公开(公告)号：US07932350B2

公开(公告)日：2011-04-26

申请号：US11463109

申请日：2006-08-08

Applicant: Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand

Inventor： Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand

IPC: C07K14/005 ,  C07K14/15 ,  C07K14/00 ,  C07H23/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C12N2740/10022 ,  C12Q1/6883 ,  C12Q1/702

Abstract: Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.

Abstract translation: 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。

公开(公告)号：US07381817B2

公开(公告)日：2008-06-03

申请号：US10637565

申请日：2003-08-11

Applicant: Glaucia Paranhos-Baccala ,  Herve Perron ,  Florence Komurian-Pradel

Inventor： Glaucia Paranhos-Baccala ,  Herve Perron ,  Florence Komurian-Pradel

IPC: C07H21/04 ,  A61K39/00

CPC classification number: C07K14/005 ,  C12N2740/10022

Abstract: The invention relates to: a nucleotide fragment of an MSRV-1 LTR-RU5 region, comprising a nucleotide sequence encoding the expression of a protein, wherein the protein comprises a peptide sequence selected from the group consisting of: SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4; complementary nucleotide fragments; probes and primers that hybridize to the fragment; proteins encoded by the fragment; antibodies directed against the proteins encoded by the fragment; and processes for detecting the presence of MSRV-1 using a probe or an antibody of the invention.

Abstract translation: 本发明涉及：MSRV-1LTR-RU5区域的核苷酸片段，其包含编码蛋白质表达的核苷酸序列，其中所述蛋白质包含选自下组的肽序列：SEQ ID NO：2，SEQ ID NO： SEQ ID NO：3和SEQ ID NO：4; 互补核苷酸片段; 与片段杂交的探针和引物; 由片段编码的蛋白质; 针对由片段编码的蛋白质的抗体; 以及使用本发明的探针或抗体检测MSRV-1的存在的方法。

公开(公告)号：US20080038279A1

公开(公告)日：2008-02-14

申请号：US10586742

申请日：2005-01-24

Applicant: Patrice Marche ,  Alexandre Rolland ,  Evelyne Jouvin-Marche ,  Herve Perron

Inventor： Patrice Marche ,  Alexandre Rolland ,  Evelyne Jouvin-Marche ,  Herve Perron

IPC: A61K39/395 ,  A61P25/18 ,  C07K16/00 ,  C12Q1/02

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/1036

Abstract: The inventive composition comprises at least one type of antibody selected in a group (i) of anti-Env-SU MSRV/HERV-W antibodies or in a group of anti-TLR4 antibodies specifically linkable with the soluble fraction of an Env protein of MSRV/HERV-W or to a TLR4 receptor of the soluble fraction of the Env protein of MSRV/HERV-W.

Abstract translation: 本发明的组合物包含选自抗-Env-SU MSRV / HERV-W抗体组（i）中的至少一种类型的抗体或与MSRV的Env蛋白的可溶性部分特异性连接的一组抗TLR4抗体 / HERV-W或MSRV / HERV-W的Env蛋白的可溶性级分的TLR4受体。

公开(公告)号：US20070031452A1

公开(公告)日：2007-02-08

申请号：US11581030

申请日：2006-10-16

Applicant: Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand ,  Jeremy Garson ,  Philip Tuke

Inventor： Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand ,  Jeremy Garson ,  Philip Tuke

IPC: C12P19/34 ,  A61K39/12

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N7/00 ,  C12N9/1241 ,  C12N2740/10022 ,  C12N2740/10051 ,  C12Q1/702

Abstract: The invention provides viral material and nucleotide fragments associated with multiple sclerosis and/or rheumatoid arthritis for use in method of diagnosis, prophylaxis, and therapy.

Abstract translation: 本发明提供了用于诊断，预防和治疗方法的与多发性硬化和/或类风湿性关节炎有关的病毒物质和核苷酸片段。

公开(公告)号：US20060223121A1

公开(公告)日：2006-10-05

申请号：US11450360

申请日：2006-06-12

Applicant: Dominique Roecklin ,  Hanno Kolbe ,  Marie-Helene Charles ,  Carine Malcus ,  Lyse Santoro ,  Herve Perron

Inventor： Dominique Roecklin ,  Hanno Kolbe ,  Marie-Helene Charles ,  Carine Malcus ,  Lyse Santoro ,  Herve Perron

IPC: G01N33/53 ,  C07K14/74 ,  C07K16/28

CPC classification number: G01N33/564 ,  A61K38/1709 ,  C07K14/47 ,  G01N33/6896 ,  G01N2800/52

Abstract: The invention concerns the use of at least one polypeptide comprising a protein fragment to obtain a diagnostic, prognostic, prophylactic or therapeutic composition for detecting, preventing or treating a pathological condition associated with a degenerative and/or neurological and/or autoimmune disease, said protein being selected among the proteins whereof the peptide sequence in native state corresponds to SEQ ID No 1, SEQ ID No 2, SEQ ID No 3, SEQ ID No 4, SEQ ID No 5, SEQ ID No 6, SEQ ID No 7, SEQ ID No 8, SEQ ID No 9, SEQ ID No 10, SEQ ID No 11, SEQ ID No 12, SEQ ID No 13, SEQ ID No 14, SEQ ID No 15, SEQ ID No 16, SEQ ID No 17, SEQ ID No 18, SEQ ID No 19, SEQ ID No 20, SEQ ID No 21, SEQ ID No 22, SEQ ID No 23, SEQ ID No 24, SEQ ID No 25, SEQ ID No 26, SEQ ID No 27, SEQ ID No 28, and SEQ ID No 29, and the peptide sequences having at least 70% identity, preferably at least 80% identity and advantageously at least 98% identity with any one of the peptide sequences SEQ ID No 1 to SEQ ID No 8 and SEQ ID No 10 to SEQ ID No 29, and the peptide sequences or fragments of said sequences belonging to a common family of proteins selected among perlecan, the precursor of the retinol-binding plasmatic protein, of the GM2 activator protein, of calgranulin B and of saponin B.

公开(公告)号：US06579526B1

公开(公告)日：2003-06-17

申请号：US09374766

申请日：1999-08-16

Applicant: Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand

Inventor： Herve Perron ,  Frederic Beseme ,  Frederic Bedin ,  Glaucia Paranhos-Baccala ,  Florence Komurian-Pradel ,  Colette Jolivet-Reynaud ,  Bernard Mandrand

IPC: A61K3912

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C12N2740/10022 ,  C12Q1/6883 ,  C12Q1/702

Abstract: Viral material, in the isolated or purified state, in which the genome comprises a nucleotide sequence chosen from the group including sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, their complementary sequences and their equivalent sequences, in particular nucleotide sequences displaying, for any succession of 100 contiguous monomers, at least 50% and preferably at least 70% homology with the said sequences SEQ ID NO:46, SEQ ID NO:51, SEQ ID NO:52, SEQ ID NO:53 and SEQ ID NO:56, respectively, and their complementary sequences.

Abstract translation: 分离或纯化状态的病毒物质，其中基因组包含选自SEQ ID NO：46，SEQ ID NO：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：53的核苷酸序列 SEQ ID NO：46，SEQ ID NO：56，其互补序列及其等同序列，特别是核苷酸序列，显示100个连续单体的任何连续序列，与所述序列SEQ ID NO：46，SEQ ID NO为至少50％，优选至少70％ ：51，SEQ ID NO：52，SEQ ID NO：53和SEQ ID NO：56及其互补序列。

公开(公告)号：US06071736A

公开(公告)日：2000-06-06

申请号：US754010

申请日：1996-11-20

Applicant: Herve Perron ,  Jean-Marie Seigneurin

Inventor： Herve Perron ,  Jean-Marie Seigneurin

IPC: A61K39/21 ,  C07K14/035 ,  C07K16/10 ,  C12N5/08 ,  C12N7/00 ,  C12N15/38 ,  C12N15/85 ,  C12P21/08 ,  G01N33/569 ,  A01N63/00 ,  C12N5/00 ,  A61K37/12

CPC classification number: G01N33/56983 ,  C07K14/005 ,  C07K16/10 ,  C12N15/85 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2740/10022 ,  C12N2740/10051 ,  G01N2469/20

Abstract: In a process for the in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis (MS), a body sample is taken from an individual suffering from MS. The sample is cultivated in a culture medium that promotes the growth of infected cells to obtain a culture of primary infected cells. A sample of the culture of primary cells or a subculture of the latter is cultivated in series, by successive passages in the culture medium to obtain the culture or cell line infected by a virus associated with MS. The culture medium also contains a beta-interferon antibody or an antibody that is directed against an antigenically close molecule, the antibody playing an inhibiting role in viral expression and allowing long-lasting expression and propagation of the viral strain in the culture or cell line.

Abstract translation: 在由多发性硬化症（MS）相关的病毒株感染的培养物或细胞系的体外生产过程中，从患有MS的个体取出身体样品。 将样品在促进感染细胞生长的培养基中培养以获得原代感染细胞的培养物。 通过在培养基中连续传代，将原代细胞培养物或后代培养物的样品串联培养，以获得由与MS相关的病毒感染的培养物或细胞系。 培养基还含有针对抗原性紧密的分子的β-干扰素抗体或抗体，所述抗体在病毒表达中起抑制作用，并允许病毒株在培养物或细胞系中的长期表达和繁殖。

公开(公告)号：US5962217A

公开(公告)日：1999-10-05

申请号：US470006

申请日：1995-06-06

Applicant: Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

Inventor： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

IPC: G01N33/569 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/21 ,  A61P25/00 ,  A61P31/12 ,  C07H21/04 ,  C07K7/06 ,  C07K14/005 ,  C07K14/15 ,  C12N5/08 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/48 ,  C12Q1/68 ,  G01N33/68 ,  C12Q1/70

CPC classification number: C07K14/005 ,  C12N7/00 ,  A61K38/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  Y10S435/912

Abstract: Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of the virus, and a second agent, or a variant of the second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.

Abstract translation: 包括与多发性硬化症相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族或病毒变体相关的人类病毒组成的第一药剂和第二药剂， 或来自相同病毒株的两种致病和/或感染因子，分别选自于1992年7月22日以保藏号V92072202和保藏号为V92072202的ECACC分别保藏的POL-2的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。

公开(公告)号：US5871996A

公开(公告)日：1999-02-16

申请号：US384137

申请日：1995-02-06

Applicant: Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

Inventor： Herve Perron ,  Francois Mallet ,  Bernard Mandrand ,  Frederic Bedin ,  Frederic Beseme

IPC: G01N33/569 ,  A61K31/70 ,  A61K35/76 ,  A61K38/00 ,  A61K39/21 ,  A61P25/00 ,  A61P31/12 ,  C07H21/04 ,  C07K7/06 ,  C07K14/005 ,  C07K14/15 ,  C12N5/08 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12N15/48 ,  C12Q1/68 ,  G01N33/68 ,  A61K39/12 ,  A61K39/395

CPC classification number: C07K14/005 ,  C12N7/00 ,  A61K38/00 ,  C12N2740/10021 ,  C12N2740/10022 ,  Y10S435/912

Abstract: Composition including two pathogenic and/or infective agents associated with multiple sclerosis, namely a first agent which consists of a human virus possessing reverse transcriptase activity and related to a family of endogenous retroviral elements, or a variant of the virus, and a second agent, or a variant of the second agent, these two pathogenic and/or infective agents originating from the same viral strain chosen from the strains designated, respectively, POL-2 deposited with the ECACC on Jul. 22, 1992 under Accession Number V92072202 and MS7PG deposited with the ECACC on Jan. 8, 1993 under Accession Number V93010816, and from their variant strains.

Abstract translation: 包括与多发性硬化症相关的两种致病和/或感染因子的组合物，即由具有逆转录酶活性并与内源性逆转录病毒元件家族或病毒变体相关的人类病毒组成的第一药剂和第二药剂， 或来自相同病毒株的两种致病和/或感染因子，分别选自于1992年7月22日以保藏号V92072202和保藏号为V92072202的ECACC分别保藏的POL-2的菌株 1993年1月8日，ECACC以保藏号V93010816和其变体菌株。

公开(公告)号：US20100285448A1

公开(公告)日：2010-11-11

申请号：US12776893

申请日：2010-05-10

Applicant: Glaucia PARANHOS-BACCALA ,  Florence Komurian-Pradel ,  Frederic Bedin ,  Mireille Sodoyer ,  Catherine Ott ,  Francois Mallet ,  Herve Perron ,  Bernard Mandrand

Inventor： Glaucia PARANHOS-BACCALA ,  Florence Komurian-Pradel ,  Frederic Bedin ,  Mireille Sodoyer ,  Catherine Ott ,  Francois Mallet ,  Herve Perron ,  Bernard Mandrand

IPC: C12Q1/70 ,  C07H21/04 ,  C12N15/63

CPC classification number: C07K14/4713 ,  C07K14/005 ,  C12N2740/10022

Abstract: An isolated polynucleotide having a nucleotide sequence selected from the group consisting of (a) SEQ ID NO: 21, (b) the full-length sequences encoding a polypeptide having a peptide sequence selected from the group consisting of SEQ ID NOs: 25 and 26, and (c) the full-length complementary sequences to the sequences set forth in (a) or (b).

Abstract translation: 一种分离的多核苷酸，其具有选自（a）SEQ ID NO：21，（b）编码具有选自SEQ ID NO：25和26的肽序列的多肽的全长序列的核苷酸序列 ，和（c）与（a）或（b）中列出的序列的全长互补序列。