公开(公告)号：US20180186840A1

公开(公告)日：2018-07-05

申请号：US15808237

申请日：2017-11-09

Applicant: President and Fellows of Harvard College

Inventor： Neel Satish Joshi ,  Peter Q. Nguyen ,  Zsofia Magarian

IPC: C07K14/245 ,  C07K14/21

CPC classification number: C07K14/245 ,  C07K14/21 ,  C07K2319/20 ,  C07K2319/735

Abstract: Described herein are methods and compositions relating to engineered curli fibers, e.g. CsgA polypeptide. In some embodiments, the methods and compositions described herein relate to functionalized biofilms.

公开(公告)号：US20180099997A1

公开(公告)日：2018-04-12

申请号：US15833814

申请日：2017-12-06

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Matthew WALDOR ,  Xiaohui ZHOU ,  Benjamin E. GEWURZ

IPC: C07K14/28 ,  A61K35/74 ,  A61K39/02

CPC classification number: C07K14/28 ,  A61K35/74 ,  A61K39/02 ,  C07K2319/00 ,  C07K2319/20 ,  C07K2319/31 ,  C07K2319/40 ,  C07K2319/50 ,  C07K2319/60

Abstract: Embodiments described are immunosuppressant therapeutics and compositions comprising a Vop protein derived from Vibro parahaemolyticus; and drug delivery vehicles derived from a V. parahaemolyticus expressing a mutant VopZ protein lacking amino acid residue 38-62.

公开(公告)号：US20180044442A1

公开(公告)日：2018-02-15

申请号：US15322411

申请日：2016-04-28

Applicant: NEWSOUTH INNOVATIONS PTY LIMITED

Inventor： John M WHITELOCK ,  Megan S LORD

IPC: C08B37/00 ,  C12P19/26 ,  A61K31/727 ,  C07K14/47

CPC classification number: C08B37/0075 ,  A61K31/727 ,  A61K38/00 ,  C07K14/4725 ,  C07K2319/02 ,  C07K2319/20 ,  C08B37/0003 ,  C12N2510/00 ,  C12N2510/02 ,  C12P19/26 ,  C12P21/005

Abstract: This present disclosure relates to a method of producing a proteoglycan having anticoagulant activity, comprising of and providing a cell transfected with a recombinant nucleic acid encoding a core protein having one or more glycosaminoglycan attachment sites; and incubating the cell under conditions to promote the production of a proteoglycan comprising the core protein linked to heparin and/or HS and optionally other glycosaminoglycan chains, and to heparin or heparan sulphate isolated from such proteoglycans that have significant anti-coagulant activity. The invention also relates to a recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate, to a cell capable of producing a proteoglycan comprising the core protein and heparin and/or heparan sulfate, and to a method of treating or preventing blood coagulation, or a condition associated with blood coagulation, using the recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate and/or the heparin and/or heparan sulfate isolated from such proteoglycans.

公开(公告)号：US20170335298A1

公开(公告)日：2017-11-23

申请号：US15673065

申请日：2017-08-09

Applicant: OZYMES ,  NATIONAL RESEARCH COUNCIL OF CANADA

Inventor： Kofi Abokitse ,  Peter C.K. Lau ,  Stephan Grosse

IPC: C12N9/18 ,  C12N9/16 ,  C11D7/50 ,  C11D3/39 ,  A23K20/189 ,  C11D3/386 ,  C09K8/582 ,  C07K19/00 ,  C12N9/96 ,  C11D3/43

CPC classification number: C12N9/18 ,  A23K20/189 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/036 ,  C07K2319/20 ,  C09K8/582 ,  C11D3/38636 ,  C11D3/38681 ,  C11D3/39 ,  C11D3/43 ,  C11D7/5004 ,  C12N9/16 ,  C12N9/96 ,  C12Y301/01074

Abstract: An isolated chimeric recombinant protein has cutinase activity. The protein includes a cutinase catalytic domain and a polymer binding domain operably linked by a proline/threonine-rich linker domain. The proline/threonine-rich linker domain includes at least 50% proline or threonine residues over a stretch of 15 to 55 consecutive amino acids.

公开(公告)号：US20170328886A1

公开(公告)日：2017-11-16

申请号：US15594131

申请日：2017-05-12

Applicant: ProteoThera, Inc. ,  Massachusetts Institute of Technology

Inventor： Parth PATWARI ,  Paul H. LIEBESNY ,  Alan J. GRODZINSKY

IPC: G01N33/50 ,  C07K14/47 ,  G01N33/60

CPC classification number: G01N33/502 ,  C07K14/47 ,  C07K14/65 ,  C07K2319/00 ,  C07K2319/20 ,  G01N33/5044 ,  G01N33/5088 ,  G01N33/60 ,  G01N2800/52

Abstract: Tools for characterizing uptake of therapeutic compounds by target tissue are disclosed along with methods for determining dosing regimen from the uptake parameters. Uptake parameters considered include partition coefficient, diffusivity, and equilibrium uptake ratio. Systems for determining partition coefficient and diffusivity in rapid uptake combinations of compounds and tissue are also reported.

公开(公告)号：US20170313747A1

公开(公告)日：2017-11-02

申请号：US15595415

申请日：2017-05-15

Applicant: Northwestern University

Inventor： Samuel I. Stupp ,  Yves Ruff

IPC: C07K14/00 ,  A61K31/713 ,  H01L51/00

CPC classification number: C07K14/001 ,  A61K31/713 ,  A61K47/60 ,  A61K47/64 ,  A61K47/6455 ,  A61K47/69 ,  C07K14/00 ,  C07K2319/20 ,  C07K2319/73 ,  H01L51/0093

Abstract: The present disclosure is directed to the preparation of nanostructures by the encapsulation of a charged compound with individual self-assembled unit nanostructures.

公开(公告)号：US20170296695A1

公开(公告)日：2017-10-19

申请号：US15504035

申请日：2016-04-05

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  NANO INTELLIGENT BIOMEDICAL ENGINEERING CORPORATION CO. LTD

Inventor： Yoon Jeong Park ,  Jin Sook Suh ,  Chong-Pyoung Chung ,  Jue-Yeon Lee ,  Yeonsu Kim

IPC: A61L27/04 ,  C07K19/00 ,  C07K7/08 ,  A61L27/00 ,  C07K7/00

CPC classification number: A61L27/04 ,  A61L27/00 ,  A61L27/306 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/404 ,  A61L2300/41 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/12 ,  C07K7/00 ,  C07K7/08 ,  C07K19/00 ,  C07K2319/00 ,  C07K2319/20

Abstract: The present invention relates to a peptide that binds specifically to the surface of zirconia, and more particularly, to a peptide conjugate obtained by linking a functional drug to the peptide so as to enable the drug to be securely fixed to the surface of zirconia to thereby maintain the activity of the drug over a long period of time. The zirconia-binding peptide according to the present invention can be securely fixed to the surface of zirconia so that the activity of a physiologically active substance introduced into the peptide can be maintained on the zirconia surface over a long period of time. Thus, the zirconia-binding peptide is useful for surgical regenerative treatment.

公开(公告)号：US09719120B2

公开(公告)日：2017-08-01

申请号：US14460938

申请日：2014-08-15

Applicant: NOVOZYMES A/S ,  NOVOZYMES NORTH AMERICA, INC.

Inventor： Shiro Fukuyama ,  Tomoko Matsui ,  Chee Leong Soong ,  Eric Allain ,  Anders Vikso Nielsen ,  Hiroaki Udagawa ,  Ye Liu ,  Junxin Duan ,  Wenping Wu ,  Lene Nonboe Andersen

IPC: C12P19/14 ,  C12P7/14 ,  C12P19/00 ,  C12P7/08 ,  C12P19/04 ,  C12P19/02 ,  C12N9/26 ,  C07H21/04 ,  C07K1/00 ,  C12N9/28 ,  C12N9/34 ,  C12N9/96 ,  C12N9/30 ,  C12P7/10

CPC classification number: C12P19/14 ,  C07K2319/00 ,  C07K2319/20 ,  C12N9/2414 ,  C12N9/2417 ,  C12N9/242 ,  C12N9/2428 ,  C12N9/96 ,  C12P7/10 ,  C12P7/14 ,  C12P19/02 ,  C12Y302/01001 ,  C12Y302/01003 ,  Y02E50/16

Abstract: The present invention relates to polypeptides comprising a carbohydrate-binding module amino acid sequence and an alpha-amylase amino acid sequence as well as to the application of such polypeptides.

公开(公告)号：US20170166619A1

公开(公告)日：2017-06-15

申请号：US15530271

申请日：2016-12-16

Applicant: Morphoplant GmbH

Inventor： Herbert P. Jennissen

IPC: C07K14/51

CPC classification number: C07K14/51 ,  A61K47/542 ,  C07K14/001 ,  C07K17/00 ,  C07K2319/20

Abstract: The invention relates to a method for producing a polypeptide which is modified with an organic group, wherein a bioactive polypeptide is covalently bound to an organic group that comprises a backbone structure having aromatic side chains, thereby forming a modified polypeptide which is constituted of the bioactive polypeptide and the group having aromatic side chains. At least one of the aromatic side chains of the group is subjected to chemical or enzymatic hydroxylation.

公开(公告)号：US20170143765A1

公开(公告)日：2017-05-25

申请号：US15419729

申请日：2017-01-30

Applicant: The Regents of the University of California

Inventor： Chia-Yung Wu ,  James Onuffer ,  Wendell A. Lim

IPC: A61K35/17 ,  C07K16/18 ,  C07K14/725 ,  C12N5/0783 ,  C07K16/28 ,  C07K14/705

CPC classification number: A61K35/17 ,  A61K47/6891 ,  A61K2039/505 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/2803 ,  C07K16/2866 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/33 ,  C07K2319/74 ,  C12N5/0636 ,  C12N9/14 ,  C12N9/90 ,  C12N2510/00 ,  C12Y502/01008

Abstract: The present disclosure provides a heterodimeric, conditionally active chimeric antigen receptor (CAR), and a nucleic acid comprising a nucleotide sequence encoding the CAR. The present disclosure provides cells genetically modified to produce the CAR. A CAR of the present disclosure can be used in various methods, which are also provided.