active ingredient. The problems are solved by eyedrops for inhibiting myopia progression in children containing, as an active ingredient, an inhibitor of the PERK (PKR-like endoplasmic reticulum kinase) pathway and/or the ATF6 (activating transcription factor 6) pathway. The problems are solved by a screening method for an inhibitor of myopia progression in children, including a step of contacting a candidate substance with an eye-derived cell, and a step of selecting the candidate substance using, as an index, change in a protein and/or a gene of the signal transduction system of PERK and/or ATF6.

公开(公告)号：US11007375B2

公开(公告)日：2021-05-18

申请号：US16044909

申请日：2018-07-25

Applicant: TOSHIBA MATERIALS CO., LTD. ,  TSUBOTA LABORATORY, INC.

Inventor： Masahiko Yamakawa ,  Hidemasa Torii ,  Toshihide Kurihara ,  Kazuo Tsubota

IPC: A61N5/00 ,  A61N5/06 ,  A61F9/00 ,  F21S2/00 ,  H01L33/50 ,  F21V9/38 ,  C09K11/77 ,  H01L25/075

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

公开(公告)号：US20200229973A1

公开(公告)日：2020-07-23

申请号：US16697283

申请日：2019-11-27

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo TSUBOTA

IPC: A61F9/00 ,  B05B17/06

Abstract: To provide a spraying device and a spraying method for moisture mist that supply at least a micro liquid to the eye, and can be used for dry eye symptom relief, drug delivery, allergy prevention, relaxation, and the like. The above-described problem is solved by a spraying device (1, 31) that supplies at least a micro liquid, and includes a spraying element (16) that sprays a mist-like substance containing the micro liquid onto a local region (50). The raw material is a liquid raw material or a solid raw material that may include a medicinal additive. The medicinal additive is preferably selected from among menthol, analgesics, antibiotics, antiallergic agents, steroids, intraocular pressure-lowering agents, and the like. The spraying device (1, 31) may be an eyeglasses-type spraying device (1) in which the local region (50) is configured by a rim (3) and a temple (6) of eyeglasses, or a cup-type spraying device (31) in which the local region (50) includes an opening (32).

公开(公告)号：US10660182B2

公开(公告)日：2020-05-19

申请号：US16473487

申请日：2017-12-26

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Kazuo Tsubota

IPC: H05B47/10 ,  H05B47/105 ,  G06F3/147

Abstract: To provide a display system such as a smartphone, a game console, a personal computer, or a liquid crystal television, including a light-emitting element that irradiates light having a specific wavelength toward a user. The above-described problem is solved by a display system (1) including a first light-emitting element (6) that emits light used for image display, a second light-emitting element (3) that irradiates light (7) within a wavelength range of 360 nm to 400 nm, inclusive, toward a user, and a control unit (10) that controls irradiation of the light (7) from the second light-emitting element (3).At this time, the second light-emitting element (3) may be a single light-emitting element integrated with the first light-emitting element (6) or a light-emitting element provided separately from the first light-emitting element (6). When separately provided from the first light-emitting element (6), the second light-emitting element (3) is preferably provided to a peripheral frame (4) of a display screen (2), in the display screen (2), or as an accessory (5).

公开(公告)号：US12023513B2

公开(公告)日：2024-07-02

申请号：US17301859

申请日：2021-04-16

Applicant: TOSHIBA MATERIALS CO., LTD. ,  TSUBOTA LABORATORY, INC.

Inventor： Masahiko Yamakawa ,  Hidemasa Torii ,  Toshihide Kurihara ,  Kazuo Tsubota

IPC: A61N5/06 ,  A61F9/00 ,  C09K11/77 ,  F21S2/00 ,  F21V9/38 ,  H01L25/075 ,  H01L33/50

CPC classification number: A61N5/0613 ,  A61F9/00 ,  A61N5/06 ,  C09K11/77342 ,  C09K11/77348 ,  C09K11/7738 ,  F21S2/00 ,  F21V9/38 ,  H01L25/0753 ,  H01L33/50 ,  H01L33/504 ,  A61N2005/0651 ,  A61N2005/0654 ,  A61N2005/0663 ,  A61N2005/0667

Abstract: A light source for myopia prevention article includes a light emitter to emit light having an emission spectrum continuing from a first wavelength of not less than 360 nm nor more than 400 nm to a second wavelength of more than 400 nm.

公开(公告)号：US20240148766A1

公开(公告)日：2024-05-09

申请号：US18253155

申请日：2021-11-15

Applicant: Hayashibara Co., Ltd. ,  Tsubota Laboratory, Inc.

Inventor： Yosuke NAKAZAWA ,  Naoki MORISHITA ,  Shin ENDO ,  Masaki MIYAKE ,  Hitoshi MITSUZUMI ,  Motoshi HAYANO ,  Kazuo TSUBOTA

IPC: A61K31/7048 ,  A23C9/13 ,  A23G3/36 ,  A23G4/12 ,  A23L2/52 ,  A23L27/30 ,  A23L33/00 ,  A23L33/125 ,  A23L33/15 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61K9/68 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/46 ,  A61P27/10

CPC classification number: A61K31/7048 ,  A23C9/1307 ,  A23C9/1322 ,  A23G3/368 ,  A23G4/126 ,  A23L2/52 ,  A23L27/30 ,  A23L33/125 ,  A23L33/15 ,  A23L33/40 ,  A61K9/0053 ,  A61K9/0056 ,  A61K9/0058 ,  A61K9/0095 ,  A61K9/1623 ,  A61K9/2013 ,  A61K9/2018 ,  A61K9/2068 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4875 ,  A61K47/02 ,  A61K47/12 ,  A61K47/26 ,  A61K47/46 ,  A61P27/10

Abstract: An object of the present invention is to provide a novel agent for adjusting hardness of a lens of an eye which can be taken easily, conveniently, and safely for a long-term, can effectively adjust the hardness of the lens, and is capable of preventing, alleviating and improving poor focus and decreased near visual acuity, such as presbyopia, caused by aging and various diseases. The present invention solves the above object by providing an agent for adjusting hardness of a lens of an eye comprising a glycosyl hesperetin as an active ingredient.

公开(公告)号：US20230364441A1

公开(公告)日：2023-11-16

申请号：US18026232

申请日：2021-09-16

Applicant: TSUBOTA LABORATORY, INC.

Inventor： Xiaoyan JIANG ,  Kiwako MORI ,  Toshihide KURIHARA ,  Kazuo TSUBOTA

IPC: A61N5/06

CPC classification number: A61N5/0613 ,  A61N2005/0663

Abstract: A device and a method for inhibiting thinning of a choroid. A choroidal thinning inhibiting device including a light source that emits violet light having a wavelength within a range from 360 nm to 400 nm, the choroidal thinning inhibiting device inhibiting thinning of a choroid by irradiation with the violet light. This device may further include a control mechanism that controls an irradiance and an irradiation time of the violet light, can be applied to ocular diseases selected from age-related macular degeneration, glaucoma, diabetic retinopathy, macular edema, eye strain, retinal vascular occlusion, triangle syndrome, central serous chorioretinopathy, retinitis pigmentosa, presbyopia, cataracts, and the like that are based on inadequate blood flow or reduced blood flow, and can be expected to prevent and treat such ocular diseases.

公开(公告)号：US11813299B2

公开(公告)日：2023-11-14

申请号：US16614176

申请日：2018-05-15

Applicant: TSUBOTA LABORATORY, INC. ,  ROHTO PHARMACEUTICAL CO., LTD.

Inventor： Kazuo Tsubota ,  Toshihide Kurihara

IPC: A61K36/16 ,  A61P27/10 ,  A61K9/00 ,  A61K31/05 ,  A61K31/202

CPC classification number: A61K36/16 ,  A61K9/0056 ,  A61K31/05 ,  A61K31/202 ,  A61P27/10

Abstract: The ophthalmic composition effective for the prevention or treatment of myopia or ocular diseases are provided. In particular, the present invention provides an ophthalmic composition effective in a growing child or a young person in whom myopia develops and progresses, as well as a middle-aged and elderly person in whom age-related ocular diseases such as cataract, glaucoma, retinal detachment, retinopathy, maculopathy, choroidal neovascularization, posterior staphyloma, and optic neuropathy develop, a functional food containing the ophthalmic composition, and a screening method capable of searching for the same. [Solution] The above problem is solved by an ophthalmic composition or functional food product containing at least one component selected from the group consisting of crocetin and its pharmaceutically acceptable salts and ginkgo leaf extract.