公开(公告)号：US09803184B2

公开(公告)日：2017-10-31

申请号：US13976557

申请日：2011-12-30

Applicant: Egisto Boschetti ,  Gérald Perret

Inventor： Egisto Boschetti ,  Gérald Perret

IPC: C07H21/00 ,  C12Q1/68 ,  C12N9/64 ,  B01J20/289 ,  C07H21/02 ,  C07H21/04 ,  C07K1/22 ,  B01J20/32

CPC classification number: C12N9/6437 ,  B01J20/289 ,  B01J20/3204 ,  B01J20/3212 ,  B01J20/3219 ,  B01J20/3274 ,  B01J20/3278 ,  C07H21/02 ,  C07H21/04 ,  C07K1/22

Abstract: The invention relates to a method for immobilizing nucleic ligands including at least one reactive amine function, by grafting on an activated solid substrate, including a step of coupling said nucleic acids on said activated solid substrate having a pH of less than 6.

公开(公告)号：US09308169B2

公开(公告)日：2016-04-12

申请号：US13462004

申请日：2012-05-02

Applicant: Jean-Marie Vogel ,  Egisto Boschetti

Inventor： Jean-Marie Vogel ,  Egisto Boschetti

IPC: A61K9/50 ,  A61K9/16 ,  A61K31/715 ,  A61K45/06

CPC classification number: A61K9/1635 ,  A61K31/715 ,  A61K45/06 ,  A61L2430/36 ,  Y10T428/2982

Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, substantially hydrophilic, non-toxic and substantially spherical polymeric material carriers which are capable of efficiently delivering bioactive therapeutic factor(s) for use in embolization drug therapy. The present invention further relates to methods of embolization gene therapy, particularly for the treatment of angiogenic and non-angiogenic-dependent diseases, using the injectable compositions.

公开(公告)号：US09017710B2

公开(公告)日：2015-04-28

申请号：US12197187

申请日：2008-08-22

Applicant: Jean-Marie Vogel ,  Egisto Boschetti ,  Richard Thomas

Inventor： Jean-Marie Vogel ,  Egisto Boschetti ,  Richard Thomas

IPC: A61F2/00 ,  A61K9/14 ,  A01N65/00 ,  A61L27/38 ,  A61L27/50 ,  A61L31/00 ,  A61L31/14 ,  A61K31/78 ,  A61K31/785

CPC classification number: A61K9/14 ,  A61K31/78 ,  A61K31/785 ,  A61L27/3804 ,  A61L27/3839 ,  A61L27/50 ,  A61L31/005 ,  A61L31/14 ,  A61L2400/06

Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres useful for tissue bulking. The invention also relates to methods of tissue bulking, particularly for the treatment of Gastro-esophageal reflux disease, urinary incontinence, or urinary reflux disease, using the injectable compositions.

Abstract translation: 本发明涉及包含可用于组织膨胀的生物相容性，可溶胀，亲水，无毒和基本上为球形的微球的可注射组合物。 本发明还涉及使用可注射组合物的组织膨胀方法，特别是用于治疗胃食管反流病，尿失禁或尿反流疾病的方法。

公开(公告)号：US20110111978A1

公开(公告)日：2011-05-12

申请号：US13004281

申请日：2011-01-11

Applicant: Egisto Boschetti ,  Lee Lomas

Inventor： Egisto Boschetti ,  Lee Lomas

IPC: C40B30/04 ,  C40B50/14 ,  B82Y5/00

CPC classification number: C07K1/047 ,  C07K1/22

Abstract: The present invention provides diverse chemical libraries bound to small particle with paramagnetic properties. Typically, the chemical structures comprise a plurality of different chemical moieties, the particles are paramagnetic and have a diameter between about 100 nm and about 10 microns, the chemical structures bound to each particular particle have substantially the same structure and the combinatorial library comprises at least 100,000 different chemical structures.

Abstract translation: 本发明提供了与具有顺磁性质的小颗粒结合的不同化学文库。 通常，化学结构包括多个不同的化学部分，颗粒是顺磁性的并且具有约100nm至约10微米之间的直径，与每个特定颗粒结合的化学结构具有基本上相同的结构，组合文库至少包含 100,000种不同的化学结构。

公开(公告)号：US07833625B2

公开(公告)日：2010-11-16

申请号：US11074591

申请日：2005-03-08

Applicant: Egisto Boschetti ,  Pier Giorgio Righetti

Inventor： Egisto Boschetti ,  Pier Giorgio Righetti

IPC: B32B5/16

CPC classification number: G01N27/44747 ,  B01D57/02 ,  B01J20/26 ,  B01J20/3204 ,  B01J20/321 ,  B01J20/3268 ,  B01J20/327 ,  B01J20/3274 ,  B01J20/3276 ,  B01J20/3282 ,  B01J20/3293 ,  B01J2220/54 ,  C07K1/16 ,  C07K1/24 ,  C07K1/28 ,  G01N27/44795 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

Abstract: Materials, apparatuses, methods, and systems for isolating and identifying mixture components on the basis of isoelectric point (“pI”). In one aspect, the materials are particles adapted to have a predetermined isoelectric point. The particles include a porous body into which a plurality of cavities extend. A substance of a predetermined isoelectric point is deposited in the cavities to provide thereby the particle's isoelectric value.

Abstract translation: 用于基于等电点（“pI”）分离和鉴定混合物组分的材料，装置，方法和系统。 在一个方面，材料是适于具有预定等电点的颗粒。 颗粒包括多个空腔延伸到其中的多孔体。 将预定等电点的物质沉积在空腔中，从而提供颗粒的等电位值。

公开(公告)号：US20070015143A1

公开(公告)日：2007-01-18

申请号：US11531863

申请日：2006-09-14

Applicant: Egisto Boschetti ,  Pierre Girot

Inventor： Egisto Boschetti ,  Pierre Girot

IPC: C12Q1/70 ,  C12Q1/68 ,  G01N33/53 ,  C12M3/00

CPC classification number: B01J20/3255 ,  B01D15/1807 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3242 ,  B01J20/3285 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2219/0074 ,  C07K1/165 ,  C07K1/22 ,  C40B40/10 ,  C40B80/00 ,  G01N33/54353 ,  G01N2001/045 ,  G01N2035/00158 ,  Y10S530/812 ,  Y10T436/25

Abstract: For certain mixed mode resins having anionic character, a ligand is joined to a solid support via a linkage that includes a mercapto-, ether- or amino-containing moiety. A suitable ligand comprises an aromatic group, a heteroaromatic group, or a heterocyclic group, optionally fused, that is sulfate-, sulfonate-, phosphonate- or phosphate-substituted and that is linked to such a moiety. These resins possess an anionic character under conditions prescribed for their use. Separation of a biological substance, such as a peptide or protein, can be accomplished with a resin of this type via a change in the pH of eluants, thereby effecting adsorption and desorption.

Abstract translation: 对于具有阴离子特性的某些混合模式树脂，配体通过包含巯基，醚或氨基部分的键连接到固体支持物上。 合适的配体包括芳族基团，杂芳族基团或杂环基团，任选地稠合，其是硫酸酯基，磺酸酯基，膦酸酯基或磷酸酯取代的，并且与该部分连接。 这些树脂在其使用条件下具有阴离子特性。 生物物质如肽或蛋白质的分离可以通过这种类型的树脂通过洗脱液的pH的变化来实现，从而进行吸附和解吸附。

公开(公告)号：US20060205010A1

公开(公告)日：2006-09-14

申请号：US10553923

申请日：2004-04-19

Applicant: Catherine Allioux ,  Egisto Boschetti ,  Virginie Brenac ,  Patrick Santambien ,  James Spencer

Inventor： Catherine Allioux ,  Egisto Boschetti ,  Virginie Brenac ,  Patrick Santambien ,  James Spencer

IPC: G01N33/53

CPC classification number: G01N33/567 ,  C07K1/22 ,  G01N33/543 ,  G01N33/6803 ,  G01N33/6842 ,  G01N33/6851

Abstract: The invention provides methods of determining the presence of host cell proteins in sample. The invention further provides methods of following the purification of target proteins. Kits and articles of manufacture are also provided.

Abstract translation: 本发明提供了确定样品中宿主细胞蛋白质存在的方法。 本发明还提供了追踪靶蛋白纯化的方法。 还提供了工具包和制品。

公开(公告)号：US20050158393A1

公开(公告)日：2005-07-21

申请号：US11030182

申请日：2005-01-07

Applicant: Phillippe Reb ,  Laurent Domas ,  Egisto Boschetti ,  Marie-Paule Leroy-Landercy

Inventor： Phillippe Reb ,  Laurent Domas ,  Egisto Boschetti ,  Marie-Paule Leroy-Landercy

IPC: A61K9/14 ,  A61K33/24 ,  A61K49/18 ,  A61P43/00

CPC classification number: A61K49/18

Abstract: The present invention relates to polymeric materials that are labeled with colloidal metals, preferably colloidal gold, to processes for producing the labeled polymeric material, and to methods of using the materials in prophylactic, therapeutic and cosmetic applications. Specifically, the invention relates to porous injectable and implantable microparticles, preferably microspheres, that are associated with colloidal metals such that the microparticles are visible or detectable under regular light, by radiological and/or magnetic resonance imaging techniques, or both. The microparticles having colloidal metals are particularly useful for embolization, dermal augmentation and tissue bulking, drug delivery, gene therapy, and other prophylactic, therapeutic or cosmetic medical applications.

Abstract translation: 本发明涉及用胶体金属（优选胶体金）标记用于生产标记的聚合物材料的方法的聚合物材料，以及在预防，治疗和美容应用中使用该材料的方法。 具体地，本发明涉及与胶体金属相关的多孔可注射和可植入的微粒，优选微球，使得微粒在常规光下是可见的或可检测的，通过放射和/或磁共振成像技术，或两者兼有。 具有胶体金属的微粒特别可用于栓塞，皮肤增生和组织膨胀，药物递送，基因治疗和其它预防，治疗或美容医学应用。

公开(公告)号：US06613234B2

公开(公告)日：2003-09-02

申请号：US09274013

申请日：1999-03-22

Applicant: Nicolas Voute ,  Egisto Boschetti ,  Pierre Girot ,  Marc Perez ,  Jean-Claude Viguie

Inventor： Nicolas Voute ,  Egisto Boschetti ,  Pierre Girot ,  Marc Perez ,  Jean-Claude Viguie

IPC: B01D1508

CPC classification number: B01J20/3204 ,  B01D15/1807 ,  B01D15/327 ,  B01D15/361 ,  B01D15/3804 ,  B01J20/0211 ,  B01J20/06 ,  B01J20/08 ,  B01J20/28069 ,  B01J20/28085 ,  B01J20/28097 ,  B01J20/282 ,  B01J20/3064 ,  B01J20/3272 ,  B01J20/3274 ,  B01J20/3282 ,  B01J2220/52

Abstract: The present invention provides porous mineral oxide beads which have large pore volumes and enhanced stability. The beads are based on a tetravalent metal oxide, such as zirconia, titania or hafnia. These highly porous beads are produced from a mixture of tetravalent mineral oxides, mineral pore inducing agents which are oxides or salts of trivalent metals, and optional binders. The porous mineral beads can be filled with a polymer gel and used for adsorption and chromatography applications.

Abstract translation: 本发明提供了具有大孔体积和增强的稳定性的多孔无机氧化物珠粒。 珠粒基于四价金属氧化物，例如氧化锆，二氧化钛或铪。 这些高度多孔的珠子由四价矿物氧化物，矿物孔诱导剂，三价金属的氧化物或盐，和任选的粘合剂的混合物制成。 多孔矿物珠可以用聚合物凝胶填充并用于吸附和色谱应用。

公开(公告)号：US06436424B1

公开(公告)日：2002-08-20

申请号：US09528990

申请日：2000-03-20

Applicant: Jean-Marie Vogel ,  Egisto Boschetti

Inventor： Jean-Marie Vogel ,  Egisto Boschetti

IPC: A61F1300

CPC classification number: A61L27/52 ,  A61L27/26 ,  C08L33/26

Abstract: The present invention relates to injectable compositions comprising biocompatible, swellable, hydrophilic, non-toxic and substantially spherical microspheres microspheres and a biocompatible carrier for use in dermal augmentation. The present invention further relates to methods of dermal augmentation, particularly for the treatment of skin contour deficiencies, using the injectable compositions.

Abstract translation: 本发明涉及可注射组合物，其包含生物相容性，可溶胀，亲水，无毒和基本上为球形的微球微球和用于皮肤增生的生物相容性载体。 本发明还涉及使用可注射组合物的皮肤增强方法，特别是用于治疗皮肤轮廓缺陷的方法。