公开(公告)号：US20220163820A1

公开(公告)日：2022-05-26

申请号：US17650266

申请日：2022-02-08

Applicant: ACUCELA INC.

Inventor： Philip M. BUSCEMI ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02B27/01 ,  G02C7/14

Abstract: Systems, devices, apparatuses and methods for an active projection system that may be incorporated into spectacles, contact lenses or provided as an add-on layer to existing spectacles or lenses. The active projection system operates to generate a stimulus or stimuli for viewing by a person's eye. The stimulus or stimuli creates an image that is defocused in front of the person's retina and can assist in slowing or stopping the progression of myopia or other refractive errors in the person.

公开(公告)号：US20210311326A1

公开(公告)日：2021-10-07

申请号：US17250507

申请日：2019-07-26

Applicant: ACUCELA INC.

Inventor： Beat WYSS ,  Jean-Noël FEHR ,  Glenn NORONHA ,  Karim HAROUD ,  Julien SAUVET ,  Hans BERNHARD ,  Christian OGGENFUSS ,  Amitava GUPTA ,  Ryo KUBOTA

IPC: G02C7/04 ,  G02C11/04 ,  G02C7/14

Abstract: A soft contact lens comprises a plurality of light sources coupled to a plurality of optical elements. The plurality of light sources and the plurality of optical elements are embedded in a soft contact lens material. Each of said plurality of optical elements generates an image focused in front of a peripheral retina of a wearer. In some embodiments, each of the images is focused at a distance in front of the peripheral retina at a location, and each of the images comprises a depth of focus and a spatial resolution. The depth of focus can be less than the distance, and the spatial resolution greater than a spatial resolution of the peripheral retina at the location.

公开(公告)号：US20210171435A1

公开(公告)日：2021-06-10

申请号：US16934715

申请日：2020-07-21

Applicant: Acucela Inc.

Inventor： Claes Olof BAVIK ,  Susan Hayes HENRY ,  Ryo KUBOTA ,  Vladimir A. KUKSA

IPC: C07C215/08 ,  C07C323/32 ,  A61K31/35 ,  A61K31/138 ,  A61K45/06 ,  C07C211/27 ,  A61K31/765 ,  C07C217/20 ,  C07D309/06 ,  A61K31/137

Abstract: Methods are provided herein for the treatment of ophthalmic diseases or conditions such as an ophthalmic disease or disorder associated with diabetes in a patient. Also provided herein are methods of treating retinopathy of prematurity in a patient. Further, provided herein are methods for treating wet age-related macular degeneration in a patient. The methods comprise administration of compounds disclosed herein to a patient in need thereof that inhibit or slow one or more signs or symptoms of such conditions.

公开(公告)号：US10952607B2

公开(公告)日：2021-03-23

申请号：US16805267

申请日：2020-02-28

Applicant: ACUCELA INC.

Inventor： Lukas Scheibler ,  Matthias Pfister ,  Urban Schnell ,  Stefan Troller ,  Ryo Kubota

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  G01B9/02

Abstract: Improved optical coherence tomography systems and methods to measure thickness of the retina are presented. The systems may be compact, handheld, provide in-home monitoring, allow the patient to measure himself or herself, and be robust enough to be dropped while still measuring the retina reliably.

公开(公告)号：US10471027B2

公开(公告)日：2019-11-12

申请号：US12830155

申请日：2010-07-02

Applicant: Ryo Kubota ,  Nancy Boman ,  Claes Bavik ,  Ian L. Scott

Inventor： Ryo Kubota ,  Nancy Boman ,  Claes Bavik ,  Ian L. Scott

IPC: A61K31/135 ,  A61K31/137 ,  A61K31/166 ,  A61K9/00 ,  A61K9/50 ,  A61K31/19 ,  A61K31/195

Abstract: Described herein are methods for the treatment of an ophthalmic disease or disorder comprising the administration of non-retinoid visual cycle modulators. Ophthalmic diseases and disorders which can be treated according to the methods provided herein include age-related macular degeneration (AMD), Stargardt's disease, glaucoma, and other disorders that adversely affect the retina.

公开(公告)号：US10201545B2

公开(公告)日：2019-02-12

申请号：US14631711

申请日：2015-02-25

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Anna Gall ,  Mark W. Orme ,  Jennifer Gage ,  Thomas L. Little, Jr. ,  Qin Jiang ,  Lana Michele Rossiter ,  Kevin F. McGee, Jr. ,  Ryo Kubota

IPC: A61K31/137 ,  A61K31/5375 ,  C07C217/18 ,  C07C211/27 ,  C07C211/28 ,  C07C211/29 ,  C07C215/08 ,  C07C215/30 ,  C07C215/42 ,  C07C215/46 ,  C07C217/16 ,  C07C217/48 ,  C07C217/54 ,  C07C217/62 ,  C07C217/72 ,  C07C225/18 ,  C07C233/05 ,  C07C237/04 ,  C07C317/28 ,  C07C323/25 ,  C07C323/32 ,  C07D295/03 ,  C07C217/10 ,  C07C225/06 ,  C07C323/33 ,  C07D207/06 ,  C07D211/14 ,  A61K31/145 ,  A61K31/167 ,  A61K31/40 ,  A61K31/4453 ,  A61K31/495

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are styrenyl derivative compounds, including but not limited to stilbene derivative compounds, and compositions comprising these compounds, that are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US09079825B2

公开(公告)日：2015-07-14

申请号：US13291948

申请日：2011-11-08

Applicant: Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

IPC: C09B11/02 ,  C07C211/00 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C317/28 ,  C07C323/25 ,  C07D277/24 ,  C07D309/06

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US08895782B2

公开(公告)日：2014-11-25

申请号：US14162672

申请日：2014-01-23

Applicant: Acucela Inc.

Inventor： Ian Leslie Scott ,  Vladimir Aleksandrovich Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Jennifer Gage ,  Feng Hong

IPC: C07D213/00 ,  C07C235/34 ,  C07C215/42 ,  C07D335/02 ,  C07C217/48 ,  C07C211/27 ,  C07C215/30 ,  C07D309/12 ,  C07C217/64 ,  C07D213/38

CPC classification number: C07C215/68 ,  C07C211/27 ,  C07C211/30 ,  C07C215/28 ,  C07C215/30 ,  C07C215/42 ,  C07C217/14 ,  C07C217/48 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C235/34 ,  C07C237/20 ,  C07C251/40 ,  C07C255/58 ,  C07C317/28 ,  C07C323/25 ,  C07C323/29 ,  C07C323/36 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D209/32 ,  C07D213/14 ,  C07D213/38 ,  C07D309/06 ,  C07D309/10 ,  C07D309/12 ,  C07D333/06 ,  C07D333/16 ,  C07D335/02

Abstract: Provided are alkynyl phenyl derivative compounds, pharmaceutical compositions thereof, and methods of treating ophthalmic diseases and disorders, such as age-related macular degeneration and Stargardt's Disease, using said compounds and compositions.

公开(公告)号：US20130197096A1

公开(公告)日：2013-08-01

申请号：US13620388

申请日：2012-09-14

Applicant: Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

Inventor： Ian L. Scott ,  Vladimir A. Kuksa ,  Mark W. Orme ,  Thomas Little ,  Anna Gall ,  Feng Hong

IPC: C07C215/20

CPC classification number: A61K31/137 ,  A61K31/165 ,  A61K31/222 ,  C07C215/20 ,  C07C217/20 ,  C07C217/60 ,  C07C217/62 ,  C07C217/64 ,  C07C217/72 ,  C07C217/84 ,  C07C225/16 ,  C07C229/38 ,  C07C233/18 ,  C07C235/08 ,  C07C251/86 ,  C07C279/08 ,  C07C309/06 ,  C07C317/28 ,  C07C323/25 ,  C07C323/33 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07D277/24 ,  C07D309/06

Abstract: The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt's Disease.

公开(公告)号：US08410168B2

公开(公告)日：2013-04-02

申请号：US12764764

申请日：2010-04-21

Applicant: Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

Inventor： Kenneth Widder ,  Jay Lichter ,  Nathan L. Mata

IPC: A01N47/10 ,  A01N47/28 ,  A01N47/40 ,  A61K31/27 ,  A61K31/275

CPC classification number: A61K31/167 ,  A61K31/16 ,  A61K31/215 ,  G01N2800/164

Abstract: Compounds that cause reversible night blindness may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.

Abstract translation: 引起可逆性夜盲症的化合物可用于治疗与视觉循环过程中积累的废物过量生产相关的眼科疾病。 我们描述使用这些化合物及其衍生物治疗例如黄斑变性和营养不良的方法和组合，或减轻与这种眼科疾病相关的症状。 这些化合物及其衍生物可以用作单一药物治疗或与其它药物或疗法组合使用。