公开(公告)号：US09492368B2

公开(公告)日：2016-11-15

申请号：US13983231

申请日：2012-01-31

申请人： Tatsuya Ishihara ,  Shimpei Ushio ,  Rohko Yamamoto ,  Takanori Ohkura ,  Shigeharu Fukuda

发明人： Tatsuya Ishihara ,  Shimpei Ushio ,  Rohko Yamamoto ,  Takanori Ohkura ,  Shigeharu Fukuda

IPC分类号： A61K8/60 ,  C07H19/167 ,  A61Q19/08 ,  A61Q19/00 ,  A61Q19/02 ,  A61K9/00 ,  C12P19/18 ,  C12P19/40

CPC分类号： A61K8/602 ,  A61K8/606 ,  A61K9/0014 ,  A61Q19/00 ,  A61Q19/001 ,  A61Q19/02 ,  A61Q19/08 ,  C07H19/167 ,  C12P19/18 ,  C12P19/40 ,  C12Y204/01019 ,  Y02P20/52

摘要： The present invention has an object to provide an external dermal agent with a sustainable anti-wrinkle action, which has both the action of enhancing the proliferation and differentiation of keratinocytes in the skin and the action of enhancing the collagen production in the skin, and which assists the maintenance and the improvement of tissue structures and physiological functions of the epidermis and the dermis, whereby providing a remarkable skin improvement effect. The present invention solves the above object by providing an external dermal agent containing α-D-glucopyranosyl-(1→3′)-adenosine and/or α-D-glucopyranosyl-(1→5′)-adenosine as an effective ingredient(s).

摘要翻译： 本发明的目的是提供具有可持续的抗皱作用的外用皮肤试剂，其具有增强皮肤角质形成细胞增殖和分化的作用以及增强皮肤中胶原蛋白生成的作用，其中 有助于维持和改善表皮和真皮的组织结构和生理功能，从而提供显着的皮肤改善效果。 本发明通过提供含有α-D-吡喃葡萄糖基 - （1→3'） - 腺苷和/或α-D-吡喃葡萄糖基 - （1→5'） - 腺苷作为有效成分的外用剂解决了上述目的（ s）。

公开(公告)号：US09295627B2

公开(公告)日：2016-03-29

申请号：US14365714

申请日：2012-12-12

申请人： HAYASHIBARA CO., LTD.

发明人： Keizo Kohno ,  Emiko Ohashi ,  Tsunetaka Ohta

IPC分类号： A61K8/60 ,  A61Q11/00 ,  A23G4/06 ,  A61Q17/00

CPC分类号： A61K8/602 ,  A23G4/06 ,  A61K8/606 ,  A61K2800/30 ,  A61Q11/00 ,  A61Q17/005

摘要： The present invention has an object to provide a mouthwash composition for preventing and/or treating periodontal diseases safely and effectively. The present invention solves the above object by providing a mouthwash composition for preventing and/or treating periodontal diseases, characterized in that it comprises, as an effective ingredient(s), one or more members selected from the group consisting of adenosine N1-oxide, 3′-glucosyladenosine N1-oxide, 5′-glucosyladenosine N1-oxide, 5′-adenosine diphosphate N1-oxide, and 5′-adenosine triphosphate N1-oxide but does not contain any saccharide assimilable by periodontal disease bacteria.

摘要翻译： 本发明的目的是提供一种安全有效地预防和/或治疗牙周疾病的漱口剂组合物。 本发明通过提供一种用于预防和/或治疗牙周病的漱口剂组合物来解决上述目的，其特征在于，它包含作为有效成分的一种或多种选自下组的一种或多种：腺苷N1-氧化物， 3'-葡糖基腺苷N1-氧化物，5'-葡糖基腺苷N1-氧化物，5'-腺苷二磷酸N1-氧化物和5'-腺苷三磷酸N1-氧化物，但不含任何可被牙周病细菌吸收的糖类。

公开(公告)号：US20160008392A1

公开(公告)日：2016-01-14

申请号：US14771917

申请日：2014-02-27

申请人： HAYASHIBARA CO., LTD.

发明人： Yoshifumi TANIGUCHI ,  Shinichiro INOUE ,  Hikaru WATANABE

IPC分类号： A61K31/718 ,  A23L1/30

CPC分类号： A61K31/718 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/716

摘要： The present invention addresses the problem of providing an agent for lifestyle-related diseases, an oral composition, and a high-fat food product that can be conveniently, safely, and continuously consumed on a daily basis. This problem is solved by an agent for lifestyle-related diseases that contains a specific branched α-glucan having the characteristics described in the present invention, an oral composition comprising the agent, and a high-fat food product comprising the same.

摘要翻译： 本发明涉及提供生活方式相关疾病的药剂，口服组合物和能够方便，安全，持续地每天消耗的高脂肪食品的问题。 这个问题由含有本发明所述特征的特定支链α-葡聚糖的生活方式相关疾病的药剂，包含该试剂的口服组合物和包含其的高脂肪食品所解决。

公开(公告)号：US08834950B2

公开(公告)日：2014-09-16

申请号：US12302454

申请日：2007-05-22

申请人： Hideki Fukushima ,  Takashi Ohtsuki ,  Naohiko Katagiri ,  Toshio Miyake

发明人： Hideki Fukushima ,  Takashi Ohtsuki ,  Naohiko Katagiri ,  Toshio Miyake

IPC分类号： A23L1/05 ,  A47J39/00 ,  A23G3/00 ,  A23L1/0522 ,  A23L1/20 ,  A23L3/3562 ,  A23L1/10 ,  A23L1/16 ,  A23L1/182 ,  A23L1/09

CPC分类号： A23L1/16 ,  A23L3/3562 ,  A23L7/00 ,  A23L7/10 ,  A23L7/109 ,  A23L7/196 ,  A23L11/00 ,  A23L29/212 ,  A23L29/30

摘要： An object of the present invention is to provide a method for inhibiting the deterioration of eating-quality characteristics of a food containing gelatinized starch and to keep their eating-quality characteristics as just prepared after a relatively prolonged storage under freezing, refrigerating, chilling or room temperature. The present invention achieves the above object by a method of permeating of maltose and/or α,α-trehalose or saccharides comprising the same and other oligosaccharides in a prescribed ratio into the above food containing gelatinized starch by admixing the saccharide to the food and holding them at relatively high temperature for a prescribed period.

摘要翻译： 本发明的一个目的是提供一种抑制含有胶凝淀粉的食物的饮食质量特性恶化的方法，并且在冷冻，冷藏，冷藏或室内相对较长时间的储存后，保持其食用品质特征。 温度。 本发明通过以下方法实现上述目的：通过将糖类和食品中含有相同含量的麦芽糖和/或α，α-海藻糖或糖类以规定比例渗透到上述含有食品的凝胶化淀粉中， 他们在较高的温度下一段规定的时间。

公开(公告)号：US20140205553A1

公开(公告)日：2014-07-24

申请号：US14222968

申请日：2014-03-24

申请人： Hayashibara Co., Ltd.

发明人： Masaki MIYAKE ,  Osamu Sano ,  Kanso Iwaki ,  Takanori Okura ,  Shigeharu Fukuda

IPC分类号： A61K8/60 ,  A61K8/49 ,  A61Q19/02

CPC分类号： A61K8/606 ,  A61K8/4953 ,  A61Q19/02 ,  C07D473/18 ,  C07H19/16 ,  C07H19/20

摘要： The present invention has objects to provide an agent for enhancing the effect of skin-whitening ingredients which enhances the skin-whitening action of skin-whitening ingredients and has an improved safeness, and to provide a skin-whitening agent, which contains the above agent and a skin-whitening ingredient(s) and has an improved and enhanced skin-whitening action. The present invention solves the above objects by providing an agent for enhancing the effect of skin-whitening ingredients, which contains one or more members selected from the group consisting of guanine and derivatives thereof as an effective ingredient(s); and a skin-whitening agent which contains the above agent along with a skin-whitening ingredient(s), particularly, one or more members selected from the group consisting of adenine including derivatives thereof and/or equol including derivatives thereof.

摘要翻译： 本发明的目的是提供增强美白成分的效果的药剂，其增强皮肤美白成分的皮肤美白作用，并且具有改善的安全性，并且提供含有上述药剂的皮肤增白剂 和一种皮肤美白成分，并具有改进和增强的皮肤美白作用。 本发明通过提供含有一种或多种选自鸟嘌呤及其衍生物作为有效成分的成分的皮肤美白成分的效果增强剂来解决上述目的。 以及皮肤增白剂，其含有上述试剂以及皮肤增白成分，特别是选自包括其衍生物的腺嘌呤和/或其衍生物的腺嘌呤中的一种或多种。

公开(公告)号：US08673608B2

公开(公告)日：2014-03-18

申请号：US13666220

申请日：2012-11-01

申请人： Hayashibara Co., Ltd

发明人： Hikaru Watanabe ,  Takuo Yamamoto ,  Tomoyuki Nishimoto ,  Keji Tsusaki ,  Kazuyuki Oku ,  Hiroto Chaen ,  Shigeharu Fukuda

IPC分类号： C12R1/06 ,  C12R1/07

CPC分类号： A23L33/21 ,  A21D2/18 ,  A23C9/1307 ,  A23C9/1544 ,  A23L2/39 ,  A23L9/20 ,  A23L11/05 ,  A23L29/35 ,  A23L33/10 ,  A23L33/18 ,  A23V2002/00 ,  A61K8/73 ,  A61K8/732 ,  A61K9/06 ,  A61K9/20 ,  A61K31/716 ,  A61K31/718 ,  A61Q11/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C08B37/0009 ,  C12N9/1051 ,  C12P19/04 ,  C12P19/18 ,  C12R1/06 ,  C12R1/09 ,  Y02P20/52 ,  A23V2250/5118 ,  A23V2200/3262 ,  A23V2200/328

摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.

摘要翻译： 本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。 本发明通过提供由葡萄糖分子构成的特征在于甲基化分析的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上 葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％ 和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡萄糖基转移酶，其制备方法及其用途。

公开(公告)号：US08633005B2

公开(公告)日：2014-01-21

申请号：US12764927

申请日：2010-04-21

申请人： Hikaru Watanabe ,  Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Hikaru Watanabe ,  Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12N9/10 ,  C12N15/54

CPC分类号： C07H3/06 ,  A23L29/35 ,  A23L33/25 ,  C12N9/2402 ,  C12N9/2405 ,  C12P19/04

摘要： A non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents, a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof are provided by use of an isocyclomaltooligosaccharide(s) having a structure represented by Formula 1, Cyclo{→6)-[α-D-Glcp-(1→4)]n-α-D-Glcp-(1→}, wherein “n” is 4 or 5.

摘要翻译： 通过提供由葡萄糖组成的新型非还原性糖类，形成非还原性糖类的新型酶，其制备方法和方法，编码该酶的DNA，重组DNA和转化体，得到非还原性糖类， DNA，包含非还原性糖的组合物及其用途通过使用具有由式1表示的结构的环状小麦寡糖，环 - { - 6） - [α-D-Glcp-（1- > 4）] n-α-D-Glcp-（1->}，其中“n”为4或5。

公开(公告)号：US20130295618A1

公开(公告)日：2013-11-07

申请号：US13980223

申请日：2012-03-07

申请人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

发明人： Takashi Shibuya ,  Seisuke Izawa ,  Tomoyuki Nishimoto ,  Shigeharu Fukuda ,  Toshio Miyake

IPC分类号： C12P19/18

CPC分类号： A61K31/7048 ,  A61K9/16 ,  C07H17/04 ,  C12P19/18 ,  C12P19/60 ,  C12Y204/01019

摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.

摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

公开(公告)号：US20130129651A1

公开(公告)日：2013-05-23

申请号：US13813760

申请日：2011-07-28

申请人： Masaki Miyake ,  Osamu Sano ,  Kanso Iwaki ,  Takanori Okura ,  Shigeharu Fukuda

发明人： Masaki Miyake ,  Osamu Sano ,  Kanso Iwaki ,  Takanori Okura ,  Shigeharu Fukuda

IPC分类号： C07H19/20 ,  C07H19/16 ,  A61Q19/02 ,  C07D473/18

CPC分类号： A61K8/606 ,  A61K8/4953 ,  A61Q19/02 ,  C07D473/18 ,  C07H19/16 ,  C07H19/20

摘要： The present invention has objects to provide an agent for enhancing the effect of skin-whitening ingredients which enhances the skin-whitening action of skin-whitening ingredients and has an improved safeness, and to provide a skin-whitening agent, which contains the above agent and a skin-whitening ingredient(s) and has an improved and enhanced skin-whitening action. The present invention solves the above objects by providing an agent for enhancing the effect of skin-whitening ingredients, which contains one or more members selected from the group consisting of guanine and derivatives thereof as an effective ingredient(s); and a skin-whitening agent which contains the above agent along with a skin-whitening ingredient(s) particularly, members derivatives thereof and/or equol including derivatives thereof.

摘要翻译： 本发明的目的是提供增强美白成分的效果的药剂，其增强皮肤美白成分的皮肤美白作用，并且具有改善的安全性，并且提供含有上述药剂的皮肤增白剂 和一种皮肤美白成分，并具有改进和增强的皮肤美白作用。 本发明通过提供含有一种或多种选自鸟嘌呤及其衍生物作为有效成分的成分的皮肤美白成分的效果增强剂来解决上述目的。 以及皮肤增白剂，其含有上述药剂以及皮肤美白成分，特别是其成分衍生物和/或雌马酚，包括其衍生物。

公开(公告)号：US20240199821A1

公开(公告)日：2024-06-20

申请号：US18553129

申请日：2022-03-31

申请人： NAGASE & CO., LTD. ,  NAGASE CHEMTEX CORPORATION ,  HAYASHIBARA CO., LTD.

发明人： Kusuo OTA ,  Takahiro NOZAKI ,  Atsushi TANAKA ,  Tetsuya HOSOMI ,  Tomoyuki NISHIMOTO ,  Manabu MIYATA

IPC分类号： C08J3/075 ,  C08J11/10

CPC分类号： C08J3/075 ,  C08J11/10 ,  C08J2303/02

摘要： The present invention provides a water-absorbing resin that is excellent in water absorption performance and is easy to be degraded. The present invention relates to a water-absorbing resin, which is a crosslinked product of a glucose polymer and forms a physical gel upon absorption of water, wherein the glucose polymer is a starch or a partially degraded starch, with an acidic group introduced therein.