公开(公告)号：US08394275B2

公开(公告)日：2013-03-12

申请号：US12811158

申请日：2008-12-16

Applicant: Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

Inventor： Christopher C. Benevides ,  Keith Fadgen ,  Michael Lavallee ,  Anthony Jeannotte

IPC: B01D15/08

CPC classification number: B01D15/14 ,  B01D15/22 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  Y10T29/49826

Abstract: A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.

Abstract translation: 制备液相色谱装置的方法包括将两个内部导管插入中间管中，将中间管插入外管中，在中间管与至少一个内管之间形成近端密封，并形成远端密封 在中间管与至少一个内部管道之间。 液相色谱装置包括外管，设置在外管中的中间管，设置在中间管中的两个内导管，中间管与至少一个内导管之间的近侧密封，以及位于中间管之间的远端密封 中间管和至少一个内部管道。

公开(公告)号：US20050160833A1

公开(公告)日：2005-07-28

申请号：US11088120

申请日：2005-03-22

Applicant: Geoff Gerhardt ,  Keith Fadgen

Inventor： Geoff Gerhardt ,  Keith Fadgen

IPC: G01F1/684 ,  G01N30/32 ,  G01N30/64 ,  G01F1/708

CPC classification number: G01F1/6847 ,  G01N30/64 ,  G01N2030/324

Abstract: A method and system for measuring the flow rate of a liquid or gas within a flow channel utilizing a centrally located excitation source and a plurality of sensor means. Said excitation means is comprised of a heating element coupled with an alternating current generator. Of the plurality of sensor means, at least one of said sensors is located in a position upstream of the excitation source location, and additionally a second of said plurality of sensors is located in a position downstream of the excitation source. Instantaneous fluid flow rate is calculated utilizing a high gain differential amplifier electrically coupled to said sensors, wherein the convectively induced inductive gradient of the flowing fluid is compared to the symmetrical zero flow induction gradient. Following such a comparison, a voltage signal proportional to the flow of fluid within the channel is derived.

公开(公告)号：US08312762B2

公开(公告)日：2012-11-20

申请号：US12282895

申请日：2007-03-16

Applicant: Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

Inventor： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

IPC: G01M30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G05D7/0688 ,  G05D16/208

Abstract: Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

Abstract translation: 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。

公开(公告)号：US20050109699A1

公开(公告)日：2005-05-26

申请号：US10723973

申请日：2003-11-26

Applicant: Geoff Gerhardt ,  Keith Fadgen

Inventor： Geoff Gerhardt ,  Keith Fadgen

IPC: G01F1/36 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  B01D21/24 ,  B01D29/88

CPC classification number: G01F1/363 ,  G01F1/68 ,  G01N30/10 ,  G01N30/30 ,  G01N30/32 ,  G01N2030/324 ,  G01N2030/326

Abstract: A method and apparatus for monitoring and controlling the nano-scale flow rate of fluid in the operating flow path of a HPLC system without relying on a nano-scale sensor in the operating flow path. A main flow sensor is disposed in the main flow path between the pump and a flow-divider. A waste flow sensor is disposed in the waste flow path downstream of the splitter. The output signal of the waste flow sensor is subtracted from the output signal of the main flow sensor in a difference circuit. The difference signal is divided by the output signal from the main flow sensor in a divider circuit. The output of the divider circuit represents an empirical split ratio of the flow-divider and is independent of media composition.

Abstract translation: 一种用于在不依赖于操作流程中的纳米级传感器的情况下监视和控制HPLC系统的操作流路中的流体的纳米流量的方法和装置。 主流量传感器设置在泵和分流器之间的主流路中。 废液流量传感器设置在分流器下游的废流路中。 在差分电路中，从主流量传感器的输出信号中减去废液流量传感器的输出信号。 差分信号除以分流器电路中的主流量传感器的输出信号。 分压电路的输出表示分流器的经验分流比，并且与介质组成无关。

公开(公告)号：US20140166562A1

公开(公告)日：2014-06-19

申请号：US14238278

申请日：2012-08-23

Applicant: Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

Inventor： Joseph D. Michienzi ,  Keith Fadgen ,  Wade P. Leveille, Sr. ,  Raymond P. Fisk ,  Frank John Marzalkowski, Jr.

IPC: B01D15/22

CPC classification number: B05B5/16 ,  B01D15/10 ,  B01D15/1871 ,  B01D15/22 ,  G01N30/60 ,  G01N30/6004 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6052 ,  G01N30/6095 ,  G01N30/7266 ,  Y10T29/49908

Abstract: Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure. A radial seal is provided by one or more uniform radial crimps at longitudinal locations on the assembly. The uniform radial crimp compresses the outer tube and underlying intermediate tube onto the inner tube to achieve a high pressure liquid tight seal between the three tubes. The length and depth of each crimp is accurately formed to accommodate the requirements of the particular application. Leakage along the tubing assembly is prevented and void volume is reduced or eliminated. No external ferrule or ferrule swaging mechanism is needed; therefore the chromatography column assembly is easily adapted for use in various chromatographic column configurations.

Abstract translation: 描述了一种色谱柱组件，其包括永久变形的外管，中间管，内管和设置在内管内的吸附剂床。 吸附剂床可以是填充色谱颗粒或多孔整体结构的形式。 在组件的纵向位置处由一个或多个均匀的径向卷曲提供径向密封。 均匀的径向卷曲将外管和下面的中间管压缩到内管上，以实现三管之间的高压液密封。 精确地形成每个卷曲的长度和深度以适应特定应用的要求。 防止管道组件的泄漏，减少或消除空隙体积。 不需要外部套圈或套圈型锻机构; 因此色谱柱组件易于适用于各种色谱柱配置。

公开(公告)号：US20100043539A1

公开(公告)日：2010-02-25

申请号：US12282895

申请日：2007-03-16

Applicant: Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

Inventor： Keith Fadgen ,  James E. Usowicz ,  Miguel Soares

IPC: G01N30/02

CPC classification number: G01N30/20 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G05D7/0688 ,  G05D16/208

Abstract: Embodiments of the present invention are directed to methods and apparatus for placing a sample in a chromatographic system. The device and method feature placing samples held in a sample loop to pressurization prior to placing such sample loop in communication with high pressure conduits.

Abstract translation: 本发明的实施方案涉及将样品置于色谱系统中的方法和装置。 该装置和方法的特征是将放置样品回路中的样品置于加压之前，使样品环与高压导管连通。

公开(公告)号：US20090205409A1

公开(公告)日：2009-08-20

申请号：US12280585

申请日：2007-03-16

Applicant: Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

Inventor： Steven J. Ciavarini ,  Stanley P. Pensak, JR. ,  Jeffrey W. Finch ,  Keith Fadgen ,  Hongji Liu

IPC: G01N30/02

CPC classification number: G01N30/34 ,  G01N30/32 ,  G01N2030/326 ,  G05D11/132

Abstract: A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.

Abstract translation: 用于色谱装置的溶剂递送子系统执行溶剂的相对低压，高流动混合以形成梯度并随后将高梯度梯度递送到分离塔。 梯度的混合是独立的，并且不干扰梯度递送。 为了形成梯度，将水性泵和有机泵的输出混合以填充储存毛细管，同时从储存毛细管的下游点排放到大气中。 梯度形成后，关闭空气，溶剂输送系统升高至高压，只有水泵运行梯度输送。 为了保持流体流的完整性，溶剂输送系统使用前馈补偿并且控制选自管道装置中的压力和流量的至少一个参数以跟随逐渐斜坡。