公开(公告)号：US20080214953A1

公开(公告)日：2008-09-04

申请号：US11712529

申请日：2007-03-01

Applicant: Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gal Aharonowitz ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/00

CPC classification number: A61B5/0059 ,  A61B5/0064 ,  A61B5/05 ,  A61B5/6834

Abstract: A measurement system and method are provided for use in characterizing a tissue. The system comprises a probe adapted for operating in either a scan mode or a measure mode, and a control unit for operating the probe. The probe comprises a sensing module for measuring one or more parameters indicative of one or more states of the tissue; and an attachment module configured and operable to enable selective operation of the probe in either one of the scan mode and the measure modes. The control unit is configured and operative to selectively operate the probe in either one of the scan and measure modes.

Abstract translation: 提供了用于表征组织的测量系统和方法。 该系统包括适于以扫描模式或测量模式操作的探针和用于操作探针的控制单元。 探针包括用于测量指示组织的一个或多个状态的一个或多个参数的感测模块; 以及附件模块，其配置和可操作以使得能够以所述扫描模式和所述测量模式中的任一个选择性地操作所述探针。 控制单元被配置和操作以选择性地在扫描和测量模式中的任何一个中操作探针。

公开(公告)号：US20080021343A1

公开(公告)日：2008-01-24

申请号：US11797167

申请日：2007-05-01

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/053

CPC classification number: A61B5/053 ,  A61B5/0538 ,  A61B5/415 ,  A61B5/418 ,  A61B10/0041 ,  A61B17/320016 ,  A61B17/320783 ,  A61B2017/00026

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。

公开(公告)号：US20070179397A1

公开(公告)日：2007-08-02

申请号：US11705143

申请日：2007-02-12

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/05

CPC classification number: A61B5/053 ,  A61B5/415 ,  A61B5/418

Abstract: The present invention relates to probes, systems, and methods for tissue characterization by its dielectric properties, wherein a physical feature of the probe is designed to define and delimit a tissue volume, at a tissue edge, where characterization takes place. Thus, the probe for tissue-edge characterization comprises: a first inner conductor, which comprises: proximal and distal ends, with respect to a tissue edge, along an x-axis; a first sharp edge, inherently associated with the proximal end; at least one feature, issuing from the first inner conductor, substantially at the proximal end, for forming at least one additional sharp edge, operative to enhance localized electrical fringe fields in the tissue, within a generally predefined tissue volume, at the tissue edge, the tissue volume being generally defined by physical parameters associated with the at least one feature; and a dielectric material, which encloses the conductor, in the y-z planes.

Abstract translation: 本发明涉及用于通过其介电特性进行组织表征的探针，系统和方法，其中探针的物理特征被设计成在组织边缘处限定和限定组织体积，其中进行表征。 因此，用于组织边缘表征的探针包括：第一内部导体，其包括：沿x轴的相对于组织边缘的近端和远端; 固有地与近端相关联的第一锋利边缘; 至少一个特征，从第一内部导体发出，基本上在近端处，用于形成至少一个额外的锋利边缘，用于在组织边缘处的通常预定的组织体积内增强组织中的局部电气条纹区域， 组织体积通常由与至少一个特征相关联的物理参数限定; 以及在y-z平面中包围导体的电介质材料。

公开(公告)号：US20070032739A1

公开(公告)日：2007-02-08

申请号：US11196732

申请日：2005-08-04

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B5/00

CPC classification number: A61B5/4381 ,  A61B5/6834

Abstract: A device and method for tissue characterization are provided, the device comprising: a structure; a first mechanism, associated with said structure, configured for exerting a first force on a tissue, for fixing the tissue to said structure, so as to substantially immobilize the tissue; and a second mechanism, associated with said structure, configured for pressing a sensor against an external surface of the immobilized tissue, thereby exerting a second force on the immobilized tissue, wherein at least a component of said first force is in opposition to at least a component of said second force, forcing the immobilized tissue against said sensor, and forcing said sensor against the immobilized tissue, bringing about an effective contact between said sensor and the immobilized tissue.

Abstract translation: 提供了用于组织表征的装置和方法，所述装置包括：结构; 与所述结构相关联的第一机构被配置为在组织上施加第一力，用于将组织固定到所述结构，以便基本上固定所述组织; 以及与所述结构相关联的第二机构，其配置成将传感器压靠在固定化组织的外表面上，从而对固定化组织施加第二力，其中所述第一力的至少一部分与至少一个 所述第二力的分量，强制所述固定化组织抵靠所述传感器，并迫使所述传感器抵靠所述固定的组织，从而在所述传感器和所述固定的组织之间产生有效的接触。

公开(公告)号：US20060253107A1

公开(公告)日：2006-11-09

申请号：US10558831

申请日：2005-03-23

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B17/00 ,  A61B18/18 ,  A61B8/00 ,  A61B5/103 ,  A61B5/117

CPC classification number: A61B5/415 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/0091 ,  A61B5/01 ,  A61B5/015 ,  A61B5/0507 ,  A61B5/053 ,  A61B5/055 ,  A61B5/06 ,  A61B5/4312 ,  A61B8/0858 ,  A61B8/12 ,  A61B8/4245 ,  A61B8/4472 ,  A61B18/082 ,  A61B34/20 ,  A61B2017/00026 ,  A61B2034/107 ,  A61B2034/2051 ,  A61B2034/2055 ,  A61B2090/061 ,  A61B2090/367 ,  A61B2090/378

Abstract: An integrated tool is provided, having a tissue-type sensor, for determining the tissue type at a near zone volume of a tissue surface, and a distance-measuring sensor, for determining the distance to an interface with another tissue type, for (i) confirming an existence of a clean margin of healthy tissue around a malignant tumor, which is being removed, and (ii) determining the depth of the clean margin. The integrated tool may further include a position tracking device and an incision instrument. The soft tissue may be held within a fixed frame, while the tumor is being removed. Additionally a method for malignant tumor removal is provided, comprising, fixing the soft tissue within a frame, performing imaging with the hand-held, integrated tool, from a plurality of locations and orientations around the soft tissue, reconstructing a three-dimensional image of the soft tissue and the tumor within, defining a desired clean margin on the reconstructed image, calculating a recommended incision path, displaying the recommended path on the reconstructed image, and cutting the tissue while determining its type, at the near zone volume of the incision surface. The method may further include continuously imaging with the cutting, continuously correcting the reconstructed image and the recommended incision path, and continuously determining the tissue type, at the near zone volume of the incision surface.

Abstract translation: 提供了一种集成工具，具有用于确定组织表面的近区域体积处的组织类型的组织型传感器和用于确定与另一组织类型的界面的距离的距离测量传感器，用于（i ）确认正在被去除的恶性肿瘤周围存在健康组织的清洁边缘，以及（ii）确定清洁边缘的深度。 集成工具还可以包括位置跟踪装置和切口装置。 当肿瘤被移除时，软组织可以保持在固定框架内。 另外，提供了一种用于恶性肿瘤去除的方法，包括：将软组织固定在框架内，利用手持式集成工具从软组织周围的多个位置和取向进行成像，重建三维图像 软组织和肿瘤内，在重建图像上限定所需的清洁边缘，计算推荐切口路径，在重建图像上显示推荐路径，以及在确定其类型的同时切割组织，在切口的近区体积处 表面。 该方法可以进一步包括连续成像切割，连续校正重建图像和推荐切口路径，以及在切口表面的近区域体积处连续地确定组织类型。

公开(公告)号：US09757098B2

公开(公告)日：2017-09-12

申请号：US13547950

申请日：2012-07-12

Applicant: Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

Inventor： Dan Hashimshony ,  Gil Cohen ,  Iddo Geltner

IPC: A61B10/02 ,  A61B17/3205 ,  A61B17/00

CPC classification number: A61B10/0275 ,  A61B17/3205 ,  A61B2017/00026 ,  A61B2017/00039 ,  A61B2017/00057

Abstract: A medical device including a tissue characterization probe having an elongated carrier for carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier within at least a distal portion thereof, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array. The elongated carrier has two integral portions including said distal portion and a hollow portion extending between a proximal end of the carrier and said distal portion. The carrier is configured for passing a predetermined treatment tool through the hollow portion thereof and enabling at least a part of the treatment tool to project from the hollow portion and extend along the distal portion.

公开(公告)号：US09498192B2

公开(公告)日：2016-11-22

申请号：US13387504

申请日：2010-08-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B10/02 ,  A61B10/06

CPC classification number: A61B10/0266 ,  A61B5/05 ,  A61B5/0538 ,  A61B10/0275 ,  A61B10/06 ,  A61B2505/05 ,  A61B2562/227

Abstract: A surgical tool for use in a tissue removal procedure from a subject is described. The surgical tool has proximal and distal regions and at least one sensor for sensing one or more predetermined conditions located at a distal region of the surgical tool. And a substantially flat signal transmission structure electrically connected with the at least one sensor and extending between the location at the distal region and the proximal region. The signal transmission structure is configured for providing impedance controlled signal transmission between the at least one sensor and the proximal region.

Abstract translation: 描述了用于来自受试者的组织去除程序的外科手术工具。 外科手术工具具有近端和远端区域和至少一个传感器，用于感测位于手术工具的远端区域的一个或多个预定条件。 以及基本平坦的信号传输结构，与所述至少一个传感器电连接并且在所述远端区域和所述近侧区域之间的位置之间延伸。 信号传输结构被配置用于在至少一个传感器和近端区域之间提供阻抗控制的信号传输。

公开(公告)号：US09301734B2

公开(公告)日：2016-04-05

申请号：US12663923

申请日：2008-07-13

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: A61B17/00 ,  A61B18/14 ,  A61B19/00 ,  A61B10/02 ,  A61B5/00

CPC classification number: A61B10/0233 ,  A61B5/00 ,  A61B10/0266 ,  A61B90/37 ,  A61B2017/00022 ,  A61B2017/00128 ,  A61B2017/00199 ,  A61B2018/1475 ,  A61B2090/061

Abstract: A medical device is presented for use in tissue characterization and treatment. The device comprises: a tissue characterization probe comprising an elongated carrier carrying an array of tissue characterization sensors arranged in a spaced-apart relationship at least along an axis of said carrier, such that progression of the probe through a tissue mass provides for locating and determining a dimension of an abnormal tissue specimen inside said tissue mass based on characterization signals from the sensors in the array, thereby enabling consequent treatment of the abnormal tissue specimen by a treatment tool.

Abstract translation: 呈现用于组织表征和治疗的医疗装置。 所述装置包括：组织表征探针，其包括细长载体，所述细长载体承载至少沿着所述载体的轴线以间隔关系布置的组织表征传感器阵列，使得所述探针通过组织块的进展提供定位和确定 基于来自阵列中的传感器的特征信号，所述组织块内部的异常组织标本的尺寸，从而能够通过治疗工具进行异常组织标本的治疗。

公开(公告)号：US09217739B2

公开(公告)日：2015-12-22

申请号：US14123249

申请日：2012-06-03

Applicant: Dan Hashimshony ,  Gil Cohen

Inventor： Dan Hashimshony ,  Gil Cohen

IPC: G01N21/00 ,  G01N33/483 ,  G01N1/06 ,  G01N1/28 ,  A61B10/00 ,  A61B19/00 ,  A61B10/02 ,  G06F19/00

CPC classification number: G01N33/4833 ,  A61B10/00 ,  A61B10/02 ,  A61B2034/107 ,  G01N1/06 ,  G01N1/286 ,  G16H40/63

Abstract: A probe device for use in a tissue inspection system is presented. The probe device comprises a probe body and a control unit at least partially incorporated in the probe body. The probe body carries at least a tissue characterization unit operable for providing sensing data indicative of at least one tissue property at measurement locations in the tissue portion being held by the probe. The control unit comprises: a processor utility for receiving and processing the sensing data and generating measured data indicative of a spatial profile of said at least one tissue property distribution within the tissue portion, and comprises at least one of the following: an imaging utility for receiving said measured data and generating and displaying an image indicative thereof thereby enabling a user to select a region of said tissue portion for further analysis; and a pattern generator module configured for receiving and analyzing said measured data and determining a pattern indicative of an arrangement of regions in said tissue portion, thereby enabling selection of at least one of the regions for further analysis.

Abstract translation: 提出了一种用于组织检测系统的探针装置。 探针装置包括探针体和至少部分地结合在探针体内的控制单元。 探针体携带至少一个组织表征单元，其可操作用于提供感测数据，该感测数据指示由探针保持的组织部分中的测量位置处的至少一个组织属性。 所述控制单元包括：处理器实用程序，用于接收和处理所述感测数据并产生指示所述组织部分内的所述至少一个组织属性分布的空间分布的测量数据，并且包括以下中的至少一个：用于 接收所述测量数据并产生和显示指示其的图像，从而使用户能够选择所述组织部分的区域用于进一步分析; 以及图案生成器模块，被配置为接收和分析所述测量数据并且确定指示所述组织部分中的区域布置的图案，由此能够选择所述区域中的至少一个用于进一步分析。

公开(公告)号：US09008756B2

公开(公告)日：2015-04-14

申请号：US12964511

申请日：2010-12-09

Applicant: Gil Cohen ,  Dan Hashimshony

Inventor： Gil Cohen ,  Dan Hashimshony

IPC: A61B5/00 ,  A61B19/00

CPC classification number: A61B19/5244 ,  A61B34/20 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/3908

Abstract: A mapping system (200) including: (a) at least one external marker (210,212,214,216) adapted for positioning outside a target (520) to define a target context; (b) at least one target marker (230) adapted for positioning with the target; (c) a data acquisition tool (221) configured to provide position coordinates for at least one data point (220) at the target (520); and (d) a registration module (300) adapted to output position coordinates of said at least one data point relative to at least a portion of the target context.

Abstract translation: 一种映射系统（200），包括：（a）适于定位在目标外部（520）以限定目标上下文的至少一个外部标记（210,212,214,216） （b）至少一个适于与靶标定位的靶标记物（230）; （c）数据采集工具（221），被配置为提供所述目标（520）处的至少一个数据点（220）的位置坐标; 和（d）适于相对于所述目标上下文的至少一部分输出所述至少一个数据点的位置坐标的注册模块（300）。