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公开(公告)号：US5538958A
公开(公告)日：1996-07-23
申请号：US468098
申请日：1995-06-06
申请人： Jeffrey P. Whitten
发明人： Jeffrey P. Whitten
IPC分类号： C07F9/38 , C07F9/40 , C07F9/6509 , C07F9/653 , A61K31/66
CPC分类号： C07F9/653 , C07F9/3808 , C07F9/4006 , C07F9/650958
摘要： The present invention is directed to a new class of beta-ketone, beta oxime and beta hydrazine phosphonate NMDA antagonists.
摘要翻译： 本发明涉及一类新型的β-酮，β肟和β肼膦酸盐NMDA拮抗剂。
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公开(公告)号：US5500419A
公开(公告)日：1996-03-19
申请号：US359678
申请日：1994-12-20
申请人： Jeffrey P. Whitten , Bruce M. Baron
发明人： Jeffrey P. Whitten , Bruce M. Baron
IPC分类号： C07F9/38 , C07F9/40 , C07F9/6509 , C07F9/653 , A61K31/675
CPC分类号： C07F9/653 , C07F9/3808 , C07F9/4006 , C07F9/650958
摘要： The present invention is directed to a new neuroprotective agent. The agent is R-4-oxo-5-phosphononorvaline. This agent is useful in the treatment of ischemic and hypoxic conditions such as stroke.
摘要翻译： 本发明涉及新的神经保护剂。 该试剂是R-4-氧代-5-膦酰基缬氨酸。 该药剂可用于治疗缺血性和缺氧性疾病如中风。
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公开(公告)号：US20130203818A1
公开(公告)日：2013-08-08
申请号：US13643537
申请日：2011-04-27
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D231/12 , C07D417/12 , C07D405/12 , C07D413/12 , C07D409/04 , C07D231/14 , C07D417/14 , C07D231/16 , C07D413/04 , C07D413/14 , C07D405/04 , C07D401/12 , C07D409/14
CPC分类号： C07D417/12 , C07C233/75 , C07C233/80 , C07C233/92 , C07C255/60 , C07C2601/02 , C07D213/81 , C07D231/12 , C07D231/14 , C07D231/16 , C07D231/18 , C07D231/56 , C07D263/57 , C07D277/34 , C07D277/56 , C07D317/62 , C07D333/38 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20120289587A1
公开(公告)日：2012-11-15
申请号：US13553726
申请日：2012-07-19
申请人： Gonul Velicelebi , Kenneth A. Stauderman , David P.M. Pleynet , Soan Cheng , Jeffrey P. Whitten
发明人： Gonul Velicelebi , Kenneth A. Stauderman , David P.M. Pleynet , Soan Cheng , Jeffrey P. Whitten
IPC分类号： A61K31/381 , A61P13/12 , A61P27/02 , A61P1/16 , A61P11/00 , A61P19/02 , A61P17/06 , A61P1/00 , A61P9/00 , A61P17/00 , A61P21/00 , A61P11/02 , A61P15/02 , A61P19/10 , A61P37/06 , A61P3/10 , A61P37/00 , A61P21/04 , A61P7/06 , A61P11/06 , A61P25/00 , A61P29/00
CPC分类号： C07D333/68 , A61K31/00 , A61K31/405
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
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公开(公告)号：US20120149673A1
公开(公告)日：2012-06-14
申请号：US13399017
申请日：2012-02-17
IPC分类号： A61K31/397 , A61K31/422 , A61K31/381 , A61K31/5375 , A61K31/4995 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , A61P13/12 , A61P27/02 , A61P1/16 , A61P11/00 , A61P1/00 , A61P17/00 , A61P19/02 , A61P21/00 , A61P11/02 , A61P15/02 , A61P19/10 , A61P37/06 , A61P3/10 , A61P7/06 , A61P11/06 , A61P17/06 , A61P25/00 , A61P29/00 , C12N5/071
CPC分类号： A61K31/397 , A61K31/42 , A61K31/437 , A61K31/535
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases, disorders or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病，病症或病症的方法。
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公开(公告)号：US08168651B2
公开(公告)日：2012-05-01
申请号：US12396084
申请日：2009-03-02
IPC分类号： A61K31/44 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US20100261725A1
公开(公告)日：2010-10-14
申请号：US12548189
申请日：2009-08-26
申请人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Gonul Velicelebi , Kenneth A. Stauderman , Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： A61K31/498 , C07D263/54 , A61K31/423 , C07D471/04 , A61K31/437 , C07D491/048 , A61K31/4355 , C07D495/04 , A61K31/381 , C07D333/36 , C07D217/00 , A61K31/47 , C07D277/62 , A61K31/428 , C07D241/36 , C07D285/06 , A61K31/433 , A61P37/06 , A61P29/00
CPC分类号： C07D409/04 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/048 , C07D495/04
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
摘要翻译： 本文描述了含有这种化合物的化合物和药物组合物，其调节储存操作的钙（SOC）通道的活性。 本文还描述了使用这种SOC通道调节剂单独和与其它化合物组合用于治疗将受益于SOC通道活性抑制的疾病或病症的方法。
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公开(公告)号：US20090239859A1
公开(公告)日：2009-09-24
申请号：US12396084
申请日：2009-03-02
IPC分类号： A61K31/5377 , C07D413/14 , C12N5/00 , A61P35/00
CPC分类号： C07D471/04 , C07D471/14 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim kinase activity and/or FMS-like tyrosine kinase (Flt) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节Pim激酶活性和/或FMS样酪氨酸激酶（Flt）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US20090105233A1
公开(公告)日：2009-04-23
申请号：US11849230
申请日：2007-08-31
IPC分类号： A61K31/519 , C07D471/04 , C07D413/14 , C07D495/04 , A61K31/4365 , A61K31/538 , A61P35/00 , A61K31/541 , A61K31/5377 , C07D279/12 , C12Q1/02
CPC分类号： C07D471/04 , C07D221/12 , C07D401/04 , C07D495/04 , C07D513/04
摘要： The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate casein kinase (CK) activity and/or poly(ADP-ribose)polymerase (PARP) activity. The invention also relates in part to methods for using such molecules.
摘要翻译： 本发明部分地涉及具有某些生物活性的分子，包括但不限于抑制细胞增殖，调节蛋白激酶活性和调节聚合酶活性。 本发明的分子可以调节酪蛋白激酶（CK）活性和/或聚（ADP-核糖）聚合酶（PARP）活性。 本发明还部分涉及使用这种分子的方法。
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公开(公告)号：US20080318938A1
公开(公告)日：2008-12-25
申请号：US12143223
申请日：2008-06-20
申请人： David M. RYCKMAN , Denis Drygin , Jeffrey P. Whitten , Kenna Anderes , Katy Trent , Levan Darjania , Mustapha Haddach , Sean O'Brien , William G. Rice
发明人： David M. RYCKMAN , Denis Drygin , Jeffrey P. Whitten , Kenna Anderes , Katy Trent , Levan Darjania , Mustapha Haddach , Sean O'Brien , William G. Rice
IPC分类号： A61K31/5383 , A61P35/02 , A61P35/00
CPC分类号： A61K31/5383
摘要： The invention relates in part to methods for inhibiting proliferation of cancer cells and treating one or more cell proliferative conditions using compounds described herein.
摘要翻译： 本发明部分地涉及使用本文所述化合物抑制癌细胞增殖和治疗一种或多种细胞增殖性病症的方法。
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