Abstract:
An apparatus includes a container, a needle, and an actuation assembly. The container contains a dose of a naloxone composition having a delivered volume of at least about 0.34 mL. The actuation assembly includes an energy storage member that produces a force on a movable member to move the needle and to deliver the dose of the naloxone composition. The 90% confidence interval of at least one of the relative mean maximum naloxone plasma concentration after dose delivery into the body (Cmax), time to reach the maximum naloxone plasma concentration (Tmax), area under the plasma concentration-time curve from pre-dose (time 0) extrapolated to infinity (AUC0-∞), or area under the plasma concentration-time curve from pre-dose (time 0) to the time of the last quantifiable concentration (Tlast) (AUC0-t) of the delivered dose to a delivered dose of a corresponding naloxone composition delivered via a manually-actuated syringe is within 80% to 125%.
Abstract:
An apparatus for discharging a dose of a fluid substance to an animal, the apparatus including: a delivery assembly adapted to discharge the dose of the substance to the animal; and a control system operatively associated with the delivery assembly so as to selectively operate the delivery assembly, wherein the control system is adapted to measure the discharge of the fluid substance from the delivery assembly such that the dose is discharged when the delivery assembly is operated.
Abstract:
The present invention uses an injection apparatus comprising: an injector which includes a mounting part on which a syringe is mounted, a needle assembly having a plurality of needles, a motor and a screw for actuating a piston of the syringe forward and backward; and a main body for controlling the forward and backward actuation of the piston of the syringe and drug injection. The present invention is configured as follows: a vacuum suction pressure is formed in the needle assembly that is in contact with the skin; injection is performed so that a drug is injected through a needle after it is determined that the needle is in close contact with the skin by comparing a sensed vacuum suction pressure value with a preset vacuum suction pressure value; and if injection is completed, the needle assembly is separated from the skin.
Abstract:
An injection system of the present invention comprises a needleless syringe; a transfer passage which connects a first space for accommodating a plurality of injection targets and a second space as a transfer destination of the plurality of injection targets, the transfer passage being installed with the needleless syringe so that an emission port of the needleless syringe is open at inside of the transfer passage; a detecting unit which is capable of detecting transfer through the transfer passage in order for the injection target existing in the first space to go toward the second space; and a control unit which performs emission of the injection objective substance from the emission port of the needleless syringe for every injection target in accordance with the transfer of the injection target, if the transfer of the injection target is detected by the detecting unit. Accordingly, the load exerted on an operator is mitigated as far as possible and the occurrence of various problems concerning the hygiene is suppressed when the injection is performed for a large number of the injection targets such as domestic animals or the like.
Abstract:
An apparatus includes a housing coupled to a medicament container, which is coupled to a needle. An injection assembly is disposed within the housing and includes an energy storage member and an actuation rod. A distal end portion of the actuation rod is disposed within the medicament container. The energy storage member can produce a force on a proximal end portion of the actuation rod sufficient to move the distal end portion of the actuation rod within the medicament container. This can convey at least a portion of a substance from the medicament container via the needle when a distal tip of the needle is disposed within a first region of a target location. The force is insufficient to move the distal end portion of the actuation rod within the medicament container when the distal tip of the needle is disposed within a second region of the target location.
Abstract:
An engine for an-auto injector for administering a dose of a liquid medicament includes a case arranged to be attached to a package syringe containing a syringe. The case contains a drive capable of, upon activation, pushing the needle from a covered position into an exposed position, and operating the syringe to supply the dose of medicament. The case contains a trigger arranged to lock the drive in a loaded state prior to manual operation and capable of, upon manual operation, releasing the drive for injections. The drive is arranged as a gas spring including a cylinder and a piston with a plunger for transmitting the spring force. A latch is arranged for preventing translating between the cylinder and the case. The latch is disengageable by the released gas spring being at least nearly fully extended thus allowing the extended gas spring to be translated in a distal direction.
Abstract:
A gas release cell for use with pneumatically actuated sharps-containing medical devices. The gas release cell has a rigid outer shell and a sealing membrane sealingly engaged with the rigid outer shell. A compressed propellant is retained within the gas release cell by the sealing membrane, and the sealing membrane is rupturable to actuate the medical device by releasing compressed propellant from the gas release cell.
Abstract:
Described herein are injection devices capable of automatically injecting substances into the soft tissue of a patient. The devices can inject low to high viscosity materials at predetermined, user selected injection rates, allowing the operator more control than a traditional syringe. The devices can allow mixing of more than one substance and/or reconstitution of a solid substance for injection. The injection devices described herein can allow the operator to easily inject one or more low to high viscosity liquid or gel soft-tissue augmentation fillers, one or more drugs, one or more other biocompatible materials, or combinations thereof.
Abstract:
Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.
Abstract:
An apparatus includes a medicament container, a first elastomeric member, a second elastomeric member and a stopper. The first and second elastomeric members are disposed within the medicament container. The first elastomeric member, a first portion of the medicament container and the second elastomeric member collectively define a medicament volume. The stopper is coupled to a distal end portion of the medicament container. The second elastomeric member, a second portion of the medicament container and the stopper collectively define a vent volume. A first retainer of the stopper is configured to engage a first portion of a carrier to limit movement of the medicament container when in a first position. A second retainer of the stopper is configured to engage a second portion of the carrier to limit movement of the medicament container when in a second position.