公开(公告)号：US20180147307A1

公开(公告)日：2018-05-31

申请号：US15881257

申请日：2018-01-26

Applicant: Allergan, Inc.

Inventor： Kaustubh S. Chitre ,  Xiaojie Yu ,  Nicholas J. Manesis

IPC: A61L2/08 ,  A61L27/52 ,  A61L27/36 ,  A61L27/24 ,  A61L2/10 ,  A61L27/20

CPC classification number: A61L2/08 ,  A61L2/084 ,  A61L2/085 ,  A61L2/10 ,  A61L27/20 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/52

Abstract: Method for sterilizing a hydrogel composition include subjecting the composition to pulsed light comprising broadband spectrum radiation, the pulsed light being at a dose effective to sterilize the composition without causing significant change in rheology of the composition.

公开(公告)号：US09962464B2

公开(公告)日：2018-05-08

申请号：US15178306

申请日：2016-06-09

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Xiaojie Yu ,  Jessamine P. Winer-Jones ,  Nicholas J. Manesis ,  Hengli Liu ,  Gabriel Njikang ,  Athene Wan Chie Chan

IPC: A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61K31/728 ,  A61K8/67 ,  A61K8/73 ,  A61Q19/08 ,  A61Q19/00 ,  A61K47/61

CPC classification number: A61L27/20 ,  A61K8/676 ,  A61K8/735 ,  A61K31/728 ,  A61K47/61 ,  A61K2800/91 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/204 ,  A61L2300/236 ,  A61L2300/402 ,  A61L2400/06 ,  A61Q19/00 ,  A61Q19/08

Abstract: Provided are injectable, hyaluronic acid-based dermal filler compositions including conjugated vitamin C derivatives. The compositions provide for extended release of active vitamin C into tissue, promoting collagenesis and other benefits to skin.

公开(公告)号：US09821086B2

公开(公告)日：2017-11-21

申请号：US14962897

申请日：2015-12-08

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61K8/65 ,  A61Q19/08 ,  A61L27/26 ,  A61L27/52 ,  A61K8/73 ,  A61K8/04 ,  A61L27/36

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L5/08 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US09593224B2

公开(公告)日：2017-03-14

申请号：US14504329

申请日：2014-10-01

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Xiaojie Yu ,  Athene Wan Chie Chan

IPC: C08J9/26 ,  A61L27/56 ,  B05D1/38 ,  B05D3/00 ,  B05D5/00

CPC classification number: C08J9/26 ,  A61L27/56 ,  A61L31/06 ,  A61L31/146 ,  A61L2400/08 ,  B01D39/1692 ,  B01D2239/1208 ,  B01D2239/1216 ,  B05D1/38 ,  B05D3/007 ,  B05D5/00 ,  C08J2201/04 ,  C08J2201/042 ,  C08J2201/0422 ,  C08J2201/0462 ,  C08J2201/0464 ,  C08J2201/05 ,  C08J2205/05 ,  C08J2207/10 ,  C08J2207/12 ,  C08J2325/10 ,  C08J2353/02 ,  C08J2375/04 ,  C08J2383/04 ,  C09D167/04 ,  C09D171/02

Abstract: Provided are porogen compositions and methods of using such porogen compositions in the manufacture of porous materials, for example, porous silicone elastomers. The porogens generally include comprising a core material and shell material different from the core material. The porogens can be used to form a scaffold for making a resulting porous elastomer when the scaffold is removed.

Abstract translation: 提供的是致孔剂组合物和在制造多孔材料例如多孔硅橡胶中使用这种致孔剂组合物的方法。 致孔剂通常包括芯材和与芯材不同的壳材料。 当去除支架时，致孔剂可用于形成用于制备所得多孔弹性体的支架。

公开(公告)号：US09205577B2

公开(公告)日：2015-12-08

申请号：US13631091

申请日：2012-09-28

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Athene Wan Chie Chan ,  Xiaojie Yu

IPC: B29C41/14 ,  B29C41/22 ,  A61L28/00 ,  A61L31/14 ,  A61L24/00

CPC classification number: A61L27/56 ,  A61F2/12 ,  A61L24/001 ,  A61L24/0036 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/34 ,  A61L28/0034 ,  A61L28/0053 ,  A61L31/041 ,  A61L31/042 ,  A61L31/06 ,  A61L31/10 ,  A61L31/14 ,  A61L31/146 ,  A61L2400/18 ,  B29C41/14 ,  B29C41/22 ,  Y10T428/2989

Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

Abstract translation: 本说明书公开了包含核心材料和壳材料的致孔剂组合物，制备这种致孔剂组合物的方法，使用这种致孔剂组合物形成这种多孔材料的方法，包含这种多孔材料的生物相容性可植入装置以及制备这种生物相容性可植入装置的方法。

公开(公告)号：US20140154491A1

公开(公告)日：2014-06-05

申请号：US14174111

申请日：2014-02-06

Applicant: ALLERGAN, INC.

Inventor： Alexei Goraltchouk ,  Jordan Thompson ,  Miriam M. Abiad ,  Kevin Ma ,  Dennis Van Epps ,  Nicholas J. Manesis

IPC: C08J9/26

CPC classification number: C08J9/26 ,  C08J9/365 ,  C08J2201/046

Abstract: Described herein are foam-like materials having substantially the same physical structure of polyurethane foams but with properties that can be tailored for a particular application. Methods of forming these foam-like materials are also described.

Abstract translation: 本文描述的是具有基本相同的聚氨酯泡沫的物理结构的泡沫状材料，但具有可针对特定应用而定制的性质。 还描述了形成这些泡沫状材料的方法。

公开(公告)号：US20130244943A1

公开(公告)日：2013-09-19

申请号：US13667581

申请日：2012-11-02

Applicant: ALLERGAN, INC.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/52

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L5/08 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

Abstract translation: 包含大分子基质和水的水凝胶可用于美容填料，例如真皮填料。 大分子基质可以包括透明质酸和胶原蛋白的交联组合。

公开(公告)号：US11833269B2

公开(公告)日：2023-12-05

申请号：US16595481

申请日：2019-10-08

Applicant: Allergan, Inc.

Inventor： Xiaojie Yu ,  Nicholas J. Manesis ,  Jacob Pollock

IPC: A61L27/24 ,  A61L27/52 ,  A61K8/73 ,  A61Q19/08 ,  A61K8/04 ,  A61L27/26 ,  A61L27/36

CPC classification number: A61L27/24 ,  A61K8/042 ,  A61K8/735 ,  A61L27/26 ,  A61L27/3695 ,  A61L27/52 ,  A61Q19/08 ,  A61K2800/91 ,  A61L2400/06 ,  A61L2430/34 ,  A61L27/26 ,  C08L5/08 ,  A61L27/26 ,  C08L89/06

Abstract: Hydrogels comprising a macromolecular matrix and water may be used for aesthetic fillers, for example, dermal fillers. The macromolecular matrix may include a crosslinked combination of hyaluronic acid and collagen.

公开(公告)号：US11083684B2

公开(公告)日：2021-08-10

申请号：US14928634

申请日：2015-10-30

Applicant: Allergan, Inc.

Inventor： Gabriel N. Njikang ,  Xiaojie Yu ,  Futian Liu ,  Nicholas J. Manesis

IPC: A61K8/73 ,  A61L27/20 ,  A61L27/52 ,  A61Q19/00 ,  C08B37/08 ,  A61K8/04 ,  A61Q19/08

Abstract: The present invention provides highly injectable, long-lasting hyaluronic acid-based hydrogel dermal filler compositions made with a di-amine or multiamine crosslinker in the presence of a carbodiimide coupling agent.

公开(公告)号：US20200237968A1

公开(公告)日：2020-07-30

申请号：US16850981

申请日：2020-04-16

Applicant: Allergan, Inc.

Inventor： Futian Liu ,  Nicholas J. Manesis ,  Xiaojie Yu ,  Athene W. Chan

IPC: A61L27/56 ,  B29C41/14 ,  B29C41/22 ,  A61L28/00 ,  A61L31/14 ,  A61L24/00 ,  A61L27/18 ,  A61L27/20 ,  A61L27/26 ,  A61L27/34 ,  A61L31/04 ,  A61L31/06 ,  A61L31/10

Abstract: The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.