公开(公告)号：US10919869B2

公开(公告)日：2021-02-16

申请号：US16302564

申请日：2017-05-17

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin Li ,  Yufang Xu ,  Rui Wang ,  Zhenjiang Zhao ,  Wenlin Song ,  Liuxin Xu

IPC: C07D277/50 ,  A61P19/02 ,  A61P37/00 ,  A61P33/00 ,  A61K31/426 ,  A61P35/00 ,  A61P17/06 ,  A61P31/04

Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

公开(公告)号：US20200140830A1

公开(公告)日：2020-05-07

申请号：US16620525

申请日：2018-04-13

Applicant: JIANGSU AOSAIKANG PHARMACEUTICAL CO., LTD. ,  EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Huilei YU ,  Yan ZHANG ,  Jianhe XU ,  Qian ZHAO ,  Jiang PAN ,  Feng LIU ,  Guoqiang LIN

IPC: C12N9/02 ,  C12P17/16 ,  C12P17/10 ,  C12P11/00

Abstract: A Bradyrhizobium monooxygenase, a gene for encoding the monooxygenase, a recombinant expression vector comprising the gene and a recombinant transformant, a method of preparing the monooxygenase by the recombinant expression transformant, and a method of preparing an optically pure chiral sulfoxide by the monooxygenase, in particular to a method of preparing prazole drugs by means of catalyzing the asymmetric oxidation of thioether, a prazole precursor. As compared with other methods of preparing an optically pure sulfoxide, the product produced by the monooxygenase of the present invention as a catalyst has high optical purity, avoids the generation of the byproduct sulfone, and has advantages of mild reaction conditions, simple and convenient operations, easy amplification, etc.

公开(公告)号：US20190241584A1

公开(公告)日：2019-08-08

申请号：US16318762

申请日：2017-07-18

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Linyong Zhu ,  Yi Yang ,  Dasheng Zhang ,  Zengmin Du ,  Bingkun Bao ,  Qiuning Lin ,  Yan Li ,  Xianjun Chen ,  Lipeng Yang ,  Chunyan Bao

IPC: C07D495/04 ,  C07D333/78 ,  C07D495/14 ,  C09B57/00 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/533 ,  C09B23/04 ,  C09B23/01

CPC classification number: C07D495/04 ,  A61K49/00 ,  C07D333/60 ,  C07D333/78 ,  C07D495/14 ,  C09B23/0058 ,  C09B23/0091 ,  C09B23/04 ,  C09B57/00 ,  C09K11/06 ,  C12Q1/68 ,  G01N33/533 ,  G01N33/68

Abstract: Provided are a fluorescent dye and a preparation process and use thereof. The fluorescent dye is able to emit a long wavelength, is sensitive and specific to viscosity, and is used for a wide range of purposes, such as viscosity testing, fluorescent labeling, quantification or detection of proteins, enzymes or nucleic acids. In addition, it can be used as a fluorescent-activated probe.

公开(公告)号：US10351891B2

公开(公告)日：2019-07-16

申请号：US15535274

申请日：2014-12-12

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Fengqing Wang ,  Dongzhi Wei ,  Liqin Xu ,  Haohao Liu ,  Xinbin Liu ,  Nenghui Chen

IPC: C12P33/02 ,  C12P33/00 ,  C12N9/10 ,  C12N9/04 ,  C12R1/32

Abstract: The present invention provides a hydroxyacyl-coenzyme A dehydrogenase gene, an acyl-coenzyme A thiolase gene, genetically engineered strains and a use thereof. The hydroxyacyl-coenzyme A dehydrogenase gene encodes a protein (i) or (ii) as follows: (i) having an amino acid sequence according to SEQ ID NO 2; (ii) derived by substituting, deleting or inserting one or more amino acids in the amino acid sequence defined by (i) and having the same function as that of the protein of (i). The present invention constructs genetically engineered Mycobacterium strains lacking of a hydroxyacyl-coenzyme A dehydrogenase gene or an acyl-coenzyme A thiolase gene, which are used in the preparation of steroidal compounds, such as 1,4-BNA, 4-BNA, 9-OH-BNA, etc. Further, the invention improves the production efficiency and product quality of steroidal drug, improves the utilization of drug precursors, reduces the production costs, and provides the advantages of mild reaction conditions, environmentally friendly, and high economic and social benefits.

公开(公告)号：US10071910B2

公开(公告)日：2018-09-11

申请号：US15033002

申请日：2013-10-31

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Chongjun Zhao ,  Jianbo Dong ,  Youfu Huang ,  Jingwei Ma ,  Xiuzhen Qian

IPC: C01B31/02 ,  C01B31/00 ,  B01J13/00

CPC classification number: C01B32/15 ,  B01J13/0052 ,  C01B32/00 ,  C01B32/05 ,  C01P2004/64 ,  C01P2006/12 ,  C01P2006/16

Abstract: Methods described herein generally relate to producing carbon aerogel. The method may include providing a carbon-containing polymeric material, and contacting the carbon-containing polymeric material with light, heat or both to produce the carbon aerogel. Systems and kits for producing carbon aerogel are also disclosed.

公开(公告)号：US09821296B2

公开(公告)日：2017-11-21

申请号：US14407757

申请日：2012-06-12

Applicant: Chongjun Zhao ,  Zhen Shao ,  Yang Xia ,  Yunlong Xu ,  Xiuzhen Qian

Inventor： Chongjun Zhao ,  Zhen Shao ,  Yang Xia ,  Yunlong Xu ,  Xiuzhen Qian

IPC: B01J23/10 ,  B01J23/50 ,  B01J23/66 ,  B01J27/10 ,  C02F1/30 ,  C02F1/32 ,  C02F1/72 ,  B01J27/08 ,  B01J35/00 ,  B01J27/125 ,  C01B3/04 ,  C01B13/02 ,  B01D53/86 ,  B01J19/12 ,  C02F1/00 ,  C02F1/28 ,  C02F1/38 ,  C02F101/30 ,  B01J37/03 ,  B01J37/04

CPC classification number: B01J27/10 ,  B01D53/8687 ,  B01D2255/104 ,  B01D2255/206 ,  B01D2255/802 ,  B01D2257/91 ,  B01J19/123 ,  B01J19/127 ,  B01J23/10 ,  B01J27/08 ,  B01J27/125 ,  B01J35/004 ,  B01J37/031 ,  B01J37/04 ,  B01J2219/0877 ,  B01J2219/1203 ,  C01B3/042 ,  C01B13/0207 ,  C02F1/004 ,  C02F1/281 ,  C02F1/288 ,  C02F1/30 ,  C02F1/32 ,  C02F1/325 ,  C02F1/385 ,  C02F1/725 ,  C02F2101/30 ,  C02F2101/308 ,  C02F2201/006 ,  C02F2303/04 ,  C02F2303/185 ,  C02F2305/10 ,  Y02A20/156 ,  Y02E60/364

Abstract: A photocatalytic composition is disclosed that includes a silver halide in combination with one or more rare earth elements. The composition may be used for the photocatalytic degradation of pollutants.

公开(公告)号：US09606121B2

公开(公告)日：2017-03-28

申请号：US14347575

申请日：2012-09-26

Applicant: East China University of Science and Technology

Inventor： Yi Yang ,  Yuzheng Zhao ,  Jing Jin ,  Qingxun Hu

IPC: G01N33/573 ,  C07K14/195 ,  C07K14/32 ,  G01N33/50 ,  G01N33/58

CPC classification number: G01N33/5735 ,  C07K14/195 ,  C07K14/32 ,  C07K2319/00 ,  C07K2319/60 ,  G01N33/5011 ,  G01N33/582 ,  G01N2500/02 ,  G01N2800/7028

Abstract: The invention relates to a genetically encoded fluorescent sensor for nicotinamide adenine dinucleotide, as well as methods of preparation and uses thereof. In one aspect, this invention relates to a sensor for detecting nicotinamide adenine dinucleotide, particularly, a recombinant fluorescent fusion protein sensor for detecting nicotinamide adenine dinucleotide. In one specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting reduced nicotinamide adenine dinucleotide (NADH); in another specific aspect, this invention relates to a recombinant fluorescent fusion protein sensor for detecting oxidized nicotinamide adenine dinucleotide (NAD+); in yet another aspect, the invention relates to a recombinant fluorescent fusion protein sensor for detecting the ratio of reduced to oxidized nicotinamide adenine dinucleotide. This invention also relates to the method of preparing the sensors, and uses of the sensors in detecting NADH, NAD+, NADH/NAD+ ratio, screening drugs and measuring NADH metabolism.

公开(公告)号：US09482619B2

公开(公告)日：2016-11-01

申请号：US14152320

申请日：2014-01-10

Applicant: East China University of Science and Technology

Inventor： Yitao Long ,  Dawei Li ,  Lulu Qu ,  Wenlei Zhai ,  Jinqun Xue ,  Wei Song

IPC: G01J3/44 ,  G01N21/65 ,  G01N21/552 ,  G01N33/18 ,  B22F1/02 ,  B22F1/00

CPC classification number: G01N21/658 ,  B22F1/0018 ,  B22F1/0051 ,  B22F1/02 ,  B22F2999/00 ,  G01N21/554 ,  G01N33/18 ,  B22F2303/01 ,  B22F2301/255 ,  B22F2303/30 ,  B22F2302/256

Abstract: Provided herein are Raman active particles and methods for their preparation and use. The particles can include a SERS-active material that is at least partially encased within a spherical porous hollow casing. In some embodiments, this can be especially advantageous when employed for water analysis and/or being employed in combination with silica particles.

Abstract translation: 本文提供的是拉曼活性颗粒及其制备和使用的方法。 颗粒可以包括至少部分地包裹在球形多孔中空壳体内的SERS-活性材料。 在一些实施方案中，当用于水分析和/或与二氧化硅颗粒组合使用时，这可能是特别有利的。

公开(公告)号：US09346985B2

公开(公告)日：2016-05-24

申请号：US14355525

申请日：2013-06-20

Applicant: Kunshan TianYang Hot Melt Adhesive Co., Ltd. ,  Shanghai TianYang Hot Melt Adhesive Co., Ltd. ,  East China University of Science and Technology

Inventor： Zhelong Li ,  Wanyu Zhu ,  Fangqun Wu ,  Zuoxiang Zeng

IPC: C09J167/00 ,  C08L29/04 ,  C09J129/14 ,  C09J167/02 ,  C08J3/24

CPC classification number: C09J167/00 ,  C08J3/246 ,  C08J2329/14 ,  C08J2367/02 ,  C08L29/14 ,  C08L67/02 ,  C09J129/14 ,  C09J167/02

Abstract: A polyester/glyoxalated polyvinyl alcohol semi-interpenetrating polymer network hot-melt adhesive and preparation method therefore, mainly includes the steps of: 1) transesterification of certain amounts of dimethyl terephthalate and another dibasic ester with 1,4-butanediol and other diols in the presence of an organotin catalyst under a nitrogen atmosphere in a reactor, completed upon the amount of distillation of a monohydric alcohol byproduct reaching greater than 95% of the theoretical amount; 2) after the temperature is maintained for a period of time, adding in a stabilizer and a polycondensation catalyst and incrementally increasing the temperature to trigger a polycondensation reaction under a reduced pressure to produce particles of a copolymer, and freezing and pulverizing the copolymer particles to produce a powder of a copolyester; 3) uniformly blending a polyvinyl alcohol/glyoxal mixture with the powder produced in step 2) at ambient temperature to produce the target product. The product is capable of forming an internal semi-interpenetrating network at application temperatures.

Abstract translation: 聚酯/乙二醛聚乙烯醇半互穿聚合物网络热熔胶及其制备方法因此主要包括以下步骤：1）将一定量的对苯二甲酸二甲酯与另一种二元酸酯与1,4-丁二醇和其它二元醇酯交换反应 在氮气气氛下在反应器中存在有机锡催化剂，在一元醇副产物的蒸馏量达到​​理论量的95％以上时完成; 2）在温度保持一段时间之后，加入稳定剂和缩聚催化剂，并逐渐增加温度以在减压下引发缩聚反应以产生共聚物颗粒，并将共聚物颗粒冷冻和粉碎 生产共聚酯粉末; 3）在环境温度下将聚乙烯醇/乙二醛混合物与步骤2）中制备的粉末均匀混合以产生目标产物。 该产品能够在应用温度下形成内部半互穿网络。

公开(公告)号：US09206339B2

公开(公告)日：2015-12-08

申请号：US14358667

申请日：2013-10-24

Applicant: SHANGHAI TIANYANG HOT MELT ADHESIVE CO., LTD. ,  EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  KUNSHAN TIANYANG HOT MELT ADHESIVE CO., LTD.

Inventor： Weilan Xue ,  Ping Zhao ,  Zhelong Li ,  Wanyu Zhu ,  Zuoxiang Zeng ,  Xu Gao ,  Juan Liu

IPC: C09D123/06 ,  H01L31/02 ,  C09J123/06 ,  C09J167/02 ,  C08L23/06 ,  H01L31/048

CPC classification number: C09J123/06 ,  C08L23/06 ,  C08L51/06 ,  C08L67/02 ,  C09D123/06 ,  C09J167/02 ,  H01L31/0201 ,  H01L31/048 ,  Y02E10/50 ,  C08L51/00 ,  C08L67/00

Abstract: A method of preparing a polyester/polyolefin hot-melt adhesive for use in a solar cell bus bar is disclosed, in which 2,6-naphthalenedicarboxylic acid and ethylene glycol are first sequentially subjected in a predetermined ratio to esterification and polycondensation in the presence of a certain amount of a titanium-based catalyst to result in a polyethylene naphthalate (PNT) with a weight-average molecular weight of 16,000˜20,000. The PNT is then melt-blended with a low-density polyethylene (LDPE) in the presence of a compatibilizer to produce the hot-melt adhesive that can be shaped into films having a high light transmittance, good mechanical properties, high heat and yellowing resistance and thus particularly suitable for use in solar cell bus bars.

Abstract translation: 公开了一种制备用于太阳能电池汇流条中的聚酯/聚烯烃热熔粘合剂的方法，其中2,6-萘二甲酸和乙二醇首先按预定比例依次经受酯化和缩聚反应， 一定量的钛基催化剂，得到重均分子量为16,000〜200,000的聚萘二甲酸乙二醇酯（PNT）。 然后在相容剂的存在下，将PNT与低密度聚乙烯（LDPE）熔融共混以制备可以成型为具有高透光性，良好机械性能，高耐热和耐黄变性的膜的热熔粘合剂 因此特别适用于太阳能电池母线。