-
公开(公告)号：US06176871B1
公开(公告)日：2001-01-23
申请号：US09172537
申请日：1998-10-14
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61B2017/22001 , A61F2/945 , A61F2/95 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , A61L31/14 , B29C35/08 , B29C49/00 , B29C49/0042 , B29C55/24 , B29C70/74 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
-
公开(公告)号：US5843743A
公开(公告)日：1998-12-01
申请号：US467815
申请日：1995-06-06
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/04 , A61K9/48 , B05D7/00 , C12N11/00 , C12N11/02
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48784 , A61K47/48876 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
-
公开(公告)号：US5801033A
公开(公告)日：1998-09-01
申请号：US480678
申请日：1995-06-07
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61K47/48 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08F290/00 , C08F290/02 , C08F290/06 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N11/04 , C12N11/02
CPC分类号： A61L27/36 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48869 , A61K9/1635 , A61K9/1647 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/3804 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F291/00 , C09D153/00 , C12N11/04 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： This invention provides novel methods for the formation of biocompatible membranes around biological materials using photopolymerization of water soluble molecules. The membranes can be used as a covering to encapsulate biological materials or biomedical devices, as a "glue" to cause more than one biological substance to adhere together, or as carriers for biologically active species. Several methods for forming these membranes are provided. Each of these methods utilizes a polymerization system containing water-soluble macromers, species which are at once polymers and macromolecules capable of further polymerization. The macromers are polymerized using a photoinitiator (such as a dye), optionally a cocatalyst, optionally an accelerator, and radiation in the form of visible or long wavelength UV light. The reaction occurs either by suspension polymerization or by interfacial polymerization. The polymer membrane can be formed directly on the surface of the biological material, or it can be formed on material which is already encapsulated.
-
公开(公告)号：US5741323A
公开(公告)日：1998-04-21
申请号：US477370
申请日：1995-06-07
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： 公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
-
公开(公告)号：US5573934A
公开(公告)日：1996-11-12
申请号：US24657
申请日：1993-03-01
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill-West , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill-West , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/04 , C12N11/02 , C12N5/06 , C12N11/08 , C08J7/04 , C08J7/16 , A61K47/32
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48784 , A61K47/48876 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
-
26.发明授权Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers 失效可光聚合的可生物降解的水凝胶作为组织接触材料和控制释放载体公开(公告)号：US06306922B1
公开(公告)日：2001-10-23
申请号：US09492011
申请日：2000-01-26
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill
IPC分类号： C08G6308
CPC分类号： A61K9/0024 , A61K9/1635 , A61K9/1647 , A61K38/47 , A61K38/49 , A61K47/32 , A61K2035/128 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/36 , A61L27/38 , A61L27/3839 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , A61L2300/424 , A61L2300/602 , C08F290/00 , C08F290/06 , C08F291/00 , C09D153/00 , C09J153/00 , C12N5/0012 , C12N5/0677 , C12N11/04 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , C12Y302/01017 , C12Y304/21068 , Y10T428/29 , Y10T428/2913 , Y10T428/2967 , Y10T428/31786 , C08L71/02
摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
摘要翻译： 描述了聚合和交联的大分子单体的水凝胶，其包含具有可生物降解的单体或低聚延伸的亲水性低聚物，其生物可降解的延伸部分在端基单体或能够聚合和交联的低聚物的自由端上终止。 亲水核心本身可以是可降解的，因此结合核心和延伸功能。 大分子单体在长波长紫外光，可见光激发或热能的影响下，使用自由基引发剂聚合。 生物降解发生在延伸低聚物内的连接处，并导致无毒且容易从体内去除的碎片。 水凝胶的优选应用包括防止外科手术后的粘连形成，药物和其他生物活性物质的控制释放，临时保护或组织表面分离，将密封组织粘附在一起，以及防止细胞附着到组织表面。
-
公开(公告)号：US5858746A
公开(公告)日：1999-01-12
申请号：US377911
申请日：1995-01-25
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill , Syed F. A. Hossainy
IPC分类号： A61K9/16 , A61K9/50 , A61K35/12 , A61K38/42 , A61K38/44 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , C08B37/08 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/00 , C12N5/071 , C12N5/077 , C12N11/04 , C12N11/02 , C12N5/06 , C08J7/16
CPC分类号： C12N11/04 , A61K38/42 , A61K38/44 , A61K47/48315 , A61K47/48784 , A61K47/48876 , A61K9/1635 , A61K9/1647 , A61K9/5026 , A61K9/5031 , A61K9/5073 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/3683 , A61L27/38 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , B82Y5/00 , C08B37/003 , C08B37/0072 , C08B37/0084 , C08F290/00 , C08F290/02 , C08F290/06 , C08F290/062 , C08F290/08 , C08F290/10 , C08F291/00 , C09D153/00 , C12N5/0012 , C12N5/0677 , A61K2035/128 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10S514/801 , Y10S530/812 , Y10S530/813 , Y10S530/815 , Y10S530/817 , Y10T428/2987 , Y10T428/2989
摘要： Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.
摘要翻译： 通过添加可自由基聚合的基团（例如含有碳 - 碳双键或三键的那些基团）来修饰水溶性大分子单体，其可在温和条件下聚合以包封组织，细胞或生物活性材料。 聚合物材料特别可用作组织粘合剂，用于包括血管的组织腔的涂层，用于细胞的涂层，例如朗格汉斯岛，涂层，塞子，用于与生物材料例如身体接触的支撑体或基底，以及作为用于 生物活性分子。
-
公开(公告)号：US5849035A
公开(公告)日：1998-12-15
申请号：US448572
申请日：1995-10-30
申请人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
发明人： Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Jeffrey A. Hubbell , Stephen J. Herman , Laurence A. Roth , Patrick K. Campbell , Kevin M. Berrigan , Peter K. Jarrett , Arthur J. Coury
IPC分类号： A61L27/00 , A61B17/22 , A61F2/00 , A61F2/02 , A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61F2/06
CPC分类号： A61F2/82 , A61F2/945 , A61F2/95 , A61L31/14 , B29C35/08 , B29C49/00 , B29C55/24 , B29C70/74 , A61B2017/22001 , A61F2210/0047 , A61F2220/0008 , A61F2250/0098 , B29C2035/0822 , B29C2035/0827 , B29C2035/0833 , B29C49/0042 , B29K2995/006 , B29L2023/00 , B29L2031/7542 , Y10S623/901
摘要： A method and apparatus for molding polymeric structures in vivo is disclosed. The structures comprise polymers that may be heated to their molding temperature by absorption of visible or near-visible wavelengths of light. By providing a light source that produces radiation of the wavelength absorbed by the polymeric material, the material may be selectively heated and shaped in vivo without a corresponding heating of adjacent tissues or fluids to unacceptable levels. The apparatus comprises a catheter having a shaping element positioned near its distal end. An emitter provided with light from at least one optical fiber is positioned within the shaping element. The emitter serves to provide a moldable polymeric article positioned on the shaping element with a substantially uniform light field, thereby allowing the article to be heated and molded at a desired treatment site in a body lumen.
摘要翻译： PCT No.PCT / US94 / 04824 Sec。 371 1995年10月30日第 102（e）日期1995年10月30日PCT 1994年4月28日PCT PCT。 第WO94 / 24962号公报 日期：1994年11月10日公开了一种用于在体内模制聚合物结构的方法和装置。 该结构包括可以通过吸收可见光或近似可见波长的光而被加热到它们的模制温度的聚合物。 通过提供产生由聚合物材料吸收的波长的辐射的光源，该材料可以在体内被选择性地加热和成形，而相邻组织或液体的相应加热不能接受。 该装置包括具有定位在其远端附近的成形元件的导管。 设置有来自至少一个光纤的光的发射器被定位在成形元件内。 发射器用于提供具有基本上均匀的光场的位于成形元件上的可成型的聚合物制品，从而允许制品在体腔内的期望的治疗部位被加热和模制。
-
公开(公告)号：US5820882A
公开(公告)日：1998-10-13
申请号：US336393
申请日：1994-11-10
CPC分类号： A61K9/5073 , A61K47/48215 , A61K47/48315 , A61K47/48869 , A61K9/5031
摘要： Biocompatible microcapsules useful for transplanting foreign material into an animal body, and the method of their production, are described, wherein the microcapsules contain an outermost layer of water soluble non-ionic polymers such as PEO to create resistance to cell adhesion on the surface of the microcapsules.
-
30.发明授权
公开(公告)号：US5567435A
公开(公告)日：1996-10-22
申请号：US468364
申请日：1995-06-06
申请人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill-West
发明人： Jeffrey A. Hubbell , Chandrashekhar P. Pathak , Amarpreet S. Sawhney , Neil P. Desai , Jennifer L. Hill-West
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K35/12 , A61K38/48 , A61K47/30 , A61K47/32 , A61L24/00 , A61L24/04 , A61L26/00 , A61L27/34 , A61L27/38 , A61L27/52 , A61L29/08 , A61L31/10 , A61L31/14 , A61L31/16 , B82B1/00 , C08F290/00 , C08F290/06 , C08F291/00 , C09D153/00 , C09J153/00 , C12N5/00 , C12N5/071 , C12N11/04 , A61K9/58 , C08G63/08 , C08G67/00
CPC分类号： A61K9/0024 , A61K38/47 , A61K38/49 , A61K47/32 , A61K9/1635 , A61K9/1647 , A61L24/0031 , A61L24/0042 , A61L24/046 , A61L26/0019 , A61L27/34 , A61L27/36 , A61L27/38 , A61L27/3839 , A61L27/52 , A61L29/085 , A61L31/10 , A61L31/145 , A61L31/148 , A61L31/16 , C08F290/00 , C08F290/06 , C08F291/00 , C09D153/00 , C09J153/00 , C12N11/04 , C12N5/0012 , C12N5/0677 , C12Y302/01017 , C12Y304/21068 , A61K2035/128 , A61L2300/424 , A61L2300/602 , C12N2533/30 , C12N2533/32 , C12N2533/40 , C12N2533/74 , Y10T428/29 , Y10T428/2913 , Y10T428/2967 , Y10T428/31786
摘要： Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.
-
-
-
-
-
-
-
-
-
搜索结果
105 条记录 (耗时 0.038 秒)
