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    THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES
    21.
    发明申请
    THERAPEUTIC AGENTS COMPRISING ELASTIN-LIKE PEPTIDES 有权
    含有类似药物的治疗药物

    公开(公告)号：US20130085099A1

    公开(公告)日：2013-04-04

    申请号：US13524812

    申请日：2012-06-15

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: C07K19/00

    CPC classification number: A61K38/28 ,  A61K38/16 ,  A61K38/2278 ,  A61K38/26 ,  A61K38/4846 ,  A61K45/06 ,  A61K47/6435 ,  A61K47/65 ,  C07K14/575 ,  C07K14/605 ,  C07K14/78 ,  C07K19/00 ,  C07K2319/31

    Abstract: The present invention provides therapeutic agents and compositions comprising elastin-like peptides (ELPs) and therapeutic proteins. In some embodiments, the therapeutic protein is a GLP-1 receptor agonist, insulin, or Factor VII/VIIa, including functional analogs. The present invention further provides encoding polynucleotides, as well as methods of making and using the therapeutic agents. The therapeutic agents have improvements in relation to their use as therapeutics, including, inter alia, one or more of half-life, clearance and/or persistence in the body, solubility, and bioavailability.

    Abstract translation: 本发明提供治疗剂和包含弹性蛋白样肽（ELP）和治疗性蛋白质的组合物。 在一些实施方案中，治疗性蛋白质是GLP-1受体激动剂，胰岛素或因子VII / VIIa，包括功能类似物。 本发明还提供编码多核苷酸，以及制备和使用治疗剂的方法。 治疗剂相对于其作为治疗剂的用途具有改进，包括尤其是身体的半衰期，清除和/或持久性中的一种或多种，​​溶解度和生物利用度。

    Methods of using bioelastomers
    25.
    发明授权
    Methods of using bioelastomers 有权

    公开(公告)号：US07364859B2

    公开(公告)日：2008-04-29

    申请号：US10153747

    申请日：2002-07-31

    Applicant: Ashutosh Chilkoti

    Inventor： Ashutosh Chilkoti

    IPC: G01N33/53

    CPC classification number: B82Y30/00 ,  A61K41/00 ,  A61K47/58 ,  C07K16/1232

    Abstract: Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location within an animal subjects. In general, the bioelastomer is conjugated to a binding compound, which is in turn used to bind a compound of interest. For targeted compound delivery, the bioelastomer is conjugated to the compound to be delivered.

    Tunable nonfouling surface of oligoethylene glycol
    26.
    发明申请
    Tunable nonfouling surface of oligoethylene glycol 审中-公开
    可聚合的低聚乙二醇的非结垢表面

    公开(公告)号：US20060057180A1

    公开(公告)日：2006-03-16

    申请号：US10783054

    申请日：2004-02-20

    Applicant: Ashutosh Chilkoti ,  Hongwei Ma

    Inventor： Ashutosh Chilkoti ,  Hongwei Ma

    IPC: A61F13/00

    CPC classification number: C09D5/00 ,  A61L27/34 ,  A61L29/085 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  B82Y30/00 ,  C08J7/12 ,  C08J7/16 ,  C09D4/00 ,  G01N33/54393 ,  Y10T428/1393 ,  Y10T428/249991

    Abstract: An article having a nonfouling surface thereon is comprises: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer, preferably by the process of surface-initiated polymerization of monomeric units thereon, with each of the monomeric units comprising a monomer core group having at least one protein-resistant head group coupled thereto, to thereby form a brush molecule on the surface portion. The brush molecule comprising a stem formed from the polymerization of the monomer core groups, and a plurality of branches formed from the hydrophilic head group projecting from the stem. Methods of making and using such articles, are also described.

    Abstract translation: 其上具有非结垢表面的物品包括：（a）具有表面部分的基底; （b）表面部分上的连接层; 和（c）形成在连接层上的聚合物层，优选通过其上单体单元的表面引发聚合的方法，其中每个单体单元包含与至少一个与蛋白质抵抗的头基团连接的单体核心基团， 从而在表面部分上形成刷子分子。 包含由单体芯基的聚合形成的茎的刷子分子和由从杆突出的亲水头基形成的多个分支。 还描述了制造和使用这些制品的方法。

    Detection assay devices and methods of making and using the same
    29.
    发明授权
    Detection assay devices and methods of making and using the same 有权
    检测测定装置及其制造和使用方法

    公开(公告)号：US08796184B2

    公开(公告)日：2014-08-05

    申请号：US12405300

    申请日：2009-03-17

    Applicant: Ashutosh Chilkoti ,  Angus Hucknall

    Inventor： Ashutosh Chilkoti ,  Angus Hucknall

    IPC: C40B40/00 ,  C40B40/08 ,  C40B40/10 ,  C40B30/04

    CPC classification number: G01N33/54366 ,  G01N33/54353

    Abstract: An article such as a biomolecular detector or biosensor having a nonfouling surface thereon includes: (a) a substrate having a surface portion; (b) a linking layer on the surface portion; and (c) a polymer layer formed on the linking layer; and (d) a first member of a specific binding pair (e.g., a protein, peptide, antibody, nucleic acid, etc.) bound to the polymer layer. Methods of making and using the articles are also described.

    Abstract translation: 诸如生物分子检测器或其上具有非结垢表面的生物传感器的物品包括：（a）具有表面部分的基底; （b）表面部分上的连接层; 和（c）形成在所述连接层上的聚合物层; 和（d）与聚合物层结合的特异性结合对（例如，蛋白质，肽，抗体，核酸等）的第一成员。 还描述了制造和使用制品的方法。

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