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    Multi-Mode Communication Ingestible Event Markers and Systems, and Methods of Using the Same
    21.
    发明申请
    Multi-Mode Communication Ingestible Event Markers and Systems, and Methods of Using the Same 有权
    多模式通信可接入事件标记和系统及其使用方法

    公开(公告)号：US20120293306A1

    公开(公告)日：2012-11-22

    申请号：US13564479

    申请日：2012-08-01

    申请人： Timothy Robertson ,  Mark J. Zdeblick

    发明人： Timothy Robertson ,  Mark J. Zdeblick

    IPC分类号： G06K7/01

    CPC分类号： H04B5/0062 ,  A61B5/0031 ,  A61B5/073 ,  A61B5/4833 ,  A61B5/4839 ,  A61B5/4848 ,  A61B5/6861 ,  A61B2562/08 ,  A61B2562/162 ,  G06K7/10297

    摘要： Aspects of the invention include multi-mode communication ingestible event marker devices. Ingestible event marker devices of the invention include an ingestible component comprising a conductive communication module and at least one additional non-conductive communication module. The non-conductive communication module may be integrated with the ingestible component or at least a portion or all of the non-conductive communication module may be associated with a packaging component of the ingestible event marker device. Additional aspects of the invention include systems that include the devices and one or more receivers, as well as methods of using the same.

    摘要翻译： 本发明的方面包括多模式通信可摄取事件标记装置。 本发明的可摄入事件标记装置包括可摄入组件，其包括导电通信模块和至少一个附加的非导电通信模块。 非导电通信模块可以与可摄取组件集成，或者非导电通信模块的至少一部分或全部可以与可摄入事件标记设备的包装组件相关联。 本发明的另外的方面包括包括装置和一个或多个接收器的系统，以及使用该装置的方法。

    Methods for configuring satellite electrodes
    22.
    发明授权
    Methods for configuring satellite electrodes 有权
    配置卫星电极的方法

    公开(公告)号：US07713194B2

    公开(公告)日：2010-05-11

    申请号：US11731034

    申请日：2007-03-29

    申请人： Mark J. Zdeblick

    发明人： Mark J. Zdeblick

    IPC分类号： A61N1/08

    CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

    摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

    摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。

    Measuring Conduction Velocity Using One or More Satellite Devices
    23.
    发明申请
    Measuring Conduction Velocity Using One or More Satellite Devices 有权
    使用一个或多个卫星设备测量传导速度

    公开(公告)号：US20080306394A1

    公开(公告)日：2008-12-11

    申请号：US12063097

    申请日：2006-08-09

    申请人： Mark J. Zdeblick ,  Timothy Robertson ,  George M. Savage

    发明人： Mark J. Zdeblick ,  Timothy Robertson ,  George M. Savage

    IPC分类号： A61B5/04

    CPC分类号： A61B5/04011

    摘要： A method for measuring the conduction velocity of a depolarization wave in a tissue employs a first satellite located within the tissue and a second that satellite is located within the tissue a distance away from the first satellite, e.g., by using the time of depolarization wave as reported from each satellite and the distance to determine velocity of the wave. Also provided are systems and kits that find use in accordance with the invention.

    摘要翻译： 用于测量组织中去极化波的传导速度的方法使用位于组织内的第一卫星，并且第二卫星位于组织内距离第一卫星一定距离，例如通过使用去极化波的时间 报道从每颗卫星和距离来确定波的速度。 还提供了根据本发明使用的系统和试剂盒。

    Apparatus and method for measuring biochemical parameters
    26.
    发明授权
    Apparatus and method for measuring biochemical parameters 有权
    用于测量生物化学参数的装置和方法

    公开(公告)号：US08558563B2

    公开(公告)日：2013-10-15

    申请号：US13390866

    申请日：2010-08-23

    申请人： Mark J. Zdeblick

    发明人： Mark J. Zdeblick

    IPC分类号： G01R27/08 ,  A61B5/053

    CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

    摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

    摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。

    Apparatus and Method for Measuring Biochemical Parameters
    29.
    发明申请
    Apparatus and Method for Measuring Biochemical Parameters 有权
    用于测量生物化学参数的装置和方法

    公开(公告)号：US20120146670A1

    公开(公告)日：2012-06-14

    申请号：US13390866

    申请日：2010-08-23

    申请人： Mark J. Zdeblick

    发明人： Mark J. Zdeblick

    IPC分类号： G01R27/08

    CPC分类号： A61B5/150229 ,  A61B5/0002 ,  A61B5/0537 ,  A61B5/14503 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/150305 ,  A61B5/150877 ,  A61B5/150969 ,  A61B5/157 ,  A61B5/6833 ,  A61B5/6846 ,  A61B10/0064 ,  A61B2560/0412

    摘要： In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.

    摘要翻译： 在第一实施例中，电极耦合到第一，第二和第三位置处的表面，第一位置比第二位置更远离第三位置。 电阻之间以不同的频率测量阻抗。 结果，在表面下方的不同区域测量阻抗，一个区域比其他区域更深于表面下方。 在第二实施例中，微流体装置执行分析。 分析可以在粘附到表面的柔性贴片内，或者可以是植入由组织包围的液体体内的固体装置。 分析可以涉及泵送流体，或者可以涉及通过微流体通道电泳分析分析物。

    Methods for configuring implantable satellite effectors
    30.
    发明授权
    Methods for configuring implantable satellite effectors 有权
    配置可植入式卫星效应器的方法

    公开(公告)号：US08123684B2

    公开(公告)日：2012-02-28

    申请号：US12624241

    申请日：2009-11-23

    申请人： Mark J. Zdeblick

    发明人： Mark J. Zdeblick

    IPC分类号： A61N1/00

    CPC分类号： A61N1/372 ,  A61B5/04011 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/36185 ,  A61N1/368 ,  A61N1/3684 ,  A61N1/3686 ,  A61N1/37211 ,  A61N1/37276 ,  A61N1/37288 ,  A61N2001/0585

    摘要： Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to the bus in system embodiments is a device such as a pacemaker that provides power and includes control circuitry. Each satellite includes satellite circuitry and one or more effectors that interact with the tissue. The satellite circuitry is coupled to the bus, and thus interfaces the controller to the one or more effectors, which may function as actuators, sensors, or both. The effectors may be electrodes that are used to introduce analog electrical signals (e.g., one or more pacing pulses) into the tissue in the local areas where the electrodes are positioned (e.g., heart muscles) or to sense analog signals (e.g., a propagating depolarization signal) within the tissue.

    摘要翻译： 用于控制用于放置在受检者体内的一个或多个模块化电路（“卫星”）的技术。 通过在包括第一和第二导电路径的总线上发送信号来控制一个或多个卫星。 在系统实施例中还耦合到总线的是诸如提供电力并包括控制电路的起搏器的装置。 每个卫星包括卫星电路和与组织相互作用的一个或多个效应器。 卫星电路耦合到总线，并且因此使控制器与一个或多个效应器接合，这些效应器可以用作致动器，传感器或两者。 效应器可以是用于将模拟电信号（例如，一个或多个起搏脉冲）引入电极定位的局部区域（例如，心脏肌肉）中的组织中或用于感测模拟信号（例如，传播 去极化信号）。