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公开(公告)号：US12048780B2
公开(公告)日：2024-07-30
申请号：US17261932
申请日：2019-07-23
IPC分类号： A61L27/38 , A61L27/26 , A61L27/52 , B33Y70/10 , B33Y80/00 , C12N5/00 , C12N5/077 , C08L71/02 , C08L89/06
CPC分类号： A61L27/38 , A61L27/26 , A61L27/52 , B33Y70/10 , B33Y80/00 , C12N5/0012 , C12N5/0656 , C08L71/02 , C08L89/06 , C12N2500/50 , C12N2513/00 , C12N2533/54 , C12N2537/10
摘要： The technology relates to a 3D printed hydrogel formed from a maleimide containing polymer cross-linked using a bis-thiol containing cross-linking agent having at least two thiol functional groups, processes for preparing the 3D printed hydrogel, and uses thereof.
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22.发明公开公开(公告)号：US20240245833A1
公开(公告)日：2024-07-25
申请号：US18583696
申请日：2024-02-21
CPC分类号： A61L27/52 , A61L27/26 , A61L27/58 , A61L2400/06 , A61L2430/16
摘要： The invention provides methods and polymer compositions for treating retinal detachment and other ocular disorders, where the methods employ polymer compositions that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer containing a plurality of thio-functional groups —R1-SH wherein R1 is an ester-containing linker, such as a thiolated poly(vinyl alcohol) polymer and (ii) an electro-functional polymer that is a biocompatible polymer containing at least one thiol-reactive group, such as a poly(ethylene glycol) polymer containing alpha-beta unsaturated ester groups.
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23.发明公开公开(公告)号：US20240239966A1
公开(公告)日：2024-07-18
申请号：US18577650
申请日：2022-07-07
申请人： MEDIFAB CO., LTD.
发明人： Mi Sun CHA , Su Hee KIM , Soo Hee LEE
CPC分类号： C08J3/075 , A61L27/20 , A61L27/3683 , A61L27/52 , C08K3/32 , C08K5/053 , A61L2400/06 , C08J2305/08
摘要： The present application relates to a composition for preparing a temperature-sensitive hydrogel and a use thereof, and provides a temperature-sensitive hydrogel composition and a method for preparing a temperature-sensitive hydrogel composition using the composition, including a first agent in a liquid formulation including an aqueous solution containing chitosan and phosphate ions, including an aqueous solution containing 0.05 wt % to 3.5 wt % of chitosan and 0.1 wt % to 40 wt % of phosphate ions, based on the total weight of the first agent composition.
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公开(公告)号：US20240238094A1
公开(公告)日：2024-07-18
申请号：US18559337
申请日：2022-05-04
申请人： Duke University
发明人： Benjamin WILEY , Huayu TONG
CPC分类号： A61F2/30756 , A61L27/06 , A61L27/34 , A61L27/52 , A61F2002/3092 , A61F2002/30971 , A61L2420/02
摘要： Hydrogel-coated orthopedic implants with surfaces that mimic the mechanical and tribological properties of cartilage, and bases that enable integration with bone for long-term fixation, and methods of forming them.
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公开(公告)号：US12029834B2
公开(公告)日：2024-07-09
申请号：US16956174
申请日：2018-12-20
发明人： Sam Wadsworth , Simon Beyer , Tamer Mohamed , Konrad Walus , Mohammad Mostofa Kamal Khan , Elli Kapyla , Julia Hwang , Joe Ault
CPC分类号： A61L27/52 , A61L27/26 , A61L27/48 , A61L2430/06
摘要： Provided herein are meniscus implant compositions, as well as method for making and using the same. The subject meniscus implants find use in repairing and/or replacing damaged or diseased meniscal tissue in a mammalian subject.
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公开(公告)号：US12029733B2
公开(公告)日：2024-07-09
申请号：US17506354
申请日：2021-10-20
IPC分类号： A61K31/455 , A61K9/00 , A61L27/52 , A61P29/00
CPC分类号： A61K31/455 , A61K9/0024 , A61L27/52 , A61P29/00 , A61L2400/06
摘要： Methods of use, formulations, and devices for delivering therapeutic drugs locally to the region of the spleen are described herein. A method for treating sepsis and other inflammatory disease conditions can include inserting a drug delivery system inside the body, advancing the device to the spleen through the splenic artery, splenic vein or other blood vessel adjacent to the splenic nerves, or within a ligament associated with the spleen, such as the splenorenal or gastrosplenic ligaments.
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公开(公告)号：US12029636B2
公开(公告)日：2024-07-09
申请号：US17902689
申请日：2022-09-02
发明人： Klearchos K. Papas
CPC分类号： A61F2/022 , A61L27/225 , A61L27/227 , A61L27/52 , A61L27/54 , A61F2220/0075
摘要： Systems featuring two or more encapsulation devices stacked together. The encapsulation devices house cells, such as but not limited to islet cells or stem cell derived beta cells or the like. e.g., for regulating blood glucose, or other cells or spheroids that can produce and release a therapeutic agent that is useful in the body, etc. The system may feature oxygen delivery, or in some cases no exogenous oxygen is delivered and vascularization of the device can help provide oxygen and other needed nutrient to the cells. The system of the present invention may be used in conjunction with other therapies such as an artificial pancreas. Stacking the devices with blood vessel formation around and in between them may allow for a decrease in the footprint that would be needed for implantation.
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公开(公告)号：US20240216583A1
公开(公告)日：2024-07-04
申请号：US18602655
申请日：2024-03-12
申请人： Poly-Med, Inc.
发明人： Michael Aaron Vaughn
CPC分类号： A61L27/52 , C08J3/075 , C08J3/246 , C08K5/20 , C08L33/26 , A61L2430/06 , C08F222/385 , C08J2433/02 , C08L2203/02
摘要： A double network hydrogel consists of a first network and a second network, where the first network is, or includes, a first polymer that is formed, at least in part, of —CH2—CH(OH)— units, and the second network is, or includes, a second polymer that is formed, at least in part, of carboxyl (COOH)-containing units or salts thereof, sulfonyl (SO3H)-containing units or salts thereof, and at least one of hydroxyl (OH)-containing units or amino (NH2)-containing units, where the hydrogel may be used as a cartilage replacement.
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公开(公告)号：US20240197963A1
公开(公告)日：2024-06-20
申请号：US18556311
申请日：2022-04-19
发明人： Yonghui DING , Cheng SUN , Guillermo AMEER
CPC分类号： A61L27/52 , A61L27/26 , A61L27/3804 , A61L27/54 , A61N5/062 , A61L2300/414 , A61L2300/62 , A61L2300/802 , A61N2005/0661
摘要： Provided herein are compositions and methods for 3D bioprinting of mechanically strong and biologically active scaffolds using emulsion bioink for the regeneration of a wide variety of tissues with biochemical functions (e.g., bone, tendon, ligament, cartilage, etc.).
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公开(公告)号：US20240197958A1
公开(公告)日：2024-06-20
申请号：US18286764
申请日：2021-12-26
CPC分类号： A61L27/34 , A61L27/46 , A61L27/52 , A61L27/56 , A61L27/58 , B33Y80/00 , C08L5/08 , A61L2430/02 , A61L2430/06
摘要： A polymer scaffold structure is created as a result of the proportional combination of β-Tricalcium Phosphate (β-TCP) that will increase the 3D and osteoconductive effect allowing/supporting cell infiltration by using extrusion deposition, in other words, added manufacturing process, and with physiological buffered HA solution with the Deep Coating Method and by increasing the transmission rate of growth factors as a result of coating and expanding their areas with the biological tissue implant, which allows its use with titanium mesh plates or contoured structures.
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