公开(公告)号：US20050123777A1

公开(公告)日：2005-06-09

申请号：US10507437

申请日：2003-03-11

Applicant: Juha Maijala ,  Johan Gron ,  Kaisa Putkisto ,  Vilho Nissinen ,  Pentti Rautiainen

Inventor： Juha Maijala ,  Johan Gron ,  Kaisa Putkisto ,  Vilho Nissinen ,  Pentti Rautiainen

IPC: B05B5/08 ,  B05B5/14 ,  B05D1/00 ,  B05D1/04 ,  B05D1/06 ,  B05D1/40 ,  B05D3/02 ,  B05D3/12 ,  B05D7/04 ,  D21H23/50 ,  D21H23/64 ,  D21H25/08 ,  B32B15/04 ,  H05C1/00

CPC classification number: B05B5/087 ,  B05B5/14 ,  B05D1/007 ,  B05D1/045 ,  B05D1/06 ,  B05D1/40 ,  B05D3/0254 ,  B05D3/12 ,  B05D7/04 ,  B05D2201/00 ,  B05D2252/02 ,  B05D2252/10 ,  B05D2401/32 ,  D21H23/50 ,  D21H23/64 ,  D21H25/08 ,  Y10T428/31678

Abstract: A film is formed on a planar surface by applying a granular layer on the planar surface by using electrostatic forces, and then finishing the granular layer to form the film. A converting line may be rebuilt to have devices employing this method. A multilayer sheet-like product comprising a film layer may be produced.

Abstract translation: 通过使用静电力在平坦表面上施加颗粒层，然后在粒状层上形成薄膜，形成薄膜。 可以重建转换线以具有采用该方法的器件。 可以制造包含膜层的多层片状产品。

公开(公告)号：US06764720B2

公开(公告)日：2004-07-20

申请号：US09858865

申请日：2001-05-16

Applicant: David Y.H. Pui ,  Da-Ren Chen

Inventor： David Y.H. Pui ,  Da-Ren Chen

IPC: B05D104

CPC classification number: B05B5/032 ,  A61F2/86 ,  B05B1/14 ,  B05B5/025 ,  B05B5/0255 ,  B05B5/08 ,  B05B5/087 ,  B05B7/0408 ,  B05B7/066 ,  B05B13/06

Abstract: Spraying apparatus and methods that employ multiple nozzle structures for producing multiple sprays of particles, e.g., nanoparticles, for various applications, e.g., pharmaceuticals, are provided. For example, an electrospray dispensing device may include a plurality of nozzle structures, wherein each nozzle structure is separated from adjacent nozzle structures by an internozzle distance. Sprays of particles are established from the nozzle structures by creating a nonuniform electrical field between the nozzle structures and an electrode electrically isolated therefrom.

Abstract translation: 提供了使用多个喷嘴结构来产生多种喷雾剂的喷涂设备和方法，例如纳米颗粒，用于各种应用，例如药物。 例如，电喷雾分配装置可以包括多个喷嘴结构，其中每个喷嘴结构通过内部喷嘴距离与相邻的喷嘴结构分开。 通过在喷嘴结构和与其电隔离的电极之间产生不均匀的电场，从喷嘴结构建立颗粒喷雾。

公开(公告)号：US06746869B2

公开(公告)日：2004-06-08

申请号：US10162031

申请日：2002-06-03

Applicant: David Y. H. Pui ,  Da-Ren Chen

Inventor： David Y. H. Pui ,  Da-Ren Chen

IPC: C12N1588

CPC classification number: B01J2/006 ,  A61K39/00 ,  A61K48/00 ,  B01J2/04 ,  B01J2219/00371 ,  B01J2219/00436 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/081 ,  B05B5/082 ,  B05B5/084 ,  B05B5/087 ,  B05B13/04 ,  C12M35/02 ,  C12N15/8207 ,  C12N15/87 ,  C12N15/895

Abstract: An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A spray of microdroplets suspending at least the particles is established forward of the spray dispenser end by creating a nonuniform electrical field between the spray dispenser end and an electrode electrically isolated therefrom. The particles are coated with at least a portion of the coating material as the microdroplet evaporates. For example, the suspension may include biological material particles.

公开(公告)号：US06743463B2

公开(公告)日：2004-06-01

申请号：US10109073

申请日：2002-03-28

Applicant: Jan Weber ,  Gordon John Kocur

Inventor： Jan Weber ,  Gordon John Kocur

IPC: A61L2700

CPC classification number: B05B5/087 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  B05B5/12 ,  B05D1/045

Abstract: A method for electrostatic spray-coating a medical device having a tubular wall, such as a stent, having an inner surface, an outer surface and openings therein. The tubular wall is grounded or electrically charged, and an electrically charged conductive core wire is located axially through the center of the stent. An electrical potential is applied to the conductive core wire to impart an electrical charge to the conductive core wire. The tubular wall is exposed to an electrically charged coating formulation, and the electrically charged coating formulation is deposited onto a portion of the tubular wall to form a coating. The electrical potentials of the conductive core wire and tubular wall can be repeatedly alternated.

公开(公告)号：US06592671B2

公开(公告)日：2003-07-15

申请号：US09769227

申请日：2001-01-25

Applicant: Hoi Cheong Steve Sun ,  Bogdan Brycki

Inventor： Hoi Cheong Steve Sun ,  Bogdan Brycki

IPC: B05B500

CPC classification number: A61K9/2072 ,  A61K9/2095 ,  B01J19/0046 ,  B01J2219/00459 ,  B01J2219/00468 ,  B01J2219/005 ,  B01J2219/00648 ,  B01J2219/00659 ,  B05B5/032 ,  B05B5/08 ,  B05B5/084 ,  B05B5/087 ,  H01L21/6831 ,  H01L21/6838 ,  H02N13/00

Abstract: The disclosure relates to an apparatus for electrostatically adhering grains to a planar substrate comprising: a. an electrostatic chuck having a collection surface with at least one grain collection zone for, when the planar substrate is layered on the collection surface, electrostatically directing charged grains to a corresponding surface on the planar substrate; and b. a pattern of holes through the electrostatic chuck allowing a source of low pressure to act through the electrostatic chuck to adhere the planar substrate.

Abstract translation: 本发明涉及一种用于将晶粒静电粘附到平面基板上的装置，包括：a。 具有收集表面的静电卡盘，所述收集表面具有至少一个颗粒收集区，用于当所述平面基板层叠在所述收集表面上时，将带电粒子静电导向所述平面基板上的相应表面; 安布 穿过静电卡盘的孔的图案允许低压源通过静电卡盘作用以粘附平面基板。

公开(公告)号：US06433154B1

公开(公告)日：2002-08-13

申请号：US09085720

申请日：1998-05-27

Applicant: Darin B. Ostrander ,  Jessica A. Gorman

Inventor： Darin B. Ostrander ,  Jessica A. Gorman

IPC: C07N2104

CPC classification number: B01J2/006 ,  A61K39/00 ,  A61K48/00 ,  B01J2/04 ,  B01J2219/00371 ,  B01J2219/00436 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/081 ,  B05B5/082 ,  B05B5/084 ,  B05B5/087 ,  B05B13/04 ,  C12M35/02 ,  C12N15/8207 ,  C12N15/87 ,  C12N15/895

Abstract: A functional mammalian growth factor receptor/yeast histidine kinase chimera in Saccharomyces cerevisiae. In a preferred embodiment, the extracellular domain of the human epidermal growth factor receptor has been fused to the intracellular kinase domain of the SLN1 gene. The SLN1 gene encodes the plasma membrane sensor kinase of the yeast high osmolarity/glycerol response MAP kinase pathway. The chimeric protein is almost completely nonfunctional because the EGFR ECD is not capable of dimerization in the absence of ligand. In the presence of ligand, however, the chimeric kinase is activated and phosphorylation through the pathway is quantitatively repressed. This measure of pathway activity can be utilized to identify agonists and antagonists of the EGFR and other tyrosine kinase growth factor receptors in yeast cells.

Abstract translation: 酿酒酵母中的功能性哺乳动物生长因子受体/酵母组氨酸激酶嵌合体。 在优选的实施方案中，人表皮生长因子受体的细胞外结构域已融合到SLN1基因的细胞内激酶结构域。 SLN1基因编码酵母高渗透压/甘油反应MAP激酶途径的质膜感受激酶。 嵌合蛋白几乎是完全无功能的，因为在不存在配体的情况下，EGFR ECD不能二聚化。 然而，在配体存在下，嵌合激酶被激活，并且通过该途径的磷酸化被定量地抑制。 该途径活性的测量可用于鉴定酵母细胞中EGFR和其他酪氨酸激酶生长因子受体的激动剂和拮抗剂。

公开(公告)号：US06399362B1

公开(公告)日：2002-06-04

申请号：US09577747

申请日：2000-05-23

Applicant: David Y. H. Pui ,  Da-Ren Chen

Inventor： David Y. H. Pui ,  Da-Ren Chen

IPC: C12M142

CPC classification number: B01J2/006 ,  A61K39/00 ,  A61K48/00 ,  B01J2/04 ,  B01J2219/00371 ,  B01J2219/00436 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/081 ,  B05B5/082 ,  B05B5/084 ,  B05B5/087 ,  B05B13/04 ,  C12M35/02 ,  C12N15/8207 ,  C12N15/87 ,  C12N15/895

Abstract: A method of introducing biological material into cells includes providing one or more target cells and establishing a spray of substantially dispersed particles including biological material. The substantially dispersed particles have an electrical charge applied thereto such that one or,more of the substantially dispersed particles of the spray is introduced into one or more of the target cells. The spray of substantially dispersed particles may be established by dispensing a spray of microdroplets suspending particles. The electrical charge is concentrated on the suspended particles as the microdroplet evaporates. The suspended particles may include carrier particles with biological material or the suspended particles may be particles of biological material alone. The space charge effect of the concentrated electrical charge on the substantially dispersed particles of the spray enable one or more of the particles to be introduced into one or more of the target cells. An apparatus for introducing biological material into one or more target cells includes a biological material source including at least biological material and a dispensing device operably connected to the biological material source to receive biological material therefrom. The dispensing device provides a spray of substantially dispersed particles of at least the biological material with the spray of substantially dispersed particles having an electrical charge applied thereto.

Abstract translation: 将生物材料引入细胞的方法包括提供一个或多个靶细胞并建立包括生物材料的基本上分散的颗粒的喷雾。 基本上分散的颗粒具有施加到其上的电荷，使得喷雾的一个或多个基本上分散的颗粒被引入到一个或多个靶细胞中。 基本上分散的颗粒的喷雾可以通过分配微滴悬浮颗粒的喷雾来建立。 当微滴蒸发时，电荷集中在悬浮颗粒上。 悬浮颗粒可以包括具有生物材料的载体颗粒，或悬浮颗粒可以是单独的生物材料颗粒。 浓缩电荷对基本分散的喷雾颗粒的空间电荷效应使得一个或多个颗粒被引入到一个或多个靶细胞中。 用于将生物材料引入一个或多个靶细胞的装置包括至少包括生物材料的生物材料源和可操作地连接到生物材料源以从其接收生物材料的分配装置。 分配装置提供至少具有生物材料的基本分散的颗粒的喷雾，其中施加有电荷的基本分散的颗粒的喷雾。

公开(公告)号：US06294024B1

公开(公告)日：2001-09-25

申请号：US09175287

申请日：1998-10-20

Applicant: Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

Inventor： Hoi Cheong Steve Sun ,  Timothy Allen Pletcher

IPC: B05C1904

CPC classification number: B05B5/087 ,  A61K9/2086 ,  A61K9/2893 ,  B01J2219/00468 ,  B05B5/08 ,  B05B5/082 ,  H02N13/00 ,  Y10T428/2991

Abstract: The present invention is directed to electrostatic chucks, methods for their use, the electrostatic deposition of objects, such as particles in a dry powder, onto recipient substrates, and the recipient substrates themselves that have been subjected to electrostatic deposition. In one aspect, the present invention provides an electrostatic chuck for electrostatically attracting an object or objects wherein the object is used in chemical or pharmaceutical assaying or manufacturing. The objects can be pharmaceutical substrates, for example, such as a pharmaceutical tablet. Additional embodiments of the invention provide chucks and their use to electrostatically attract particles, such as a pharmaceutically active ingredient, to a substrate, such as a tablet. In one aspect, the electrostatic chuck comprises a floating electrode, and is used to selectively attract particles to a substrate above the floating electrode, thereby providing for charge imaging for the deposition of particles in a selected image. Additionally, the invention provides comprising a sensing electrode, optionally for use with an electrostatic chuck, for sensing the number of particles attracted to the objects on the chuck or other substrate, thereby providing for deposition of an accurate amount of particles. Furthermore, the present invention provides objects having selected areas in which particles are applied to the object via electrostatic means.

Abstract translation: 本发明涉及静电卡盘，它们的使用方法，诸如干粉末中的物体的静电沉积到受体基底上，以及已经经过静电沉积的受体底物本身。 一方面，本发明提供一种用于静电吸引物体的静电吸盘，其中该物体用于化学或药物测定或制造。 物体可以是药物底物，例如药物片剂。 本发明的另外的实施方案提供了卡盘及其用于静电吸引诸如药物活性成分的颗粒到底物例如片剂。 一方面，静电卡盘包括浮动电极，并且用于选择性地将颗粒吸引到浮动电极上方的衬底上，从而为选定图像中的颗粒沉积提供电荷成像。 另外，本发明提供了包括感测电极，可选地与静电卡盘一起使用，用于感测吸附到卡盘或其它基底上的物体的颗粒的数量，从而提供精确量的颗粒的沉积。 此外，本发明提供了具有通过静电装置将颗粒施加到物体的选择区域的物体。

公开(公告)号：US06280524B1

公开(公告)日：2001-08-28

申请号：US09366910

申请日：1999-08-04

Applicant: Shieh-Hsien Lin ,  Jen-Yun Huang ,  Lung-Tsai Kuang

Inventor： Shieh-Hsien Lin ,  Jen-Yun Huang ,  Lung-Tsai Kuang

IPC: B05C502

CPC classification number: B05B5/087 ,  B05B14/10 ,  B05D1/045 ,  B05D1/08 ,  Y02P70/36

Abstract: An apparatus for electrostatically coating powder on a flat panel and a method for using such apparatus are provided. In the apparatus, a heating device is used to heat a panel to be coated and positioned on a powder spray chamber to a temperature of at least 100° C. and simultaneously charging the panel with a negative voltage of at least 20,000 volts. The high temperature and the high voltage of the otherwise non-conductive panel result in a panel that is electrostatically conductive. Powder particles that are charged with a high positive voltage are then injected toward the panel surface by an air pressure of at least 0.8 kg/cm2 until particles are adhered to the panel surface. The present invention novel method can be used advantageously at low costs due to its simple processing steps and as an environmentally friendly process since no solvent needs to be evaporated and released into the atmosphere. The present invention novel method further provides a low cost method for fabricating flat panel display devices due to its simplified processing steps.

Abstract translation: 提供了一种用于在平板上静电涂覆粉末的设备以及使用这种设备的方法。 在该装置中，加热装置用于将待涂覆的面板加热至粉末喷雾室至100℃的温度，同时以至少20,000伏的负电压对面板充电。 否则非导电面板的高温和高电压导致静电导电的面板。 然后，通过至少0.8kg / cm 2的空气压力将充满高正电压的粉末颗粒注入面板表面，直到颗粒粘附到面板表面。 本发明的新方法由于其简单的加工步骤和作为环境友好的方法可以以低成本有利地使用，因为不需要将溶剂蒸发并释放到大气中。 本发明的新方法由于其简化的处理步骤而进一步提供了一种用于制造平板显示装置的低成本方法。

公开(公告)号：US06093557A

公开(公告)日：2000-07-25

申请号：US92794

申请日：1998-06-05

Applicant: David Y. H. Pui ,  Da-Ren Chen

Inventor： David Y. H. Pui ,  Da-Ren Chen

IPC: A61K39/00 ,  A61K48/00 ,  B01J2/00 ,  B01J2/04 ,  B05B5/025 ,  B05B5/03 ,  B05B5/053 ,  B05B5/08 ,  C12M3/00 ,  C12N15/82 ,  C12N15/87 ,  C12N15/89 ,  C12N13/00

CPC classification number: B01J2/006 ,  B01J2/04 ,  B05B5/025 ,  B05B5/03 ,  B05B5/0533 ,  B05B5/081 ,  B05B5/082 ,  B05B5/084 ,  B05B5/087 ,  C12M35/02 ,  C12N15/8207 ,  C12N15/87 ,  C12N15/895 ,  A61K39/00 ,  A61K48/00 ,  B01J2219/00371 ,  B01J2219/00436 ,  B05B13/04

Abstract: A method of introducing biological material into cells includes providing one or more target cells and establishing a spray of substantially dispersed particles including biological material. The substantially dispersed particles have an electrical charge applied thereto such that one or more of the substantially dispersed particles of the spray is introduced into one or more of the target cells. The spray of substantially dispersed particles may be established by dispensing a spray of microdroplets suspending particles. The electrical charge is concentrated on the suspended particles as the microdroplet evaporates. The suspended particles may include carrier particles with biological material or the suspended particles may be particles of biological material alone. The space charge effect of the concentrated electrical charge on the substantially dispersed particles of the spray enable one or more of the particles to be introduced into one or more of the target cells.

Abstract translation: 将生物材料引入细胞的方法包括提供一个或多个靶细胞并建立包括生物材料的基本上分散的颗粒的喷雾。 基本上分散的颗粒具有施加到其上的电荷，使得一个或多个基本分散的喷雾颗粒被引入一个或多个靶细胞。 基本上分散的颗粒的喷雾可以通过分配微滴悬浮颗粒的喷雾来建立。 当微滴蒸发时，电荷集中在悬浮颗粒上。 悬浮颗粒可以包括具有生物材料的载体颗粒，或悬浮颗粒可以是单独的生物材料颗粒。 浓缩电荷对基本分散的喷雾颗粒的空间电荷效应使得一个或多个颗粒被引入到一个或多个靶细胞中。