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    Systems and Methods for Extending Imaging Depth Range of Optical Coherence Tomography Through Optical Sub-Sampling
    21.
    发明申请
    Systems and Methods for Extending Imaging Depth Range of Optical Coherence Tomography Through Optical Sub-Sampling 有权
    通过光子采样扩展光学相干层析成像深度范围的系统和方法

    公开(公告)号：US20100150422A1

    公开(公告)日：2010-06-17

    申请号：US12635435

    申请日：2009-12-10

    申请人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G06K9/00

    CPC分类号： A61B5/6852 ,  A61B5/0066

    摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

    摘要翻译： 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上解析和明确地表征至少一个部分的表征。

    Method and apparatus for three-dimensional spectrally encoded imaging
    22.
    发明授权
    Method and apparatus for three-dimensional spectrally encoded imaging 有权
    用于三维光谱编码成像的方法和装置

    公开(公告)号：US07551293B2

    公开(公告)日：2009-06-23

    申请号：US10997789

    申请日：2004-11-24

    申请人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    发明人： Dvir Yelin ,  Brett E. Bouma ,  Nicusor Iftimia ,  Guillermo J. Tearney

    IPC分类号： G01J3/45 ,  G01B9/02 ,  G01B11/02

    CPC分类号： G01B11/2441 ,  A61B1/042 ,  A61B5/1077 ,  G01B9/02027 ,  G01B9/02044 ,  G01B11/2509

    摘要： A method and apparatus for providing information associated with at least one portion of a sample can be provided. For example, at least one wavelength of electro-magnetic radiation provided on a sample can be encoded to determine at least one transverse location of the portion. A relative phase between at least one first electro-magnetic radiation electro-magnetic radiation being returned from a sample and at least one second electro-magnetic radiation returned from a reference can be obtained to determine at least one relative depth location of the portion. Further, the information of the portion can be provided based on the transverse location and the relative depth location. For example, the information can be depth information and/or three-dimensional information associated with the portion of the sample.

    摘要翻译： 可以提供用于提供与样本的至少一部分相关联的信息的方法和装置。 例如，可以对提供在样品上的至少一个电磁辐射波长进行编码，以确定该部分的至少一个横向位置。 可以获得从样品返回的至少一个第一电磁辐射电磁辐射与从参考物返回的至少一个第二电磁辐射之间的相对相位，以确定该部分的至少一个相对深度位置。 此外，可以基于横向位置和相对深度位置来提供该部分的信息。 例如，信息可以是与样本部分相关联的深度信息和/或三维信息。

    ARRANGEMENTS AND METHODS FOR MULTIDIMENSIONAL MULTIPLEXED LUMINESCENCE IMAGING AND DIAGNOSIS
    23.
    发明申请
    ARRANGEMENTS AND METHODS FOR MULTIDIMENSIONAL MULTIPLEXED LUMINESCENCE IMAGING AND DIAGNOSIS 审中-公开
    多元多光子成像和诊断的安排和方法

    公开(公告)号：US20080206804A1

    公开(公告)日：2008-08-28

    申请号：US12016051

    申请日：2008-01-17

    申请人： Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

    发明人： Guillermo J. Tearney ,  Brett E. Bouma ,  Leilei Peng ,  Tayyaba Hasan ,  Sarika Verma

    IPC分类号： C12Q1/02 ,  C12M1/34 ,  G01N21/63 ,  G01N21/76

    CPC分类号： G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/6456 ,  G01N21/6489 ,  G01N33/582 ,  G01N2201/1296

    摘要： Exemplary embodiments of arrangements and methods providing information associated with a sample are described. For example, using such exemplary arrangements and methods, it is possible to receive an unpartitioned electro-magnetic radiation from the sample. Further, first data associated with first luminescent characteristics of at least one first molecule of the sample and second data associated with second luminescent characteristics of at least one second molecule of the sample can be obtained based on the unpartitioned electro-magnetic radiation. At least two of the photo-luminescent properties of the sample may be measured simultaneously as a function of the first and second data. Further, the information regarding the molecules of the sample may be determined as a function of the photo-luminescent properties.

    摘要翻译： 描述了提供与样本相关联的信息的布置和方法的示例性实施例。 例如，使用这样的示例性布置和方法，可以从样品接收未分割的电磁辐射。 此外，可以基于未分割的电磁辐射获得与样品的至少一个第一分子的第一发光特性相关联的第一数据和与样品的至少一个第二分子的第二发光特性相关的第二数据。 可以同时测量样品的至少两种光致发光性质作为第一和第二数据的函数。 此外，关于样品分子的信息可以根据光致发光性质来确定。

    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFRARED LIGHT
    24.
    发明申请
    SYSTEMS AND PROCESSES FOR PROVIDING ENDOGENOUS MOLECULAR IMAGING WITH MID-INFRARED LIGHT 审中-公开
    用中红外光提供内源性分子成像的系统和方法

    公开(公告)号：US20070171433A1

    公开(公告)日：2007-07-26

    申请号：US11624277

    申请日：2007-01-18

    申请人： Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G01B11/14

    CPC分类号： G01N21/3563 ,  G01J3/02 ,  G01J3/021 ,  G01J3/42 ,  G01N21/031 ,  G01N21/45 ,  G01N21/4795 ,  G01N2021/1787

    摘要： Exemplary systems and processes for generating information associated with at least one portion of a sample are provided. In one exemplary embodiment, at least one electromagnetic radiation can be received from the at least one portion, whereas the electromagnetic radiation has a wavenumber that is between approximately 5,000 cm−1 and 600 cm−1. The information can be generated which includes structural data, molecular data and/or chemical data of the portion. The information can be generated based on (a) at least one phase of the at least one electromagnetic radiation, and/or (b) at least one refractive index of the at least one portion. According to another exemplary embodiment, the electromagnetic radiation having a first wavenumber can be transmitted to the portion which has at least two substances, whereas a refractive index of one of the substances at a second wavenumber is approximately the same as a refractive index of another one of the substances at the second wavenumber. The electromagnetic radiation can be controlled such that the first wavenumber substantially matches the first wavenumber to reduce scattering within the portion.

    摘要翻译： 提供了用于产生与样本的至少一部分相关联的信息的示例性系统和过程。 在一个示例性实施例中，可以从至少一个部分接收至少一个电磁辐射，而电磁辐射具有介于约5000cm -1至600cm -1之间的波数 。 可以生成包括该部分的结构数据，分子数据和/或化学数据的信息。 可以基于（a）至少一个电磁辐射的至少一个相位和/或（b）至少一个部分的至少一个折射率来生成信息。 根据另一示例性实施例，具有第一波数的电磁辐射可以传输到具有至少两种物质的部分，而第二波数处的物质之一的折射率与另一物质的折射率近似相同 的物质在第二个波数。 可以控制电磁辐射使得第一波数基本上与第一波数匹配以减少该部分内的散射。

    Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
    25.
    发明授权
    Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging 有权
    用于提供用于高速多普勒光学频域成像的束扫描图案的系统和方法

    公开(公告)号：US09375158B2

    公开(公告)日：2016-06-28

    申请号：US12183630

    申请日：2008-07-31

    申请人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： A61B5/05 ,  A61B5/026 ,  A61B5/00

    CPC分类号： A61B5/0261 ,  A61B5/0066 ,  A61B5/0073

    摘要： An exemplary apparatus and/or an exemplary method can be provided using which, it is possible (e.g., with at least one first arrangement) to measure an amplitude and/or a phase of at least one electromagnetic radiation provided from a particular portion of a sample. Further, it is possible (e.g., using at least one second arrangement) to scan a location of the particular portion along a path from a first point of the sample to a second point of the sample. In addition, it is possible to control the scan (e.g., with the second arrangement) such that the scan may comprise at least one first segment having a positive velocity and at least one segment having a negative velocity. A first distance of the first segment and/or the second segment can be smaller than a second distance between the first and second points.

    摘要翻译： 可以提供示例性的装置和/或示例性方法，其可以（例如，利用至少一个第一布置）来测量从特定部分提供的至少一个电磁辐射的幅度和/或相位 样品。 此外，可以（例如，使用至少一个第二布置）沿着从样品的第一点到样品的第二点的路径扫描特定部分的位置。 此外，可以控制扫描（例如，利用第二布置），使得扫描可以包括具有正速度的至少一个第一段和至少一个具有负速度的段。 第一段和/或第二段的第一距离可以小于第一和第二点之间的第二距离。

    Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
    26.
    发明授权
    Systems and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling 有权
    通过光学子采样扩展光学相干断层扫描成像深度范围的系统和方法

    公开(公告)号：US08937724B2

    公开(公告)日：2015-01-20

    申请号：US12635435

    申请日：2009-12-10

    申请人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    发明人： Benjamin J. Vakoc ,  Wang Y. Oh ,  Guillermo J. Tearney ,  Brett E. Bouma

    IPC分类号： G01B11/02 ,  A61B5/00

    CPC分类号： A61B5/6852 ,  A61B5/0066

    摘要： Exemplary embodiments of systems and methods can be provided which can generate data associated with at least one sample. For example, using at least one first arrangement, it is possible to forward at least one first radiation to the sample(s) so as to cause at least one second radiation to be provided from the sample(s) that can be based on the first radiation(s). In addition, using at least one second arrangement, it is possible to receive the second radiation from the sample(s), generate a plurality of distinct measurements regarding at least one portion of the sample(s) based the second radiation(s), and characterize the portion(s) over a plurality of continuous resolvable depth points thereof which are associated with the distinct measurements. Further, the characterization of the at least one portion can be resolved and distinctly characterized at a number of the depth points which is greater than a number of the distinct measurements.

    摘要翻译： 可以提供可以生成与至少一个样本相关联的数据的系统和方法的示例性实施例。 例如，使用至少一个第一布置，可以将至少一个第一辐射转发到样品，以便使得至少一个第二辐射从可以基于该样品的样品提供 第一次辐射。 另外，使用至少一个第二布置，可以从样品接收第二辐射，基于第二辐射产生关于样品的至少一部分的多个不同的测量结果， 并且通过与不同测量相关联的多个连续可分辨深度点来表征部分。 此外，可以在多个不同的测量值的多个深度点上解析和明确地表征至少一个部分的表征。