Method for producing α-amino acid including phosphorus and production intermediates thereof
    24.
    发明授权
    Method for producing α-amino acid including phosphorus and production intermediates thereof 有权
    包括磷的α-氨基酸的生产方法和生产中间体

    公开(公告)号:US07795464B2

    公开(公告)日:2010-09-14

    申请号:US12442011

    申请日:2007-09-19

    Abstract: A method for efficiently producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, useful as a herbicide, by a catalytic asymmetric synthesis reaction with a high asymmetric yield. The method includes a step in which a compound represented by the below formula (1) and a benzylamine are reacted in the presence of dehydrating agent, then the resulting mass is reacted with hydrogen cyanide in the presence of an asymmetric catalyst, followed by acid hydrolysis, further followed by elimination of a protective group. [chemical formula 1] (1) (where, R1 represents a C1-4 alkyl group).

    Abstract translation: 通过具有高不对称产率的催化不对称合成反应有效生产可用作除草剂的L-2-氨基-4-(羟甲基氧膦基) - 丁酸的方法。 该方法包括在脱水剂的存在下使由下式(1)表示的化合物和苄胺反应的步骤,然后将所得物质与氰化氢在不对称催化剂的存在下反应,随后进行酸水解 ,然后除去保护基。 [化学式1](1)(其中,R1表示C1-4烷基)。

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