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公开(公告)号:US07997831B2
公开(公告)日:2011-08-16
申请号:US12610753
申请日:2009-11-02
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US07611309B2
公开(公告)日:2009-11-03
申请号:US11998557
申请日:2007-11-30
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US07311476B2
公开(公告)日:2007-12-25
申请号:US10979848
申请日:2004-11-01
IPC分类号: B65G51/00
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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公开(公告)号:US07293581B2
公开(公告)日:2007-11-13
申请号:US11591213
申请日:2006-11-01
CPC分类号: F16K99/0001 , F15C5/00 , F16K99/0005 , F16K99/0007 , F16K99/0009 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K2099/0069 , F16K2099/0071 , F16K2099/0074 , F16K2099/0076 , F16K2099/008 , F16K2099/0084 , G05D7/0694 , Y10T29/49412 , Y10T137/87314
摘要: A latching microregulator for regulating liquid flow on micro-scale levels comprises a substrate having an inlet port and an outlet port, a valve element defining a valve chamber for opening and closing the inlet port, and an actuator assembly for actuating the valve element. The valve chamber is configured to contain a volume of fluid, and the inlet port and the outlet port are in fluid communication with the valve chamber to provide a liquid flow path through the chamber. The actuator assembly comprises a cantilever beam for moving the valve element between an open position and a closed position, an actuator, such as a piezoelectric element, for moving the cantilever beam, and a latch, such as a permanent magnet, for securing the cantilever beam in the closed position. A flow regulation system comprises a plurality of fluid channels of varied flow conductance and a plurality of latching microregulators for selectively blocking or allowing flow through each of the fluid channels.
摘要翻译: 用于调节微量级液体流动的闭锁微调节器包括具有入口端口和出口端口的基板,限定用于打开和关闭入口端口的阀室的阀元件以及用于致动阀元件的致动器组件。 阀室被构造成容纳一定体积的流体,并且入口端口和出口端口与阀室流体连通以提供通过该腔室的液体流动路径。 致动器组件包括用于在打开位置和关闭位置之间移动阀元件的悬臂梁,用于移动悬臂梁的致动器(例如压电元件)以及用于固定悬臂的闩锁(例如永磁体) 梁处于关闭位置。 流量调节系统包括多个不同流量的流体通道和多个用于选择性地阻塞或允许流过每个流体通道的闭锁微调节器。
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25.
公开(公告)号:US20060278288A1
公开(公告)日:2006-12-14
申请号:US11433781
申请日:2006-05-12
申请人: John Gilbert , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Sebastian Bohm , Manish Deshpande
IPC分类号: F15C1/04
CPC分类号: B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
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公开(公告)号:US07104405B2
公开(公告)日:2006-09-12
申请号:US10940143
申请日:2004-09-13
IPC分类号: B07C5/38
CPC分类号: B03B5/00 , B01L3/5027 , B07C5/34 , F15C5/00 , F16K99/0001 , F16K99/0028 , F16K99/0046 , F16K99/0048 , F16K99/0061 , F16K2099/0084 , G01N15/14 , G01N2015/149 , Y10S209/906 , Y10S209/932
摘要: A method and apparatus for sorting particles moving through a closed channel system of capillary size comprises a bubble valve for selectively generating a pressure pulse to separate a particle having a predetermined characteristic from a stream of particles. The particle sorting system may further include a buffer for absorbing the pressure pulse. The particle sorting system may include a plurality of closely coupled sorting modules which are combined to further increase the sorting rate. The particle sorting system may comprise a multi-stage sorting device for serially sorting streams of particles, in order to decrease the error rate.
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27.
公开(公告)号:US20050145497A1
公开(公告)日:2005-07-07
申请号:US11053819
申请日:2005-02-08
申请人: Johh Gilbert , Manish Deshpande
发明人: Johh Gilbert , Manish Deshpande
CPC分类号: B01L3/502715 , B01L3/06 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C30B7/00 , C30B29/58
摘要: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system.
摘要翻译: 用于在微流体系统中整合微流体组分的系统和方法使得微流体系统能够执行选定的微流体功能。 封盖模块包括用于执行微流控功能的微流体元件。 封盖模块堆叠在具有微流管道的微流体衬底上,以将微流控功能结合到系统中。
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公开(公告)号:US20050123450A1
公开(公告)日:2005-06-09
申请号:US10979848
申请日:2004-11-01
申请人: John Gilbert , Manish Deshpande , Bernard Bunner
发明人: John Gilbert , Manish Deshpande , Bernard Bunner
CPC分类号: B65G51/08 , B01F13/0062 , B01F13/0064 , B01J2219/00822 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00891 , B01L3/502776 , B01L2200/0636 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0887 , B01L2400/0487 , B65G51/00 , G01N15/1404 , G01N15/1484 , G01N2015/1409
摘要: A microfabricated sheath flow structure for producing a sheath flow includes a primary sheath flow channel for conveying a sheath fluid, a sample inlet for injecting a sample into the sheath fluid in the primary sheath flow channel, a primary focusing region for focusing the sample within the sheath fluid and a secondary focusing region for providing additional focusing of the sample within the sheath fluid. The secondary focusing region may be formed by a flow channel intersecting the primary sheath flow channel to inject additional sheath fluid into the primary sheath flow channel from a selected direction. A sheath flow system may comprise a plurality of sheath flow structures operating in parallel on a microfluidic chip.
摘要翻译: 用于产生鞘流的微细鞘层流动结构包括用于输送护套流体的初级鞘流动通道,用于将样品注入主鞘流道中的鞘液中的样品入口,用于将样品聚焦在 护套流体和辅助聚焦区域,用于提供样品在护套液体内的附加聚焦。 次要聚焦区域可以由与主鞘流道相交的流动通道形成,以从选定的方向将另外的鞘流体注入主鞘流动通道。 护套流动系统可以包括在微流体芯片上并行操作的多个护套流动结构。
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29.
公开(公告)号:US20050109410A1
公开(公告)日:2005-05-26
申请号:US11021251
申请日:2004-12-21
申请人: John Gilbert , Sebastian Bohm , Manish Deshpande
发明人: John Gilbert , Sebastian Bohm , Manish Deshpande
CPC分类号: B01L3/502738 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2300/089 , B01L2400/0415 , B01L2400/06 , B01L2400/0688 , B01L2400/082 , B07C5/34 , F16K99/0001 , F16K99/0017 , F16K99/0019 , F16K99/0034 , F16K99/0036 , F16K99/004 , F16K99/0046 , F16K99/0048 , F16K2099/0074 , F16K2099/008 , F16K2099/0084 , G01N2015/149 , Y10T29/49405 , Y10T137/0318 , Y10T137/0396 , Y10T137/0497 , Y10T137/2076 , Y10T137/2082 , Y10T137/2191 , Y10T137/2196 , Y10T137/2202 , Y10T137/2207 , Y10T137/2213 , Y10T137/2224 , Y10T436/143333 , Y10T436/25375
摘要: A microfluidic system includes a bubble valve for regulating fluid flow through a microchannel. The bubble valve includes a fluid meniscus interfacing the microchannel interior and an actuator for deflecting the membrane into the microchannel interior to regulate fluid flow. The actuator generates a gas bubble in a liquid in the microchannel when a sufficient pressure is generated on the membrane.
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公开(公告)号:US06878271B2
公开(公告)日:2005-04-12
申请号:US10329018
申请日:2002-12-23
CPC分类号: B01L3/502715 , B01L3/06 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/028 , B01L2200/146 , B01L2300/041 , B01L2300/047 , B01L2300/0681 , B01L2400/0481 , B01L2400/0655 , B01L2400/0666 , C30B7/00 , C30B29/58
摘要: A system and method for integrating microfluidic components in a microfluidic system enables the microfluidic system to perform a selected microfluidic function. A capping module includes a microfluidic element for performing a microfluidic function. The capping module is stacked on a microfluidic substrate having microfluidic plumbing to incorporate the microfluidic function into the system.
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