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55 条记录 (耗时 0.065 秒)

    Clonidine formulation in a polyorthoester carrier
    22.
    发明授权
    Clonidine formulation in a polyorthoester carrier 有权
    聚异丁酸酯载体中的可乐定制剂

    公开(公告)号：US09132119B2

    公开(公告)日：2015-09-15

    申请号：US12412024

    申请日：2009-03-26

    申请人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    发明人： Christopher M. Hobot ,  Phillip E. McDonald ,  Keith R. Hildebrand

    IPC分类号： A61F2/00 ,  A61K31/415 ,  A61K9/00 ,  A61K9/16 ,  A61K9/06

    CPC分类号： A61K31/4168 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/06 ,  A61K9/1647 ,  A61K31/415 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. The treatments include the administration of one or more drug depots at or near a target site wherein the drug depots include an effective amount of clonidine formulated within a polyorthoester. By administration of one or more drug depots at or near the target site, one can relieve pain caused by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 治疗包括在靶位点处或附近施用一个或多个药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的可乐定。 通过管理目标部位处或附近的一个或多个药物库，可以减轻由不同来源引起的疼痛，包括但不限于脊椎椎间盘突出症（即坐骨神经痛），脊柱脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

    Bupivacaine formulation in a polyorthoester carrier
    23.
    发明授权
    Bupivacaine formulation in a polyorthoester carrier 有权
    布比卡因配方在聚原酸酯载体中

    公开(公告)号：US08956642B2

    公开(公告)日：2015-02-17

    申请号：US12426005

    申请日：2009-04-17

    申请人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    发明人： Christopher M. Hobot ,  Michael E. Benz ,  Keith R. Hildebrand ,  Bryant J. Pudil

    IPC分类号： A61F2/00 ,  A01N43/40 ,  A61K31/445 ,  A61L31/16

    CPC分类号： A61K31/445 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/1641 ,  A61K9/1694 ,  A61K9/5031 ,  A61L31/16 ,  A61L2300/402 ,  A61L2300/602

    摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.

    摘要翻译： 提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

    Anti-infective medical device
    24.
    发明授权
    Anti-infective medical device 有权
    抗感染医疗器械

    公开(公告)号：US08691258B2

    公开(公告)日：2014-04-08

    申请号：US11008445

    申请日：2004-12-09

    申请人： Kenneth T. Heruth ,  Christopher M. Hobot ,  William J. Hooper ,  Mark S. Lent ,  Ruchika Singhal ,  Robert M. Skime ,  Randall V. Sparer ,  Maura G. Donovan ,  William J. Bertrand

    发明人： Kenneth T. Heruth ,  Christopher M. Hobot ,  William J. Hooper ,  Mark S. Lent ,  Ruchika Singhal ,  Robert M. Skime ,  Randall V. Sparer ,  Maura G. Donovan ,  William J. Bertrand

    IPC分类号： A61F13/00 ,  A01N25/00

    CPC分类号： A61N1/05 ,  A61N1/0568 ,  A61N1/375

    摘要： Implantable medical devices (IMDS) having anti-infective properties are described. Anti-infective agents are disposed in, on, or about at least a portion of a surface of the medical device. The anti-infective agents are disposed in or on a vehicle, which may be in the form of a coating layer or covering. The vehicle may be biodegradable so that, over time, the anti-infective agent is removed from a tissue location into which the device is implanted, reducing the likelihood that microorganisms resistant to the anti-infective agent will develop. IMDs having an anti-infective agent and an anti-activity agent disposed therein, thereabout, or thereon are also described. The anti-activity agent interferes with the activity of the anti-infective agent, may be released from a surface at the IMD at a time when activity of the anti-infective agent is no longer desired, and may reduce the likelihood that microorganisms resistant to the anti-infective agent will develop.

    摘要翻译： 描述具有抗感染性的植入式医疗装置（IMDS）。 抗感染剂设置在医疗装置的表面的至少一部分上，其上或附近。 抗感染剂设置在车辆中或车辆上，其可以是涂层或覆盖物的形式。 载体可以是可生物降解的，使得随着时间的推移，抗感染剂从植入装置所在的组织位置移除，降低了抗感染剂抗微生物的可能性。 还描述了其上设置有抗感染剂和抗活性剂的IMD，其上或其上。 干扰抗感染剂的活性的抗活性剂可以在不再需要抗感染剂的活性的时候从IMD的表面释放，并且可能降低抗微生物抗性的可能性 抗感染剂会发展。

    Dexamethasone Formulations in a Bioegradable Material
    28.
    发明申请
    Dexamethasone Formulations in a Bioegradable Material 有权
    生物可降解材料中的地塞米松配方

    公开(公告)号：US20090263455A1

    公开(公告)日：2009-10-22

    申请号：US12105864

    申请日：2008-04-18

    申请人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    发明人： John Zanella ,  Vanja King ,  Christopher M. Hobot ,  Stephen M. Cox ,  William McKay ,  Kathy Remsen

    IPC分类号： A61K9/00 ,  A61P43/00

    CPC分类号： A61K31/573 ,  A61K9/0002 ,  A61K9/0024 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

    摘要： Effective treatments of acute pain for extended periods of time are provided. Through the administration of an effective amount of dexamethasone at or near a target site, one can relieve pain cause by diverse sources, including but not limited to spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain as well as pain that is incidental to surgery. When appropriate formulations are provided within biodegradable polymers, this relief can be continued for at least twenty-five days. In some embodiments, the relief can be for at least fifty days, at least one hundred days, at least one hundred and thirty-five days or at least one hundred and eighty days.

    摘要翻译： 提供了长期急性疼痛的有效治疗方法。 通过在目标部位或附近施用有效量的地塞米松，可以减轻不同来源的疼痛，包括但不限于椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛 作为手术附带的疼痛。 当在可生物降解的聚合物中提供适当的制剂时，这种缓解可以持续至少二十五天。 在一些实施例中，浮雕可以是至少五十天，至少一百天，至少一百三十五天或至少一百八十天。