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公开(公告)号：US07301016B2
公开(公告)日：2007-11-27
申请号：US10184648
申请日：2002-06-27
申请人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
发明人： Rachel E. Meyers , Mark Williamson , Kevin R. Leiby , Rosana Kapeller-Libermann , Peter J. Olandt , Kyle J. MacBeth , Laura A. Rudolph-Owen , Fong-Ying Tsai , John J. Hunter
IPC分类号： C07H1/00 , C07H5/00 , C07H19/00 , C07H21/00 , C07H21/02 , C08B37/00 , C12Q1/68 , C12P21/06 , C12P19/34 , C12N1/12 , C12N1/20 , C12N15/00 , C12N15/06
CPC分类号： C12Q1/6883 , A01K2217/05 , A61K38/00 , A61K39/00 , C07K14/47 , C07K16/40 , C07K2319/00 , C12N9/1007 , C12N9/1025 , C12N9/1029 , C12N9/1048 , C12N9/1051 , C12N9/1096 , C12N9/93 , C12Q1/48 , C12Q2600/156 , C12Q2600/158 , C12Y602/01001 , C12Y602/01016
摘要： The invention provides isolated nucleic acids molecules, designated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, and 53320 nucleic acid molecules, which encode novel human transferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 gene has been introduced or disrupted. The invention still further provides isolated 33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 proteins, fusion proteins, antigenic peptides and anti-33877, 47179, 26886, 25552, 32132, 32244, 23680, 32624, 47174, 60491, 46743, 27417, 27960, 32252, or 53320 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252和53320核酸分子，其编码新的人转移酶家族成员 。 本发明还提供反义核酸分子，含有33877,47179,26886,25552,32132,32244,23680,3262,47174,60491,46743,27417,27960,32252或53320核酸分子的重组表达载体，宿主细胞 已经引入了表达载体的非人类转基因动物以及其中已经引入了33877,47179,26886,25552,32232,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320基因的非人类转基因动物，或 中断了 本发明还进一步提供了分离的33877,47179,26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320蛋白，融合蛋白，抗原肽和抗33877,47179， 26886,25552,32132,32244,23680,32624,47174,60491,46743,27417,27960,32252或53320抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07198929B2
公开(公告)日：2007-04-03
申请号：US10892276
申请日：2004-07-15
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C12Y207/01037
摘要： The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供了编码新型蛋白激酶的分离的核酸分子，命名为激酶核酸分子。 本发明还提供反义核酸分子，含有激酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了激酶基因的非人类转基因动物。 本发明还进一步提供分离的14790蛋白，融合蛋白，抗原肽和抗激酶抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US06864078B2
公开(公告)日：2005-03-08
申请号：US09515806
申请日：2000-02-29
CPC分类号： C12N9/1205 , A61K38/00 , A61K48/00 , C12Y207/01037
摘要： The invention provides an isolated nucleic acid molecule, designated as a kinase nucleic acid molecule, which encodes a novel protein kinase. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing kinase nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a kinase gene has been introduced or disrupted. The invention still further provides isolated 14790 proteins, fusion proteins, antigenic peptides and anti-kinase antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供了编码新型蛋白激酶的分离的核酸分子，命名为激酶核酸分子。 本发明还提供反义核酸分子，含有激酶核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中已经引入或破坏了激酶基因的非人类转基因动物。 本发明还进一步提供分离的14790蛋白，融合蛋白，抗原肽和抗激酶抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。
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公开(公告)号：US09458202B2
公开(公告)日：2016-10-04
申请号：US12625533
申请日：2009-11-24
申请人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
发明人： Huw M. Nash , David Allen Annis , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata
CPC分类号： G01N33/68 , A61K31/02 , C07K2/00 , C07K14/001 , C07K14/4705 , C07K14/4747 , C07K14/4748
摘要： The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译： 本发明提供了相对于其相应多肽具有改进性质的生物活性的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法，例如在治疗应用中。
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公开(公告)号：US20130072439A1
公开(公告)日：2013-03-21
申请号：US13497522
申请日：2010-09-22
申请人： Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
发明人： Huw M. Nash , Rosana Kapeller-Libermann , Jia-wen Han , Tomi K. Sawyer , Justin Noehre , Noriyuki Kawahata
摘要： Disclosed are peptidomimetic macrocycles comprising a helix, such as an alpha helix, and methods of using such macrocycles for the treatment of disease such as cancer. In other aspects, the peptidomimetic macrocycle comprises an a,a-disubstituted amino acid, or may comprise a crosslinker linking the a-positions of at least two amino acids or at least one of said two amino acids may be an a,a-disubstituted amino acid. Further included is the targeting of components of the Wnt signaling pathway such as the Tcf4-/3-catenin complex.
摘要翻译： 公开了包含螺旋的拟肽大环化合物，例如α螺旋，以及使用这种大环化合物治疗诸如癌症的疾病的方法。 在其它方面，拟肽大环化合物包含a，α-二取代的氨基酸，或可以包含连接至少两个氨基酸的a-位的交联剂或所述两个氨基酸中的至少一个可以是a， 氨基酸。 进一步包括靶向Wnt信号通路的组分，例如Tcf4- / 3-连环蛋白复合物。
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26.发明申请HUMAN DIACYLGLYCEROL ACYLTRANSFERASE 2 (DGAT2) FAMILY MEMBERS AND USES THEREFOR 审中-公开人类胆固醇ACYLTRANSFERASE 2（DGAT2）家族成员及其用途公开(公告)号：US20120177661A1
公开(公告)日：2012-07-12
申请号：US13424574
申请日：2012-03-20
IPC分类号： A61K39/395 , C12N5/10 , C12N1/21 , C12N1/19 , C12N9/10 , C07K16/40 , G01N33/566 , C12N9/96 , C12Q1/48 , C12Q1/68 , C12N9/99 , C12N5/071 , A61K38/45 , A61P3/04 , A61P3/06 , C12N15/54
CPC分类号： C12N9/1029 , A01K2217/05 , C07K16/40 , C12Q1/48 , C12Y203/0102 , G01N33/573 , G01N2333/91051 , G01N2800/044
摘要： The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylglycerol acyltransferase family members. The invention also provides recombinant expression vectors containing DGAT2 family member nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a DGAT2 family member gene has been introduced or disrupted. The invention still further provides isolated DGAT2 family member proteins, fusion proteins, antigenic peptides and anti-DGAT2 family member antibodies. Methods of use of the provided DGAT2 family member compositions for screening, diagnostic and therapeutic methods in connection with obesity disorders are also disclosed.
摘要翻译： 本发明涉及用于诊断和治疗肥胖症及相关代谢紊乱的组合物和方法。 本发明提供编码二酰基甘油酰基转移酶家族成员的分离的核酸分子，称为DGAT2家族成员核酸分子。 本发明还提供了含有DGAT2家族成员核酸分子的重组表达载体，已引入表达载体的宿主细胞，以及导入或破坏了DGAT2家族成员基因的非人类转基因动物。 本发明还进一步提供分离的DGAT2家族成员蛋白，融合蛋白，抗原肽和抗DGAT2家族成员抗体。 还公开了所提供的DGAT2家族成员组合物用于与肥胖症有关的筛选，诊断和治疗方法的方法。
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公开(公告)号：US20090326192A1
公开(公告)日：2009-12-31
申请号：US12420816
申请日：2009-04-08
申请人： Huw M. Nash , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Vincent Guerlavais , Matthew Iadanza
发明人： Huw M. Nash , Rosana Kapeller-Libermann , Tomi K. Sawyer , Noriyuki Kawahata , Vincent Guerlavais , Matthew Iadanza
IPC分类号： C07K2/00
CPC分类号： C07K7/56 , C07K1/1077 , C07K1/113 , C07K1/1136 , G01N33/68 , G01N2500/04
摘要： The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of preparing and using such macrocycles, for example in therapeutic applications.
摘要翻译： 本发明提供了相对于其相应多肽具有改进性质的生物活性的拟肽大环化合物。 本发明另外提供了制备和使用这种大环化合物的方法，例如在治疗应用中。
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公开(公告)号：US07410785B2
公开(公告)日：2008-08-12
申请号：US11325013
申请日：2006-01-04
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。 本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。 本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。 还提供了利用本发明组合物的诊断方法。
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公开(公告)号：US07288392B2
公开(公告)日：2007-10-30
申请号：US10649156
申请日：2003-08-27
CPC分类号： C12N9/1205 , A61K38/00 , C07C51/215 , C07C57/04
摘要： The invention relates to novel kinase nucleic acid sequences and proteins. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及新型激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
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30.发明申请Novel human protein kinase, phosphatase, and protease family members and uses thereof 失效新型人蛋白激酶，磷酸酶和蛋白酶家族成员及其用途公开(公告)号：US20070099274A1
公开(公告)日：2007-05-03
申请号：US11636948
申请日：2006-12-11
申请人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
发明人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为53070,15985,26583,21953，m32404,14089和23436核酸分子，其编码新的人蛋白激酶家族成员，丝氨酸/苏氨酸蛋白激酶家族成员，丝氨酸/苏氨酸磷酸酶家族成员 ，脯氨酰寡肽酶家族成员，胰蛋白酶家族成员，胰蛋白酶丝氨酸蛋白酶家族成员和泛素蛋白酶家族成员。 本发明还提供反义核酸分子，含有53070,15985,26583,21953，m32404,14089或23436核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中53070 ，15985,26583,21953，m32404,14089或23436基因已被引入或破坏。 本发明还进一步提供了分离的53070,15985,26583,21953，m32404,14089或23436蛋白，融合蛋白，抗原肽和抗-53070,15985,26583,21953，m32404,14089或23436抗体。 还提供了利用本发明组合物的诊断方法。
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