公开(公告)号：US6153652A

公开(公告)日：2000-11-28

申请号：US976295

申请日：1997-11-21

Applicant: Jing Wu ,  Jay S. Tung ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Clark N. Eid ,  James E. Audia

Inventor： Jing Wu ,  Jay S. Tung ,  Jeffrey S. Nissen ,  Thomas E. Mabry ,  Lee H. Latimer ,  Clark N. Eid ,  James E. Audia

IPC: A61K31/198 ,  A61K31/223 ,  A61K31/277 ,  A61K31/44 ,  A01N37/18 ,  A01N37/12 ,  A01N37/44 ,  A61K31/165

CPC classification number: A61K31/277 ,  A61K31/198 ,  A61K31/223 ,  A61K31/44

Abstract: Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

Abstract translation: 公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默氏病的效用。 还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及用这种药物组合物预防性和治疗性治疗阿尔海默氏病的方法。

公开(公告)号：US20220135957A1

公开(公告)日：2022-05-05

申请号：US17349933

申请日：2021-06-17

Applicant: Jing Wu ,  Lingqia Su ,  Yan Huang

Inventor： Jing Wu ,  Lingqia Su ,  Yan Huang

IPC: C12N9/18 ,  C12N9/92 ,  C12N9/10 ,  C12N15/75

Abstract: Disclosed is a method for promoting extracellular expression of proteins in B. subtilis using cutinase, which belongs to the technical fields of genetic engineering, enzyme engineering and microbial engineering. It teaches co-expressing a cutinase mutant and a target protein in B. subtilis to promote extracellular expression of the target protein which is naturally located inside cells. The target protein includes xylose isomerase, 4,6-α-glucosyltransferase, 4-α-glucosyltransferase, trehalose synthase, branching enzyme and the like. The invention can achieve extracellular expression of intracellularly localized target protein, improve the production efficiency, reduce the production cost and simplify the subsequent extraction process.

公开(公告)号：US10508279B2

公开(公告)日：2019-12-17

申请号：US15891564

申请日：2018-02-08

Applicant: Jing Wu ,  Quan Zhang ,  Liming Liu ,  Xiulai Chen ,  Jia Liu ,  Qiuling Luo

Inventor： Jing Wu ,  Quan Zhang ,  Liming Liu ,  Xiulai Chen ,  Jia Liu ,  Qiuling Luo

IPC: C12N1/20 ,  C12N15/70 ,  C12N9/10 ,  C12N9/90 ,  C12P19/24 ,  C12P19/26

Abstract: The present invention relates to the field of biotechnology engineering. It provides a recombinant Escherichia coli that can produce fructosylated chondroitin with high yields and the method for constructing the recombinant strain. The present invention discloses a method for constructing an expression plasmid pETM6R1-RBS-glmM-GGGS-glmS that contains a glmM and a glmS gene under regulation of ribosome binding sites. The recombinant plasmid was transformed into E. coli K4 to obtain a recombinant E. coli strain ZQ33 that can produce fructosylated chondroitin up to 3.99 g·L−1 by fed-batch fermentation in a 5-L fermentor, which was increased by 108.90% compared to that of the wild type strain.

公开(公告)号：US20170005393A1

公开(公告)日：2017-01-05

申请号：US15008583

申请日：2016-01-28

Applicant: Jing Wu

Inventor： Jing Wu

IPC: H01Q1/24 ,  H01Q23/00 ,  H01Q9/04

CPC classification number: H01Q1/243 ,  H01Q9/42

Abstract: An antenna module is provided in the present disclosure. The antenna module includes a printed circuit board and a metal frame surrounding the printed circuit board. The metal frame includes a metal radiating portion, and a first feed point, a second feed point, a first ground point and a second ground point are disposed on the printed circuit board and electrically connected to the metal radiating portion. The first feed point and the second feed point are symmetrically disposed at two opposite sides of a central axis of the printed circuit board; the first ground point and the second ground point are respectively disposed corresponding to the first feed point and the second feed point. The present disclosure also provides a mobile device using the antenna module.

Abstract translation: 在本公开中提供了一种天线模块。 天线模块包括印刷电路板和围绕印刷电路板的金属框架。 金属框架包括金属辐射部分，并且第一馈电点，第二馈电点，第一接地点和第二接地点设置在印刷电路板上并电连接到金属辐射部分。 第一供电点和第二供电点对称地设置在印刷电路板的中心轴线的两个相对侧上; 第一接地点和第二接地点分别对应于第一馈电点和第二馈电点设置。 本公开还提供了使用天线模块的移动设备。

公开(公告)号：US09455497B2

公开(公告)日：2016-09-27

申请号：US14597362

申请日：2015-01-15

Applicant: Jing Wu

Inventor： Jing Wu

IPC: H01Q1/38 ,  H01Q5/385 ,  H01Q19/00 ,  H01Q5/392

CPC classification number: H01Q5/385 ,  H01Q5/392 ,  H01Q19/005

Abstract: A multi-band antenna includes a radiating antenna member, a first parasitic antenna member, and a second parasitic antenna member. The radiating antenna member includes a feeding unit, a high frequency (HF) radiating unit and a low frequency (LF) radiating unit, the HF radiating unit and the LF radiating unit extend from the feeding unit. The first parasitic antenna member includes an HF grounding part, and an HF parasitic unit extending from the HF grounding part and adjacent to the HF radiating unit. The second parasitic antenna member includes an LF grounding part, and an LF parasitic unit extending from the LF grounding part and electromagnetically coupled to the LF radiating unit. The feeding unit is arranged between the HF grounding part and the LF grounding part; the feeding unit and the HF radiating unit define a receiving slot, and the HF parasitic unit is arranged in the receiving slot.

Abstract translation: 多频带天线包括辐射天线构件，第一寄生天线构件和第二寄生天线构件。 辐射天线构件包括馈电单元，高频（HF）辐射单元和低频（LF）辐射单元，HF辐射单元和LF辐射单元从馈送单元延伸。 第一寄生天线构件包括HF接地部分和从HF接地部分延伸并且与HF辐射单元相邻的HF寄生单元。 第二寄生天线构件包括LF接地部分和从LF接地部分延伸并且电磁耦合到LF辐射单元的LF寄生单元。 馈电单元布置在HF接地部分和LF接地部分之间; 馈送单元和HF辐射单元限定接收槽，并且HF寄生单元布置在接收槽中。

公开(公告)号：US20160228509A9

公开(公告)日：2016-08-11

申请号：US13852079

申请日：2013-03-28

Applicant: Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

Inventor： Alan Buckler ,  Chao-Min Chen ,  Chantale T. Guy ,  Jeffrey Hewett ,  Chris Lu ,  Jing Wu

IPC: A61K38/18 ,  A61K38/16 ,  A61K31/7088 ,  A61K45/06 ,  A61K39/395 ,  G01N33/50

CPC classification number: A61K38/1875 ,  A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61K45/06 ,  G01N33/5091 ,  G01N33/74 ,  G01N2333/495 ,  G01N2800/7052 ,  A61K2300/00

Abstract: The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10.

公开(公告)号：US20140063921A1

公开(公告)日：2014-03-06

申请号：US13045528

申请日：2011-03-11

Applicant: Xueti Tang ,  Jing Wu

Inventor： Xueti Tang ,  Jing Wu

IPC: G11C11/16 ,  H01L43/12

CPC classification number: G11C11/1675 ,  G11C11/16 ,  G11C11/161 ,  H01L43/12

Abstract: A method and system for providing a magnetic junction residing on a substrate and usable in a magnetic device are described. The magnetic junction includes a first pinned layer, a first nonmagnetic spacer layer having a first thickness, a free layer, a second nonmagnetic spacer layer having a second thickness greater than the first thickness, and a second pinned layer. The first nonmagnetic spacer layer resides between the pinned layer and the free layer. The first pinned layer resides between the free layer and the substrate. The second nonmagnetic spacer layer is between the free layer and the second pinned layer. Further, the magnetic junction is configured such that the free layer is switchable between a plurality of stable magnetic states when a write current is passed through the magnetic junction.

Abstract translation: 描述了一种用于提供驻留在基板上并可用于磁性装置中的磁性结的方法和系统。 磁结包括第一被钉扎层，具有第一厚度的第一非磁性间隔层，具有大于第一厚度的第二厚度的自由层，第二非磁性间隔层，以及第二钉扎层。 第一非磁性间隔层位于被钉扎层和自由层之间。 第一被钉扎层位于自由层和基底之间。 第二非磁性间隔层位于自由层和第二被钉扎层之间。 此外，磁结被配置为使得当写入电流通过磁结时，自由层可在多个稳定磁状态之间切换。

公开(公告)号：US20140011239A1

公开(公告)日：2014-01-09

申请号：US13935519

申请日：2013-07-04

Applicant: Jing Wu ,  Lingqia Su ,  Jian Chen

Inventor： Jing Wu ,  Lingqia Su ,  Jian Chen

IPC: C12N9/20 ,  C12P21/00

CPC classification number: C12N9/20 ,  C12N9/2408 ,  C12N9/2414 ,  C12N9/2434 ,  C12N9/248 ,  C12P21/00 ,  C12P21/02

Abstract: The present invention provides a method of increasing extracellular secretion of secretory proteins by co-expressing the secretory proteins with a mature cutinase. Cutinase can improve the permeability of E. coli cell membrane without destroying the membrane, and thus facilitate cross-membrane transfer of the secretory proteins co-expressed in E. coli. Increased extracellular secretion of target proteins can shorten cell culture time, reduce the formation of inclusion bodies and increase production of target proteins.

Abstract translation: 本发明提供了通过用成熟角质酶共表达分泌蛋白来增加分泌蛋白的细胞外分泌的方法。 角质酶可以改善大肠杆菌细胞膜的通透性，而不破坏膜，从而促进大肠杆菌中共表达的分泌蛋白的跨膜转移。 靶蛋白的细胞外分泌增加可以缩短细胞培养时间，减少包涵体的形成并增加靶蛋白的产生。

公开(公告)号：US20130127252A1

公开(公告)日：2013-05-23

申请号：US13298828

申请日：2011-11-17

Applicant: William S. Yerazunis ,  Jing Wu ,  Bingnan Wang ,  Koon Hoo Teo

Inventor： William S. Yerazunis ,  Jing Wu ,  Bingnan Wang ,  Koon Hoo Teo

IPC: H02J17/00 ,  H01F38/14

CPC classification number: H01F38/14 ,  H01F27/006 ,  H02J5/005 ,  H02J50/12

Abstract: A system that transfers energy wirelessly includes a transmitter of the energy and a receiver of the energy. A housing made of a material that approximates properties of a perfect magnetic conductor. The housing is arranged to direct a magnetic field from the transmitter to the receiver to improve an efficiency of the energy transfer from the transmitter to the receiver.

Abstract translation: 无线传输能量的系统包括能量的发射器和能量的接收器。 由材料制成的外壳，其接近完美磁导体的特性。 壳体被布置成将来自发射器的磁场引导到接收器，以提高从发射器到接收器的能量传递的效率。

公开(公告)号：US07759382B2

公开(公告)日：2010-07-20

申请号：US10559823

申请日：2004-06-04

Applicant: Jay S. Tung ,  Lee H. Latimer ,  Jing Wu ,  Albert Garofalo ,  Michael A. Pleiss ,  Darren Dressen ,  Ashley Guinn ,  Scott A. Jenkins ,  Jennifer Sealy ,  John Tucker ,  David W. G. Wone

Inventor： Jay S. Tung ,  Lee H. Latimer ,  Jing Wu ,  Albert Garofalo ,  Michael A. Pleiss ,  Darren Dressen ,  Ashley Guinn ,  Scott A. Jenkins ,  Jennifer Sealy ,  John Tucker ,  David W. G. Wone

IPC: A61K31/415 ,  C07D231/10

CPC classification number: C07D231/40 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12

Abstract: This invention is directed to acylated amino acid amidyl pyrazoles and related compounds of Formula I. The invention is also directed to a pharmaceutical formation comprising such compound or in a pharmaceutically acceptable salt form thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity, and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.

Abstract translation: 本发明涉及酰化氨基酸酰氨基吡唑和式I的相关化合物。本发明还涉及包含这种化合物或其药学上可接受的盐形式的药物组合物。 本发明进一步涉及一种抑制β-淀粉样蛋白肽释放和/或合成的方法，一种抑制γ-分泌酶活性的方法，以及用于治疗与β-淀粉样蛋白肽生产相关的神经障碍的方法。 该方法包括向宿主施用包含有效量的式I化合物的药物制剂。式I化合物可用于预防和治疗阿尔茨海默氏病。