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公开(公告)号：US06261544B1
公开(公告)日：2001-07-17
申请号：US09249841
申请日：1999-02-15
IPC分类号： A61K31765
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q5/006 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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22.发明授权Redox and photoinitiator priming for improved adherence of gels to substrates 失效氧化还原和光引发剂引发，以提高凝胶对底物的粘附性
公开(公告)号：US5844016A
公开(公告)日：1998-12-01
申请号：US478104
申请日：1995-06-07
申请人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
发明人： Amarpreet S. Sawhney , David A. Melanson , Chandrashekar P. Pathak , Jeffrey A. Hubbell , Luis Z. Avila , Mark T. Kieras , Stephen D. Goodrich , Shikha P. Barman , Arthur J. Coury , Ronald S. Rudowsky , Douglas J. K. Weaver
IPC分类号： A61B17/00 , A61B17/08 , A61L24/00 , A61L24/04 , A61L24/06 , A61L29/00 , A61L31/00 , C08F2/48 , C08F2/50 , C08F4/00 , C08F4/40 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/14 , C08F291/00 , C09D4/00 , C09D7/00 , C09D171/00 , C09J151/00 , C08F4/42
CPC分类号： A61L24/0031 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/06 , C08F2/48 , C08F265/04 , C08F271/00 , C08F283/00 , C08F289/00 , C08F290/06 , C08F290/062 , C08F290/14 , C08F291/00 , C09D4/00 , C09J151/00 , A61B17/00491 , A61B17/085 , A61B2017/00495 , A61L2300/00 , Y10S602/90 , Y10S602/904
摘要： An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.
摘要翻译： 公开了与施加的表面高度附着的改进的屏障或药物递送系统，以及用于制造屏障的方法。 屏障可以通过用光引发剂染色组织，将含有可聚合阻挡材料溶液和光引发剂的溶液施加到组织上，以及在暴露于光下聚合聚合物溶液来制备。 所得聚合物强烈地粘附到组织表面，并且在其余施用体积中形成凝胶。 可聚合的阻挡材料对于密封组织表面和防止流体泄漏的接头非常有用。 该方法可用于将预先形成的障碍物粘附到组织或其它表面，或将组织表面彼此粘附。 组织表面可以彼此粘附以修复伤口。 除了光化学引发剂之外，还可以使用非光化学引发剂以及化学引发剂和光化学引发剂的组合。
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公开(公告)号：US5799384A
公开(公告)日：1998-09-01
申请号：US736001
申请日：1996-10-23
申请人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
发明人： Robert S. Schwartz , John Bresnahan , Rebecca M. Bergman , Arthur J. Coury , Elaine Lindell , Vincent W. Hull , Michael Dror
CPC分类号： A61F2/88 , A61F2/0077 , A61F2/07 , A61F2/958 , A61F2002/825 , A61F2240/001 , A61F2250/0067 , Y10T156/1026 , Y10T29/49885 , Y10T29/49906 , Y10T29/4994 , Y10T29/49982 , Y10T29/49984 , Y10T29/49986
摘要： A radially expandable stent for implantation within a body lumen having a generally cylindrical body with open proximal and distal ends, the cylindrical body comprising a plurality of metal elements joined to allow flexing of the cylindrical body along the longitudinal axis of the body whereby the stent can conform to a curved body lumen and a polymeric film extending between the metal elements of the stent. The stent provides a biocompatible polymeric surface to contact and support a body lumen and also a flexible structure to allow the stent to conform closely to bends in a body lumen. The stent is especially useful for repairing an injury to blood vessels caused during angioplasty procedures.
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公开(公告)号：US5618850A
公开(公告)日：1997-04-08
申请号：US401931
申请日：1995-03-09
IPC分类号： A61K9/00 , A61K8/365 , A61K8/67 , A61K8/72 , A61K8/73 , A61K8/85 , A61K8/86 , A61K8/90 , A61K31/07 , A61K31/355 , A61K31/59 , A61K31/765 , A61K31/78 , A61K31/79 , A61K45/00 , A61K47/48 , A61P1/00 , A61P3/02 , A61P17/00 , A61P25/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P33/10 , A61P43/00 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61K31/77
CPC分类号： A61Q19/00 , A61K8/365 , A61K8/671 , A61K8/73 , A61K8/731 , A61K8/735 , A61K8/85 , A61K8/86 , A61K8/90 , A61K2800/57 , A61Q17/04 , A61Q19/007 , A61Q19/02 , A61Q19/08 , A61Q5/006 , Y10S514/83 , Y10S514/844 , Y10S514/847 , Y10S514/852 , Y10S514/863 , Y10S514/865 , Y10S514/887 , Y10S514/919 , Y10S514/944 , Y10S514/945 , Y10S514/947 , Y10S514/969
摘要： A method for alleviating the symptoms of a cosmetic or dermatologic skin condition is described. An effective amount of a poly(hydroxy acid)/polymer conjugate in a pharmaceutically or cosmetically acceptable vehicle is provided. Topical compositions of the conjugates with another cosmetic or dermatological agent, and compounds of the conjugates having attached physiologically active functional groups, are also provided.
摘要翻译： 描述了一种减轻化妆品或皮肤病症状的方法。 提供在药学或化妆品可接受的载体中有效量的聚（羟基酸）/聚合物缀合物。 还提供了与另一种化妆品或皮肤病学试剂的缀合物的局部组合物，以及具有附着的生理活性官能团的缀合物的化合物。
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公开(公告)号：US4883854A
公开(公告)日：1989-11-28
申请号：US251261
申请日：1988-09-30
CPC分类号： C08G18/3831 , C08G18/5045 , C08G18/61 , C08G71/04
摘要： By reacting polyamines with ethylene carbonate, hydroxyethyl urethane diols and polyols are produced. These diols and polyols are particularly useful for the synthesis of polyurethanes by reaction with diisocyanates or polyisocyanates.
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公开(公告)号：US4846182A
公开(公告)日：1989-07-11
申请号：US551055
申请日：1983-11-14
CPC分类号： G01N33/84 , A61B5/4266 , G01N33/526 , Y10T436/193333
摘要： Preparation of an absorbent quantitative test device in the form of a flat patch. When placed on the skin of a subject, the device collects a fixed volume of sweat. It is particularly intended to be used in screen testing for cystic fibrosis by measuring the chloride level in sweat and providing a visual indication when the level is in excess of a predetermined concentration. A fill tab indicator undergoes a color change when the fixed volume of sweat has been collected signifying completion of the test. The device includes two concentric circular reaction areas of chemically treated absorbent paper or the like. The sweat sample is introduced into the device at the center of the first or inner circular reaction area which contains a chemical composition capable of reacting with all chloride in the sweat sample below a predetermined concentration value to screen out that amount of chloride. A second or outer ring-shaped reaction area contains a chemical composition which indicates a color change for any chloride reaching it in excess of the predetermined concentration value. The color change in the outer ring-shaped portion thereby provides a quantitative indication of the pressure of a concentration of chloride in the subject's sweat in excess of the predetermined concentration level.
摘要翻译： 制备平面贴片形式的吸收剂定量测试装置。 当放置在受试者的皮肤上时，该装置收集固定体积的汗液。 特别旨在通过测量汗液中的氯化物含量并在水平超过预定浓度时提供视觉指示来用于囊性纤维化的屏幕测试。 当收集的固定体积的汗水表示测试完成时，填充标签指示器会发生颜色变化。 该装置包括化学处理的吸收纸等的两个同心圆形反应区域。 汗液样品在第一或内部圆形反应区域的中心被引入到装置中，该区域包含能够使低于预定浓度值的汗液样品中的所有氯化物反应的化学组成，以筛除该量的氯化物。 第二个或外部环形反应区域包含化学组成，其指示任何达到超过预定浓度值的氯化物的颜色变化。 外环形部分中的颜色变化从而提供了超过预定浓度水平的受试者汗水中氯浓度的压力的定量指示。
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27.发明授权公开(公告)号：US10907001B2
公开(公告)日：2021-02-02
申请号：US15760830
申请日：2016-09-19
发明人： Arthur J. Coury , Marvin J. Slepian
IPC分类号： C08G75/02 , C08G75/20 , C08F228/02 , C08G85/00 , C08G81/00 , C08G75/23 , C08G75/0286 , C08L81/00 , C08G75/00 , A61L27/16 , A61L29/04 , A61L31/04 , C08F236/04 , C08F299/02 , C08K5/41 , C08G75/04 , C08G75/045 , A61L27/54 , A61L29/16 , A61L31/16
摘要： Polymers having mechanical properties approaching or exceeding commercial elastomers and engineering thermoplastics, but improved biostability, are described herein. In one embodiment, the polymers have a hard segment containing one or more disulfoxide or disulfone moieties and a soft segment connected to the hard segment to form an elastomeric polymer. The polymer is resistant to oxidation and/or hydrolytic degradation, particularly in vivo, which allows for the use of these materials in implants/devices which are implanted for an extended period of time. The ratio or percentage by weight of soft segment to hard segment can be varied based on the physical and mechanical properties of the desired device.
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28.发明授权Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties 有权具有非污垢表面的制品及其制备方法，而不改变体积物理性能公开(公告)号：US08574660B2
公开(公告)日：2013-11-05
申请号：US13156904
申请日：2011-06-09
申请人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
发明人： Douglas J. K. Weaver , Jun Li , Zheng Zhang , Abby N. Deleault , Eric W. Marchese , Phu C. Nguyen , Chad C. Huval , Michael A. Bouchard , Arthur J. Coury , Christopher R. Loose
IPC分类号： A61L33/00
CPC分类号： A61L33/0088 , A61L33/027 , B05D3/10 , B05D7/54 , C09D5/1693 , Y10T428/24802 , Y10T428/25 , Y10T428/31504 , Y10T428/31551 , Y10T428/31609
摘要： Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.
摘要翻译： 本文描述了用于制备在包括聚合物表面的基底上具有低污损表面的医疗装置和其它制品的方法。 聚合物表面材料可以具有一定范围的聚合物主链和取代基，同时为制品提供高效，生物相容性和非结垢性表面。 这些方法包括处理底物以降低基材表面上或在基材中的化学物质的浓度，而不改变装置或制品的体积物理特性，然后在经处理的基材表面上形成接枝聚合物层。
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29.发明授权Multiblock biodegradable hydrogels for drug delivery and tissue treatment 有权用于药物递送和组织治疗的多嵌段可生物降解水凝胶公开(公告)号：US07250177B2
公开(公告)日：2007-07-31
申请号：US11158565
申请日：2005-06-22
申请人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
发明人： Chandrashekhar P. Pathak , Shikha P. Barman , C. Michael Philbrook , Amarpreet S. Sawhney , Arthur J. Coury , Luis Z. Avila , Mark T. Kieras
CPC分类号： A61K9/5138 , A61K9/0014 , A61K9/0019 , A61K9/1075 , A61K9/1274 , A61K9/146 , A61K9/2027 , A61K9/5146 , A61K9/7015 , A61K47/32 , A61K47/34 , A61L15/58 , A61L15/60 , A61L24/0031 , A61L24/0042 , A61L24/046 , C08G63/00 , C08G65/329 , C08L71/02 , Y10S424/13 , Y10S524/916 , Y10S525/941 , C08L71/00 , C08L2666/14
摘要： Gel-forming macromers including at least four polymeric blocks, at least two of which are hydrophobic and at least one of which is hydrophilic, and including a crosslinkable group are provided. The macromers can be covalently crosslinked to form a gel on a tissue surface in vivo. The gels formed from the macromers have a combination of properties including thermosensitivity and lipophilicity, and are useful in a variety of medical applications including drug delivery and tissue coating.
摘要翻译： 提供包含至少四个聚合物嵌段的凝胶形成大分子单体，其中至少两个是疏水性的，并且其中至少一个是亲水的，并且包括可交联基团。 大分子单体可以共价交联以在体内在组织表面上形成凝胶。 由大分子单体形成的凝胶具有包括热敏性和亲油性的性质的组合，并且可用于各种医疗应用，包括药物递送和组织包衣。
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30.再颁专利Polymerizable biodegradable polymers including carbonate or dioxanone linkages 有权可聚合的可生物降解聚合物，包括碳酸盐或二氧杂环己酮键公开(公告)号：USRE39713E1
公开(公告)日：2007-07-03
申请号：US10351930
申请日：2003-01-23
申请人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Lyman , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
发明人： Amarpreet S. Sawhney , Peter K. Jarrett , Arthur J. Coury , Ronald S. Rudowsky , Michelle D. Lyman , Luis Z. Avila , David J. Enscore , Stephen D. Goodrich , William C. Nason , Fei Yao , Douglas Weaver , Shikha P. Barman
IPC分类号： A61F2/02
CPC分类号： C08G63/64 , A61K9/1635 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L31/06 , A61L31/148 , C08L67/04
摘要： Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.
摘要翻译： 描述了包括由碳酸酯或二恶烷酮基团形成的至少一种可水解键，至少一种水溶性聚合物嵌段和至少一种可聚合基团的水溶性大分子单体及其制备和使用方法。 大分子单体优选在长波长紫外光或可见光激发的影响下使用自由基引发剂进行聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 大分子单体可用于包封细胞，以受控的方式递送预防性，治疗性或诊断性药物，堵塞组织中的渗漏，防止外科手术后的粘连形成，暂时保护或分离组织表面，以及将组织粘附或密封在一起。
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