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公开(公告)号：US10954375B2
公开(公告)日：2021-03-23
申请号：US15172131
申请日：2016-06-02
Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Inventor： Xuanhe Zhao , Shaoting Lin , Hyunwoo Yuk , Teng Zhang , German A P Hernandez
IPC: C08L33/26 , C09D201/02 , B32B27/04 , B32B27/30 , B05D3/04 , B05D3/10 , C08L35/00 , C09D133/26 , C09D135/00 , C09J133/26 , C09J135/00 , H01B1/12
Abstract: A robust hydrogel-solid hybrid formed of a substrate material having a nonporous and non-topographically patterned surface and a tough hydrogel bonded to the surface, the tough hydrogel having over 90 wt % water, and the hydrogel being bonded to provide interfacial toughness over 300 Jm−2, and even over 1000 Jm−2. The hydrogel is formed of polyacrylamide or polyethylene glycol diacrylate, which provide long-chain polymer networks, and chitosan, hyaluronan, or alginate, which provide mechanically dissipative components. An anchor, which can be a silane, a sulfide, or an amine, is disposed between the surface and the hydrogel to provide chemical bonding between the surface and the long-chain networks of the hydrogel.
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公开(公告)号：US20190240356A1
公开(公告)日：2019-08-08
申请号：US16318958
申请日：2017-07-20
Applicant: Massachusetts Institute of Technology
Inventor： Timothy Kuan-Ta Lu , Xinyue Liu , Tzu-Chieh Tang , Eléonore Claire Tham , Xuanhe Zhao
IPC: A61K49/00 , C12Q1/6897 , C12N15/70 , A61B5/00
CPC classification number: A61K49/0097 , A61B5/6806 , A61B5/6833 , A61K49/0073 , C12N11/04 , C12N11/10 , C12N15/63 , C12N15/70 , C12Q1/6897
Abstract: Provided herein, in some embodiments, are hydrogel-elastomer and hydrogel-alginate devices, compositions and associated methods to encapsulate living cells.
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公开(公告)号：US11884845B2
公开(公告)日：2024-01-30
申请号：US17110841
申请日：2020-12-03
Applicant: Massachusetts Institute of Technology , Mayo Foundation for Medical Education and Research
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Xinyu Mao , Christoph Nabzdyk
IPC: C09J105/08 , C09J133/02 , A61L24/00 , C09J11/06 , C09J9/00 , C09J151/00
CPC classification number: C09J105/08 , A61L24/0042 , A61L24/0094 , C09J9/00 , C09J11/06 , C09J133/02 , C09J151/003 , A61L2400/04 , C09J2483/00
Abstract: A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.
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公开(公告)号：US20240009346A1
公开(公告)日：2024-01-11
申请号：US17669442
申请日：2022-02-11
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Heejung Roh , Aristidis Veves , Georgios Theocharidis
CPC classification number: A61L26/008 , C09J11/06 , A61L26/0052 , A61L26/0038 , A61L26/0033 , A61L26/0066 , A61L26/0095 , A61L2430/34 , A61L2400/16
Abstract: A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
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公开(公告)号：US20230331892A1
公开(公告)日：2023-10-19
申请号：US18302697
申请日：2023-04-18
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Xinyue Liu , Xiaoyu Chen
IPC: C08F283/00 , C08J3/09 , C09D5/16 , C09D151/08
CPC classification number: C08F283/006 , C08J3/092 , C09D5/1662 , C09D5/1637 , C09D151/08 , C08J2351/00
Abstract: This disclosure relates to modified polyurethanes, specifically polyurethanes modified with one or more lipophilic groups, and tough organogels comprising such modified polyurethanes.
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Patent Agency Ranking
公开(公告)号：US20220259463A1
公开(公告)日：2022-08-18
申请号：US17666642
申请日：2022-02-08
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Heejung Roh
Abstract: A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.
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27.发明申请公开(公告)号：US20220110619A1
公开(公告)日：2022-04-14
申请号：US17497497
申请日：2021-10-08
Applicant: Massachusetts Institute of Technology , Mayo Foundation for Medical Education and Research
Inventor： Xuanhe Zhao , Hyunwoo Yuk , Sarah J Wu , Christoph Nabzdyk
IPC: A61B17/00 , A61L24/06 , A61B17/072
Abstract: Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials.
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公开(公告)号：US11148389B2
公开(公告)日：2021-10-19
申请号：US16085692
申请日：2016-06-27
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Hyunwoo Yuk
IPC: A61L27/52 , A61L31/12 , A61L31/14 , B32B7/04 , B32B7/10 , B32B25/04 , B32B25/14 , B32B3/30 , B32B3/08 , B32B27/06 , B32B5/32 , B32B25/20 , B32B3/20 , A61L27/44 , A61L27/60 , B32B27/08 , B32B37/18
Abstract: Hydrogel-elastomer hybrids with interfacial bonding tougher than epidermis-dermis interfaces and functional micro-channels and micro-patterns can be created by pre-shaping both elastomers and hydrogels before bonding to conserve their micro-structures, modifying cured elastomer surfaces with benzophenone for chemical bonding with hydrogels, and harnessing dissipative properties of tough hydrogels to achieve robust interfaces.
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公开(公告)号：US11103324B2
公开(公告)日：2021-08-31
申请号：US16997213
申请日：2020-08-19
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Yoonho Kim
Abstract: Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein.
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公开(公告)号：US20210059779A1
公开(公告)日：2021-03-04
申请号：US16997213
申请日：2020-08-19
Applicant: Massachusetts Institute of Technology
Inventor： Xuanhe Zhao , Yoonho Kim
Abstract: Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein.
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